Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions

A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and a slight blue-shift in fluorescence in the presence of zinc; however, a decrease in relaxation rate was observed. Consequently, the ability of the well-known zinc chelator, BPEN, was assessed for relaxivity response when conjugated to the gadolinium chelate. The success of this probe [GdL2], lead to the inclusion of the same zinc-probing moiety alongside a longer wavelength emitting fluorophore, rhodamine [GdL3], to arrive at the final iteration of these first generation dual-modal zinc-sensing probes. The compounds give insight into the design protocols required for the successful imaging of zinc ions

Dynamic Optimization of Nitrogen Use in Agriculture

Agricultural production is highly dependent on inorganic substances including fertilizers. High-yielding crop varieties, such as corn, require large amounts of primary nutrients including nitrogen, phosphorus and potassium. Farmers often add a surplus of nutrients to crops to maximize yields. Utilization of primary nutrients has increased by more than 300% while that of nitrogen alone has increased by more than 600% between 1960 and 2007 (USDA, 2009). From 1964 to 2007, the use of nitrogen in the corn sector alone increased from 1,623,000 to 5,714,000 nutrient tons (USDA, 2009). While increasing production, increased fertilizer use can potentially create negative externalities in the form of nitrate-nitrogen contamination in groundwater. Groundwater is the source of drinking water for about half the total U.S. population and nearly all of the rural population, and it provides over 50 billion gallons per day for agricultural needs (USGS, 2009). In the U.S. the main source of nitrate pollution in the groundwater results from the actions of farmers through the use of fertilizers and other chemicals (Haller, et al. 2009). Nitrogen-nitrate contamination can have adverse human affects including methemoglobinemia or ―blue-baby‖ syndrome (Majumdar, 2003). The potential for nitrate contamination in corn production is especially problematic as corn alone accounts for over 90% of feed grains produced in the U.S. (USDA, 2009). The USDA estimates that approximately 80 million acres of land is planted to corn, with the majority in the Heartland region (the Midwest) of the U.S. (2009). The Heartland region is primarily rural and much of the population there derives its drinking water from groundwater. Therefore, the potential for groundwater contamination is greatly increased in this region.Environmental Economics, Nitrogen/Nitrate Contamination, Dynamic Optimization, Agriculture, Agricultural and Food Policy, Demand and Price Analysis, Environmental Economics and Policy, C61, C63, Q10, Q51, Q53,

Dynamic Optimization of Nitrogen Use in Agriculture

Agricultural and Food Policy, Crop Production/Industries,

Intellectual Property Laws in Harmony with NAFTA: The Courts as Mediators Between the Global and the Local

This paper will argue that domestic courts can pro- vide a forum within which to mediate between these two extremes, to reconcile the ‘‘global’’ and the ‘‘local’’ — but that the courts themselves must adapt to meet the challenges that globalization places upon them. More specifically, the paper begins by setting out a framework for understanding harmonization of laws under NAFTA as one that encourages rather than eliminates diversity of law. The paper then studies the prevailing approaches to statutory interpretation that Canadian courts, most especially the Supreme Court of Canada and the Federal Court of Appeal, have been employing in deciding IP cases in a post-NAFTA environment to determine whether any or all of these approaches could effectively balance the ‘‘global’’ and the ‘‘local’’. This analysis is intended as a starting point for further inquiry about the role of domestic judicial decision-making in an era increasingly marked by an impetus towards the global harmonization of laws

Intellectual Property Laws in Harmony with NAFTA: The Courts as Mediators Between the Global and the Local

This paper will argue that domestic courts can pro- vide a forum within which to mediate between these two extremes, to reconcile the ‘‘global’’ and the ‘‘local’’ — but that the courts themselves must adapt to meet the challenges that globalization places upon them. More specifically, the paper begins by setting out a framework for understanding harmonization of laws under NAFTA as one that encourages rather than eliminates diversity of law. The paper then studies the prevailing approaches to statutory interpretation that Canadian courts, most especially the Supreme Court of Canada and the Federal Court of Appeal, have been employing in deciding IP cases in a post-NAFTA environment to determine whether any or all of these approaches could effectively balance the ‘‘global’’ and the ‘‘local’’. This analysis is intended as a starting point for further inquiry about the role of domestic judicial decision-making in an era increasingly marked by an impetus towards the global harmonization of laws

Tectonics and volcanism of Eastern Aphrodite Terra: No subduction, no spreading

Eastern Aphrodite Terra is approximately equal in size to the western North American Cordillera, from Mexico to Alaska. Its size and unique landforms make it an important area for understanding the tectonics of Venus, yet models for its formation are diametrically opposed. This region is part of the Equatorial Highlands, which was proposed as a region of lithospheric thinning, isostatic uplift, and attendant volcanism. Eastern Aphrodite Terra is dominated by circular structures within which deformation and volcanism are intimately related. These structures are marked by radial and concentric fractures, and volcanic flows that emanate from a central vent, as well as from concentric fracture sets. Cross-cutting relations between flows and concentric fracture sets indicate that outer concentric fracture sets are younger than inner fracture sets. The circular structures are joined by regional northeast- to east-trending fractures that dominantly postdate formation of the circular structures. We propose that the circular structures 'grow' outward with time. Although these structures probably represent addition of crust to the lithosphere, they do not represent significant lithospheric spreading or convergence, and the region does not mark the boundary between two distinct tectonic plates. This region is not easily explained by analogy with either terrestrial midocean rifts or subduction zones. It is perhaps best explained by upwelling of magma diapirs that blister the surface, but do not cause significant lithospheric spreading. Further study of the structural and volcanic evolution of this region using Magellan altimetry and SAR data should lead to better understanding of the tectonic evolution of this region

Dynamics of rapidly spinning blob-filaments: fluid theory with a parallel kinetic extension

Blob-filaments (or simply 'blobs') are coherent structures formed by turbulence and sustained by nonlinear processes in the edge and scrape-off layer (SOL) of tokamaks and other magnetically confined plasmas. The dynamics of these blob-filaments, in particular their radial motion, can influence the scrape-off layer width and plasma interactions with both the divertor target and with the main chamber walls. Motivated by recent results from the XGC1 gyrokinetic simulation code reported on elsewhere [J. Cheng et al. submitted to Nucl. Fusion and available at arXiv:2302.02877v1], a theory of rapidly spinning blob-filaments has been developed. The theory treats blob filaments in the closed flux surface region or the region that is disconnected from sheaths in the SOL. It extends previous work by treating blob spin, arising from partially or fully adiabatic electrons, as the leading order effect and retaining inertial (ion charge polarization) physics in next order. Spin helps to maintain blob coherency and affects the blob's propagation speed. Dipole charge polarization, treated perturbatively, gives rise to blob-filaments with relatively slow radial velocity, comparable to that observed in the simulations. The theory also treats the interaction of rapidly spinning blob filaments with a zonal flow layer. It is shown analytically that the flow layer can act like a transport barrier for these structures. Finally parallel electron kinetic effects are incorporated into the theory. Various asymptotic parameter regimes are discussed and asymptotic expressions for the radial and poloidal motion of the blob-filaments are obtained.Comment: 31 pages, 2 figures, accepted in the journal Physics of Plasmas 30, 072302 (2023

An evaluation of low volume high-intensity intermittent training (HIIT) for health risk reduction in overweight and obese men

Abstract ᅟ Both sprint interval training (SIT) and high-intensity intermittent training (HIIT) have been described as time-efficient strategies for inducing favourable metabolic and cardiorespiratory adaptations in healthy and diseased participants. Background To date, little attention has been given to profiling the potential health benefits of HIIT or modified HIIT training within overweight and obese cohorts with particular focus on inflammation. Within this pilot trial, we tested the hypothesis that 6 sessions of HIIT performed over 2 weeks with 1–2 days’ rest would improve aerobic capacity, glucose metabolism and inflammatory profile in an overweight and obese male cohort. Additionally, we profiled the potential health benefits of 4 HIIT sessions performed over the same period. Methods 18 overweight or obese males (BMI = 31.2 ± 3.6; V̇O2 = 30.3 ± 4.4 ml.kg.min-1) were studied before and 72 h after HIIT. Training sessions consisted of 10 x 1 min intervals at 90% HRpeak separated by 1 min recovery periods. Exercise was performed either 6 (group 1, n = 8) or 4 (group 2, n = 10) times over a 2 week period. Results After training no changes were detected from baseline for body composition, aerobic capacity, glucose metabolism or inflammatory profile (p > 0.05) in either group. Conclusion Both 6 and 4 sessions of HIIT performed over a 2-week period are ineffective in improving selected health markers within an overweight and obese cohort. Trial registration This trial reports data from human participants and was retrospectively registered on 22/02/2017 with the ISRCTN registry, trial number ISRCTN90672085

Preliminary Analysis: Impacts of the $8.50 Minimum Wage on Santa Fe Businesses, Workers and the Santa Fe Economy (Revised)

This is the preliminary analysis of data relating to the impacts of the $8.50 minimum wage mandated by the Living Wage Ordinance on Santa Fe workers, businesses and the Santa Fe economy. The final report will include a more complete analysis of data collected under this first phase of the research project and a statistical analysis of microdata available after the beginning of 2006