Changing Circulation Structure and Precipitation Characteristics in Asian Monsoon Regions: Greenhouse Warming vs. Aerosol Effects

Using model outputs from CMIP5 historical integrations, we have investigated the relative roles of anthropogenic emissions of greenhouse gases (GHG) and aerosols in changing the characteristics of the large-scale circulation and rainfall in Asian summer monsoon (ASM) regions. Under GHG warming, a strong positive trend in low-level moist static energy (MSE) is found over ASM regions, associated with increasing large-scale land-sea thermal contrast from 1870's to present. During the same period, a mid tropospheric convective barrier (MCB) due to widespread reduction in relative humidity in the mid- and lower troposphere is strengthening over the ASM regions, in conjunction with expanding areas of anomalous subsidence associated with the Deep Tropical Squeeze (DTS) [Lau and Kim, 2015]. The opposing effects of MSE and MCB lead to enhanced total ASM rainfall, but only a partial strengthening of the southern portion of the monsoon meridional circulation, coupled to anomalous multi-cellar overturning motions over ASM land. Including anthropogenic aerosol emissions strongly masks MSE but enhances MCB via increased stability in the lower troposphere, resulting in an overall weakened ASM circulation with suppressed rainfall. Rainfall characteristics analyses indicate that under GHG, overall precipitation efficiency over the ASM region is reduced, manifesting in less moderate but more extreme heavy rain events. Under combined effects of GHG and aerosols, precipitation efficiency is unchanged, with more moderate, but less extreme rainfall

Neutrino Oscillations and Lepton Flavor Mixing

In view of the recent announcement on non-zero neutrino mass from Super-Kamiokande experiment, it would be very timely to investigate all the possible scenarios on masses and mixings of light neutrinos. Recently suggested mass matrix texture for the quark CKM mixing, which can be originated from the family permutation symmetry and its suitable breakings, is assumed for the neutrino mass matrix and determined by the four combinations of solar, atmospheric and LSND neutrino data and cosmological hot dark matter bound as input constraints. The charged-lepton mass matrix is assumed to be diagonal so that the neutrino mixing matrix can be identified directly as the lepton flavor mixing matrix and no CP invariance violation originates from the leptonic sector. The results favor hierarchical patterns for the neutrino masses, which follow from the case when either solar-atmospheric data or solar-HDM constraints are used.Comment: Latex, 9 page

Azimuthal Correlation in Lepton-Hadron Scattering via Charged Weak-Current Processes

We consider the azimuthal correlation of the final-state particles in charged weak-current processes. This correlation provides a test of perturbative quantum chromodynamics. The azimuthal asymmetry is large in the semi-inclusive processes in which we identify a final-state hadron, say, a charged pion compared to that in the inclusive processes in which we do not identify final-state particles and use only the calorimetric information. In semi-inclusive processes the azimuthal asymmetry is more conspicuous when the incident lepton is an antineutrino or a positron than when the incident lepton is a neutrino or an electron. We analyze all the possible charged weak-current processes and study the quantitative aspects of each process. We also compare this result to the ep scattering with a photon exchange.Comment: 25 pages, 2 Postscript figures, uses RevTeX, fixes.st

Midweek Increase in U.S. Summer Rain and Storm Heights, Suggests Air Pollution Invigorates Rainstorms

Tropical Rainfall Measuring Mission (TRMM) satellite data show a significant midweek increase in summertime rainfall over the southeast U.S., due to afternoon intensification. TRMM radar data show a significant midweek increase in rain area and in the heights reached by afternoon storms. Weekly variations in model-reanalysis wind patterns over the region and in rain-gauge data are consistent with the satellite data. A midweek decrease of rainfall over the nearby Atlantic is also seen. EPA measurements of particulate concentrations show a midweek peak over much of the U.S. These observations are consistent with the theory that anthropogenic air pollution suppresses cloud-drop coalescence and early rainout during the growth of thunderstorms over land, allowing more water to be carried above the 0 C isotherm, where freezing yields additional latent heat, invigorating the storms--most dramatically evidenced by the shift in the midweek distribution of afternoon-storm heights--and producing large ice hydrometeors. The enhanced convection induces regional convergence, uplifting and an overall increase of rainfall. Compensating downward air motion suppresses convection over the adjacent ocean areas. Pre-TRMM-era data suggest that the weekly cycle only became strong enough to be detectable beginning in the 1980's. Rain-gauge data also suggest that a weekly cycle may have been detectable in the 1940's, but with peak rainfall on Sunday or Monday, possibly explained by the difference in composition of aerosol pollution at that time. This "weekend effect" may thus offer climate researchers an opportunity to study the regional climate-scale impact of aerosols on storm development and monsoon-like circulation

On the Divergence-Free Condition in Godunov-Type Schemes for Ideal Magnetohydrodynamics: the Upwind Constrained Transport Method

We present a general framework to design Godunov-type schemes for multidimensional ideal magnetohydrodynamic (MHD) systems, having the divergence-free relation and the related properties of the magnetic field B as built-in conditions. Our approach mostly relies on the 'Constrained Transport' (CT) discretization technique for the magnetic field components, originally developed for the linear induction equation, which assures div(B)=0 and its preservation in time to within machine accuracy in a finite-volume setting. We show that the CT formalism, when fully exploited, can be used as a general guideline to design the reconstruction procedures of the B vector field, to adapt standard upwind procedures for the momentum and energy equations, avoiding the onset of numerical monopoles of O(1) size, and to formulate approximate Riemann solvers for the induction equation. This general framework will be named here 'Upwind Constrained Transport' (UCT). To demonstrate the versatility of our method, we apply it to a variety of schemes, which are finally validated numerically and compared: a novel implementation for the MHD case of the second order Roe-type positive scheme by Liu and Lax (J. Comp. Fluid Dynam. 5, 133, 1996), and both the second and third order versions of a central-type MHD scheme presented by Londrillo and Del Zanna (Astrophys. J. 530, 508, 2000), where the basic UCT strategies have been first outlined

Actin-dependent intranuclear repositioning of an active gene locus in vivo

Although bulk chromatin is thought to have limited mobility within the interphase eukaryotic nucleus, directed long-distance chromosome movements are not unknown. Cajal bodies (CBs) are nuclear suborganelles that nonrandomly associate with small nuclear RNA (snRNA) and histone gene loci in human cells during interphase. However, the mechanism responsible for this association is uncertain. In this study, we present an experimental system to probe the dynamic interplay of CBs with a U2 snRNA target gene locus during transcriptional activation in living cells. Simultaneous four-dimensional tracking of CBs and U2 genes reveals that target loci are recruited toward relatively stably positioned CBs by long-range chromosomal motion. In the presence of a dominant-negative mutant of β-actin, the repositioning of activated U2 genes is markedly inhibited. This supports a model in which nuclear actin is required for these rapid, long-range chromosomal movements

Telomeric Overhang Length Determines Structural Dynamics and Accessibility to Telomerase and ALT-Associated Proteins

SummaryThe G-rich single-stranded DNA at the 3′ end of human telomeres can self-fold into G-quaduplex (GQ). However, telomere lengthening by telomerase or the recombination-based alternative lengthening of telomere (ALT) mechanism requires protein loading on the overhang. Using single-molecule fluorescence spectroscopy, we discovered that lengthening the telomeric overhang also increased the rate of dynamic exchanges between structural conformations. Overhangs with five to seven TTAGGG repeats, compared with four repeats, showed much greater dynamics and accessibility to telomerase binding and activity and loading of the ALT-associated proteins RAD51, WRN, and BLM. Although the eight repeats are highly dynamic, they can fold into two GQs, which limited protein accessibility. In contrast, the telomere-specific protein POT1 is unique in that it binds independently of repeat number. Our results suggest that the telomeric overhang length and dynamics may contribute to the regulation of telomere extension via telomerase action and the ALT mechanism

Inpatient Antipsychotic Drug Use in 1998, 1993, and 1989

OBJECTIVE: Patterns of clinical use of antipsychotic agents have changed greatly in the past decade. The authors’ goal was to examine these patterns. METHOD: They evaluated medication use in all McLean Hospital inpatients treated with antipsychotic drugs during 3 months in 1998 (N=349) and compared the results with McLean Hospital inpatients treated with antipsychotics in 1993 (N=299) and Boston area inpatients in 1989 (N=50). RESULTS: The most commonly prescribed antipsychotics in 1998 were atypical agents; olanzapine was prescribed more often than risperidone or quetiapine, which were prescribed more often than other antipsychotics. Two or more antipsychotics were prescribed at some time during their hospitalization for 150 (43%) of the patients in 1998. The total discharge dose in chlorpromazine equivalents for the 349 patients for whom antipsychotics were prescribed at discharge was 371 mg/day, 29% higher than the total discharge dose for patients in 1993 and 46% greater than the dose in 1989. The dose of antipsychotics was greater for patients with psychotic illnesses than for those with affective illnesses. Higher doses were associated with greater clinical improvement, polypharmacotherapy, and younger patient age. CONCLUSIONS: Emerging trends toward higher total antipsychotic doses and polypharmacotherapy require critical assessments of cost-benefit relationships

Molecular architecture of transcription factor hotspots in early adipogenesis

SummaryTranscription factors have recently been shown to colocalize in hotspot regions of the genome, which are further clustered into super-enhancers. However, the detailed molecular organization of transcription factors at hotspot regions is poorly defined. Here, we have used digital genomic footprinting to precisely define factor localization at a genome-wide level during the early phase of 3T3-L1 adipocyte differentiation, which allows us to obtain detailed molecular insight into how transcription factors target hotspots. We demonstrate the formation of ATF-C/EBP heterodimers at a composite motif on chromatin, and we suggest that this may be a general mechanism for integrating external signals on chromatin. Furthermore, we find evidence of extensive recruitment of transcription factors to hotspots through alternative mechanisms not involving their known motifs and demonstrate that these alternative binding events are functionally important for hotspot formation and activity. Taken together, these findings provide a framework for understanding transcription factor cooperativity in hotspots