Absence of reflex vascular responses from the intrapulmonary circulation in anaesthetised dogs

The aim of this investigation was to determine whether reflex cardiovascular responses were obtained to localised distension of the intrapulmonary arterial and venous circulations in a preparation in which the stimuli to other major reflexogenic areas were controlled and the lung was shown to possess reflex activity. Dogs were anaesthetised with [alpha]-chloralose, artificially ventilated, the chests widely opened and a cardiopulmonary bypass established. The intrapulmonary region of the left lung was isolated and perfused through the left pulmonary artery and drained through cannulae in the left pulmonary veins via a Starling resistance. Intrapulmonary arterial and venous pressures were controlled by the rate of inflow of blood and the pressure applied to the Starling resistance. Pressures to the carotid, aortic and coronary baroreceptors and heart chambers were controlled. Responses of vascular resistance were assessed from changes in perfusion pressures to a vascularly isolated hind limb and to the remainder of the subdiaphragmatic circulation (flows constant). The reactivity of the preparation was demonstrated by observing decreases in vascular resistance to large step changes in carotid sinus pressure (systemic vascular resistance decreased by -40 ± 5 %), chemical stimulation of lung receptors by injection into the pulmonary circulation of veratridine or capsaicin (resistance decreased by -32 ± 4 %) and, in the four dogs tested, increasing pulmonary stroke volume to 450 ml (resistance decreased by -24 ± 6 %). However, despite this evidence that the lung was innervated, increases in intrapulmonary arterial pressure from 14 ± 1 to 43 ± 3 mmHg or in intrapulmonary venous pressure from 5 ± 2 to 34 ± 2 mmHg or both did not result in any consistent changes in systemic or limb vascular resistances. In two animals tested, however, there were marked decreases in efferent phrenic nerve activity. These results indicate that increases in pressure confined to the intrapulmonary arterial and venous circulations do not cause consistent reflex vascular responses, even though the preparation was shown to be reflexly active and the lung was shown to be innervated

Reflex responses from the main pulmonary artery and bifurcation in anaesthetised dogs

This study was undertaken to determine the reflex cardiovascular and respiratory responses to discrete stimulation of pulmonary arterial baroreceptors using a preparation in which secondary modulation of responses from other reflexes was prevented. Dogs were anaesthetised with [alpha]-chloralose, artificially ventilated, the chests widely opened and a cardiopulmonary bypass established. The main pulmonary arterial trunk, bifurcation and extrapulmonary arteries as far as the first lobar arteries on each side were vascularly isolated and perfused through the left pulmonary artery and drained via the right artery through a Starling resistance which controlled pulmonary arterial pressure. Pressures distending systemic baroreceptors and reflexogenic regions in the heart were controlled. Reflex vascular responses were assessed from changes in perfusion pressures to a vascularly isolated hind limb and to the remainder of the subdiaphragmatic systemic circulation, both of which were perfused at constant flows. Respiratory responses were assessed from recordings of efferent phrenic nerve activity. Increases in pulmonary arterial pressure consistently evoked increases in both perfusion pressures and in phrenic nerve activity. Both vascular and respiratory responses were obtained when pulmonary arterial pressure was increased to above about 30 mmHg. Responses increased at higher levels of pulmonary arterial pressures. In 13 dogs increases in pulmonary arterial pressure to 45 mmHg increased systemic perfusion pressure by 24 ± 7 mmHg (mean ± S.E.M.) from 162 ± 11 mmHg. Setting carotid sinus pressure at different levels did not influence the vascular response to changes in pulmonary arterial pressure. The presence of a negative intrathoracic pressure of -20 mmHg resulted in larger vascular responses being obtained at lower levels of pulmonary arterial pressure. This indicates that the reflex may be more effective in the intact closed-chest animal. These results demonstrate that stimulation of pulmonary arterial baroreceptors evokes a pressor reflex and augments respiratory drive. This reflex is likely to be elicited in circumstances where pulmonary arterial pressure increases and the negative excursions of intrathoracic pressure become greater. They are likely, therefore, to be involved in the cardio-respiratory response to exercise as well as in pathological states such as pulmonary hypertension or restrictive or obstructive lung disease

Blood mobilization from the liver of the anaesthetized dog

The abdominal circulation contains a high proportion of the total blood volume and this can change either passively in response to changes in vascular distending pressure or actively (termed a capacitance response) to changes in sympathetic nervous activity. The liver is the largest abdominal organ and this study was designed to evaluate its potential contribution to overall vascular capacitance and compliance. In chloralose anaesthetized dogs, the liver was vascularly isolated, perfused through the portal vein and hepatic artery at either constant pressures or constant flows and drained from the hepatic veins at constant pressure. Changes in vascular resistance were assessed from changes in inflow pressures or flows and hepatic blood volume was determined by differences between net inflow and outflow. During constant flow perfusion the change in hepatic volume (capacitance change) in response to supramaximal stimulation of sympathetic nerves at 16 Hz was (mean ± S.E.M.) -2·40 ± 0·61 ml (kg body weight)-1. This response was not significantly different during constant pressure perfusion. The changes in portal venous and hepatic arterial pressures during stimulation at constant flow perfusion were +0·67 ± 0·13 and +4·92 ± 0·67 kPa, respectively. The compliance of the liver, assessed as the change in volume to a change in hepatic venous pressure, was +5·44 ± 0·18 ml kg-1 kPa-1. These results indicate that the liver has a major capacitance role, comparable to that of the canine spleen and, in addition, is highly compliant. No evidence was found to suggest that a sphincter on the hepatic outflow exists. Assuming similar responses occur in humans, who do not possess a large contractile spleen, the liver would be the most important controllable blood reservoir in the body

Geometric Aspects of D-branes and T-duality

We explore the differential geometry of T-duality and D-branes. Because D-branes and RR-fields are properly described via K-theory, we discuss the (differential) K-theoretic generalization of T-duality and its application to the coupling of D-branes to RR-fields. This leads to a puzzle involving the transformation of the A-roof genera in the coupling.Comment: 26 pages, JHEP format, uses dcpic.sty; v2: references added, v3: minor change

A rigorous evaluation of crossover and mutation in genetic programming

The role of crossover and mutation in Genetic Programming (GP) has been the subject of much debate since the emergence of the field. In this paper, we contribute new empirical evidence to this argument using a rigorous and principled experimental method applied to six problems common in the GP literature. The approach tunes the algorithm parameters to enable a fair and objective comparison of two different GP algorithms, the first using a combination of crossover and reproduction, and secondly using a combination of mutation and reproduction. We find that crossover does not significantly outperform mutation on most of the problems examined. In addition, we demonstrate that the use of a straightforward Design of Experiments methodology is effective at tuning GP algorithm parameters

Crossover from 2-dimensional to 1-dimensional collective pinning in NbSe3

We have fabricated NbSe$_3$ structures with widths comparable to the Fukuyama-Lee-Rice phase-coherence length. For samples already in the 2-dimensional pinning limit, we observe a crossover from 2-dimensional to 1-dimensional collective pinning when the crystal width is less than 1.6 $\mu$m, corresponding to the phase-coherence length in this direction. Our results show that surface pinning is negligible in our samples, and provide a means to probe the dynamics of single domains giving access to a new regime in charge-density wave physics.Comment: 4 pages, 2 figures, and 1 table. Accepted for publication in Physical Review

Boundary States for Supertubes in Flat Spacetime and Godel Universe

We construct boundary states for supertubes in the flat spacetime. The T-dual objects of supertubes are moving spiral D1-branes (D-helices). Since we can obtain these D-helices from the usual D1-branes via null deformation, we can construct the boundary states for these moving D-helices in the covariant formalism. Using these boundary states, we calculate the vacuum amplitude between two supertubes in the closed string channel and read the open string spectrum via the open closed duality. We find there are critical values of the energy for on-shell open strings on the supertubes due to the non-trivial stringy correction. We also consider supertubes in the type IIA Godel universe in order to use them as probes of closed timelike curves. This universe is the T-dual of the maximally supersymmetric type IIB PP-wave background. Since the null deformations of D-branes are also allowed in this PP-wave, we can construct the boundary states for supertubes in the type IIA Godel universe in the same way. We obtain the open string spectrum on the supertube from the vacuum amplitude between supertubes. As a consequence, we find that the tachyonic instability of open strings on the supertube, which is the signal of closed time like curves, disappears due to the stringy correction.Comment: 26 pages, 3 figures, v2: explanations added, references added, v3: explanations adde

Counting Supertubes

The quantum states of the supertube are counted by directly quantizing the linearized Born-Infeld action near the round tube. The result is an entropy $S = 2\pi \sqrt{2 (Q_{D0}Q_{F1}-J)}$, in accord with conjectures in the literature. As a result, supertubes may be the generic D0-F1 bound state. Our approach also shows directly that supertubes are marginal bound states with a discrete spectrum. We also discuss the relation to recent suggestions of Mathur et al involving three-charge black holes.Comment: 15 pages, v2: reference corrected; v3: few corrections and explicit derivation of a relation are added to appendix

Relating branes and matrices

We construct a general map between a Dp-brane with magnetic flux and a matrix configuration of D0-branes, by showing how one can rewrite the boundary state of the Dp-brane in terms of its D0-brane constituents. This map gives a simple prescription for constructing the matrices of fuzzy spaces corresponding to branes of arbitrary shape and topology. Since we explicitly identify the D0-brane degrees of freedom on the brane, we also derive the D0-brane charge of the brane in a very direct way including the A-genus term. As a check on our formalism, we use our map to derive the abelian-Born-Infeld equations of motion from the action of the D0-brane matrices.Comment: 28 pages, Late

Avalanches and the Renormalization Group for Pinned Charge-Density Waves

The critical behavior of charge-density waves (CDWs) in the pinned phase is studied for applied fields increasing toward the threshold field, using recently developed renormalization group techniques and simulations of automaton models. Despite the existence of many metastable states in the pinned state of the CDW, the renormalization group treatment can be used successfully to find the divergences in the polarization and the correlation length, and, to first order in an $\epsilon = 4-d$ expansion, the diverging time scale. The automaton models studied are a charge-density wave model and a ``sandpile'' model with periodic boundary conditions; these models are found to have the same critical behavior, associated with diverging avalanche sizes. The numerical results for the polarization and the diverging length and time scales in dimensions $d=2,3$ are in agreement with the analytical treatment. These results clarify the connections between the behaviour above and below threshold: the characteristic correlation lengths on both sides of the transition diverge with different exponents. The scaling of the distribution of avalanches on the approach to threshold is found to be different for automaton and continuous-variable models.Comment: 29 pages, 11 postscript figures included, REVTEX v3.0 (dvi and PS files also available by anonymous ftp from external.nj.nec.com in directory /pub/alan/cdwfigs