19,341 research outputs found

    Predicting long-term prognosis in severe alcoholic hepatitis

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    Stimulated Raman scattering in an optical parametric oscillator based on periodically poled MgO-doped stoichiometric LiTaO3

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    The evolution versus pump power of the spectrum of a singly resonant optical parametric oscillator based on an MgO-doped periodically poled stoichiometric lithium tantalate crystal is observed. The onset of cascade Raman lasing due to stimulated Raman scattering in the nonlinear crystal is analyzed. Spurious frequency doubling and sum-frequency generation phenomena are observed and understood. A strong reduction of the intracavity Raman scattering is obtained by a careful adjustment of the cavity losses.Comment: 6 figure

    Identification of Cytotoxic Flavor Chemicals in Top-Selling Electronic Cigarette Refill Fluids.

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    We identified the most popular electronic cigarette (EC) refill fluids using an Internet survey and local and online sales information, quantified their flavor chemicals, and evaluated cytotoxicities of the fluids and flavor chemicals. "Berries/Fruits/Citrus" was the most popular EC refill fluid flavor category. Twenty popular EC refill fluids were purchased from local shops, and the ingredient flavor chemicals were identified and quantified by gas chromatography-mass spectrometry. Total flavor chemical concentrations ranged from 0.6 to 27.9 mg/ml, and in 95% of the fluids, total flavor concentration was greater than nicotine concentration. The 20 most popular refill fluids contained 99 quantifiable flavor chemicals; each refill fluid contained 22 to 47 flavor chemicals, most being esters. Some chemicals were found frequently, and several were present in most products. At a 1% concentration, 80% of the refill fluids were cytotoxic in the MTT assay. Six pure standards of the flavor chemicals found at the highest concentrations in the two most cytotoxic refill fluids were effective in the MTT assay, and ethyl maltol, which was in over 50% of the products, was the most cytotoxic. These data show that the cytotoxicity of some popular refill fluids can be attributed to their high concentrations of flavor chemicals

    Effects of grassland management on soil organic carbon density in agro-pastoral zone of Northern China

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    The objective of this study was to estimate the soil organic carbon (SOC) in grasslands with different management measures including: (1) uncontrolled or free grazing grassland (FG); (2) grassland enclosured, excluding grazing and mowing (EG); (3) grassland enclosured and mowed early in October every year (MG) and (4) grassland enclosured under controlled grazing (CG) by examining soil bulk density and SOC content from 0 to 50 cm soil depth in agro-pastoral ecotone, Northern China. The results showed that, by implementing CG, EG and MG practices, the grasslands in agro-pastoral ecotone of Northern China achieved higher SOC storage on decade scales when compared to FG field. CG field had the highest SOC density in 0 to 50 cm soil layer, while the least SOC density was displayed by FG. However, SOC density was similar between MG and EG plots. CG increased SOC concentration by 56.08% and SOC density by 4.96 kg/m2 when compared to FG practice. In addition, it was likely to give positive financial returns in providing livestock products when compared to EG practice. CG therefore was the most feasible and benign short-term grassland management option which could deposit even higher carbon dioxide in agro-pastoral ecotone in Northern China.Key words: Agro-pastoral zone, soil organic carbon density, grassland management, Northern China

    Sub-kHz-level relative stabilization of an intracavity doubled continuous wave optical parametric oscillator using Pound-Drever-Hall scheme

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    We report the relative frequency stabilization of an intracavity frequency doubled singly resonant optical parametric oscillator on a Fabry-Perot\'etalon. The red/orange radiation produced by the frequency doubling of the intracavity resonant idler is stabilized using the Pound-Drever-Hall locking technique. The relative frequency noise of this orange light, when integrated from 1 Hz to 50 kHz, corresponds to a standard deviation of 700 Hz. The frequency noise of the pump laser is shown experimentally to be transferred to the non resonant signal beam

    A Component-oriented Framework for Autonomous Agents

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    The design of a complex system warrants a compositional methodology, i.e., composing simple components to obtain a larger system that exhibits their collective behavior in a meaningful way. We propose an automaton-based paradigm for compositional design of such systems where an action is accompanied by one or more preferences. At run-time, these preferences provide a natural fallback mechanism for the component, while at design-time they can be used to reason about the behavior of the component in an uncertain physical world. Using structures that tell us how to compose preferences and actions, we can compose formal representations of individual components or agents to obtain a representation of the composed system. We extend Linear Temporal Logic with two unary connectives that reflect the compositional structure of the actions, and show how it can be used to diagnose undesired behavior by tracing the falsification of a specification back to one or more culpable components

    Mutation Symmetries in BPS Quiver Theories: Building the BPS Spectra

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    We study the basic features of BPS quiver mutations in 4D N=2\mathcal{N}=2 supersymmetric quantum field theory with G=ADEG=ADE gauge symmetries.\ We show, for these gauge symmetries, that there is an isotropy group GMutG\mathcal{G}_{Mut}^{G} associated to a set of quiver mutations capturing information about the BPS spectra. In the strong coupling limit, it is shown that BPS chambers correspond to finite and closed groupoid orbits with an isotropy symmetry group GstrongG\mathcal{G}_{strong}^{G} isomorphic to the discrete dihedral groups Dih2hGDih_{2h_{G}} contained in Coxeter(G)(G) with % h_{G} the Coxeter number of G. These isotropy symmetries allow to determine the BPS spectrum of the strong coupling chamber; and give another way to count the total number of BPS and anti-BPS states of N=2\mathcal{N}=2 gauge theories. We also build the matrix realization of these mutation groups GstrongG% \mathcal{G}_{strong}^{G} from which we read directly the electric-magnetic charges of the BPS and anti-BPS states of N=2\mathcal{N}=2 QFT4_{4} as well as their matrix intersections. We study as well the quiver mutation symmetries in the weak coupling limit and give their links with infinite Coxeter groups. We show amongst others that Gweaksu2\mathcal{G}_{weak}^{su_{2}} is contained in GL(2,Z){GL}({2,}\mathbb{Z}) ; and isomorphic to the infinite Coxeter I2∞{I_{2}^{\infty}}. Other issues such as building G\mathcal{G}%_{weak}^{so_{4}} and Gweaksu3\mathcal{G}_{weak}^{su_{3}} are also studied.Comment: LaTeX, 98 pages, 18 figures, Appendix I on groupoids adde

    A computational framework to emulate the human perspective in flow cytometric data analysis

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    Background: In recent years, intense research efforts have focused on developing methods for automated flow cytometric data analysis. However, while designing such applications, little or no attention has been paid to the human perspective that is absolutely central to the manual gating process of identifying and characterizing cell populations. In particular, the assumption of many common techniques that cell populations could be modeled reliably with pre-specified distributions may not hold true in real-life samples, which can have populations of arbitrary shapes and considerable inter-sample variation. <p/>Results: To address this, we developed a new framework flowScape for emulating certain key aspects of the human perspective in analyzing flow data, which we implemented in multiple steps. First, flowScape begins with creating a mathematically rigorous map of the high-dimensional flow data landscape based on dense and sparse regions defined by relative concentrations of events around modes. In the second step, these modal clusters are connected with a global hierarchical structure. This representation allows flowScape to perform ridgeline analysis for both traversing the landscape and isolating cell populations at different levels of resolution. Finally, we extended manual gating with a new capacity for constructing templates that can identify target populations in terms of their relative parameters, as opposed to the more commonly used absolute or physical parameters. This allows flowScape to apply such templates in batch mode for detecting the corresponding populations in a flexible, sample-specific manner. We also demonstrated different applications of our framework to flow data analysis and show its superiority over other analytical methods. <p/>Conclusions: The human perspective, built on top of intuition and experience, is a very important component of flow cytometric data analysis. By emulating some of its approaches and extending these with automation and rigor, flowScape provides a flexible and robust framework for computational cytomics
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