Strength Analysis of a Composite Turbine Blade Using Puck Failure Criteria

The strength analysis of an existing 5-meter composite wind turbine blade using Tsai- Wu and Puck failure criteria is presented. Finite element analysis is performed on the blade under static flap wise loading. ANSYS APDL scripting language is used to implement Puck failure criteria and degradation rules for the progressive failure analysis of the blade. Evaluation and visualization of Tsai-Wu inverse reserve factors and Puck failure exposures in the blade is done with the help of the Ansys ACP/Post module. The results of this study indicate that the blade is not able resist extreme load case and needs to be redesigned. Root and trailing edge of the blade have the highest risk of failure initiation. Linear analysis using Tsai-Wu and Puck failure criteria is compared with the nonlinear analysis using progressive Puck failure criteria. It is concluded that progressive analysis is necessary for a more realistic simulation of blade failure mechanisms. Results of the analysis will be used to calibrate structural test set-up of the blade

GADD45A (growth arrest and DNA-damage-inducible, alpha)

Review on GADD45A (growth arrest and DNA-damage-inducible, alpha), with data on DNA, on the protein encoded, and where the gene is implicated

YPEL3 (yippee-like 3 (Drosophila))

Short communication on YPEL3, with data on DNA/RNA, on the protein encoded and where the gene is implicated

YPEL5 (yippee-like 5 (Drosophila))

Review on YPEL5, with data on DNA/RNA, on the protein encoded and where the gene is implicated

CXXC5 (CXXC finger protein 5)

Review on CXXC5, with data on DNA/RNA, on the protein encoded and where the gene is implicated

The ligand-mediated nuclear mobility and interaction with estrogen-responsive elements of estrogen receptors are subtype specific

17 beta-Estradiol (E-2) plays important roles in functions of many tissues. E-2 effects are mediated by estrogen receptor (ER) alpha and beta. ERs regulate transcriptions through estrogen-responsive element (ERE)-dependent and ERE-independent modes of action. ER binding to ERE constitutes the basis of the ERE-dependent pathway. Direct/indirect ER interactions with transcription complexes define ERE-independent signaling. ERs share functional features. Ligand-bound ERs nevertheless induce distinct transcription profiles. Live cell imaging indicates a dynamic nature of gene expressions by highly mobile ERs. However, the relative contribution of ER mobility at the ERE-independent pathway to the overall kinetics of ER mobility remains undefined. We used fluorescent recovery after a photo-bleaching approach to assess the ligand-mediated mobilities of ERE binding-defective ERs, EREBD. The decrease in ER alpha mobility with E-2 or the selective ER modulator 4-hydroxyl-tamoxifen (4HT) was largely due to the interaction of the receptor with ERE. Thus, ER alpha bound to E-2 or 4HT mediates transcriptions from the ERE-independent pathway with remarkably fast kinetics that contributes fractionally to the overall motility of the receptor. The antagonist Imperial Chemical Industries 182 780 immobilized ER alpha s. The mobilities of ER beta and ER beta(EBD) in the presence of ligands were indistinguishable kinetically. Thus, ER beta mobility is independent of the nature of ligands and the mode of interaction with target sites. Chimeric ERs indicated that the carboxyl-termini are critical regions for subtype-specific mobility. Therefore, while ERs are highly mobile molecules interacting with target sites with fast kinetics, an indication of the hit-and-run model of transcription, they differ mechanistically to modulate transcriptions. Journal of Molecular Endocrinology (2012) 49, 249-26

MOAP1 (Modulator Of Apoptosis 1)

Short communication on MOAP1, with data on DNA/RNA, on the protein encoded and where the gene is implicated

CXXC5 as an unmethylated CpG dinucleotide binding protein contributes to estrogen-mediated cellular proliferation.

Evidence suggests that the CXXC type zinc finger (ZF-CXXC) protein 5 (CXXC5) is a critical regulator/integrator of various signaling pathways that include the estrogen (E2)-estrogen receptor α (ERα). Due to its ZF-CXXC domain, CXXC5 is considered to be a member of the ZF-CXXC family, which binds to unmethylated CpG dinucleotides of DNA and through enzymatic activities for DNA methylation and/or chromatin modifications generates a chromatin state critical for gene expressions. Structural/functional features of CXXC5 remain largely unknown. CXXC5, suggested as transcription and/or epigenetic factor, participates in cellular proliferation, differentiation, and death. To explore the role of CXXC5 in E2-ERα mediated cellular events, we verified by generating a recombinant protein that CXXC5 is indeed an unmethylated CpG binder. We uncovered that CXXC5, although lacks a transcription activation/repression function, participates in E2-driven cellular proliferation by modulating the expression of distinct and mutual genes also regulated by E2. Furthermore, we found that the overexpression of CXXC5, which correlates with mRNA and protein levels of ERα, associates with poor prognosis in ER-positive breast cancer patients. Thus, CXXC5 as an unmethylated CpG binder contributes to E2-mediated gene expressions that result in the regulation of cellular proliferation and may contribute to ER-positive breast cancer progression

The potential contribution of miRNA-200-3p to the fatty acid metabolism by regulating AjEHHADH during aestivation in sea cucumber

The sea cucumber (Apostichopus japonicus) has become a good model organism for studying environmentally-induced aestivation by a marine invertebrate more recently. In the present study, we hypothesized that miRNA-200-3p may contribute to establish rapid biological control to regulate fatty acid meta

The positive role of hope on the relationship between loneliness and unhappy conditions in Hungarian young adults: How pathways thinking matters!

In this study, we examined loneliness and hope components as predictors of unhappy conditions (viz., anxious symptoms, depressive symptoms, & suicidal ideation) in young adults. The sample was comprised of 489 Hungarian college students. Results of conducting hierarchical regression analyses indicated that loneliness and hope pathways (but not hope agency) were important unique predictors of anxious symptoms, depressive symptoms, and suicidal ideation. Moreover, in part, consistent with the notion that hope might buffer the negative effects of loneliness on unhappy conditions, evidence for a significant Loneliness × Hope Pathways interaction effect in predicting each of the three indices of unhappy conditions was found. In contrast, the Loneliness × Hope Agency interaction effect was not found to be significant. Some implications of the present findings for the study and treatment of unhappy conditions in adults are discussed