Performance assessment of pulse blanking mitigation in presence of multiple Distance Measuring Equipment/Tactical Air Navigation interference on Global Navigation Satellite Systems signals

It is known that the Aeronautical Radio Navigation Systems sharing the Global Navigation Satellite Systems (GNSS) frequency band represent a threat to the satellite-based navigation services. Distance Measuring Equipment (DME) and Tactical Air Navigation (TACAN) systems broadcast strong pulsed ranging signals within the Global Positioning System L5 and Galileo E5a frequency bands where the aviation positioning aids services are allocated. This study provides an experimental assessment of the DME/TACAN interference effect on the GNSS receivers performance in scenarios where the presence of several transmitters in view generates radio-frequency interference hard to mitigate by means of the classical solutions. In detail, analysis in terms of the receiver performance will be presented by showing the effect of the non-ideal pulse blanking on the GNSS signal quality. The optimal set-up of the mitigation process, investigated by means of a software simulation, is provided

Identification of DC thermal steady-state differential inductance of ferrite power inductors

In this paper, we propose a method for the identification of the differential inductance of saturable ferrite inductors adopted in DC–DC converters, considering the influence of the operating temperature. The inductor temperature rise is caused mainly by its losses, neglecting the heating contribution by the other components forming the converter layout. When the ohmic losses caused by the average current represent the principal portion of the inductor power losses, the steady-state temperature of the component can be related to the average current value. Under this assumption, usual for saturable inductors in DC–DC converters, the presented experimental setup and characterization method allow identifying a DC thermal steady-state differential inductance profile of a ferrite inductor. The curve is obtained from experimental measurements of the inductor voltage and current waveforms, at different average current values, that lead the component to operate from the linear region of the magnetization curve up to the saturation. The obtained inductance profile can be adopted to simulate the current waveform of a saturable inductor in a DC–DC converter, providing accurate results under a wide range of switching frequency, input voltage, duty cycle, and out-put current values

Progress on the hybrid gun project at UCLA

UCLA/INFN-LNF/Univ. Rome has been developing the hybrid gun which has an RF gun and a short linac for velocity bunching in one structure. After the cavity was manufactured at INFN-LNF in 2012, tests of the gun was carried out at UCLA. The field in the standing wave part was 20 % smaller than the simulation but the phase advance was fine. The cavity was commissioned successfully up to 13 MW. The beam test was performed at 11.5 MW and demonstrated the bunch compression

The free-electron laser harmonic cascade

Free-electron laser (FEL) devices based on a sequence of amplifiers with a harmonic relation between the resonant frequencies of each section have been proposed to extend to shorter wavelengths the FEL operating range. Because of the practical limit on the tunability of undulator magnets, the e-beam energy still represents the main constraint on the shortest reachable wavelength of the cascade. In this paper, we propose a scheme where the undulators of the cascade are tuned at different, not-harmonic, fundamental frequencies having instead one of the higher order harmonics at a common frequency. A short and intense seed pulse in such a system creates a superradiant pulse which harmonically seeds the following undulator at the common multiple frequency. The microbunching at the higher harmonic in the second undulator is enhanced by the modulation of the previous undulator so that lasing at shorter wavelengths may be obtained with a relatively low-energy electron beam

Expanded Endoscopic Approach for Anterior Skull Base Tumors: Experience of a Multidisciplinary Skull Base Team

Abstract: The aim of this study is to describe the experience of a multidisciplinary skull base team with transnasal endoscopic surgery for anterior cranial base tumors. A retrospective chart review was conducted on patients who underwent an exclusive expanded transnasal approach to the anterior skull base in the period from December 2014 to November 2015. Data on patient demographics, tumor characteristics, surgical information, imaging, and postoperative complications were collected and analyzed. From a total of 120 patients with skull base diseases managed by the skull base team, 36 were admitted to this study. The overall complication rate in this series was 16.7%, gross total resection was achieved in 32 cases (88.9%) and postoperative CSF leakage occurred in 5 cases (13.9%). Our preliminary results confirm that an exclusive endoscopic transnasal approach to the anterior cranial base

Insights into the G-rich VEGF-binding aptamer V7t1: when two G-quadruplexes are better than one!

The G-quadruplex-forming VEGF-binding aptamer V7t1 was previously found to be highly polymorphic in a K+-containing solution and, to restrict its conformational preferences to a unique, well-defined form, modified nucleotides (LNA and/or UNA) were inserted in its sequence. We here report an in-depth biophysical characterization of V7t1 in a Na+-rich medium, mimicking the extracellular environment in which VEGF targeting should occur, carried out combining several techniques to analyse the conformational behaviour of the aptamer and its binding to the protein. Our results demonstrate that, in the presence of high Na+ concentrations, V7t1 behaves in a very different way if subjected or not to annealing procedures, as evidenced by native gel electrophoresis, size exclusion chromatography and dynamic light scattering analysis. Indeed, not-annealed V7t1 forms both monomeric and dimeric G-quadruplexes, while the annealed oligonucleotide is a monomeric species. Remarkably, only the dimeric aptamer efficiently binds VEGF, showing higher affinity for the protein compared to the monomeric species. These findings provide new precious information for the development of improved V7t1 analogues, allowing more efficient binding to the cancer-related protein and the design of effective biosensors or theranostic devices based on VEGF targeting