La trombosi venosa profonda in gravidanza: caso clinico

Sulle base di un caso clinico di recente giunto alla nostra osservazione abbiamo ritenuto di esporre le linee guida più attuali per la prevenzione e il trattamento delle TVP in gravidanza. Il tromboembolismo venoso in gravidanza e nel puerperio rimane la maggior causa di mortalità e morbilità. La gravidanza, infatti, rappresenta di per sé una predisposizione alla TVP. Fattori di rischio specifici possono essere identificati prima o durante la gravidanza ed il parto. Grazie all’introduzione di nuove strategie diagnostiche tipo l’EcoColor-Doppler ed il dosaggio del D-dimero plasmatico è possibile prevenire la trombosi venosa profonda ed evitare le complicanze tromboemboliche. L’elasto-compressione degli arti inferiori e il trattamento farmacologico con EBPM rappresentano nei soggetti a rischio un buon protocollo di prevenzion

Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of <i>Candida</i> Skin Infections

The increasing development of resistance of Candida species to traditional drugs represents a great challenge to the medical field for the treatment of skin infections. Essential oils were recently proposed to increase drug effectiveness. Herein, we developed and optimized (23 full factorial design) Mediterranean essential oil (Rosmarinus officinalis, Lavandula x intermedia &#8220;Sumian&#8222;, Origanum vulgare subsp. hirtum) lipid nanoparticles for clotrimazole delivery, exploring the potential synergistic effects against Candida spp. Small sized nanoparticles (&lt;100 nm) with a very broad size distribution (PDI &lt; 0.15) and long-term stability were successfully prepared. Results of the in vitro biosafety on HaCaT (normal cell line) and A431 (tumoral cell line), allowed us to select Lavandula and Rosmarinus as anti-proliferative agents with the potential to be used as co-adjuvants in the treatment of non-tumoral proliferative dermal diseases. Results of calorimetric studies on biomembrane models, confirmed the potential antimicrobial activity of the selected oils due to their interaction with membrane permeabilization. Nanoparticles provided a prolonged in vitro release of clotrimazole. In vitro studies against Candida albicans, Candida krusei and Candida parapsilosis, showed an increase of the antifungal activity of clotrimazole-loaded nanoparticles prepared with Lavandula or Rosmarinus, thus confirming nanostructured lipid carriers (NLC) containing Mediterranean essential oils represent a promising strategy to improve drug effectiveness against topical candidiasis

Anatomia umana. Fondamenti. Con istituzioni di istologia. Con e-book. Con espansione online

Una presentazione degli argomenti semplice e completa e una trattazione chiara e rigorosa sono le caratteristiche salienti di quest’opera che conduce all’apprendimento dell’Anatomia umana, modulando la materia attraverso diversi livelli di approfondimento, secondo necessità o interessi dello studente. Le nozioni fondamentali sono presentate in maniera esaustiva e stimolante dal punto di vista grafico, sempre con il supporto di schemi di sintesi, nelle colonne a lato del testo, per facilitare lo studio e il ripasso degli argomenti. Un ampio apparato iconografico si integra con il testo, tramite immagini, disegni e grafici che favoriscono un apprendimento visivo. Sommari e tabelle riassuntive aprono la trattazione dei diversi argomenti, per visualizzare i punti cardine fondamentali. Testi in corpo minore affrontano la trattazione più approfondita di argomenti, quali nozioni di anatomia topografica, vascolarizzazione e innervazione, morfologia microscopica, anatomia funzionale e anatomia clinica. Nell’area web: Esercizi di autovalutazione; Flash card, immagini mute e con leggende per guidare al riconoscimento delle strutture anatomiche; Accesso alla versione digitale del libro

The impact of UEFA Euro 2020 football championship on Takotsubo Syndrome: Results of a multicenter national registry

ObjectivesThe UEFA 2020 European Football Championship held in multiple cities across Europe from June 11 to July 11, 2021, was won by Italy, providing an opportunity to examine the relationship between emotional stress and the incidence of acute cardiovascular events (ACE). Methods and resultsCardiovascular hospitalizations in the Cardiac Care Units of 49 hospital networks in Italy were assessed by emergency physicians during the UEFA Euro 2020 Football Championship. We compared the events that occurred during matches involving Italy with events that occurred during the remaining days of the championship as the control period. ACE was assessed in 1,235 patients. ACE during the UEFA Euro 2020 Football Championship semifinal and final, the most stressful matches ended with penalties and victory of the Italian team, were assessed. A significant increase in the incidence of Takotsubo Syndrome (TTS) by a factor of 11.41 (1.6-495.1, P < 0.003), as compared with the control period, was demonstrated during the semifinal and final, whereas no differences were found in the incidence of ACS [IRR 0.93(0.74-1.18), P = 0.57]. No differences in the incidence of ACS [IRR 0.98 (0.87-1.11; P = 0.80)] or TTS [IRR 1.66(0.80-3.4), P = 0.14] were found in the entire period including all matches of the UEFA Euro 2020 compared to the control period. ConclusionsThe data of this national registry demonstrated an association between the semifinal and final of UEFA Euro 2020 and TTS suggesting that it can be triggered by also positive emotions such as the victory in the European Football Championship finals

Data_Sheet_1_The impact of UEFA Euro 2020 football championship on Takotsubo Syndrome: Results of a multicenter national registry.PDF

ObjectivesThe UEFA 2020 European Football Championship held in multiple cities across Europe from June 11 to July 11, 2021, was won by Italy, providing an opportunity to examine the relationship between emotional stress and the incidence of acute cardiovascular events (ACE).Methods and resultsCardiovascular hospitalizations in the Cardiac Care Units of 49 hospital networks in Italy were assessed by emergency physicians during the UEFA Euro 2020 Football Championship. We compared the events that occurred during matches involving Italy with events that occurred during the remaining days of the championship as the control period. ACE was assessed in 1,235 patients. ACE during the UEFA Euro 2020 Football Championship semifinal and final, the most stressful matches ended with penalties and victory of the Italian team, were assessed. A significant increase in the incidence of Takotsubo Syndrome (TTS) by a factor of 11.41 (1.6–495.1, P ConclusionsThe data of this national registry demonstrated an association between the semifinal and final of UEFA Euro 2020 and TTS suggesting that it can be triggered by also positive emotions such as the victory in the European Football Championship finals.</p