Bioactive molecule prediction using extreme gradient boosting

Following the explosive growth in chemical and biological data, the shift from traditional methods of drug discovery to computer-aided means has made data mining and machine learning methods integral parts of today's drug discovery process. In this paper, extreme gradient boosting (Xgboost), which is an ensemble of Classification and Regression Tree (CART) and a variant of the Gradient Boosting Machine, was investigated for the prediction of biological activity based on quantitative description of the compound's molecular structure. Seven datasets, well known in the literature were used in this paper and experimental results show that Xgboost can outperform machine learning algorithms like Random Forest (RF), Support Vector Machines (LSVM), Radial Basis Function Neural Network (RBFN) and Naïve Bayes (NB) for the prediction of biological activities. In addition to its ability to detect minority activity classes in highly imbalanced datasets, it showed remarkable performance on both high and low diversity datasets

A survey on drug related problems in cervical cancer patients receiving chemotherapy in Ahmadu Bello University Teaching Hospital Zaria

A drug-related problem (DRP) is an event or circumstance involving drug therapy that actually or potentially interferes with desired outcome. The complexities in drug regimens used in cervical cancer chemotherapy has led to more serious problems. The aim of this study is to investigate DRPs in cervical cancer patients receiving chemotherapy. The study was a retrospective cross sectional study on patients receiving cervical cancer chemotherapy at Ahmadu Bello University Teaching Hospital Zaria (ABUTH). Patients’ medication charts were reviewed from July, 2015 to June, 2016. Data were collected using the Pharmaceutical Care Network Europe (PCNE) Classification of DRP V 6.20. A total of 224 DRPs cases were identified from 65 cervical cancer patients. The DRPs were mostly on treatment effectiveness (28.1%), adverse reaction (29.0%), and cost (26.8%), while the causes were majorly drug selection (28.1%) and dose selection (29.0%). The risk factors for the DRPs were found to be comorbidities and polypharmacy. In conclusion, DRPs were common among cervical cancer patients receiving chemotherapy at ABUTH. Pharmacist interventions to achieve a better therapeutic outcome are necessary.Keywords: Cervical cancer, chemotherapy, drug related problem, pharmacist, polypharmac

Analysis of Agricultural Extension Methods Used by Extension Workers for Conflict Resolution among Agro – Pastoralists in Adamawa State, Nigeria

The study was conducted to analyze the agricultural extension methods used in conflict resolution among agro – pastoralists in Adamawa State, Nigeria. A multi – stage random sampling technique was used to select 160 respondents who were administered interview schedules. Data were analyzed using descriptive statistics (frequencies and percentages) statistics and inferential (multiple regression) statistics. The study indicated that livestock destruction of farmlands was the major (50.63%) source of conflict among the respondents. The results revealed that the major (55.0%) source of conflict resolution among the respondents was community leaders in conflict resolutions. The study showed that truce was the most important type of conflict resolution used by respondents (59.38%). Majority (82.5%) of the respondents preferred face to face extension contact methods used for learning conflict resolution. All the positive significant relationship at 5% levels indicated that, an increase in each of these extension methods is likely to increase in conflict resolutions among agro – pastoralists. The study recommended that extension working environment should be strengthened with motivational mechanism to achieve the desired impact on conflict resolution among agro – pastoralists in the study area. Key words: Sources of conflict, Conflict Resolution and Agro – Pastoralists, Adamawa State, Nigeri

GPU-based multiple back propagation for big data problems

The big data era has become known for its abundance in rapidly generated data of varying formats and sizes. With this awareness, interest in data analytics and more specifically predictive analytics has received increased attention lately. However, the massive sample sizes and high dimensionality peculiar with these datasets has challenged the overall performance of one of the most important components of predictive analytics of our present time, Machine Learning. Given that dimensionality reduction has been heavily applied to the problems of high dimensionality, this work presents an improved scheme of GPU based Multiple Back Propagation (MBP) with feature selection for big high dimensional data problems. Elastic Net was used for automatic feature selection of high dimensional biomedical datasets before classification with GPU based MBP and experimental results show an improved performance over the previous scheme with MBP

Phytochemical analysis, analgesic and antipyretic properties of ethanolic leaf extract of Vernonia amygdalina Del.

Introduction: Vernonia amygdalina Del. has been traditionally used in relieving pain and inflammatory conditions as well as in treatment of feverish conditions by local people of the North-east Nigeria. Consequently this study aims at evaluating the phytochemical content, antipyretic and analgesic properties of V. amygdalina (biter leaf).Methods: The leaf of V. amygdalina was soxhlet extracted with ethanol and sequentially partitioned using solvent of different polarities. Phytochemical test was conducted to ascertain the secondary metabolites present in the extract using standard procedures. Acute toxicity (LD50) of the extract on laboratory rats was estimated by following protocols of Lorke. The antinociceptive activity of the ethanolic extract was also evaluated using acetic acid induced pain and hot plate method.Results: The results revealed the presence of tannins, phlobatannins, saponins, carbohydrates, cardioactive glycoside, flavonoids, alkaloids, steroids and terpenes. Anthraquinones were absent in the extract. The intraperitoneal LD50 was found to be 3721 mg/kg. On administration of 5000 mg/kg dose of the extract via oral route, there was no dead. The extract demonstrated significant antinociceptive activities as 36.0 ± 0.81, 43.8 ± 0.11 and 52.8±0.37 (Mean number of writhings) respectively for the doses 600, 400 and 200 mg/kg i.p.) as compared to the control (60.0 ± 0.11). High dose of 400 mg/kg significantly reduced rectal temperature (P < 0.05)Conclusion: These results demonstrated the medicinal potentiality of V. amygdalina and might be used as analgesic, and antipyretic agent. Phytochemicals found in such as flavonoids, tannins, alkaloids and steroids seem to be implicated in having such pharmacological activities

ABSORBED DOSE RATES ABOVE SOILS AND ROCK OUTCROPS IN SELECTED AREAS OF ABEOKUTA, NIGERIA

Outdoor absorbed dose rates were measured in selected areas of Abeokuta in Nigeria; some with rock outcrops and others with soil overburden. Measurements were carried out using a Geiger Muller Survey Meter and a Global Positioning System (GPS). Result shows absorbed dose rates ranged from 1.0 x 103 to 1.3 x 103 nGy/hr among the rock outcrop areas and from 0.6 x 103 to 0.8 x 103 nGy/hr among the soil -covered areas. The average absorbed dose rate was 1180 ±3 nGy/hr for the rock outcrop areas and 689 ±3 nGy/hr for the soil -covered areas and assuming 0.4 occupancy factor, the corresponding average annual effective dose rates were calculated to be 2.89 ± 0.01 mSv/yr for the rock outcrop areas and 1.69 ± 0.01 mSv/yr for the soil –covered areas based on occupancy factor of 0.4. The mean annual effective dose rates for both the rock outcrop and soil covered areas were  found to be higher than 1mSv/yr, the recommended dose limit for the public.     &nbsp

MEASUREMENT OF RADIATION DOSE IN SELECTED CEMENT STORES IN ABEOKUTA, OGUN STATE, USING GM SURVEY METER

Measurements were carried out using a Geiger Muller Survey Meter and a Global Positioning System (GPS) to find  the outdoor absorbed dose rates in selected cement stores in Abeokuta, Ogun State, Nigeria. The outdoor  absorbed dose rates  (control sites 10m away from cement depot) ranged from 400 nGy/hr) (Sapon) to 740 nGy/hr (Adatan) with the mean 554.7 ± 0.08 nGy/hr  and the indoor absorbed dose rate (store) ranged from 740 nGy/hr  (Lafenwa1&2) to 1240 nGy/hr (Isale-Ake) with the mean 909.3 ± 16 nGy/hr. The corresponding annual effective dose rates for the control sites ranged from 1.13 mSv/yr (sapon) to 2.09 mSv/yr (Adatan) with the mean 1.57 ± 0.32  mSv/yr, while it ranged from 2.45 mSv/yr (Lafenwa1&2) to 4.11 mSv/yr (Isale ake) for the cement depots  with the mean 3.01 ± 0.52 mSv/yr. It has been revealed from this study that cement may enhance exposure to radiation, since the value of the absorbed dose rates in the stores are higher than thoseof the control sites. The values for the annual effective dose calculated are higher than 1mSv/yr. &nbsp

SERUM IMMUNOGLOBULIN PROFILE OF Trypanosoma congolense - INFECTED SHEEP IN RELATION TO PARASITAEMIA AND CHANGES IN CIRCULATING LEUCOCYTE AND ERYTHROCYTE MASS

Trypanosomiasis is a major problem in developing countries most especially Africa and the incriminating agents are T. congolense, T.vivax. T.brucei in small ruminants. It has high morbity  and mortality Rates of 70% and 20% respectively . The experimental animals were four Rams which were used as control and infected group, Parameters for this experiment were recorded before infection. Following inoculation with T.congolense, 2 mls of blood was collected from the sheep in vacutainers for serum biochemical assay. Enzyme linked immunosorbent assay was used to assay IGG and IGM concentrations and 1ml of blood was collected in vacutainers with anti coagulant to check leucocytic and erythrocytic index.This was done every day until day 6 and then every other day. Clinical signs observed post infection were , Anemia, Hematuria ,Rhinitis, dyspnea ,emaciation and paralysis of the fore and hind limbs and death .Statistical tables and charts were used for analyses. The  role of   Hypoprotenemia , IGG and IGM  in experimental infection with Trypanosoma congolense   were looked at. The anemia was Normocytic normochromic and later became Microcytic hypochromic, PCV Recorded on the first day prior to infection was 27%  and on the last day of  infection became 6% . Leucocytosis was Degenerative and Leucopenia was also observed Perhaps due to the antigenic nature of the parasite. On first day WBC count was 8.5 x109/L and Prior to death Leucocytosis of 6.1x 109 /L. Hypoproteneimia was also seen with Blood urea Nitrogen and Alanine aminotransferase falling to values below normal 55U/L and 155mg/dl respectively. There were also fluctuations in the values of IGG and IGM  with initial values of 1.4 and 0.71 µg/ML  and terminal values of 0.34 and 0.21 /L. The organs looked at Kidneys,Lungs,Heart and Liver were all in their initial stages of destruction , they were inflamed,edematous , congested and necrotic . Hypoprotenemia, , immune suppression,dyspnea ,Anemia and Leucopenia  may be the cause of death in Trypanosomiasis. Keywords:Leucopenea,Anemia,Trypanosoma,immunogobuins,Hypoprotenemia DOI: 10.7176/JBAH/11-6-06 Publication date:March 31st 202

Dittrichia graveolens (L.) Greuter, a Rapidly Spreading Invasive Plant: Chemistry and Bioactivity

Dittrichia graveolens L. Greuter belonging to the Asteraceae family, is an aromatic herbaceous plant native to the Mediterranean region. This plant species has been extensively studied for its biological activities, including antioxidant, antitumor, antimicrobial, antifungal, anti-inflammatory, anticholinesterase, and antityrosinase, and for its peculiar metabolic profile. In particular, bioactivities are related to terpenes and flavonoids metabolites, such as borneol (40), tomentosin (189), inuviscolide (204). However, D. graveolens is also well known for causing health problems both in animals and humans. Moreover, the species is currently undergoing a dramatic northward expansion of its native range related to climate change, now including North Europe, California, and Australia. This review represents an updated overview of the 52 literature papers published in Scopus and PubMed dealing with expansion, chemistry (262 different compounds), pharmacological effects, and toxicology of D. graveolens up to October 2021. The review is intended to boost further studies to determine the molecular pathways involved in the observed activities, bioavailability, and clinical studies to explore new potential applications