The Prevalence of Neoplasm Diseases and Investigation of Some Biochemical Serum Parameters

Aim: The aim of this work, investigating the skin, lung, and bone marrow-related cancer prevalence and biochemical serum parameters of all these cancer patients. Materials and Methods: The skin, lung, and bone marrow cancer patient's biochemical serum data were examined retrospectively using a hospital information system. Results: Basal cell carcinoma patients number were recorded as 155 with 63%, squamous cell carcinoma patients number were enrolled in73 with 30% and malign melanoma patients number were noted as 10 with 4%. Skin cancers were recorded to be the most seen cancer type in 246 patients with 22% between 2013-2017 years. All types of cancer patient's numbers were calculated as 1134 between these years. The very common incidences of basal cell carcinoma and squamous cell carcinoma cancers were observed on the upper part of the body, respectively on the face-cheek, nose, ear, eyelid, and lip. In this study, there was seen a statistically significant difference between skin cancer patient’s serum glucose, aspartate aminotransferase, alanine aminotransferase, sodium, bilirubin direct, bilirubin total, creatinine, urea level, and control group serum parameters level, p lt;0.05. The lung cancer patient numbers were recorded as 119 with 10.4 %, bone marrow patients numbers were enrolled in 113 with 10%. Two cancer groups were statistically different in terms of 5-years survival. Log Rank X2 = 8.68, p = 0.003, p lt;0.05. Conclusions: We recorded that skin cancer types and regions on the upper parts of the body were more because of exposure to the sun. The lung cancer survival rate was lower than bone marrow cancer. Moreover, we strongly emphasized that measuring the biochemical serum parameters was statistically significant in the diagnosis of cancer patients

Stope gravidnosti s obzirom na promjer folikula i edema endometrija tijekom dvije uzastopne ovulacije kobila arapske pasmine različitih dobnih skupina

The study aimed to evaluate the pregnancy rates of mares in different age groups based on follicle diameter and uterine edema during two consecutive ovulations in three breeding seasons. Thirty Arabian mares were divided into two groups: below and equal to 10 years (Group A=54) and above 10 years old (Group B=36). Throughout the breeding season, the diameters of ovulatory follicles and uterine edema were recorded. After the first ovulation, when the follicle diameters of all mares in both Group A and Group B were analyzed independently of age, and compared between pregnant and non-pregnant mares, no differences were found (P>0.05). The differences between the agerelated groups were insignificant (P>0.05). Follicle diameters between pregnant and non-pregnant mares at the second ovulation were significantly different (P0.05). Differences between uterine edema values determined in mares that were pregnant and nonpregnant in two consecutive ovulations were found to be insignificant in terms of pregnancy (P>0.05). As a result, although preovulatory diameter is not a reliable marker for pregnancy detection, it remains an important parameter for determining ovulation and artificial insemination timing. Uterine edema is only useful for determining the timing of insemination and is not associated with pregnancy. Moreover, since similar pregnancy rates were observed among different age groups, age alone is not a sufficient parameter for assessing reproductive efficiency in mares.Cilj je istraživanja bio procijeniti stope gravidnosti u kobila različitih dobnih skupina na temelju promjera folikula i edema endometrija za vrijeme dviju uzastopnih ovulacija u tri sezone parenja. Trideset kobila arapske pasmine podijeljeno je u dvije skupine: dobna skupina do 10 godina, uključujući i desetogodišnje kobile (skupina A=54), i dobna skupina iznad 10 godina (skupina B=36). Tijekom rasplodne sezone bilježeni su promjer folikula i edem endometrija. Nakon prve ovulacije, kada je analiziran promjer folikula u svih kobila u skupinama A i B, neovisno o dobi, te su uspoređene gravidne i negravidne kobile, nije bilo znakovitih razlika (P>0,05). Nije bilo znakovitih razlika ni s obzirom na dobnu skupinu (P>0,05). Pri drugoj je ovulaciji uočena znakovita razlika (P0,05) u stopi gravidnosti s obzirom na dob kobila. U dvije uzastopne ovulacije nije uočena znakovita razlika s obzirom na edem endometrija u gravidnih i negravidnih kobila (P>0,05). Može se zaključiti da premda promjer predovulacijskog folikula nije pouzdan pokazatelj u otkrivanju gravidnosti, on je i dalje važan za određivanje vremena ovulacije i umjetnog osjemenjivanja. Edem endometrija koristan je samo u određivanju vremena inseminacije i nije povezan s gravidnošću. Također, s obzirom na to da su u različitim dobnim skupinama uočene slične stope gravidnosti, sama dob nije dovoljan pokazatelj reproduktivne učinkovitosti u kobila

Structural switching aptamer-based electrochemical sensor for mycotoxin patulin detection

In this study, an electrochemical and aptamer-based aptasensor was developed for the sensitive detection of patulin, a mycotoxin commonly found in fruits and fruit-based products. The aptasensor used an innovative structural switching signal-off platform for detecting patulin. The aptamer immobilization on screen-printed carbon electrodes was achieved through Au electrodeposition and thiol group (-SH) route. Response surface methodology was used to determine the optimal incubation times for the aptamer, blocking agent, and target molecule, which were found to be 180 min, 40 min, and 89 min, respectively. The response of the aptamer to different concentrations of patulin was measured using square wave voltammetry by exploiting the structural switching mechanism. The sensor response was determined by quantifying differences in the aptasensor's background current. The aptasensor exhibited a linear working range of 1–25 μM and a low detection limit of 3.56 ng/mL for patulin. The aptasensor's relative standard deviation and accuracy were determined to be 0.067 and 94.4%, respectively. A non-specific interaction was observed at low concentrations of two other mycotoxins, ochratoxin A and zearalenone. The interference from ochratoxin A in the measurements was below 10%. In real sample tests using apple juice, interference, particularly at low concentrations, had changed the recovery of patulin negatively with a significant effect on the structural switching behavior. Nevertheless, at a concentration of 25 ng/mL, the interference effect was eliminated, and the recovery standard deviation improved to 6.6%. The aptasensor's stability was evaluated over 10 days, and it demonstrated good performance, retaining 13.12% of its initial response. These findings demonstrate the potential of the developed electrochemical aptasensor for the sensitive detection of patulin in fruit-based products, with prospects for application in food safety and quality control

Oxidant/Antioxidant Status, PON1 and ARES Activities, Trace Element Levels, and Histological Alterations in Sheep with Cystic Echinococcosis

Background: Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI), nitric oxide (NO), zinc (Zn), copper (Cu) levels, paraoxonase (PON1), arylesterase (ARES) activities, and biochemical changes were studied on sheep with cystic echinococcosis. Methods: The materials were taken from 2-3 yr old sheep slaughtered in Van Province, Turkey in 2017. Before the slaughter, blood samples were collected from the healthy sheep, while various organs of animals were examined for hydatid cysts after the slaughter. Thirty sheep were protoscolex positive, hydatic group, while 30 sheep that did not have any pathological lesions in organ examinations were accepted as the control group. TOS levels, PON1 and ARES activities, and Zn levels were determined by commercial kits, while Cu levels were determined by atomic absorption spectrophotometer. The collected data were then statistically analyzed. Results: Serum TOS and OSI levels were significantly higher in sheep with cystic echinococcosis compared to the control group (P<0.001). TAS levels (P<0.01), PON1 and ARES activities, on the other hand, were significantly higher in control group compared to the cystic echinococcosis group (P<0.001). There were no significant differences in Zn, NO and Cu levels between the groups. Conclusion: PON1 and ARES activities increased in sheep infected with cyst hydatid. The decline of antioxidant reserves in the metabolism results in excessive amounts of free radicals, along with alterations of the normal histological structure of the cystic organ and changes in trace element metabolism

Synthesis and Biological Evaluation of Novel Dihydro [2,3D] Pyridine Substituted Enaminosulfonamide Compounds as Potent Human Erythrocyte Carbonic Anhydrase II (hCAII) Inhibitors

Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesizedand their effects on carbonic anhydrase II (hCAII) have been evaluated. Pyrido [2,3 d] pyrimidines were synthesized from barbituric acid derivatives, malonanitrile, aldehyde derivatives inbasic condition and then hydrolyzed with hydrochloric acid. The targeted compounds were synthesized from amino sulfanilamide, dihydro [2,3D] pyridine compounds, and triethylorthoformate. 1H NMR, 13C NMR, FT-IR and elemental analysis were used for the structural analysisof the compounds. The half maximal inhibitory concentration (IC50) values of the compoundswere determined to be between 27.03 and 104.39 ?M for hCA II and 19.85-76.64 ?M for Ki

Study of the effects of the hand grip and finger strengths on the friction and petrissage - the massage manipulations - of the students who take massage courses: Kütahya City example

In this research, the effect of the hand grip and finger strengths on the power development between the friction and petrissage techniques - the massage manipulations - have been studied. To the study that has been structured as a single group pretest/post test, 36 healthy males who are the students of the University of Dumlupınar, Academy of Physical Education and Sports and who take massage courses (age = 19.72 ± 1.56 years (average ± Sd)) have been included. The practical massage course has continued for 12 weeks, two days a week for a total of one hour and the hand grip strength of both hands (right hand grip strength = RHG, left hand grip strength = LHG) and the grip strength of both fingers (right finger strength = RF, left finger strength = LF) have been recorded at the beginning. For the measurements carried out before and later of the study with regard to the hand grip strength, a Takkei branded hand dynamometer and with regard to the finger grip strength a (baseline) branded pinch meter have been used. All measurements have been repeated twice and for the analysis, the average values obtained from two deads have been used. For statistical analysis, with regard to the changes in the pre test-post test finger strength and hand grip strength, paired-samples t test has been used. The significance limit has been defined as p<0.05. For all values, the average, standard error and standard deviation have been used. It has been observed that the both hands’ finger strengths and both hands’ grip strengths have developed from the pre test phase to the post test phase (p<0.01) and these developments are similar for both hands’ grip strengths and both hands’ grip strengths (p>0.05). It is possible to report that massaging regularly with both hands is efficient for the development of the finger and hand grip strengths; especially, with regard to the friction (circular movements that are generally carried out with fingers) and petrissage (kneading that is generally carried out with the palm) techniques

Study of the effects of the hand grip and finger strengths on the friction and petrissage - the massage manipulations - of the students who take massage courses: Kütahya City example

In this research, the effect of the hand grip and finger strengths on the power development between the friction and petrissage techniques - the massage manipulations - have been studied. To the study that has been structured as a single group pretest/post test, 36 healthy males who are the students of the University of Dumlupınar, Academy of Physical Education and Sports and who take massage courses (age = 19.72 ± 1.56 years (average ± Sd)) have been included. The practical massage course has continued for 12 weeks, two days a week for a total of one hour and the hand grip strength of both hands (right hand grip strength = RHG, left hand grip strength = LHG) and the grip strength of both fingers (right finger strength = RF, left finger strength = LF) have been recorded at the beginning. For the measurements carried out before and later of the study with regard to the hand grip strength, a Takkei branded hand dynamometer and with regard to the finger grip strength a (baseline) branded pinch meter have been used. All measurements have been repeated twice and for the analysis, the average values obtained from two deads have been used. For statistical analysis, with regard to the changes in the pre test-post test finger strength and hand grip strength, paired-samples t test has been used. The significance limit has been defined as p0.05). It is possible to report that massaging regularly with both hands is efficient for the development of the finger and hand grip strengths; especially, with regard to the friction (circular movements that are generally carried out with fingers) and petrissage (kneading that is generally carried out with the palm) techniques

Investigation of the Effect of Vertimax V8 Elastic Resistance Platform and Classic Strength Training on Dynamic Balance in Basketball Players

This study aimed to investigate the effects on the dynamic balance of two different resistance training in male basketball players. 25 male basketball players who were over 18 participated in the study voluntarily. Participants were divided into two groups by using random sampling method as VertiMax strength training group and traditional strength training group (VertiMax, n=13; classic, n=12). Both training programs were administered 3 times a day for 6 weeks. In standing position, the dynamic balance values recorded on the right and left foot for 60 seconds were assessed by using EasyTech Libra Oscillating balance board. The scores used in the assessments were IBP (index of balance precision), recovery time right (return time of the visual helix balance from right side), and recovery time left (return time of the visual helix balance from left side). All tests were performed with visual feedback. Statistical analysis used three-factor mixed ANOVA. At the end of the training period, IBP (index of balance precision), recovery time right (return time of the visual helix balance from right side), recovery time left (return time of the visual helix balance from left side) showed that dynamic balance scores were similar in the VertiMax and classic training groups for right and left feet. VertiMax group in dynamic balance, the changes in IBP and recovery time right scores were found to be better. In both training groups, when the recovery time right values of the right and left feet were compared at the end of the process, it was seen that the rotation time from the right side of the visual helix motion area of the left leg was shorter (p<0.05). The results show that the VertiMax strength training included in the pre-season exercises positively affects participants’ balance performance

Bazı yem ve gübre sanayi kimyasallarının hyalüronidaz üzerine in vitro etkileri

ABSTRACT This study investigates in vitro effects of some chemicals, used as a spreading factor on therapeutic and various medical fields and applied frequently in forage and fertilizer industry on bovine testicular hyaluronidase (BTH) which is substantially effective in glucotechnological applications and delivery of artificial insemination. BTH was purified through ammonium sulfate precipitation method and affinity gel (Sepharose-4B-L- tyrosine -m-anisidine). The inhibiton effects of Fe2SO4, C2H4N4, K2SiF6, CH2N2, CH4N2O and indole-butyric acid were determined on purified BTH. IC50 values of these chemicals were found as 7.097, 5.775, 6.854, 5.317, 4.617, 4.265 ×10-2 mM respectively and at the end of research, indole-butyric acid (IBA) was found as the strongest inhibitory effect compound by the value of IC50 with 4.265×10-2 mM