Predicting Implantation Outcome from Imbalanced IVF Dataset

Abstract-Predicting implantation outcomes of invitro fertilization (IVF) embryos is critical for the success of the treatment. We have applied Naive Bayes classifier to an original IVF dataset in order to discriminate embryos according to implantation potentials. The dataset we analyzed represents an imbalanced distribution of positive and negative instances. In order to deal with the problem of imbalance, we examined the effects of over sampling the minority class, under sampling the majority class and adjustment of the decision threshold on the classification performance. We have used features of Receiver Operating Characteristics (ROC) curves in the evaluation of experiments. Our results revealed that it is possible to obtain optimum True Positive and False Positive Rates simply by adjusting the decision threshold. Under-sampling experiments show that we can achieve same prediction performance with less data as well as 736 embryo samples

Dandy-Walker Variant in A Fetus of an ICSI Twin Gestation: A Case Report

Dandy-Walker variant (DWV) might be considered as one of the borderlines in the examination of fetal brain. We report the first case of a DWV in a fetus conceived by ICSI. A 34 year-old woman underwent assisted reproductive treatment due to male factor infertility. A twin gestation was achieved, one of the fetuses was diagnosed as DWV on 22 weeks' ultrasound examination. Fetal MRI confirmed the diagnosis. The couple did not allow fetal karyotyping. Pregnancy continued uneventfully. Associated cardiac and minor skeletal anomalies were seen in the postpartum examination of the affected newborn. She died six days after birth due to pulmonary insufficiency. Karyotype analysis of the affected infant performed after birth was reported to be partial trisomy 9. Parental karyotype analysis was further performed and balanced reciprocal translocation t(4;9) was found in the mother. A careful posterior fossa evaluation should be performed as part of routine anatomical survey in ICSI conceptions. Upon the detection of an anomaly, a comprehensive fetal ultrasound for associated abnormalities and karyotype analysis are vital for obstetric management and neonatal survival

Synthesis and acidic properties of some new potential biologically active 4-acylamino-4,5-dihydro-1<i>H</i>-1,2,4-triazol-5-one derivatives

1527-15313-Alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2 react with acyl halides such as chloroacetyl chloride, dichloroacetyl chloride and isobutyryl chloride to give the corresponding 3-alkyl(aryl)-4-chloroacetylamino-4,5-dihydro-1 H-1,2,4-triazol-5-ones 3, 3-alkyl(aryl)-4-(dichloroacetylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 4 and 3-alkyl(aryl)-4-isobutyrylamino-4,5-dihydro-1 H-1,2,4-triazol-5-ones 5, respectively. The newly synthesized compounds have been characterized by elemental analyses, IR, 1H NMR, 13C NMR and UV spectral data. In addition, all ten new compounds are titrated potentiometrically with tetrabutylammonium hydroxide in four different non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N dimethylformamide. The half neutralization potential values and the corresponding pKa values have been determined for all the cases. Thus, the effects of solvents and molecular structure upon acidity are investigated

Left ventricular hypertrophy is associated with increased sirtuin level in newly diagnosed hypertensive patients

Cinier, Goksel/0000-0001-5064-1816; Cetin, Mustafa/0000-0001-6342-436X; duman, hakan/0000-0002-1441-7320WOS: 000473509900003PubMed: 30230925Background: Arterial hypertension is one of the leading causes of mortality and morbidity in general population. Sirtuin 1 (SIRT1) has diverse anti-inflammation, anti-oxidant, and anti-apopytosis effects on endothelium and is associated with endothelial aging and dysfunction. the objective of this study was to evaluate the relation of serum SIRT1 level with left ventricular hypertrophy (LVH) in newly diagnosed hypertensive patients. Methods: One hundered and twenty-five consecutive, newly diagnosed hypertensive patients were divided into two groups with regard to presence of LVH and compared to 40 healthy control subjects. LVH was determined by transthoracic echocardiography using the cube formula. Serum SIRT1 level was analyzed with enzyme-linked immunosorbent assay. Results: Serum SIRT1 level was significantly higher in patients with LVH compared to those without LVH (14.3 +/- 3.9 ng/ml vs. 7.9 +/- 3.6 ng/ml, P < 0.001) and healthy control subjects (14.3 +/- 3.9 ng/ml vs 6.6 +/- 2.0 ng/ml, P < 0.001). Multivariate logistic regression analysis revealed higher serum SIRT1 level independently predicted LVH in hypertensive patients (OR 1.50; 95% CI, 1.30-1.73; P < 0.001). Receiver-operating characteristic curve analysis demonstrated a cutoff value of 9.4 had a sensitivity of 90% and specificity of 74% for the prediction of LVH (AUC 0.885; 95% CI, 0.815-0.935; P < 0.0001). Conclusion: SIRT1 was a powerful biomarker for predicting LVH in hypertensive patients

Symptomatic Remission Determines Functional Improvement and Quality of Life in Schizophrenia

WOS: 000391572500008PubMed: 28360807Introduction: Schizophrenia is a chronic illness that negatively affects the quality of life and psychosocial functions. Defined criteria to assess remission in schizophrenia are considered to be useful in the longterm follow-up of patients and in discriminating diagnostic factors. This study investigated the quality of life and functionality in schizophrenia patients in symptomatic remission (R-Sch) and not in remission (NonR- Sch). Methods: Sociodemographic data were collected for 40 R-Sch and 40 Non-R-Sch patients, and the following scales were administered: the Clinical Global Impression-Severity (CGI-S) Scale; Positive and Negative Syndrome Scale (PANSS), World Health Organization Quality of Life Questionnaire-Short Form, Turkish Version (WHOQOL-BREF-TR), Quality of Life Scale for Schizophrenia Patients (QLS), and Global Assessment of Functioning Scale (GAF). Results: the total and all subscale scores of PANSS and the CGI-S score were significantly lower in the R-Sch group than in the NonR- Sch group, whereas the GAF scores and all subscales of QLS and WHOQOL-BREF-TR were significantly higher. Conclusion: This study demonstrates that improvement in symptoms in schizophrenia patients improves quality and functionality in all areas of life, suggesting that an improvement in symptoms is the most important determinant of functional recovery in the treatment of schizophrenia

Impact of elective frozen vs. fresh embryo transfer strategies on cumulative live birth: Do deleterious effects still exist in normal & hyper responders?

BackgroundIs freeze-all strategy effective in terms of cumulative live birth rates (CLBRs) in all patients?MethodsThis retrospective single-center study analyzed the CLBRs of 2523 patients undergoing fresh or electively frozen blastocyst transfer cycles. In 1047, cycles, the fresh embryo transfer (ET) strategy was applied for the 1st ET, whereas electively frozen ET (e-FET) was performed in 1476 cycles. Female age ≤ 37 and blastocysts frozen via vitrification were included. The patients in each arm were further stratified into four subgroups according to the number of oocytes retrieved as follows: Group A: 1-5, group B: 6-10, group C: 11-15 and group D: 16-25 oocytes retrieved. The primary endpoint was the CLBR. The secondary endpoints were the ovarian hyperstimulation syndrome (OHSS) rate and the live birth rates (LBRs) following fresh ETs and e-FETs for the first transfers.Result(s)The CLBR was similar between the fresh ET and e-FET arms in group A (35/76 (46.1%) vs 29/67 (43.3%), p = 0.74) and group B (165/275 (60%) vs 216/324 (66.7%), p = 0.091), whereas significantly higher rates were detected in favor of the e-FET arm within group C (328/460 (71.3%) vs 201/348 (57.8%), pConclusionCompared with a fresh-transfer strategy, the e-FET strategy resulted in a higher CLBR among patients with >10 oocytes retrieved during stimulated cycles