PEGASO: LONG DURATION BALLOONS FROM NORTH POLE

In a joint effort, the Italian Space Agency (ASI) and Andoya Rocket Range (ARR) have initiated the development of a European balloon center in Svalbard, Norway that is an ideal location for performing Long Duration Balloon (LDB) flights. After the identification of the launch location several light balloon flights have been performed since 2003. The 2004 campaign utilized a 10000 m³ balloon produced for the program by Aerostar of Sulfur Springs, Texas USA. This flight lasted 40 days and was an excellent test of the small PEGASO payload, developed (for use in Antarctica) by the National Institute of Geophysics and Volcanology (INGV) with the PNRA (Progetto Nazionale di Ricerche in Antartide) sponsorship. This payload uses an IRIDIUM based bi-directional telemetry system. During summer 2005 two flights have been performed using balloons of the same size. They carried an updated telemetry and a scientific payload which analyzed the magnetic field of the Earth. The Institute of Information Science and Technology (ISTI-CNR) team computed predictions of the balloons trajectories, both before and during flights, as well as statistical evaluations of the seasonal flight windows at the beginning of the ASI LDB program. The 2004 and 2005 missions have been defined to investigate the stratospheric winds structure and they tested the possibility for future heavy LDB flights. The Italian scientific community foresees this kind of missions from 2007-2008 campaigns. Next sections, starting from a general overview of the Italian LDB program, give the description of the Pegaso flights and, in particular, the adopted technical solutions for the on-board and ground-based equipments.PublishedVOLTERRA, PISA1.10. TTC - Telerilevamentoope

PEGASO: LONG DURATION BALLOONS FROM NORTH POLE

In a joint effort, the Italian Space Agency (ASI) and Andoya Rocket Range (ARR) have initiated the development of a European balloon center in Svalbard, Norway that is an ideal location for performing Long Duration Balloon (LDB) flights. After the identification of the launch location several light balloon flights have been performed since 2003. The 2004 campaign utilized a 10000 m³ balloon produced for the program by Aerostar of Sulfur Springs, Texas USA. This flight lasted 40 days and was an excellent test of the small PEGASO payload, developed (for use in Antarctica) by the National Institute of Geophysics and Volcanology (INGV) with the PNRA (Progetto Nazionale di Ricerche in Antartide) sponsorship. This payload uses an IRIDIUM based bi-directional telemetry system. During summer 2005 two flights have been performed using balloons of the same size. They carried an updated telemetry and a scientific payload which analyzed the magnetic field of the Earth. The Institute of Information Science and Technology (ISTI-CNR) team computed predictions of the balloons trajectories, both before and during flights, as well as statistical evaluations of the seasonal flight windows at the beginning of the ASI LDB program. The 2004 and 2005 missions have been defined to investigate the stratospheric winds structure and they tested the possibility for future heavy LDB flights. The Italian scientific community foresees this kind of missions from 2007-2008 campaigns. Next sections, starting from a general overview of the Italian LDB program, give the description of the Pegaso flights and, in particular, the adopted technical solutions for the on-board and ground-based equipments

Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Objectives: ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- A nd older-onset patients are still incompletely understood. Methods: We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: <65 years or ≥65 years. We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). Results: A total of 1338 patients with AAV were included: 66% had disease onset at <65 years of age [female 50%; mean age 48.4 years (s.d. 12.6)] and 34% had disease onset at ≥65 years [female 54%; mean age 73.6 years (s.d. 6)]. ANCA (MPO) positivity was more frequent in the older group (48% vs 27%; P = 0.001). Younger patients had higher rates of musculoskeletal, cutaneous and ENT manifestations compared with older patients. Systemic, neurologic,cardiovascular involvement and worsening renal function were more frequent in the older-onset group. Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6 month VDI ≥5, compared with 7% of younger patients (P = 0.01). Older age was an independent risk factor for early death within 6 months from diagnosis [hazard ratio 2.06 (95% CI 1.07, 3.97); P = 0.03]. Conclusion: Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients

Proyecto de elaboración de un plan de negocio para una empresa

En este proyecto desarrollamos un plan de negocios que nos permitió identificar un mercado potencial y demostrar lo rentable que sería ingresar al mismo. La demanda de energía en los hogares y negocios es cada vez mayor, este aumento se explica por la instalación de nuevos equipos eléctricos y malas costumbres de consumo, como dejar luces encendidas en habitaciones vacías, mantener los equipos eléctricos en modo de espera o encendidos de forma innecesaria. Tomando como base lo anterior, elaboramos un plan de negocio para introducir al mercado un dispositivo electrónico que reduzca el consumo innecesario de energía eléctrica en equipos de potencia media. Reducción que permitirá el ahorro de dinero y la disminución de la contaminación del medio ambiente. Nuestro producto “SafeElectric”, será introducido en los hogares del sector norte de Guayaquil y de acuerdo a la planificación de ventas, se extenderá por el resto de la ciudad. Nuestro gran reto es hacer que el cliente conozca el dispositivo, compruebe el ahorro que va a obtener y la seguridad que le brinda, además del beneficio al medio ambiente. Los indicadores financieros son coherentes con los resultados de nuestro estudio de mercado. Las razones tales como liquidez y rentabilidad están soportadas por flujos que han sido sometidos a varios escenarios demostrando la conveniencia del proyect