Ein Vater der kognitiven Psychologie: Adriaan Dingeman de Groot (1914–2006)/A father of cognitive psychology: Adriaan Dingeman de Groot (1914-2006)

Adriaan D. de Groot wurde am 26. Oktober 1914 in Santpoort (Holland) geboren. An der Universität Amsterdam studierte er Physik, Mathematik und Psychologie; daneben betrieb er seine große Leidenschaft, das Schachspiel, in dem er es zu Meisterehren brachte. In seiner bahnbrechenden Promotion (De Groot, 1946; engl. “Thought and Choice in Chess”, 1965) vereinte er sein Interesse am Schach und an der Psychologie und präsentierte eine detaillierte Analyse der Denkvorgänge beim Schachspiel, die einen Meilenstein der beginnenden kognitiven Revolution in der Psychologie setzte und schnell zum Klassiker wurde

Paradigms in the trade–climate nexus: ‘liberal environmentalism’, the Environmental Goods Agreement and the role of the EU

What explains the evolution of negotiations on liberalising environmentally friendly goods and services over the past 15 years and the EU’s position on these? In December 2016 negotiators did not succeed in their goal of concluding an Environmental Goods Agreement (EGA) in Geneva. This was considered by many participants and observers as a missed opportunity for a win-win for the global economy and the environment. Protectionist wrangling over which products should be on a list for speedy liberalisation was seen as the main reason why the negotiations (temporarily) failed. However, we show that the environmental objectives of these negotiations had already gradually been pushed to the back by commercial objectives. While there had been attempts in early phases of the negotiations to make the environmental effects of goods primordial, in the end a commercial logic prevailed. We point to the importance of the paradigm of ‘liberal environmentalism’, which makes it difficult to promote trade-conditioning measures in an already commercially biased policy subsystem. We focus particularly on the EU as one of the key actors in the EGA negotiations. Through a number of interviews with European policy-makers and civil society representatives, and desk research of negotiating documents and secondary literature, we find evidence of the prevalence of liberal environmentalist thinking, the dominance of trade actors in the policy subsystem and difficulties for environmental actors to penetrate these negotiations. We conclude that trying to reconcile trade and environmental objectives in a synergetic (‘win-win’) manner does not make a successful conclusion necessarily easier

Adjunctive intravitreal dexamethasone in the treatment of acute endophthalmitis following cataract surgery

Edward F Hall1, Garrett R Scott1, David C Musch1,2, David N Zacks11Department of Ophthalmology and Visual Sciences, Medical School; 2Department of Epidemiology, School of Public Health; University of Michigan, Ann Arbor, MI, USAPurpose: Controversy exists regarding the use of intravitreal dexamethasone (IVD) as an anti-inflammatory adjunct to intravitreal antibiotics in patients with acute endophthalmitis following cataract surgery. The purpose of this project was to evaluate our experience regarding the effect of adjunctive IVD use on visual outcomes in such patients.Design: Retrospective, comparative case series.Methods: Study population: Patients treated for acute endophthalmitis following cataract surgery from 1995–2004. Intervention: In addition to standard intravitreal antibiotic treatment, some patients also received a single adjunctive injection of IVD. Primary outcome measures: Median visual acuity at last follow-up and percentage of patients achieving a ≥3-line improvement in visual acuity. Secondary outcome measures: Inflammatory index scoring, including amount of cell and flare, height of hypopyon, and presence of fibrin as a function of time after treatment.Results: Twenty-six eyes were treated with and 38 eyes without adjunctive IVD. Median presenting visual acuity was Hand Motion in both groups. Median visual acuity at last followup measured 20/40 in the IVD group and 20/50 in the No-IVD group (p = 0.75). Seventy-three percent of patients in the IVD group and 82% of patients in the No-IVD group achieved a ≥3-line improvement in visual acuity (p = 0.42). No significant difference was detected between the IVD and No-IVD groups for any of the three measures of inflammation.Conclusion: The use of IVD did not significantly improve the final median visual acuity, the chance of achieving a ≥3-line improvement in visual acuity, or the amount of intraocular inflammation. Based on these findings, and the possible detrimental effect of IVD on visual outcomes previously reported in the literature, the use of IVD does not appear to be warranted as a routine adjunctive treatment in postoperative endophthalmitis.Keywords: endophthalmitis, dexamethasone, intravitreal injectio

Detectable contributions of colloids to soil P and C content in arid and hyperarid region of the Atacama (Chile)

Atacama Desert is mainly known as the driest place on Earth where life has been developed under arid to hyper arid conditions since Oligocene-Miocene. Therefore, soils of Atacama contain fingerprints of past and present life which might be used as an analog to study the evolution of life under equivalent arid conditions, like Mars. In this study, we quantify the colloidal phosphorus and carbon distribution in the first 10 cm of soil profile along an altitudinal transect. Samples were taken along a transect in the region of Quebrada Aroma spanning from the arid Percordillera of the Andes (2720 m a.s.l.) towards the hyper arid core of the desert (1340 m a.s.l.). Water dispersible colloids (WDC) were separated and measured using the field-flow-field fractionation (FFF) method and subsequently their Corg and P content were characterized and quantified by detectors (DLS, ICP-MS, UV, OCD, fluorescence). Data was compared to total C, P and (available) Olsen-P also measured in the samples. The Olsen-P (available-P) varied within the Aroma transect from ca. 2 to 8 mg P kg-1, but was not related to either altitude or depth in the upper soil (0-10 cm). Colloidal P contents ranged from <0.1 to 4 mg P kg-1 soil, with increasing trend from low to higher elevations. Thereby, suggesting an increasing proportion of the available P potential being present in the WDC fraction. The Colloidal Corg content of the Aroma transect did range from 65 to 90 (for sites 2020 to 1340m) and 110 mg Corg kg-1 soil WDC (2720 m). Colloidal Corg content as a function of the altitude showed a similar trend to the Corg content of the soils: the highest colloidal Corg content was found at 2720 m. The proportion of soil Corg within the colloidal fraction was up to 6% of the bulk soil organic matter (OM) content, as the OM content was intensively enriched in the colloidal fraction. Further quantification of phosphorus and carbon content in WDC in deeper part of soil is required to obtain a more comprehensive view of role of colloidal inputs and dynamics in the Atacama Desert

Nucleon structure from mixed action calculations using 2+1 flavors of asqtad sea and domain wall valence fermions

We present high statistics results for the structure of the nucleon from a mixed-action calculation using 2+1 flavors of asqtad sea and domain wall valence fermions. We perform extrapolations of our data based on different chiral effective field theory schemes and compare our results with available information from phenomenology. We discuss vector and axial form factors of the nucleon, moments of generalized parton distributions, including moments of forward parton distributions, and implications for the decomposition of the nucleon spin.Comment: 68 pages, 47 figures. Main revision points: improved discussion of chiral fits and systematic uncertainties, several minor refinements. Accepted for publication in Phys.Rev.

On the comprehensibility and perceived privacy protection of indirect questioning techniques

On surveys that assess sensitive personal attributes, indirect questioning aims at increasing respondents’ willingness to answer truthfully by protecting confidentiality. However, the assumption that subjects understand questioning procedures fully and trust them to protect their privacy is tested rarely. In a scenario-based design, we compared four indirect questioning procedures in terms of comprehensibility and perceived privacy protection. All indirect questioning techniques were found less comprehensible for respondents than a conventional direct question used for comparison. Less-educated respondents experienced more difficulties when confronted with any indirect questioning technique. Regardless of education, the Crosswise Model was found most comprehensible among the four indirect methods. Indirect questioning was perceived to increase privacy protection in comparison to a direct question. Unexpectedly, comprehension and perceived privacy protection did not correlate. We recommend assessing these factors separately in future evaluations of indirect questioning

Effects of ventilation strategy on distribution of lung inflammatory cell activity

Introduction: Leukocyte infiltration is central to the development of acute lung injury, but it is not known how mechanical ventilation strategy alters the distribution or activation of inflammatory cells. We explored how protective (vs. injurious) ventilation alters the magnitude and distribution of lung leukocyte activation following systemic endotoxin administration. Methods: Anesthetized sheep received intravenous endotoxin (10 ng/kg/min) followed by 2 h of either injurious or protective mechanical ventilation (n = 6 per group). We used positron emission tomography to obtain images of regional perfusion and shunting with infused 13N[nitrogen]-saline and images of neutrophilic inflammation with 18F-fluorodeoxyglucose (18F-FDG). The Sokoloff model was used to quantify 18F-FDG uptake (Ki), as well as its components: the phosphorylation rate (k3, a surrogate of hexokinase activity) and the distribution volume of 18F-FDG (Fe) as a fraction of lung volume (Ki = Fe × k3). Regional gas fractions (fgas) were assessed by examining transmission scans. Results: Before endotoxin administration, protective (vs. injurious) ventilation was associated with a higher ratio of partial pressure of oxygen in arterial blood to fraction of inspired oxygen (PaO2/FiO2) (351 ± 117 vs. 255 ± 74 mmHg; P < 0.01) and higher whole-lung fgas (0.71 ± 0.12 vs. 0.48 ± 0.08; P = 0.004), as well as, in dependent regions, lower shunt fractions. Following 2 h of endotoxemia, PaO2/FiO2 ratios decreased in both groups, but more so with injurious ventilation, which also increased the shunt fraction in dependent lung. Protective ventilation resulted in less nonaerated lung (20-fold; P < 0.01) and more normally aerated lung (14-fold; P < 0.01). Ki was lower during protective (vs. injurious) ventilation, especially in dependent lung regions (0.0075 ± 0.0043/min vs. 0.0157 ± 0.0072/min; P < 0.01). 18F-FDG phosphorylation rate (k3) was twofold higher with injurious ventilation and accounted for most of the between-group difference in Ki. Dependent regions of the protective ventilation group exhibited lower k3 values per neutrophil than those in the injurious ventilation group (P = 0.01). In contrast, Fe was not affected by ventilation strategy (P = 0.52). Lung neutrophil counts were not different between groups, even when regional inflation was accounted for. Conclusions: During systemic endotoxemia, protective ventilation may reduce the magnitude and heterogeneity of pulmonary inflammatory cell metabolic activity in early lung injury and may improve gas exchange through its effects predominantly in dependent lung regions. Such effects are likely related to a reduction in the metabolic activity, but not in the number, of lung-infiltrating neutrophils

The mating-specific Gα interacts with a kinesin-14 and regulates pheromone-induced nuclear migration in budding yeast

As a budding yeast cell elongates toward its mating partner, cytoplasmic microtubules connect the nucleus to the cell cortex at the growth tip. The Kar3 kinesin-like motor protein is then thought to stimulate plus-end depolymerization of these microtubules, thus drawing the nucleus closer to the site where cell fusion and karyogamy will occur. Here, we show that pheromone stimulates a microtubule-independent interaction between Kar3 and the mating-specific Gα protein Gpa1 and that Gpa1 affects both microtubule orientation and cortical contact. The membrane localization of Gpa1 was found to polarize early in the mating response, at about the same time that the microtubules begin to attach to the incipient growth site. In the absence of Gpa1, microtubules lose contact with the cortex upon shrinking and Kar3 is improperly localized, suggesting that Gpa1 is a cortical anchor for Kar3. We infer that Gpa1 serves as a positional determinant for Kar3-bound microtubule plus ends during mating. © 2009 by The American Society for Cell Biology

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features of Alzheimer’s disease (AD). In addition to astrocyte and microglial reactivity, emerging evidence suggests a role of gut microbiota in regulating innate immunity and influencing brain function. Here, we examine the role of the host microbiome in regulating amyloidosis in the APP(SWE)/PS1(ΔE9) mouse model of AD. We show that prolonged shifts in gut microbial composition and diversity induced by long-term broad-spectrum combinatorial antibiotic treatment regime decreases Aβ plaque deposition. We also show that levels of soluble Aβ are elevated and that levels of circulating cytokine and chemokine signatures are altered in this setting. Finally, we observe attenuated plaque-localised glial reactivity in these mice and significantly altered microglial morphology. These findings suggest the gut microbiota community diversity can regulate host innate immunity mechanisms that impact Aβ amyloidosis

Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility

Author Posting. © The Author(s), 2016. This is the author's version of the work. It is posted here by permission of American Physiological Society for personal use, not for redistribution. The definitive version was published in American Journal of Physiology-Gastrointestinal and Liver Physiology 310 (2016): G973-G988, doi:10.1152/ajpgi.00017.2016.Gut dysbiosis, host genetics, and environmental triggers are implicated as causative factors in inflammatory bowel disease (IBD), yet mechanistic insights are lacking. Longitudinal analysis of ulcerative colitis patients following total colectomy with ileal anal anastomosis (IPAA) where >50% develop pouchitis, offers a unique setting to examine cause vs. effect. To recapitulate human IPAA, we employed a mouse model of surgically created blind self-filling (SFL) and self- emptying (SEL) ileal loops using wild-type (WT), IL-10 KO (IL10), and TLR4 KO (T4), and IL10/T4 double KO mice. After 5 weeks, loop histology, host gene/protein expression, and bacterial 16s rRNA profiles were examined. SFL exhibit fecal stasis due to directional motility oriented towards the loop end, whereas SEL remain empty. In wild type mice, SFL, but not SEL, develop pouch-like microbial communities without accompanying active inflammation. However, in genetically susceptible IL-10-/- deficient mice, SFL, but not SEL, exhibit severe inflammation and mucosal transcriptomes resembling human pouchitis. The inflammation associated with IL- 10-/- required TLR4, as animals lacking both pathways displayed little disease. Furthermore, germ-free IL10-/- mice conventionalized with SFL, but not SEL, microbiota populations develop severe colitis. These data support essential roles of stasis-induced, colon-like microbiota, TLR4- mediated colonic metaplasia, and genetic susceptibility in the development of pouchitis and possibly UC. However, these factors by themselves are not sufficient. Similarities between this model and human UC/pouchitis provide opportunities for gaining insights into the mechanistic basis of IBD and for identification of targets for novel preventative and therapeutic interventions.NIDDK DK42086 (DDRCC), UH3 DK083993, Leona and Harry Helmsley Trust (SHARE), R37 DK47722, T32 DK07074, F32 DK105728, Gastrointestinal Research Foundation of Chicago, Peter and Carol Goldman Family Research grant.2017-06-0