Negative ion Time Projection Chamber operation with SF6_{6} at nearly atmospheric pressure

We present measurements of drift velocities and mobilities of some innovative negative ion gas mixtures at nearly atmospheric pressure based on SF$_{6}$ as electronegative capture agent and of pure SF$_{6}$ at various pressures, performed with the NITEC detector. NITEC is a Time Projection Chamber with 5 cm drift distance readout by a GEMPix, a triple thin GEMs coupled to a Quad-Timepix chip, directly sensitive to the deposited charge on each of the 55 $\times$ 55 $\mu$m$^2$ pixel. Our results contribute to expanding the knowledge on the innovative use of SF$_{6}$ as negative ion gas and extend to triple thin GEMs the possibility of negative ion operation for the first time. Above all, our findings show the feasibility of negative ion operation with He:CF$_4$:SF$_{6}$ at 610 Torr, opening extremely interesting possibility for next generation directional Dark Matter detectors at 1 bar

MicroRNA Signature in Human Normal and Tumoral Neural Stem Cells

MicroRNAs, also called miRNAs or simply miR‐, represent a unique class of non‐coding RNAs that have gained exponential interest during recent years because of their determinant involvement in regulating the expression of several genes. Despite the increasing number of mature miRNAs recognized in the human species, only a limited proportion is engaged in the ontogeny of the central nervous system (CNS). miRNAs also play a pivotal role during the transition of normal neural stem cells (NSCs) into tumor‐forming NSCs. More specifically, extensive studies have identified some shared miRNAs between NSCs and neural cancer stem cells (CSCs), namely miR‐7, ‐124, ‐125, ‐181 and miR‐9, ‐10, ‐130. In the context of NSCs, miRNAs are intercalated from embryonic stages throughout the differentiation pathway in order to achieve mature neuronal lineages. Within CSCs, under a different cellular context, miRNAs perform tumor suppressive or oncogenic functions that govern the homeostasis of brain tumors. This review will draw attention to the most characterizing studies dealing with miRNAs engaged in neurogenesis and in the tumoral neural stem cell context, offering the reader insight into the power of next generation miRNA‐targeted therapies against brain malignancies

Coalescence instability in chromospheric partially ionized plasmas

This is the author accepted manuscript. The final version is available from AIP Publishing via the DOI in this recordData availability: The data that support the findings of this study are available from the corresponding author upon reasonable request. The (PIP) code is available at the following url: https://github.com/AstroSnow/PIPFast magnetic reconnection plays a fundamental role in driving explosive dynamics and heating in the solar chromosphere. The reconnection time scale of traditional models is shortened at the onset of the coalescence instability, which forms a turbulent reconnecting current sheet through plasmoid interaction. In this work we aim to investigate the role of partial ionisation on the development of fast reconnection through the study of the coalescence instability of plasmoids. Unlike the processes occurring in fully ionised coronal plasmas, relatively little is known about how fast reconnection develops in partially ionised plasmas of the chromosphere. We present 2.5D numerical simulations of coalescing plasmoids in a single fluid magnetohydrodynamic (MHD) model, and a two-fluid model of a partially ionised plasma (PIP). We find that in the PIP model, which has the same total density as the MHD model but an initial plasma density two orders of magnitude smaller, plasmoid coalescence is faster than the MHD case, following the faster thinning of the current sheet and secondary plasmoid dynamics. Secondary plasmoids form in the PIP model where the effective Lundquist number S = 7.8·103 , but are absent from the MHD case where S = 9.7·103 : these are responsible for a more violent reconnection. Secondary plasmoids also form in linearly stable conditions as a consequence of the non-linear dynamics of the neutrals in the inflow. In the light of these results we can affirm that two-fluid effects play a major role on the processes occurring in the solar chromosphere.Science and Technology Facilities Council (STFC

Experimental results of crystal-assisted slow extraction at the SPS

The possibility of extracting highly energetic particles from the Super Proton Synchrotron (SPS) by means of silicon bent crystals has been explored since the 1990's. The channelling effect of a bent crystal can be used to strongly deflect primary protons and eject them from the synchrotron. Many studies and experiments have been carried out to investigate crystal channelling effects. The extraction of 120 and 270 GeV proton beams has already been demonstrated in the SPS with dedicated experiments located in the ring. Presently in the SPS, the UA9 experiment is performing studies to evaluate the possibility to use bent silicon crystals to steer particle beams in high energy accelerators. Recent studies on the feasibility of extraction from the SPS have been made using the UA9 infrastructure with a longer-term view of using crystals to help mitigate slow extraction induced activation of the SPS. In this paper, the possibility to eject particles into the extraction channel in LSS2 using the bent crystals already installed in the SPS is presented. Details of the concept, simulations and measurements carried out with beam are presented, before the outlook for the future is discussed.Comment: 4 pages, 7 figures, submitted to to International Particle Accelerator Conference (IPAC) 2017 in Copenhagen, Denmar

A triple GEM gamma camera for medical application

Abstract A Gamma Camera for medical applications 10 × 10 cm 2 has been built using a triple GEM chamber prototype. The photon converters placed in front of the three GEM foils, has been realized with different technologies. The chamber, High Voltage supplied with a new active divider made in Frascati, is readout through 64 pads, 1 mm 2 wide, organized in a row of 8 cm long, with LHCb ASDQ chip. This Gamma Camera can be used both for X-ray movie and PET-SPECT imaging; this chamber prototype is placed in a scanner system, creating images of 8 × 8 cm 2 . Several measurements have been performed using phantom and radioactive sources of Tc 99 m ( 140 keV ) and Na 22 ( 511 keV ) . Results on spatial resolution and image reconstruction are presented