Polymorphonuclear Leucocytes and Protease Inhibitors in the Gingival Crevice

This thesis presents the results of a cross sectional clinical study of the PMN granule markers elastase and lactoferrin in conjunction with the major protease inhibitors alpha 1 antitrypsin and alpha 2 macroglobulin in the gingival crevice. 10 subjects with chronic adult periodontitis were selected. Each subject had GCF collected from a healthy site, a gingivitis site and a periodontitis site. The samples were analysed by ELISA. Analysis of the date confirmed that the sites were separated on the basis of clinical findings. With regard to the PMN granule markers, elastase was not able to discriminate between periodontal sites on the basis of absolute amounts or concentration whereas statistically significant differences were observed in relation to the absolute amount of lactoferrin at healthy and periodontitis sites. The relationship between lactoferrin and elastase changed significantly when comparing healthy and gingivitis sites with periodontitis sites, where a 10-fold decrease in the relative release of elastase was noted. It is proposed that this relationship of PMN granule markers may be a useful indicator of periodontal breakdown. In addition it may indicate basic changes in the dynamics of PMN activity in the gingival crevice in relation to the disease state. With regard to protease inhibitors, alpha 1 antitrypsin increased significantly in absolute amounts at sites of inflammation but remained unchanged in relation to its concentration. Alpha 2 macroglobulin increased at sites of inflammation in absolute amounts and was at highest concentration at sites of gingivitis. At sites of inflammation the amount of protease inhibitor relative to elastase increased. Thus, there was no evidence of a defective, host related protease inhibitor mechanism

An Encouragement of Television News History Research: A Roundtable Discussion.

The article focuses on the speech by four scholars including Mary E. Beadle, Madeleine Liseblad and Mike Conway, delivered at the 2016 American Journalism Historians Association annual conference held in Saint Petersburg, Florida, on television news history research. Beadle discusses the lack of material in local television history research. Liseblad discusses the challenges and opportunities of television history research in Europe while Conway discusses access to historic broadcasts

The language–gesture connection: Evidence from aphasia

A significant body of evidence from cross-linguistic and developmental studies converges to suggest that co-speech iconic gesture mirrors language. This paper aims to identify whether gesture reflects impaired spoken language in a similar way. Twenty-nine people with aphasia (PWA) and 29 neurologically healthy control participants (NHPs) produced a narrative discourse, retelling the story of a cartoon video. Gesture and language were analysed in terms of semantic content and structure for two key motion events. The aphasic data showed an influence on gesture from lexical choices but no corresponding clausal influence. Both the groups produced gesture that matched the semantics of the spoken language and gesture that did not, although there was one particular gesture–language mismatch (semantically “light” verbs paired with semantically richer gesture) that typified the PWA narratives. These results indicate that gesture is both closely related to spoken language impairment and compensatory

A shorter working week: A radical and pragmatic proposal

Transition to a shorter working week

Identification of Outer Continental Shelf Renewable Energy Space-Use Conflicts and Analysis of Potential Mitigation Measures

The ocean accommodates a wide variety of uses that are separated by time of day, season, location, and zones. Conflict can and does occur, however, when two or more groups wish to use the same space at the same time in an exclusive manner. The potential for conflict is well known and the management of ocean space and resources has been, and is being, addressed by a number of State, regional, and Federal organizations, including, among others, coastal zone management agencies, state task forces, and regional fisheries management councils. However, with new and emerging uses of the ocean, such as aquaculture and offshore renewable energy, comes the potential for new types of space-use conflicts in ocean waters. In recent years, the Bureau of Ocean Energy Management (BOEM) (formerly the Minerals Management Service [MMS]) has examined ocean space-use conflicts and mitigation strategies in the context of offshore oil and gas exploration and production and sand and gravel dredging, activities that are both subject to BOEM regulation and oversight. BOEM now has authority to issue leases on the Outer Continental Shelf (OCS) for renewable energy projects, but seeks additional information on potential conflicts between existing uses of the ocean environment and this new form of activity. The broad purpose of this study was to begin to fill this gap by (1) identifying potential spaceuse conflicts between OCS renewable energy development and other uses of the ocean environment, and (2) recommending measures that BOEM can implement in order to promote avoidance or mitigation of such conflicts, thereby facilitating responsible and efficient development of OCS renewable energy resources. The result is a document intended to serve as a desktop resource that BOEM can use to inform its decision making as the agency carries out its statutory and regulatory responsibilities

Association Between Specific Childhood Adversities and Symptom Dimensions in People With Psychosis: Systematic Review and Meta-Analysis

Despite the accepted link between childhood abuse and positive psychotic symptoms, findings between other ad versities, such as neglect, and the remaining dimensions in people with psychosis have been inconsistent, with evidence not yet reviewed quantitatively. The aim of this study was to systematically examine quantitatively the association between broadly defined childhood adversity (CA), abuse (sexual/physical/emotional), and neglect (physical/emo tional) subtypes, with positive, negative, depressive, manic, and disorganized dimensions in those with psychosis. A search was conducted across EMBASE, MEDLINE, PsychINFO, and Cochrane Libraries using search terms related to psychosis population, CA, and psychopatholog ical dimensions. After reviewing for relevance, data were extracted, synthesized, and meta-analyzed. Forty-seven papers were identified, including 7379 cases across 40 studies examining positive, 37 negative, 20 depressive, 9 disorganized, and 13 manic dimensions. After adjustment for publication bias, general adversity was positively as sociated with all dimensions (ranging from r = 0.08 to r = 0.24). Most forms of abuse were associated with de pressive (ranging from r = 0.16 to r = 0.32), positive (ran ging from r = 0.14 to r = 0.16), manic (r = 0.13), and negative dimensions (ranging from r = 0.05 to r = 0.09), while neglect was only associated with negative (r = 0.13) and depressive dimensions (ranging from r = 0.16 to r = 0.20). When heterogeneity was found, it tended to be explained by one specific study. The depressive dimension was influenced by percentage of women (ranging from r = 0.83 to r = 1.36) and poor-quality scores (ranging from r = −0.21 and r = −0.059). Quality was judged as fair overall. Broadly defined adversity and forms of abuse increase transdimensional severity. Being exposed to ne glect during childhood seems to be exclusively related to negative and depressive dimensions suggesting specific effects

Signatures of Adaptation and Acclimatization to Reef Flat and Slope Habitats in the Coral Pocillopora damicornis

Strong population-by-habitat interactions across environmental gradients arise from genetic adaptation or acclimatization and represents phenotypic variation required for populations to respond to changing environmental conditions. As such, patterns of adaptation and acclimatization of reef-building corals are integral to predictions of the future of coral reefs under climate warming. The common brooding coral, Pocillopora damicornis, exhibits extensive differences in host genetic and microbial symbiont community composition between depth habitats at Heron Island in the southern Great Barrier Reef, Australia. An 18-month reciprocal field transplant experiment was undertaken to examine the environmental and genetic drivers behind variation in survival, weight gain, heat tolerance and algal symbiont community between the reef flat and slope habitats. We observed population-by-habitat interactions for in situ partial mortality and weight gain, where trait-related fitness of natives was greater than transplants in most cases, consistent with local adaptation. On average, flat colonies transplanted to the slope had a relatively low partial mortality but minimal weight gain, whereas slope colonies transplanted to the flat had relatively high partial mortality and average weight gain. Experimental heat tolerance was always higher in colonies sourced from the flat, but increased when slope colonies were transplanted to the flat, providing evidence of acclimatization in these colonies. The performance of certain slope to flat transplants may have been driven by each colony’s algal symbiont (Symbiodiniaceae) community, and flat variants were observed in a small number of slope colonies that either had a fixed flat composition before transplantation or shuffled after transplantation. Host genotypes of previously identified genetic outlier loci could not predict survival following transplantation, possibly because of low sample size and/or polygenic basis to the traits examined. Local environmental conditions and Symbiodiniaceae composition may provide insight into the adaptive potential to changing environmental conditions

Fruit and vegetable consumption and bone mineral density; the Northern Ireland Young Hearts Project

BackgroundStudies examining the relation between bone mineral density (BMD) and fruit and vegetable consumption during adolescence are rare.ObjectiveOur objective was to determine whether usual fruit and vegetable intakes reported by adolescents have any influence on BMD.DesignBMD was measured by dual-energy X-ray absorptiometry at the nondominant forearm and dominant heel in a random sample of 12-y-old boys (n = 324), 12-y-old girls (n = 378), 15-y-old boys (n = 274), and 15-y-old girls (n = 369). Usual fruit and vegetable consumption was assessed by an interviewer-administered diet history method. Relations between BMD and fruit and vegetable intake were assessed by using regression modeling.ResultsUsing multiple linear regression to adjust for the potential confounding influence of physical and lifestyle factors, we observed that 12-y-old girls consuming high amounts of fruit had significantly higher heel BMD (β = 0.037; 95% CI: 0.017, 0.056) than did the moderate fruit consumers. No other associations were observed.ConclusionHigh intakes of fruit may be important for bone health in girls. It is possible that fruit's alkaline-forming properties mediate the body's acid-base balance. However, intervention studies are required to confirm the findings of this observational study

The impact of impaired semantic knowledge on spontaneous iconic gesture production

Background: Previous research has found that people with aphasia produce more spontaneous iconic gesture than control participants, especially during word-finding difficulties. There is some evidence that impaired semantic knowledge impacts on the diversity of gestural handshapes, as well as the frequency of gesture production. However, no previous research has explored how impaired semantic knowledge impacts on the frequency and type of iconic gestures produced during fluent speech compared with those produced during word-finding difficulties. Aims: To explore the impact of impaired semantic knowledge on the frequency and type of iconic gestures produced during fluent speech and those produced during word-finding difficulties. Methods & Procedures: A group of 29 participants with aphasia and 29 control participants were video recorded describing a cartoon they had just watched. All iconic gestures were tagged and coded as either “manner”, “path only”, “shape outline” or “other”. These gestures were then separated into either those occurring during fluent speech or those occurring during a word-finding difficulty. The relationships between semantic knowledge and gesture frequency and form were then investigated in the two different conditions. Outcomes & Results: As expected, the participants with aphasia produced a higher frequency of iconic gestures than the control participants, but when the iconic gestures produced during word-finding difficulties were removed from the analysis, the frequency of iconic gesture was not significantly different between the groups. While there was not a significant relationship between the frequency of iconic gestures produced during fluent speech and semantic knowledge, there was a significant positive correlation between semantic knowledge and the proportion of word-finding difficulties that contained gesture. There was also a significant positive correlation between the speakers’ semantic knowledge and the proportion of gestures that were produced during fluent speech that were classified as “manner”. Finally while not significant, there was a positive trend between semantic knowledge of objects and the production of “shape outline” gestures during word-finding difficulties for objects. Conclusions: The results indicate that impaired semantic knowledge in aphasia impacts on both the iconic gestures produced during fluent speech and those produced during word-finding difficulties but in different ways. These results shed new light on the relationship between impaired language and iconic co-speech gesture production and also suggest that analysis of iconic gesture may be a useful addition to clinical assessment

Making Up Instruments: Design Fiction for Value Discovery in Communities of Musical Practice

The design of a new technology entails the materialisation of values emerging from the specific community, culture and context in which that technology is created. Within the domain of musical interaction, HCI research often examines new digital tools and technologies which can carry unstated cultural assumptions. This paper takes a step back to present a value discovery exercise exploring the breadth of perspectives different communities might have in relation to the values inscribed in fictional technologies for musical interaction. We conducted a hands-on activity in which musicians active in different contexts were invited to envision not-yet-existent musical instruments. The activity revealed several sources of influence on participants’ artefacts, including cultural background, instrumental training, and prior experience with music technology. Our discussion highlights the importance of cultural awareness and value rationality for the design of interactive systems within and beyond the musical domain