Using digital pens to expedite the marking procedure

This is the Post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2010 Inderscience PublishersDigital pens have been introduced over the last six years and have demonstrated that they can be used effectively for collecting, processing and storing data. These properties make them ideal for use in education, particularly in the marking procedure of multiple-choice questions (MCQ). In this report, we present a system that was designed to expedite the marking procedure of MCQ, for use at any educational level. The main element of the system is a digital pen, i.e. given to the students prior to the examination. On return of the pen, the system immediately recognises the students' answers and produces their results. In this specific research, four groups of students were studied and a variety of data were collected, concerning issues, such as accuracy, time gained by the use of the system and the impressions of the students. The pedagogic value of the use of the system is also presented

Advanced General Aviation Turbine Engine (GATE) concepts

Concepts are discussed that project turbine engine cost savings through use of geometrically constrained components designed for low rotational speeds and low stress to permit manufacturing economies. Aerodynamic development of geometrically constrained components is recommended to maximize component efficiency. Conceptual engines, airplane applications, airplane performance, engine cost, and engine-related life cycle costs are presented. The powerplants proposed offer encouragement with respect to fuel efficiency and life cycle costs, and make possible remarkable airplane performance gains

Research and Teacher Education: The BERA-RSA inquiry. Policy and Practice within the United Kingdom.

Across the four jurisdictions of the United Kingdom (England, Northern Ireland, Scotland and Wales) initial teacher education (ITE) is under active development, with its content, location, control and quality often the focuses of sustained debate. Statutory and professional requirements for the sector inevitably reflect differing assumptions about teaching, teacher knowledge and governance. In exploring ITE across the four jurisdictions, this paper reviews policies and practices through two major focuses: first, the relationships between the declared teacher standards (competencies/competences) and research-informed teacher education provision; second, the ‘turn or (re)turn to the practical’ in teacher education, including policy declarations, changes in practices, and emphases and effects of the discourse(s) of relevance

Intensity mapping cross-correlations II: HI halo models including shot noise

HI intensity mapping data traces the large-scale structure matter distribution using the integrated emission of neutral hydrogen gas (HI). The cross-correlation of the intensity maps with optical galaxy surveys can mitigate foreground and systematic effects, but has been shown to significantly depend on galaxy evolution parameters of the HI and the optical sample. Previously, we have shown that the shot noise of the cross-correlation scales with the HI content of the optical samples, such that the shot noise estimation infers the average HI masses of these samples. In this article, we present an adaptive framework for the cross-correlation of HI intensity maps with galaxy samples using our implementation of the halo model formalism (Murray et al 2018, in prep) which utilises the halo occupation distribution of galaxies to predict their power spectra. We compare two HI population models, tracing the spatial halo and the galaxy distribution respectively, and present their auto- and cross-power spectra with an associated galaxy sample. We find that the choice of the HI model and the distribution of the HI within the galaxy sample have minor significance for the shape of the auto- and cross-correlations, but highly impact the measured shot noise amplitude of the estimators, a finding we confirm with simulations. We demonstrate parameter estimation of the HI halo occupation models and advocate this framework for the interpretation of future experimental data, with the prospect of determining the HI masses of optical galaxy samples via the cross-correlation shot noise.Comment: 15 pages, 8 figures, 3 tables. Comments welcom

The Application of CRISPR Technology to High Content Screening in Primary Neurons

Axon growth is coordinated by multiple interacting proteins that remain incompletely characterized. High content screening (HCS), in which manipulation of candidate genes is combined with rapid image analysis of phenotypic effects, has emerged as a powerful technique to identify key regulators of axon outgrowth. Here we explore the utility of a genome editingapproach referred to as CRISPR (Clustered Regularly Interspersed Palindromic Repeats) for knockout screening in primary neurons. In the CRISPR approach a DNA-cleaving Cas enzyme is guided to genomic target sequences by user-created guide RNA (sgRNA), where it initiates a double-stranded break that ultimately results in frameshift mutation and loss of protein production. Using electroporation of plasmid DNA that co-expresses Cas9enzyme and sgRNA, we first verified the ability of CRISPR targeting to achieve protein-level knockdown in cultured postnatal cortical neurons. Targeted proteins included NeuN (RbFox3) and PTEN, a well-studied regulator of axon growth. Effective knockdown lagged at least four days behind transfection, but targeted proteins were eventually undetectable by immunohistochemistry in \u3e 80% of transfected cells. Consistent with this, anti-PTEN sgRNA produced no changes in neurite outgrowth when assessed three days post-transfection. When week-long cultures were replated, however, PTEN knockdown consistently increased neurite lengths. These CRISPR-mediated PTEN effects were achieved using multi-well transfection and automated phenotypic analysis, indicating the suitability of PTEN as a positive control for future CRISPR-based screening efforts. Combined, these data establish an example of CRISPR-mediated protein knockdown in primary cortical neurons and its compatibility with HCS workflows

Network formation of tissue cells via preferential attraction to elongated structures

Vascular and non-vascular cells often form an interconnected network in vitro, similar to the early vascular bed of warm blooded embryos. Our time-lapse recordings show that the network forms by extending sprouts, i.e., multicellular linear segments. To explain the emergence of such structures, we propose a simple model of preferential attraction to stretched cells. Numerical simulations reveal that the model evolves into a quasi-stationary pattern containing linear segments, which interconnect above the critical volume fraction of 0.2. In the quasi-stationary state the generation of new branches offset the coarsening driven by surface tension. In agreement with empirical data, the characteristic size of the resulting polygonal pattern is density-independent within a wide range of volume fractions

Characterization of the CBC2 readout ASIC for the CMS strip-tracker high-luminosity upgrade

The CMS Binary Chip 2 (CBC2) is a full-scale prototype ASIC developed for the front-end readout of the high-luminosity upgrade of the CMS silicon strip tracker. The 254-channel, 130 nm CMOS ASIC is designed for the binary readout of double-layer modules, and features cluster-width discrimination and coincidence logic for detecting high-PT track candidates. The chip was delivered in January 2013 and has since been bump-bonded to a dual-chip hybrid and extensively tested. The CBC2 is fully functional and working to specification: we present the result of electrical characterization of the chip, including gain, noise, threshold scan and power consumption, together with the performance of the stub finding logic. Finally we will outline the plan for future developments towards the production version

Inverse Simulation as a Tool for Fault Detection and Isolation in Planetary Rovers

With manned expeditions to planetary bodies beyond our own and the Moon currently intractable, the onus falls upon robotic systems to explore and analyse extraterrestrial environments such as Mars. These systems typically take the form of wheeled rovers, designed to navigate the difficult terrain of other worlds. Rovers have been used in this role since Lunokhod 1 landed on the Moon in 1970. While early rovers were remote controlled, communication latency with bodies beyond the Moon and the desire to improve mission effectiveness have resulted in increasing autonomy in planetary rovers. With an increase in autonomy, however, comes an increase in complexity. This can have a negative impact on the reliability of the rover system. With a fault-free system an unlikely prospect and human assistance millions of miles away, the rover must have a robust fault detection, isolation and recovery (FDIR) system. The need for comprehensive FDIR is demonstrated by the recent Chinese lunar rover, Yutu (or “Jade Rabbit”). Yutu was rendered immobile 42 days after landing and remained so for the duration of its operational life: 31 months. While its lifespan far exceeded its expected value, Yutu's inability to move severely impaired its ability to perform its mission. This clearly highlights the need for robust FDIR. A common approach to FDIR is through the generation and analysis of residuals. Output residuals may be obtained by comparing the outputs of the system with predictions of those outputs, obtained from a mathematical model of the system which is supplied with the system inputs. Output residuals allow simple detection and isolation of faults at the output of the system. Faults in earlier stages of the system, however, propagate through the system dynamics and can disperse amongst several of the outputs. This problem is exemplified by faults at the input, which can potentially excite every system state and thus manifest in every output residual. Methods exist for decoupling and analysing output residuals such that input faults may be isolated, however, these methods are complex and require comprehensive development and testing. A conceptually simpler approach is presented in this paper. Inverse simulation (InvSim) is a numerical method by which the inputs of a system are obtained for a desired output. It does so by using a Newton-Raphson algorithm to solve a non-linear model of the system for the input. When supplied with the outputs of a fault-afflicted system, InvSim produces the input required to drive a fault-free system to this output. The fault therefore manifests itself in this generated input signal. The InvSim-generated input may then be compared to the true system input to generate input residuals. Just as a fault at an output manifests itself in the residual for that output alone, a fault at an input similarly manifests itself only in the residual for that input. InvSim may also be used to generate residuals at other locations in the system, by considering distinct subsystems with their own inputs and outputs. This ability is tested comprehensively in this paper. Faults are applied to a simulated rover at a variety of locations within the system structure and residuals generated using both InvSim and conventional forward simulation. Residuals generated using InvSim are shown to facilitate detection and isolation of faults in several locations using simple analyses. By contrast, forward simulation requires the use of complex analytical methods such as structured residuals or adaptive thresholds

TA Mentoring: Issues and Questions

The widespread use of graduate teaching assistants (TAs) in higher education has generated a search for techniques to improve the quality of teaching of TAs as well as enhance the entire TA experience. One such technique is mentoring. This paper attempts to accomplish four things: (a) delineate issues to be addressed, (b) share feedback from educators with mentoring experience, (c) present questions to guide decision making, and (d) provide a bibliography of literature on mentoring. The information presented comes from a questionnaire administered to basic course directors, a conference discussion on mentoring and the personal experiences of the authors