Obesidad como factor asociado a migraña en pacientes del hospital Belén de Trujillo

Demostrar si la obesidad es un factor asociado a migraña en pacientes del Hospital Belén de Trujillo. Material y Métodos: Se llevó a cabo un estudio de tipo, analítico, observacional, prospectivo, de casos y controles.. La población de estudio estuvoconstituida por 68 pacientes para los casos y 136 para los controles que fuerónatendidos en Consultorios Externos de Neurología y de Cirugía General del Hospital Belén de Trujillo; durante el periodo Enero –03 Marzo 2016. Resultados:Según las características demográficas; la migraña fue más frecuente entre los 31 y 40 años (32%); en el sexo femenino con un 68%; y con respecto a la procedencia, se observa que el 29.4% de loscasos de migraña pertenecen al distrito de Trujillo con 29.4%, la relación de la obesidad como factor de riesgo asociado a migraña se obtuvo un Odds Ratio de 1.2 con un intervalo de confianza al 95% (1.06-3.493), un estadístico Chi cuadrado de Pearson: 4.74 y un p- valor: 0.029 (<0.05). La media obtenida de IMC en los obesos fue 31.1 Kg/m 2 con un intervalo de confianza al 95% entre 30.84 - 31.43 Kg/m Conclusiones:La obesidad es un factor asociado a migraña en pacientes del Hospital Belén de Trujillo. La media obtenida deíndice de masa corporal como factor asociado a migraña es de 31.1Kg/m2. 2To determine whether obesity is a factor associated with migraine patients in the Hospital Belen of Trujillo. Materials and methods: It was made an analytic, observational, prospective, case-control study. The population purpose of this study was formed by 68 patients for cases and 136 for controls that were attended in External Consulting Rooms of Neurology and General Surgery at Hospital Belen of Trujillo from January 2003 to March 2016. Results: According to demographic characteristics, migraine was more frequent between 31 and 40 years old (32%), in females with 68%, and according to origin, 29,4% of cases of migraine are in Trujillo district. Relationship with obesity as risk factor associated to migraine got an Odds Ratio of 1,2 with confidence interval of 95% (1.06-3.493), Pearson’s Chi Square statistics of 4.74 and p- value of 0.029 (<0.05). The mean of IMC in obese people was 31.1 kg/m2 with confidence interval of 95% bertween 30.84 – 31.43 Kg/m Conclusions: obesity is a risk factor associated to migraine in Hospital Belen of Trujillo’s patients. The mean of body mass rating as risk factor associated to migraine is 31.1 Kg/m

EasyData: Componente para la Generación Automática de Linked Data en Proyectos Ruby on Rails

El proyecto describe el desarrollo de un componente o gema para el lenguaje Ruby y el framework Rails de desarrollo de aplicaciones web, cuya función es la generaci on automática de Linked Data en RDF del proyecto en que se instala la gema. El componente realiza la ingeniería inversa del modelo de datos, permite administrar el modelo RDF y el control de acceso a los elementos del modelo y a las URI para consulta, y genera automáticamente microdatos RDFa que se añaden a las vistas de la aplicación

Synthesis of Combretastatin A-4 and 3 0 -Aminocombretastatin A-4 derivatives with Aminoacid Containing Pendants and Study of their Interaction with Tubulin and as Downregulators of the VEGF, hTERT and c-Myc Gene Expression

Natural product combretastatin A-4 (CA-4) and its nitrogenated analogue 3 0 -aminocombretastatin A-4 (AmCA-4) have shown promising antitumor activities. In this study, a range of CA-4 and AmCA-4 derivatives containing amino acid pendants have been synthesized in order to compare their biological actions with those of their parent compounds. Thus, inhibition of cell proliferation on tumor cell lines HT-29, MCF-7 and A-549, as well as on the nontumor cell line HEK-273; in vitro tubulin polymerization; mitotic cell arrest; action on the microtubule cell network and inhibition of VEGF, hTERT, and c-Myc genes have been evaluated. Some AmCA-4 derivatives bearing L-amino acids exhibited inhibition of cell proliferation at low nanomolar levels exceeding the values shown by AmCA-4. Furthermore, while CA-4 and AmCA-4 derivatives do not show significant effects on the in vitro tubulin polymerization and cell cycle arrest, some selected CA-4 and AmCA-4 derivatives are able to cause total depolymerization of the microtubule network on A-549 cells. The best results were obtained in the inhibition of gene expression, particularly on the VEGF gene, in which some AmCA-4 derivatives greatly exceeded the inhibition values achieved by the parent compound

Aldol Reactions between L-Erythrulose Derivatives and Chiral α-Amino and α -Fluoro Aldehydes: Competition between Felkin–Anh and Cornforth Transition States

Both matched and mismatched diastereoselection have been observed in aldol reactions of a boron enolate of a protected l-erythrulose derivative with several chiral α-fluoro and α-Amino aldehydes. Strict adherence to the Felkin–Anh model for the respective transition structures does not account satisfactorily for all the observed results, as previously observed in the case of α-oxygenatedaldehydes. In some cases, only the Cornforth model provides a good explanation. The factors that influence this dichotomy are discussed and a general mechanistic model is proposed for aldol reactions with a-heteroatom-substituted aldehydes. Additional support for the model was obtained from density functional calculation

Inhibitory effect of cytotoxic stilbenes related to resveratrol on the expression of the VEGF, hTERT and c-Myc genes

A group of thirty-nine stilbene derivatives, prepared by means of Heck coupling reactions, has been investigated for their cytotoxicity, as well as for their ability to inhibit the production of the vascular endothelial growth factor (VEGF) and the activation of telomerase. The ability of these compounds to inhibit proliferation of two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell line (HEK-293) was first determined. Subsequently, we determined the capacity of the compounds to inhibit the secretion of VEGF in the aforementioned cell lines and to downregulate the expression of the VEGF, hTERT and c-Myc genes, the two latter involved in the control of the activation of telomerase. One of the synthetic stilbenes, (E)-4-(4-methoxystyryl)aniline, showed strong cytotoxicity and proved able to cause a marked decrease both in the secretion of VEGF and in the expression of the hTERT and c-Myc genes, in all cases at concentrations in the low nanomolar range

Convergent, stereoselective syntheses of the glycosidase inhibitors broussonetines D and M

The first syntheses of the polyhydroxylated alkaloids (iminosugars) broussonetines D and M glycosidase inhibitors of the pyrrolidine class, have been performed in a convergent, stereocontrolled way from D-serine as the chiral starting material. A cross metathesis step was one key feature of the synthesis. The versatility of the synthetic concept chosen permits the access to many members of this compound family, both natural ones and analogues thereo

Synthesis and evaluation of biphenyl derivatives as potential downregulators of VEGF protein secretion and telomerase-related gene expressions

A group of 47 biphenyl functionalized compounds, prepared by means of Suzuki couplings, has been investigated for their cytotoxicity on two tumoral cell lines (HT-29 and MCF-7) and one non tumoral cell line (HEK-293). 29 selected compounds have been investigated for their ability to inhibit the production of the vascular endothelial growth factor (VEGF). Subsequently, the capacity of the compounds to downregulate the expression of the VEGF, h-TERT and c-Myc genes, the two latter involved in the control of the activation of telomerase, has also been determined.Financial support has been granted to M.C. by the Ministerio de Economía y Competitividad of Spain (project CTQ2014- 52949-P), by the Consellería d´Empresa, Universitat i Ciencia de la Generalitat Valenciana (projects PROMETEO/2013/027 and ACOMP/2014/ 274) and by the University Jaume I (project PI- 1B2011-37). M. S.-P. thanks the University Jaume I for a predoctoral fellowship

Study of human remains from the Cañada Real Dolmen deposited at the Department of Anatomy and Human Embriology of the Faculty of Medicine, Seville University

Don Juan de Mata Carriazo entregó dos lotes de huesos humanos procedentes de su excavación del Dolmen de Cañada Real: uno fue depositado en el Museo Arqueológico de Sevilla, mientras que el otro fue llevado a la Facultad de Medicina de la Universidad. Una vez publicados los resultados de los restos óseos del museo, nos detenemos aquí en la descripción de este segundo depósito.Mr. Juan de Mata Carriazo handed over two sets of human bones from his excavation of the ‘Dolmen de Cañada Real’: one was deposited at the Archaeological Museum of Seville, while another was taken to the Medicine Faculty of the University. Once the bone remains housed at the museum have been published, we study the second ones

Novel multitarget inhibitors with antiangiogenic and immunomodulator properties

By means of docking studies, seventeen compounds T.1-T17 have been designed and evaluated as multitarget inhibitors of VEGFR-2 and PD-L1 proteins in order to overcome resistance phenomena offered by cancer. All these designed molecules display a urea moiety as a common structural feature and eight of them (T.1-T8) further contain a 1,2,3-triazol moiety. The antiproliferative activity of these molecules on several tumor cell lines (HT-29, MCF-7, HeLa, A549, HL-60), on the endothelial cell line HMEC-1 and on the non-tumor cell line HEK-293 has been determined. The urea derivatives were also evaluated for their antiangiogenic properties, whereby their ability to inhibit tubulogenesis and kinase activity employing flow cytometry, ELISA, immunofluorescence and western blot techniques was measured. In addition, these techniques were also employed to investigate the immunomodulator action of the synthetic compounds on the inhibition of PD-L1 and c-Myc proteins. Compound T.2, 1-(3-chlorophenyl)-3-(2-(4-(4-methoxybenzyl)-1H-1,2,3-triazol-1-yl)ethyl)urea, has shown similar results to sorafenib in both down-regulation of VEGFR-2 and inhibition of the kinase activity of this receptor. Furthermore, compound T.14, (E)-1-(4-chlorophenyl)-3-(3-(4-methoxystyryl)phenyl)urea, improves the effect of T.2 as regards tube formation of endothelial cells and inhibition of VEGFR-2 tyrosine kinase activity. In addition, T.14 improves the effect of the experimental drug BMS-8 in the inhibition of PD-L1 and c-Myc proteins