Methods of probe microscopy in the study of topography and elastic properties of cold-resistant elastomers

The work was carried out under the financial support of the Russian Science Fund, grant 14-29-00198-П(sample preparation and scanning electron microscopy) and the Federal Agency of Scientific Organizations - Agreement No 007-ГЗ/Ч3363/26 (scanning probe microscopy)

Probe microscopy and another microscopy methods for investigation of the surface of non-homogeneous materials

Тонкие покрытия, состоящие из оксидов l, Zr и Y, нанесенных на стальную подложку из нержавеющей стали, исследовались до и после триботехнических испытаний. Показано, что покрытия на основе диоксида циркония, стабилизированного иттрием, увеличивают ресурс работы материала.Thin over layers (Al, Zr and Y oxides), deposited on stainless steel substrate, were investigated before and after the friction tests. It was shown that covering by zirconium oxide (stabilized by yttrium) leads to increase of operation life of composition.Работа проведена при поддержке гранта РФФИ 15-08-06298

Эффективность и безопасность вакцины Гам-КОВИД-Вак у пациентов с иммуновоспалительными ревматическими заболеваниями: предварительные данные проспективного наблюдения

Objective: to study the efficacy and safety of the Gam-COVID-Vac vaccine in patients with immunoinflammatory rheumatic diseases (IRD) in a prospective study.Material and methods. The study included 42 patients with IRD and 57 individuals without IRD (control group) who received at least one component of Gam-COVID-Vac. Immunization with the first component of the vaccine was carried out from March 25th to August 1st, 2022, the second – 3 weeks after the first dose. On days 1, 3 and 7 after administration of the first and second components, the study participants provided information on adverse events (AEs) by telephone. All subjects were examined by a rheumatologist 1, 3 and 6 months after complete immunization. The observation period after immunization with the second dose was 6 months.Results and discussion. 42 patients received the first component of the vaccine, and 39 patients received two components. In the control group, 57 subjects were immunized with two components of the vaccine. 30–180 days after vaccination with two components of Gam-COVID-Vac, 3 (7.7%) patients were diagnosed with SARS-CoV-2 infection, which was confirmed by polymerase chain reaction. In all cases, a mild course of COVID-19 without signs of pneumonia was observed. There were no cases of COVID-19 in the control group. After immunization with the first component, a combination of at least one local and one systemic AE (SAE) was documented in 28.6% of patients with IRD and 33.3% of individuals in the control group (p>0.05). No AEs were recorded in 42.9% and 36.8% of cases respectively (p>0.05). After vaccination with the second component, a combination of ≥1 local AE and SAE was recorded in 15.4 % of patients with IRD and 22.8% of individuals in the control group (p>0.05). No AEs occurred in 71.8% and 56.1% of cases respectively (p>0.05). In 10.3% of patients with IRD and 12.3 % of those without IRD (p>0.05), a combination of local and systemic AEs was recorded after the introduction of both first and second components. No AEs were observed in 35.9% and 28.1% of cases, respectively (p>0.05). The overall rate of IRD exacerbations was 4.8%.Conclusion. Based on the available data, vaccination against COVID-19 appears to be effective and quite safe in patients with IRD.Цель исследования – изучить эффективность и безопасность вакцины Гам-КОВИД-Вак у больных с иммуновоспалительными ревматическими заболеваниями (ИВРЗ) в проспективном исследовании.Материал и методы. В исследование включено 42 пациента с ИВРЗ и 57 лиц без ИВРЗ (контрольная группа), получивших как минимум один компонент Гам-КОВИД-Вак. Иммунизация первым компонентом вакцины проводилась с 25 марта по 1 августа 2022 г., вторым – через 3 нед после введения первой дозы. В 1-й, на 3-й и 7-й день после введения первого и второго компонентов информацию о нежелательных явлениях (НЯ) участники исследования сообщали по телефону. Через 1, 3 и 6 мес после полной вакцинации все они были осмотрены ревматологом. Период наблюдения после иммунизации второй дозой составил 6 мес.Результаты и обсуждение. Первый компонент вакцины получили 42 пациента, два компонента – 39. В контрольной группе 57 испытуемых иммунизированы двумя компонентами вакцины. Через 30–180 дней после вакцинации двумя компонентами Гам-КОВИД-Вак инфекция SARS-CoV-2, подтвержденная методом полимеразной цепной реакции, диагностирована у 3 (7,7%) больных. При этом во всех случаях отмечено легкое течение COVID-19 без признаков пневмонии. В контрольной группе случаев COVID-19 не было. После иммунизации первым компонентом сочетание как минимум 1 местного и 1 системного НЯ (СНЯ) документировано у 28,6% пациентов с ИВРЗ и 33,3% лиц контрольной группы (p>0,05). НЯ не зарегистрированы соответственно в 42,9% и 36,8% случаев (p>0,05). После вакцинации вторым компонентом сочетание 1 местного НЯ и СНЯ зафиксировано у 15,4% больных с ИВРЗ и 22,8% лиц контрольной группы (p>0,05). НЯ отсутствовали в 71,8% и 56,1% случаев соответственно (p>0,05). У 10,3% пациентов с ИВРЗ и 12,3% лиц без ИВРЗ (p>0,05) сочетание местных и системных НЯ зарегистрировано после введения как первого, так и второго компонента. Не отмечено НЯ в 35,9% и 28,1% случаев соответственно (p>0,05). Общая частота обострений ИВРЗ составила 4,8%.Заключение. Согласно полученным данным, вакцинация против COVID-19 у больных с ИВРЗ представляется эффективной и достаточно безопасной

EFFICIENCY EVALUATION OF ENTERPRISE INFORMATION SYSTEMS WITH NON-UNIFORM LOAD

The paper deals with the problem of characteristics evaluation for enterprise information systems at the design stage. In the design of ERP-systems the most interest characteristic is not the average time, but the probability of timely delivery of different type messages (for example, command, service, multimedia, files, etc.) from the sender to the recipient. In addition,the possibility of using the priority information management built on the basis of service disciplines of general form with mixed priorities needs to be considered. An open queuing network with non-uniform data flow is used for solution of this problem. The method for calculation of information systems characteristics is proposed based on the decomposition of the network model. The end results obtained with this approach and by means of priority management are approximate because different classes of message streams at the output and input nodes of the computer system differ from the simple ones. However, result errors of the proposed analytical method are in acceptable limits for engineering calculations as it was shown by simulation in a wide range of parameters corresponding to real systems. Obtained results are usable for optimization problem solution of data transmission networks in modern information systems, involving routing algorithm definition and priorities specification for different classes of messages to provide given delivery time

Subjective Well-Being of High School Students Belonging to Indigenous Peoples of the North as a Basis for Readiness to Choose a Profession

Introduction.The preservation and well-being of the indigenous peoples of the Russian North is directly related to the national identity, the values for sustaining vital activities, the continuation and development of traditional crafts. Thus, the professional self-determination of the oncoming generation from the Russian North is the basis for the preservation of their national heritage.The aim of the present publication was to determine the subjective grounds for the formation of personal readiness to choose a profession among high school students studying and living in the Arctic.Methodology and research methods. the empirical base of the research was formed by the obtained data using psychodiagnostic tools. The indicators were the subjective well-being of schoolchildren and their readiness for professional selfdetermination. 119 high school students aged 14-17 from educational institutions of the Yamal-Nenets Autonomous District of the Tyumen Region and the city of Tyumen took part in the testing of these complex constructs. The statistical data analysis was carried out along with comparative and correlation analyses.Results. The research results show the interrelated differences between indicators of subjective well-being and readiness to choose a profession among indigenous high schools students of the Russian North and their non-indigenous peers. The analysis of the statistical validity of differences using the Student’s t-test demonstrated that high school students of the indigenous minorities of the Russian North have higher rates of psycho-emotional stability. Also, they are more independent and optimistic about choosing a profession. The results of the correlation analysis revealed that indigenous high school students of the Russian North have certain advantages over their non-indigenous peers when coping with the challenges of choosing a career. For instance, indigenous high school students are much less dependent on the indicators of subjective well-being. Their stronger psycho-emotional response to harsh living conditions increases their motivation for early professional self-determination.Scientific novelty. The current study enhances the understanding of the influence of relationships between personal characteristics and subjective well-being on the readiness to choose a career by graduates of secondary schools located in the Arctic.Practical significance. The research findings and conclusions could be exploited in order to build up more accurate and targeted system of career guidance support for high school students of the indigenous peoples of the North, as well as for other nationalities living in harsh climatic conditions

4-WEEK OPEN-LABEL CONTROLLED RANDOMIZED COMPARATIVE STUDY OF THE INJECTABLE AND TABLETTED FORMULATIONS OF METHOTREXATE IN RHEUMATOID ARTHRITIS

Objective: to estimate the advantages and disadvantages of using the injectable formulation of methotrexate (MT) (Methoject (MTJ)) in rheumatoid arthritis (RA) in clinical practice. Subjects and methods. A 24-week open-label controlled randomized comparative study evaluated the therapeutic and side effects of MTJ and methotrexate tablets in RA and clarified whether MTJ treatment might be continued if its tabletted formulation was discontinued because of adverse reactions. Results and discussion. MTJ was found to be more effective than the tabletted formulation of MT and as a whole; and following 3-month therapy, more patients receiving MTJ achieved an ACR20 response. The advantage of MTJ was also retained 6 months after therapy. Higher transaminase levels were noted in 2 patients, one in each group. Switching from MT to MTJ noticeably reduced the number of adverse reactions in the majority of patients from an additional group. Conclusion. As compared to MT, MTJ used in RA patients is more effective when given in an equivalent dose, exerts a therapeutic effect more rapidly, and induces adverse gastrointestinal reactions less frequently

Subjective Well-Being of High School Students Belonging to Indigenous Peoples of the North as a Basis for Readiness to Choose a Profession

Introduction. The preservation and well-being of the indigenous peoples of the Russian North is directly related to the national identity, the values for sustaining vital activities, the continuation and development of traditional crafts. Thus, the professional self-determination of the oncoming generation from the Russian North is the basis for the preservation of their national heritage. The aim of the present publication was to determine the subjective grounds for the formation of personal readiness to choose a profession among high school students studying and living in the Arctic. Methodology and research methods. the empirical base of the research was formed by the obtained data using psychodiagnostic tools. The indicators were the subjective well-being of schoolchildren and their readiness for professional selfdetermination. 119 high school students aged 14-17 from educational institutions of the Yamal-Nenets Autonomous District of the Tyumen Region and the city of Tyumen took part in the testing of these complex constructs. The statistical data analysis was carried out along with comparative and correlation analyses. Results. The research results show the interrelated differences between indicators of subjective well-being and readiness to choose a profession among indigenous high schools students of the Russian North and their non-indigenous peers. The analysis of the statistical validity of differences using the Student’s t-test demonstrated that high school students of the indigenous minorities of the Russian North have higher rates of psycho-emotional stability. Also, they are more independent and optimistic about choosing a profession. The results of the correlation analysis revealed that indigenous high school students of the Russian North have certain advantages over their non-indigenous peers when coping with the challenges of choosing a career. For instance, indigenous high school students are much less dependent on the indicators of subjective well-being. Their stronger psycho-emotional response to harsh living conditions increases their motivation for early professional self-determination. Scientific novelty. The current study enhances the understanding of the influence of relationships between personal characteristics and subjective well-being on the readiness to choose a career by graduates of secondary schools located in the Arctic. Practical significance. The research findings and conclusions could be exploited in order to build up more accurate and targeted system of career guidance support for high school students of the indigenous peoples of the North, as well as for other nationalities living in harsh climatic conditions.Введение. Сохранение самобытности и благосостояния коренных малочисленных народов Севера подразумевает сбережение их национально-культурной идентичности, ценностных ориентиров жизнедеятельности, продолжение и развитие традиционных промыслов. К ключевым факторам такого сохранения и защиты от размывания национального достояния относится социально-профессиональное самоопределение подрастающего поколения северян. Цель исследования, изложенного в статье, состояла в выявлении субъективных оснований для формирования личностной готовности к выбору профессии у старшеклассников, обучающихся и проживающих в условиях Арктики. Методология и методы. Эмпирическую базу изыскания составили установленные при помощи психодиагностического инструментария данные о субъективном благополучии школьников и готовности их к профессиональному самоопределению. В тестировании этих многофакторных конструктов приняли участие 119 подростков в возрасте 14-17 лет, обучающихся в образовательных учреждениях Ямало-Ненецкого автономного округа Тюменской области и города Тюмени. Статистическая обработка данных осуществлялась с применением методов сравнительного и корреляционного анализа. Результаты исследования свидетельствуют о существовании различий во взаимосвязях показателей субъективного благополучия и готовности к профессиональному выбору у старшеклассников, принадлежащих к коренному населению Севера, и их «некоренных» сверстников. Анализ статистической достоверности различий с применением t-критерия Стьюдента показал, что школьники-аборигены обладают более высокой стрессоустойчивостью, стремлением к взрослому поведению и более самостоятельны и оптимистичны в ситуации профессионального самоопределения. Корреляционный анализ обнаружил некоторые преимущества юных представителей коренных жителей Севера перед неавтохтонными ровесниками в преодолении трудностей выбора профессии: первые в отличие от вторых в меньшей степени зависят от показателей субъективного благополучия, а усиление психоэмоционального реагирования организма на неблагоприятные условия жизни лишь повышает их мотивацию к скорейшему профсамоопределению. Научная новизна. Проведенное исследование расширяет представления о влиянии личностных характеристик и субъективного благополучия на готовность к выбору профессии выпускников общеобразовательных школ, расположенных на арктических территориях. Практическая значимость. Результаты работы и выводы авторов позволяют более точно и адресно выстроить систему профориентационного сопровождения обучающихся в старших классах представителей коренных малочисленных народов Севера, а также других национальностей, проживающих в суровых климатических зонах