Sallandik abisi -- earthquake stress in Turkey.

This project, conducted on site in Istanbul and Kocaeli, Turkey, gathered data on the persistence of Post Traumatic Stress Disorder in surviving victims and rescue workers of 1999 Kocaeli Earthquake. Through literature review, qualitative and focus group interviews, the team detected continuing symptoms and proposed 17 immediate and long-term solutions including prompt and continuing psychological counseling, greater educational publicity through media competitions and film/TV treatments, accelerated housing re-construction, identification of contractors on building , and technological innovations for search and rescue

Assessment of In Vitro Antigenotoxic Effect of Nigella Sativa Oil

Objectives: Cyclophosphamide (CP) is an alkylating agent widely used as an antineoplastic and immunosuppressive agent. The genotoxicity of CP has been studied in a variety of in vivo and in vitro systems and is routinely used as a positive control in genotoxicity tests. Traditional medicine Nigella sativa L., (N. sativa), Ranunculaceae family, especially in the Eastern Mediterranean countries, especially in many countries, and is widely used in many countries as a spice and folk medicine since the time of Dioscorides used as a plant. In this study, it was aimed to show the protective effects of N. sativa oil at different concentrations against the genotoxic effects of CP by micronucleus test. Materials and Methods: For this purpose, healthy cells were treated in vitro with N. sativa oil at concentrations of 1, 5, 10 mu g/mL and CP as positive control for 68 hours. The micronuclei were then counted. Results: No significant increase in micronucleus frequency was observed when the application of N. sativa oil at concentrations of 1, 5. 10 mu g/mL compared with the negative control. There was a decrease in the number of micronucleus in all three concentrations (1, 5, 10 mu g/mL) compared to the CP group in the groups treated with N. sativa oil and CP. Conclusion: It has been shown that N. sativa oil may have protective effects against genotoxicity agents in vitro. But more work is needed to understand the mechanism of the genotoxicity effects of N. sativa oil

Is the presence of Demodex folliculorum increased with impaired glucose regulation in polycystic ovary syndrome?

Demodex parasites may cause skin and eyelash lesions by settling on the pilosebaceous unit. This parasite plays a role in the pathophysiology of acne in polycystic ovarian syndrome (PCOS). We aimed to examine the relationship between Demodex folliculorum and blood glucose control in patients with PCOS with skin and eyelash lesions. Forty-four patients with PCOS with skin lesions were enrolled in the study. At least two specimens were taken from the skin lesions using the standard method and at least six epilated eyelashes were taken from both eyes under a biomicroscope and evaluated using a light microscope. The demographic characteristics, body mass index (BMI) and clinical parameters of the patients were recorded. Demodex folliculorum was present at a rate of 59.1% in the skin lesions of the patients with PCOS, 40.9% in eyelash samples and 43.18% in both skin and lashes. Homeostasis model assessment of insulin resistance (HOMA-IR), glycosylated haemoglobin (HB A1c) concentrations, and BMIs were significantly higher in the patients who had D. folliculorum in skin samples than in those without (p = .010, p = .007 and p = .02). Impaired glucose regulation may explain the pathophysiology of the increased D. folliculorum presence in the skin lesions of patients with PCOS.Impact statement What is already known on this subject? Although several studies on Demodex folliculorum and PCOS have been conducted, we have not yet found a study that examines D. folliculorum parasites in the eyelashes and skin correlating with glucose regulation in PCOS. This study presents new information about the relationship between the presence of D. folliculorum and impaired glucose regulation in women with PCOS. What do the results of this study add? D. folliculorum is seen more commonly in skin lesions in patients with PCOS with impaired blood glucose regulation. What are the implications of these findings for clinical practice and/or further research? D. folliculorum is present in both skin and eyelash lesions in patients with PCOS. These lesions may be prevented by avoiding unregulated glucose levels and obesity. In future studies, the investigation of the resorption of D. folliculorum parasites in skin lesions with the continuation of normal glucose levels in patients with PCOS will reveal a more interesting linkage

Early-Loaded One-Stage Implants Retaining Mandibular Overdentures By Two Different Mechanisms: 5-Year Results

Purpose: To compare the biologic and prosthetic outcomes of implants loaded early to retain mandibular overdentures by means of two different attachment systems. Materials and Methods: Patients were screened according to specific inclusion/exclusion criteria and randomly allocated to treatment groups involving two-implant-supported early loaded mandibular overdentures retained by ball attachments or Locator attachments. Marginal bone loss, Plaque Index, peri-implant infection, Bleeding Index, prosthetic complications, and Kaplan-Meier survival estimates of the groups were assessed at the 5-year recall. Results: Among the 29 patients (58 implants) who completed the study, one implant was lost during healing; all implants survived after prosthesis delivery. Bone loss in the ball attachment group (0.77 +/- 0.05 mm) was significantly greater than that in the Locator group (0.59 +/- 0.03 mm). The Plaque and Bleeding indices of both groups were comparable, and peri-implant inflammation scores in both groups were zero for all implants. The frequencies of activation of the matrix, replacement of the matrix, and denture reline in the ball attachment group were significantly higher than those observed in the Locator group. While assessments for the absence of any complication showed that the 1- and 3-year Kaplan-Meier survival probabilities of both groups were comparable, when activation of the retainer was excluded, survival probabilities of the ball attachment group were higher. Conclusions: The biologic outcomes of early loaded mandibular overdentures retained by ball attachments or Locators were comparable. Although the frequency of prosthetic complications with ball attachments was higher, this did not decrease the survival probability for the treatment

Omentin and chemerin and their association with obesity in women with polycystic ovary syndrome

WOS: 000336790400005PubMed ID: 24524360We aimed to investigate whether overweight/obesity is associated with omentin and chemerin. The study group consisted of 81 women with Polycystic ovarian syndrome (PCOS) (41 lean, BMI25 kg/m(2)) and 61 healthy subjects (31 lean, BMI25 kg/m(2); control group). The clinical, endocrine, metabolic parameters, plasma omentin and chemerin levels were measured in patients and compared to control. In all subjects with PCOS (n = 80), serum chemerin levels were higher compared with those of the controls (n = 58) (7.71 +/- 1.78 ng/mL versus 6.94 +/- 0.82 ng/mL, p = 0.003). However, serum omentin levels were not significantly different between the PCOS subjects and the controls (1.55 +/- 0.43 ng/mL versus 1.69 +/- 0.37 ng/mL, p = 0.056). The mean chemerin concentrations were significantly elevated in the obese PCOS group compared with the obese control subjects (8.98 +/- 1.45 ng/mL versus 7.02 +/- 0.67 ng/mL, p = 0.000) and the nonobese PCOS group compared with the obese control subjects (6.57 +/- 1.17 ng/mL versus 7.02 +/- 0.67 ng/mL, p = 0.000). In conclusion, fat mass seems to be the main determinant factor of increased chemerin and decreased omentin in women with PCOS.Namik Kemal UniversityNamik Kemal UniversityThe contribution of all authors and project partners is acknowledged, along with the support of Namik Kemal University

Silica coating of the pore walls of a microporous polycaprolactone membrane to be used in bone tissue engineering

Polycaprolactone/silica microporous hybrid membranes were produced in two steps: A microporous polycaprolactone membrane with an interconnected porosity of 80% was obtained via a freeze extraction procedure, then silica was formed by a sol-gel reaction inside the micropores using tetraethyl orthosilicate, TEOS, as silica precursor. It is shown that silica forms a thin coating layer homogeneously distributed over the pore walls when sol-gel reaction is catalyzed by hydrochloric acid, while it forms submicron spherical particles when using basic catalyzer. Some physical properties and the viability and osteoblastic differentiation of bone marrow rat mesenchymal stem cells cultured on pure and hybrid membranes were studied.Contract grant sponsors: COOPEN Project. Turkish Academy of Sciences, TUBA; VI National R&D&I Plan 2008-2011; Iniciativa Ingenio 2010; Consolider Program; CIBER Actions; Instituto de Salud Carlos III; European Regional Development FundDemirdogen, B.; Plazas Bonilla, CE.; Trujillo, S.; Perilla, J.; Elcin, A.; Elcin, YM.; Gómez Ribelles, JL. (2014). Silica coating of the pore walls of a microporous polycaprolactone membrane to be used in bone tissue engineering. Journal of Biomedical Materials Research Part A. 102(9):3229-3236. https://doi.org/10.1002/jbm.a.34999S32293236102

CAD/CAM Glass Ceramics for Single-Tooth Implant Crowns: A Finite Element Analysis

Purpose:To evaluate the load distribution of CAD/CAM mono-ceramic crowns supported with single-tooth implants in functional area.Materials and Methods:A 3-dimensional numerical model of a soft tissue-level implant was constructed with cement-retained abutment to support glass ceramic machinable crown. Implant-abutment complex and the retained crown were embedded in a O 1.5 x 1.5 cm geometric matrix for evaluation of mechanical behavior of mono-ceramic CAD/CAM aluminosilicate and leucite glass crown materials. Laterally positioned axial load of 300 N was applied on the crowns. Resulting principal stresses in the mono-ceramic crowns were evaluated in relation to different glass ceramic materials.Results:The highest compressive stresses were observed at the cervical region of the buccal aspect of the crowns and were 89.98 and 89.99 MPa, for aluminosilicate and leucite glass ceramics, respectively. The highest tensile stresses were observed at the collar of the lingual part of the crowns and were 24.54 and 25.39 MPa, respectively.Conclusion:Stresses induced upon 300 N static loading of CAD/CAM aluminosalicate and leucite glass ceramics are below the compressive strength of the materials. Impact loads may actuate the progress to end failure of mono-ceramic crowns supported by metallic implant abutments