The carvacrol ameliorates acute pancreatitis-induced liver injury via antioxidant response

Acute pancreatitis (AP) may cause significant persistent multi-organ dysfunction. Carvacrol (CAR) possesses a variety of biological and pharmacological properties. The aim of the present study was to analyze the hepatic protection of CAR on AP induced by cerulein and to explore the underlying mechanism using in vivo studies. The rats were randomized into groups to receive (1) no therapy; (2) 50 A mu g/kg cerulein at 1-h intervals by four intraperitoneal injection (i.p.); (3) 50, 100 and 200 mg/kg CAR by one i.p.; and (4) cerulein + CAR after 2 h of cerulein injection. 12 h later, serum was provided to assess the blood AST, ALT and LDH values. Also, liver tissues were obtained for histological and biochemical measurements. Liver oxidative stress markers were evaluated by changes in the amount of lipid peroxides measured as MDA and changes in tissue antioxidant enzyme levels, SOD, CAT and GSH-Px. Histopathological examination was performed using scoring systems. Oxidative damage to DNA was quantitated in studied tissues of experimental animals by measuring the increase in 8-hydroxydeoxyguanosine (8-OHdG) formations. We found that the increasing doses of CAR decreased pancreatitis-induced MDA and 8-OH-dG levels. Moreover, the liver SOD, CAT and GSH-Px activities in the AP + CAR group were higher than that of the rats in the AP group. In the treatment groups, AST, ALT and LDH were reduced. Besides, necrosis, coagulation and inflammation in the liver were alleviated (p < 0.05). We suggest that CAR could be a safe and potent new drug candidate for treating AP through its antioxidative mechanism of action for the treatment of a wide range of disorders related to hepatic dysfunction

The Effect of Sport on the Level of Positivity and Well-Being in Adolescents Engaged in Sport Regularly

Sport, an element of universal culture, is a prominent tool that brings individuals with different languages, races and religions together. Sport is generally defined as activities that positively affect the psychological health of people and bring about social and moral benefits besides its physical benefits. Mental well-being is defined as the individual's awareness of their own abilities, their abilities to overcome stress in life, being productive and useful in business life and contributing to community via the their ability (WHO, 2004). Positivity is defined as the main determinant of subjective well-being and is expressed as a tendency to evaluate all aspects of life that is already good. This study aimed to investigate whether sport is effective on mental well-being and positivity. In the study pre-test, post-test experimental design with control group was used and “Warwick-Edinburgh Mental Well-being (WEMWBS)” scale developed by Tennant et al. (2007), which was adapted into Turkish by Keldal (2015) and “The Positivity Scale” scale developed by Caprara and et al. (2012), and adapted into Turkish by Çıkrıkçı, Çiftçi and Gençdoğan (2015) were used as the data collection tools. When the original form of mental wellbeing scale compared with its version adapted into Turkish are compared, the reliability coefficient Cronbach Alpha was found to be as .92. On the other hand, the internal consistency coefficient for the Positivity Scale was found to be .75 and its test-retest reliability coefficient was found to be .91. As parametric assumptions are met, Variance Analysis, Tukey test, Paired-Samples t-test was used. For the analysis of data obtained through counting, Chi Square was used and level of significance was taken as 0.05. The study group is composed by forming 3 groups of 20 students from 10th grade students. The groups were equalled in terms of some variables like age, gender, sports background etc. The groups were called as the sports activities group, social activities group and the control group. While the participants in the experimental group were engaged in regular and scheduled sports activities including training and contests, the participants in the social activities group engaged in regular social activities. The participants in the control group led their routine lives. After a period of 10 weeks, the tests given at the beginning of the study were administrated again, and test scores of the students in all three groups were compared.According to the results of the study, when the pre-test and post-test positivity scores of the individuals in all three groups were compared, the differences between the groups were not found to be insignificant (p>0.05). When post-test mental well-being scores were compared, the difference was found significant (p0.05). There was a decrease in the positivity scores of the control group from the pre-test to post-test and difference was found significant (p0.05)

Yönetim Bilgi Sistemi Olarak E-Okul Uygulamalarının Değerlendirilmesi

The purpose of the study is to determine the perceptions of the teachers and principals of primary schools in Muş Province of Turkey on the status of the existing competence of e-school as a management information system and to make an assessment of the e-school management information system.  This study was designed as a survey study. The population comprises of 1698 teachers and school principals working in the state primary schools in the central district of Muş province during the 2010-2011 educational year. The sample consists of 835 randomly selected teachers and school principals. The results showed that there is not a statistically significant difference between the perceptions of the majority of the teachers and the school principals who think that the e-school system is adequate in terms of institutional affairs, student affairs and student report card works period. On the other hand, there is a statistically significant difference regarding the teachers’ and school principals’ perceptions of the favorite place of access to e-school and adequacy of the eschool system.  ÖZ. Bu araştırmanın amacı; ilköğretim okullarındaki yönetici ve öğretmenlerin yönetim bilgi sistemi olarak “E- okul”un mevcut yeterlilik durumuna yönelik görüşlerini belirlemek ve e-okul yönetim bilgi sisteminin bir değerlendirmesini yapmaktır. Araştırmada veri toplama aracı olarak araştırmacılar tarafından geliştirilen “Yönetim Bilgi Sistemi Olarak E-okul Uygulamalarının Değerlendirilmesi Anketi (YBSEA)” kullanılmıştır. Araştırmanın çalışma evrenini 2010-2011 eğitim-öğretim yılında Muş ili merkez ve merkeze bağlı ilköğretim okullarında görev yapmakta olan 1698 öğretmen ve örneklemini ise bu evren içerisinden tesadüfî olarak seçilen 835 öğretmen ve yönetici oluşturmaktadır. Araştırma sonuçlara göre; ilköğretim okullarında görev yapmakta olan yönetici ve öğretmenler, yönetim bilgi sistemi olarak e-okul uygulamaları hakkında genel anlamda olumlu bir görüşe sahiptirler.E-okul uygulamalarını yeterli gören yönetici ve öğretmen görüşleri arasında kurum, karne ve öğrenci işlemleri, boyutlarında bir farklılık görülmezken, e-okulun yeterliliği konusunda erişimde tercih edilen mekan değişkeni açısından öğretmenler lehinde anlamlı görüş farklılığı bulunmaktadı

Liken ekstrelerinin sağlıklı ratlar üzerindeki etkileri ve bu ekstrelerin diyabete bağli çoklu organ yetmezliğinin önlenmesinde medikal kullanımı

In the present study, we firstly assessed Cetraria islandica and Pseudevernia furfuracae to avoid detrimental effects on multiple tissues of rats. Diabetes mellitus (DM) with the subsequent generation of oxidative stress represents a major risk factor for organs. The second aim of this study is to investigate whether administration of both lichens could prevent type 1 diabetes (T1D)-induced organ dysfunctions. During two weeks, both control and diabetic rats were treated with aqueous lichen extracts. The metabolic changes were determined. On day 14, after animals were decapitated, required samples for biochemical and genetic analysis were collected. Oxidative damage of DNA was estimated by measuring the increase in 8-hydroxy-2'-deoxyguanosine formation. Biochemical parameters were used to observe and evaluate the functional changes in tissues. Experimental data showed that the increasing doses of lichens alone have not any detrimental effect on above parameters. Moreover, C. islandica decreased the diabetes-induced glucose and malondialdehyde (MDA) levels. Thus, it seemed that the antioxidant treatment has an important effect on the organ failure in ill rats. However, the protective effect of C. islandica was inadequate on diabetes-induced disorders and DNA damages. Lichens are a safe in the studied dose range but the power of C. islandica is limited because of intensive oxidative stress in essential organs of T1D rats

The marine arthropods of Turkey

This recent checklist of marine arthropods found on the coasts of Turkey represents a total of 1531 species belonging to 7 classes: Malacostraca (766 species), Maxillopoda (437 species), Ostracoda (263 species), Pycnogonida (27 species), Arachnida (26 species), Branchiopoda (7 species), and Insecta (5 species). Seventy-fve species were classifed as alien species in the region. Tis paper also includes the frst record of the amphipod Melita valesi from the Levantine coast of Turkey (Kaş, Gulf of Antalya).This recent checklist of marine arthropods found on the coasts of Turkey represents a total of 1531 species belonging to 7 classes: Malacostraca (766 species), Maxillopoda (437 species), Ostracoda (263 species), Pycnogonida (27 species), Arachnida (26 species), Branchiopoda (7 species), and Insecta (5 species). Seventy-fve species were classifed as alien species in the region. Tis paper also includes the frst record of the amphipod Melita valesi from the Levantine coast of Turkey (Kaş, Gulf of Antalya)

Kalite iyileştirmede veri madenciliği kullanımı ve geliştirilmesi

TÜBİTAK MAG30.06.2009Bu projede amaç, sanayi kuruluşlarında ürün ve süreçlerin kalitesini iyileştirmeye yönelik veri madenciliği (VM) yaklaşımlarını belirlemek ve daha etkili yaklaşımlar geliştirmektir. Projede imalat sanayi kuruluşlarının ürün ve süreçlerinin kalitesini iyileştirme ile ilgili kalitenin tanımlanması, tahmin edilmesi, sınıflandırılması ve parametrelerinin optimizasyonu problemleri ele alınmıştır. Bu problemlerin çözümü için veri hazırlama ve önişlemenin yanısıra kümeleme, tahmin etme, sınıflandırma, birliktelik analizi ve optimizasyon VM işlevlerinin gerekli olabileceği belirlenmiştir. Bu kapsam dahilinde geniş bir literatür taraması yapılmış ve değişik imalat sektörlerinde etkinlik gösteren altı kuruluş ziyaret edilmiştir. Bunlardan üçünün sağladığı veriler üzerinde uygun VM metotları uygulanmış ve sonuçlar karşılaştırılmıştır. Bu karşılaştırma sonucunda belli VM işlevleri için kalite iyileştirme amaçlarına en uygun VM metotları belirlenmiş ve uygulayıcılara önerilmiştir. Projenin yöntem geliştirme kısmında ise uygulama aşamasında karşılaşılan bazı problemlerin giderilmesi ve mevcut yöntemlerin kullanım kolaylığı ve/veya etkililiğinin artırılması yönünde çalışmalar gerçekleştirilmiştir. Sonuçta, kalite verilerinin yeniden örneklenmesi için bir yöntem; parametrik olmayan alternatif bir regresyon yaklaşımı (CMARS); ikili sınıflandırmada kullanımı kolay olan Mahalanobis Taguchi Sistemi metodunun çok sınıf ve ayrıca parametre optimizasyonu için uyarlamalar; bulanık sınıflandırmada kalite verilerine uygun alternatif yaklaşımlar (bulanık regresyona dayalı modeller) ve parametrik olmayan bulanık tahmin etme ve sınıflandırma fonksiyonları; parametre optimizasyonunda çekicilik fonksiyonlarının optimizasyonu için alternatif yaklaşımlar ve birliktelik kurallarının seçimi için bir yöntem geliştirilmiştir. Bu sonuçların ve metotların kalite iyileştirme alanında uygulayıcıların çalışmalarına yön vermesi ve bunların kullanım kolaylığı ile etkililiğini artırması beklenmektedir.The objective of this project is to identify the data mining (DM) approaches that can effectively improve product and process quality in industrial organizations, and to develop more effective approaches. In the project, quality definition, prediction, classification and parameter optimization problems associated with product and process quality improvement in manufacturing industries are considered. For the solution of these problems, clustering, prediction, classification, association and optimization functions of DM as well as data preparation and preprocessing are determined as relevant. A comprehensive literature survey has been performed and six manufacturing companies operating in different sectors have been visited, within this context. Appropriate DM methods are applied on data sets obtained from three of these companies, and the results are compared. As a result, the most appropriate DM methods are suggested for specific DM functions and quality improvement purposes. In the method development part of the project, studies are performed to overcome some problems encountered during the applications, and to increase ease of use and effectiveness of the VM methods. As a result, a resampling method for quality data; an alternative nonparametric approach (CMARS) for regression; adaptations of an easy to use binary classification method, Mahalanobis Taguchi system, to multiple classes and also to parameter optimization; alternative approaches for fuzzy classification of quality data (models based on fuzzy regression) and nonparametric fuzzy functions; alternative approaches for optimization of desirability functions in parameter optimization; and a method for reduction of association rules are developed. It is expected that these results and approaches guide practitioners in quality improvement area, and incease the ease of use and effectiveness of them

Bir notar helikopterinin antitork sistemi için matematiksel model geliştirilmesi.

The anti-torque mechanism of a NOTAR helicopter is a complex system including vertical tail and pressurized tail boom which provides air ejection used for both circulation control around the boom and creating directed jet air at the end of the boom. This thesis targets the modeling of this mechanism and integrating it to a helicopter simulation model. Flight tests are performed on the MD 600N helicopter to verify the results. Finally, the simulation is compared with flight test data.M.S. - Master of Scienc

Development Of Open Leadership Scale

Bu araştırmanın amacı, sosyal medya temelli bir liderlik türü olan açık liderlik için örgütlerin açık liderlik seviyelerini ölçen geçerli ve güvenilir, likert tipi bir ölçek geliştirmektir. Araştırmanın çalışma grubunu Muş Alparslan Üniversitesinde görev yapmakta olan 176 akademik, 97 idari personel olmak üzere 273 katılımcı oluşturmaktadır. Ölçme aracının yapı geçerliğini tespit etmek amacıyla açımlayıcı (AFA) ve doğrulayıcı faktör analizleri (DFA); güvenirlik için ise Cronbach's Alfa katsayısı, madde toplam korelasyonları, İki Yarı Test (Spearman Brown) ve maddelerin alt ve üst % 27'lik gruplarda t-testi ile karşılaştırılması yapılmıştır. Nihai olarak ölçme aracının üç alt boyuttan ve 23 ifadeden oluştuğu; açıkladığı toplam varyansın ise %61,40 olduğu tespit edilmiştir. Açımlayıcı faktör analizinin ardından yapılan doğrulayıcı faktör analizine göre üç boyutlu ölçek yapısının iyi bir uyum verdiği bulunmuştur (X2/df1.96, RMSEA.06. RMR.06, NFI.97, CFI.98, IFI.98, RFI.97, AGFI.85, GFI.88). Ölçeğin güvenirlik analizi sonucunda iç tutarlılık katsayısının, ?.95 iki yarı test güvenirliğinin ise r.91 olduğuna ulaşılmıştır. Araştırma sonuçları, "Açık Liderlik Ölçeği (ALÖ)"nin üç boyutlu bir yapıda ve özellikle liderlik çalışmalarında kullanılacak türde geçerli ve güvenilir bir ölçme aracı olduğunu göstermiştir.The purpose of this research is to develop a likert type scale which measures open leadership levels of organizations. The study group consists of 273 participants, 176 academic and 97 administrative personnel who work in Muş Alparslan University. For the analysis of data regarding the validity and reliability of the developed scale following analyses were conducted; content validity, construct validity, t-test for the significant difference between the item mean correlations of top and bottom %27 of the group, corrected item-total correlations, Cronbach Alpha internal consistency coefficients, and split-half test correlations (Spearman Brown). And in order to establish structural validity an exploratory factor analysis has been used and to ensure the factor selection was valid a confirmatory factor analysis was used. As a result of analysis, the draft scale consisted of 23 items and the total explained variance is %61.40. The subscales of the scale are determined as three factors: the acceptance of power and continuous sharing, curiosity to promote and accountability, effective use of social networking. These subscales are found to be consistent with the literature. And according to confirmatory factor analysis, model's fit index obtained via CFA was examined and Chi-square value (x2 438.39, n 273, sd223, p0.00) is observed to be significant. Fit index values are; RMSEA; 0.06, RMR; 0.06, GFI; 0.88, AGFI; 0.85, CFI; 0.98, IFI; 0.98, NFI; 0.97; x2/df 1.96). These values shows that the scale is a good model. For the realibility of the scale of whose internal consistency was analyzed, Cronbach Alpha value is estimated to be .095. Finally, evidences reached for validity and reliability show that the OLS can be validly and reliably used for measuring open leadership levels among organizations