62 research outputs found
Silenced Expression of NFKBIA in Lung Adenocarcinoma Patients with a Never-smoking History
Nuclear factor of κ-light polypeptide gene enhancer in B cells inhibitor α (NFKBIA), which is a tumor suppressor gene, was found to be silenced in lung adenocarcinomas. We examined NFKBIA expression, mutations in the EGFR and K-ras genes, and EML4-ALK fusion in 101 resected lung adenocarcinoma samples from never-smokers. NFKBIA expression was evaluated using immunohistochemistry. NFKBIA expression was negative in 16 of the 101 samples (15.8%). EGFR and K-ras mutations and EML4-ALK fusion were detected in 61 (60.5%), 1 (1.0%), and 2 (2.0%) of the 101 samples, respectively, in a completely mutually exclusive manner. Negative NFKBIA expression was observed significantly more frequently among the tumors with none of the three genetic alterations compared to those with such alterations (p=0.009). In addition, negative NFKBIA expression was significantly more frequent among the EGFR-wild type samples compared to the EGFR-mutant samples (p=0.013). In conclusion, NFKBIA expression was silenced in adenocarcinomas without EGFR/K-ras mutations or EML4-ALK fusion, suggesting that the silencing of NFKBIA may play an important role in the carcinogenesis of adenocarcinomas independent of EGFR/K-ras mutations or EML4-ALK fusion
Multiple gastrointestinal stromal tumors in neurofi bromatosis type 1 treated with laparoscopic surgery
Gastrointestinal stromal tumors (GISTs) have been reported to occasionally occur in patients with
neurofi bromatosis type 1 (NF-1), and many cases have had multiple lesions predominantly involving
the small intestine. We report herein a case of multiple GISTs associated with NF-1 from whom laparoscopic
surgery was benefi cial. In a 79-year-old female admitted with anemia and melena, the
abdominal computed tomography revealed a tumor arising from the small intestine. Laparoscopic
surgery was performed, and another small tumor was revealed during laparoscopic observation.
Extracorporeal partial and wedge resection of the small intestine were undertaken. Both lesions
were diagnosed as typical GISTs of low risk. Laparoscopic surgery would be useful for examination
and a minimally invasive approach to tumors of the small intestine, especially on cases with the possibility
of multiple tumors.</p
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