Ruolo del Lapatinib nel trattamento adiuvante del carcinoma mammario HER-2 positivo

Aim: HER2 receptor is a molecular target for breast cancer therapy. Two drugs acts against this receptor: Trastuzumab, a monoclonal antibody efficacy both in metastatic and adiuvant setting and Lapatinib, an orally kinase inhibitor both HER1 and HER2 receptors, approved for HER2-positive metastatic breast-cancer. The study establish efficacy and safety of Lapatinib in early stage HER2 over-expressing breast cancer and examines prognostic and predictive role of HER2 and HER1 receptors. Methods: Women with early-stage HER2 positive breast cancer, not previously treated with trastuzumab, but pretreated with adjuvant chemotherapy, were randomly assigned to receive Lapatinib 1500 mg or placebo orally once daily, for 12 months or until disease recurrence. Primary endpoint was disease-free survival (DFS). Safety and overall survival (OS) were secondary endpoints. Results: Twelve women were enrolled. Five patients discontinued treatment: two for withdrawal consence and three for toxicity (skin-rush G3 in one case and diarrhea G2 in other two). Seven women completed 1-yr therapy: 3 didn't show toxicity and four had skin toxicity G1-2; a patient had a dose reduction. After 24 months of follow-up, 6 patients are disease free and a patient died after 3 months from diagnosis of SNC metastases (May 2009). Conclusions: Lapatinib showed a good safety profile. Diarrhea and skin-rush were the most common side-effects and were mostly moderate and treatable. Follow-up is too short for disease free survival datas

COMPARISON OF THE QUALITY OF VEGETABLE OILS DESIGNED FOR THE FRYING FOOD

The object of the research was to investigate the quality of vegetable oils for cooking food. The analysis used two types of oils - oil Fritol and Promienna. Both oils were purchased commercially. Oil changes were observed at frying French fries. At the same changes were observed oil stored at room temperature and the temperature in the refrigerator. The determined parameters included the measurement of polar materials in oil with electronic device Testo 265 for measuring the quality of cooking oil. Determination of change in the texture of oil during the oil deterioration by device Texturometer TA.XT Plus and determination the peroxide value by STN EN ISO 3960:2007. The work is also evaluating the results of the studied parameters. In all compared cases based on the content of the TPM showed higher heat resistance oil Fritol and sample of oil stored in the refrigerator.https://doi.org/10.5219/21

Enhanced Channel Estimation in mm-Wave MIMO Systems Leveraging Integrated Communication and Sensing

This paper tackles the challenge of wideband MIMO channel estimation within indoor millimeter-wave scenarios. Our proposed approach exploits the integrated sensing and communication paradigm, where sensing information aids in channel estimation. The key innovation consists of employing both spatial and temporal sensing modes to significantly reduce the number of required training pilots. Moreover, our algorithm addresses and corrects potential mismatches between sensing and communication modes, which can arise from differing sensing and communication propagation paths. Extensive simulations demonstrate that the proposed method requires 4x less pilots compared to the current state-of-the-art, marking a substantial advancement in channel estimation efficiency

Advanced Tri-Sectoral Multi-User Millimeter-Wave Smart Repeater

Smart Repeaters (SR) can potentially enhance the coverage in Millimeter-wave (mmWave) wireless communications. However, the angular coverage of the existing two-panel SR is too limited to make the SR a truly cost-effective mmWave range extender. This paper proposes the usage of a tri-sectoral Advanced SR (ASR) to extend the angular coverage with respect to conventional SR. We propose a multi-user precoder optimization for ASR in a downlink multi-carrier communication system to maximize the number of served User Equipments (UEs) while guaranteeing constraints on per-UE rate and time-frequency resources. Numerical results show the benefits of the ASR against conventional SR in terms of both cumulative spectral efficiency and number of served UEs (both improved by an average factor 2), varying the system parameters

Monitoring of Carbonated Hydroxyapatite Growth on Modified Polycrystalline CVD-Diamond Coatings on Titanium Substrates

Production of diamond coatings on titanium substrates has demonstrated as a promising strategy for applications ranging from biosensing to hard tissue engineering. The present study focuses on monitoring the nucleation and growth of bone-like carbonated-hydroxyapatite (C-HA) on polycrystalline diamond (PCD) synthetized on titanium substrate by means of a hot filament chemical vapor deposition (HF-CVD) method. The surface terminations of diamond coatings were selectively modified by oxidative treatments. The process of the C-HA deposition, accomplished by precipitation from simulated body fluid (SBF), was monitored from 3 to 20 days by Raman spectroscopy analysis. The coupling of morphological and structural investigations suggests that the modulation of the PCD surface chemistry enhances the bioactivity of the produced materials, allowing for the formation of continuous C-HA coatings with needle-like texture and chemical composition typical of those of the bone mineral. Specifically, after 20 days of immersion in SBF the calculated carbonate weight percent and the Ca/P ratio are 5.5% and 2.1, respectively. Based on these results, this study brings a novelty in tailoring the CVD-diamond properties for advanced biomedical and technological applications

Discrimination périodique à partir d’observations multi-temporelles

Cet article s’attaque au problème de discrimination instantanée de données temporelles périodiques. Nous proposons un classifieur linéaire non-stationnaire, régularisé par rapport à sa complexité temporelle. Le modèle est également étendu au cas multi-classe. Cette approche est testée sur des simulations numériques ainsi que des séries temporelles d’images satellites. Les résultats illustrent un très bon comportement

Industrial carbon emission intensity: a comprehensive dataset of European regions.

The dataset has been developed within the framework of the EU EIT-Climate Kic Flagship Project “Re-Industrialise” and it includes data of Carbon Emission Intensity (CEI) from industrial sources for the European Regions. CEI is considered as a proxy for analysing the Industrial Sustainability Transition pathways and is calculated as the ratio between CO2 equivalent emissions (CO2e) and Gross Domestic Product (GDP) of the industrial sector over a nine-year timespan, i.e. from 2008 to 2016. CO2e data at plant level have been retrieved from EU Emission Trading System (EU ETS) register and aggregated at different geographical scales, corresponding to the nested structure of NUTS (Nomenclature of Territorial Units for Statistics), proposed by EUROSTAT. Industrial GDP data have been selected from EUROSTAT database to match the industrial sectors covered by EU ETS

Generation of the human induced pluripotent stem cell (hiPSC) line PSMi003-A from a patient affected by an autosomal recessive form of Long QT Syndrome type 1

Abstract We generated human induced pluripotent stem cells (hiPSCs) from dermal fibroblasts of a 51 years old female patient homozygous for the mutation c.535 G>A p.G179S on the KCNQ1 gene, causing a severe form of autosomal recessive Long QT Syndrome type 1 (AR-LQT1), not associated with deafness. The hiPSCs, generated using four retroviruses each encoding for a reprogramming factor OCT4, SOX2, KLF4, cMYC, are pluripotent and can differentiate into spontaneously beating cardiomyocytes (hiPSC-CMs)