3,221 research outputs found

    Intellectual ability in children with anxiety: a replication and exploration of the differences

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    The purpose of this study was to examine the effect of anxiety on the intellectual functioning of children. Specifically, the current researchers sought to replicate previous findings that children with higher levels of anxiety have significantly lower scores on tests of intelligence. A second goal was to examine possible reasons for these deficits, including possible deficits in working memory and/or attention. Participants were divided into two groups with high and low anxiety, based on a self-report measure, though none of the children reported clinically problematic anxiety. The participants were 19 children (10 males, 9 females) who were recruited from the community and from an anxiety clinic. Children were administered an intelligence test and a memory test by a trained clinician. Parents and children were also asked to complete self-report measures of anxiety symptoms and other problem behaviors. Contrary to the hypothesis, those with higher levels of anxiety scored significantly higher on the intelligence test then children reporting lower anxiety. No differences were found between the groups on the measures of working memory or attention, therefore meditational analyses were not undertaken. Possible explanations of these findings, as well as limitations and recommendations for future research are also explored

    Western Reserve Farmers\u27 Insurance Co. Advertisement, June 1850

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    Printed advertising pamphlet for the Western Reserve Farmer\u27s Insurance Co.https://digitalcommons.otterbein.edu/cornell_ephemera/1094/thumbnail.jp

    An Optimal Control Model of Technology Transition

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    This paper discusses the use of optimization software to solve an optimal control problem arising in the modeling of technology transition. We set up a series of increasingly complex models with such features as learning-by-doing, adjustment cost, and capital investment. The models are written in continuous time and then discretized by using different methods to transform them into large-scale nonlinear programs. We use a modeling language and numerical optimization methods to solve the optimization problem. Our results are consistent with ndings in the literature and highlight the impact the discretization choice has on the solution and accuracy.

    First Experiences Integrating PC Distributed I/O Into Argonne's ATLAS Control System

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    First Experiences Integrating PC Distributed I/O Into Argonne's ATLAS Control System The roots of ATLAS (Argonne Tandem-Linac Accelerator System) date back to the early 1960s. Located at the Argonne National Laboratory, the accelerator has been designated a National User Facility, which focuses primarily on heavy-ion nuclear physics. Like the accelerator it services, the control system has been in a constant state of evolution. The present real-time portion of the control system is based on the commercial product Vsystem [1]. While Vsystem has always been capable of distributed I/O processing, the latest offering of this product provides for the use of relatively inexpensive PC hardware and software. This paper reviews the status of the ATLAS control system, and describes first experiences with PC distributed I/O.Comment: ICALEPCS 2001 Conference, PSN WEAP027, 3 pages, 1 figur

    An analysis of depot level repairables carcass management and position controls under the Advanced Traceability and Control (ATAC) program

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    Repairables are components andor sub assemblies which can be repaired if they become unserviceable. Repairables are typically high cost, long procurement leadtime items. Because of these characteristics, significant economies can be achieved by repairing these items rather than discarding them when they become unserviceable. Historically, these carcasses have been difficult to manage because, when they broke, maintenance personnel were primarily concerned with replacing them with ready-for-issue units; what happened to the carcass was of little concern. Defense Management Review Decision (DMRD) 901's objective to reduce supply system costs includes an initiative to achieve savings by retaining retrograde carcasses returned from the fleet at the first turn-in point rather than shipping them immediately to the repair depot or designated storage site. This thesis analyzes the operation of the ATAC Program to determine a 'ship or hold' decision for returned carcasses. A thorough study of ATAC's background, current management controls and operating procedures, and results from previous studies were combined with on-site hub observations to show how and why the ATAC system works. Because of ATAC, the DMRD 901 initiative to retain carcasses at their first turn-in point is not cost effective except for those items experiencing rapid phase-out or numerous upgrades. Detailed indicators to measure and monitor ATAC cost and performance effectiveness need to be implemented.http://archive.org/details/annalysisofdepot1094527594Lieutenant Commander, United States NavyLieutenant, United States NavyApproved for public release; distribution is unlimited

    Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori.

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    Half the world's population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is essential for survival in the acidic environment of the stomach. The channel is closed at neutral pH and opens at acidic pH to allow the rapid access of urea to cytoplasmic urease. Urease produces NH(3) and CO(2), neutralizing entering protons and thus buffering the periplasm to a pH of roughly 6.1 even in gastric juice at a pH below 2.0. Here we report the structure of HpUreI, revealing six protomers assembled in a hexameric ring surrounding a central bilayer plug of ordered lipids. Each protomer encloses a channel formed by a twisted bundle of six transmembrane helices. The bundle defines a previously unobserved fold comprising a two-helix hairpin motif repeated three times around the central axis of the channel, without the inverted repeat of mammalian-type urea transporters. Both the channel and the protomer interface contain residues conserved in the AmiS/UreI superfamily, suggesting the preservation of channel architecture and oligomeric state in this superfamily. Predominantly aromatic or aliphatic side chains line the entire channel and define two consecutive constriction sites in the middle of the channel. Mutation of Trp 153 in the cytoplasmic constriction site to Ala or Phe decreases the selectivity for urea in comparison with thiourea, suggesting that solute interaction with Trp 153 contributes specificity. The previously unobserved hexameric channel structure described here provides a new model for the permeation of urea and other small amide solutes in prokaryotes and archaea

    Speeding up protein folding: mutations that increase the rate at which Rop folds and unfolds by over four orders of magnitude

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    BackgroundThe dimeric four-helix-bundle protein Rop folds and unfolds extremely slowly. To understand the molecular basis for the slow kinetics, we have studied the folding and unfolding of wild-type Rop and a series of hydrophobic core mutants.ResultsMutation of the hydrophobic core creates stable, dimeric, and wild-type-like proteins with dramatically increased rates of both folding and unfolding. The increases in rates are dependent upon the number and position of repacked residues within the hydrophobic core.ConclusionRop folds by a rapid collision of monomers to form a dimeric intermediate with substantial helical content, followed by a slow rearrangement to the final native structure. Rop unfolding is a single extremely slow kinetic phase. The slow steps of both folding and unfolding are dramatically increased by hydrophobic core replacements, suggesting that their main effect is to substantially decrease the energy of the transition state

    Advanced ceramic coating development for industrial/utility gas turbine applications

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    The effects of ceramic coatings on the lifetimes of metal turbine components and on the performance of a utility turbine, as well as of the turbine operational cycle on the ceramic coatings were determined. When operating the turbine under conditions of constant cooling flow, the first row blades run 55K cooler, and as a result, have 10 times the creep rupture life, 10 times the low cycle fatigue life and twice the corrosion life with only slight decreases in both specific power and efficiency. When operating the turbine at constant metal temperature and reduced cooling flow, both specific power and efficiency increases, with no change in component lifetime. The most severe thermal transient of the turbine causes the coating bond stresses to approach 60% of the bond strengths. Ceramic coating failures was studied. Analytic models based on fracture mechanics theories, combined with measured properties quantitatively assessed both single and multiple thermal cycle failures which allowed the prediction of coating lifetime. Qualitative models for corrosion failures are also presented
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