3,226 research outputs found
Occupational stress facing nurse academics—A mixed-methods systematic review
© 2019 John Wiley & Sons Ltd Aim: To better understand occupational stress faced by nurse academics. Methods: A mixed-methods systematic review, following the Joanna Briggs Institute [JBI], (Joanna Briggs Institute Reviewers’ Manual: 2014 edition, 2014) process. Studies were assessed for quality and risk of bias by using standardised critical appraisal instruments from the Joanna Briggs Institute. In addition, processes and reporting were checked against the Equator guidelines. See Appendix S1. Results: The review revealed that nursing academics do experience occupational stress, including burnout. Occupational stress for academic nurses is associated with various factors including work–life balance, workload issues, resources and support, and adapting to change. However, much of the literature focuses on nurses during the initial transition from clinical to academic environment, with rather less focus on established mid-to-late career nurse academics. Discussion: Occupational stress and burnout are evident in the university academic workforce, adversely affecting the well-being of academic nurses, and the long-term sustainability of the academic nursing workforce. While there is considerable literature focusing on the novice academic nurse, particularly during the transition period, rather less is known about occupational stress among academic nurses across the career trajectory. Various strategies to deal with the negative consequences of occupational stress are identified, including (a) quality mentors for novice and younger nursing academics; (b) training in resilience building for novice academics; (c) supporting collegial relationships and reducing bullying; (d) assistance for professional development and research; (e) better support and resources to overcome increasing workloads; and (f) greater work-related empowerment to enhance job satisfaction. Conclusion: There is a need for a broader whole-of-career research focus to more fully identify, explore and mitigate the occupational stressors that negatively affect the academic nurse workforce. Relevance to clinical practice: A strong and resilient academic nurse workforce is essential for the sustainability of the profession. Organisations should review their work practices and provide greater work-related empowerment to reduce occupational stressors among nursing academics
easySTORM: a robust, lower-cost approach to localisation and TIRF microscopy
TIRF and STORM microscopy are super-resolving fluorescence imaging modalities for which current implementations on standard microscopes can present significant complexity and cost. We present a straightforward and low-cost approach to implement STORM and TIRF taking advantage of multimode optical fibres and multimode diode lasers to provide the required excitation light. Combined with open source software and relatively simple protocols to prepare samples for STORM, including the use of Vectashield for non-TIRF imaging, this approach enables TIRF and STORM imaging of cells labelled with appropriate dyes or expressing suitable fluorescent proteins to become widely accessible at low cost
The quantum-classical crossover of a field mode
We explore the quantum-classical crossover in the behaviour of a quantum
field mode. The quantum behaviour of a two-state system - a qubit - coupled to
the field is used as a probe. Collapse and revival of the qubit inversion form
the signature for quantum behaviour of the field and continuous Rabi
oscillations form the signature for classical behaviour of the field. We
demonstrate both limits in a single model for the full coupled system, for
states with the same average field strength, and so for qubits with the same
Rabi frequency.Comment: 6 pages, 3 figures (in this version the figures, text and references
have all been expanded
Ear wax management in primary care: what the busy GP needs to know
Cerumen (or earwax), a self-cleaning agent, protects the outer ear. Sometimes this does not work and wax gets impacted, blocking the ear canal. This is a major reason for primary care consultation. Hearing difficulty due to untreated wax impaction can lead to social isolation and depression.1 Yet there is little quality evidence to guide practice for such a common condition. Further, people find it difficult to access NHS earwax services. This article provides new data on symptoms and severity, and reviews management options and patient preferences
Thallium under extreme compression
We present a combined theoretical and experimental study of the high-pressure
behavior of thallium. X-ray diffraction experiments have been carried out at
room temperature up to 125 GPa using diamond-anvil cells, nearly doubling the
pressure range of previous experiments. We have confirmed the hcp-fcc
transition at 3.5 GPa and determined that the fcc structure remains stable up
to the highest pressure attained in the experiments. In addition, HP-HT
experiments have been performed up to 8 GPa and 700 K by using a combination of
x-ray diffraction and a resistively heated diamond-anvil cell. Information on
the phase boundaries is obtained, as well as crystallographic information on
the HT bcc phase. The equation of state for different phases is reported. Ab
initio calculations have also been carried out considering several potential
high-pressure structures. They are consistent with the experimental results and
predict that, among the structures considered in the calculations, the fcc
structure of thallium is stable up to 4.3 TPa. Calculations also predict the
post-fcc phase to have a close-packed orthorhombic structure above 4.3 TPa.Comment: 29 pages, 14 figure
Single photon quantum non-demolition in the presence of inhomogeneous broadening
Electromagnetically induced transparency (EIT) has been often proposed for
generating nonlinear optical effects at the single photon level; in particular,
as a means to effect a quantum non-demolition measurement of a single photon
field. Previous treatments have usually considered homogeneously broadened
samples, but realisations in any medium will have to contend with inhomogeneous
broadening. Here we reappraise an earlier scheme [Munro \textit{et al.} Phys.
Rev. A \textbf{71}, 033819 (2005)] with respect to inhomogeneities and show an
alternative mode of operation that is preferred in an inhomogeneous
environment. We further show the implications of these results on a potential
implementation in diamond containing nitrogen-vacancy colour centres. Our
modelling shows that single mode waveguide structures of length in single-crystal diamond containing a dilute ensemble of NV
of only 200 centres are sufficient for quantum non-demolition measurements
using EIT-based weak nonlinear interactions.Comment: 21 pages, 9 figures (some in colour) at low resolution for arXiv
purpose
Quantum Dynamics of Three Coupled Atomic Bose-Einstein Condensates
The simplest model of three coupled Bose-Einstein Condensates (BEC) is
investigated using a group theoretical method. The stationary solutions are
determined using the SU(3) group under the mean field approximation. This
semiclassical analysis using the system symmetries shows a transition in the
dynamics of the system from self trapping to delocalization at a critical value
for the coupling between the condensates. The global dynamics are investigated
by examination of the stable points and our analysis shows the structure of the
stable points depends on the ratio of the condensate coupling to the
particle-particle interaction, undergoes bifurcations as this ratio is varied.
This semiclassical model is compared to a full quantum treatment, which also
displays the dynamical transition. The quantum case has collapse and revival
sequences superposed on the semiclassical dynamics reflecting the underlying
discreteness of the spectrum. Non-zero circular current states are also
demonstrated as one of the higher dimensional effects displayed in this system.Comment: Accepted to PR
Quantum Computation by Communication
We present a new approach to scalable quantum computing--a ``qubus
computer''--which realises qubit measurement and quantum gates through
interacting qubits with a quantum communication bus mode. The qubits could be
``static'' matter qubits or ``flying'' optical qubits, but the scheme we focus
on here is particularly suited to matter qubits. There is no requirement for
direct interaction between the qubits. Universal two-qubit quantum gates may be
effected by schemes which involve measurement of the bus mode, or by schemes
where the bus disentangles automatically and no measurement is needed. In
effect, the approach integrates together qubit degrees of freedom for
computation with quantum continuous variables for communication and
interaction.Comment: final published versio
Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
We present an approach to quantify drug-target engagement using in vivo fluorescence endomicroscopy, validated with in vitro measurements. Doxorubicin binding to chromatin changes the fluorescence lifetime of histone-GFP fusions that we measure in vivo at single-cell resolution using a confocal laparo/endomicroscope. We measure both intra- and inter-tumor heterogeneity in doxorubicin chromatin engagement in a model of peritoneal metastasis of ovarian cancer, revealing striking variation in the efficacy of doxorubicin-chromatin binding depending on intra-peritoneal or intravenous delivery. Further, we observe significant variations in doxorubicin-chromatin binding between different metastases in the same mouse and between different regions of the same metastasis. The quantitative nature of fluorescence lifetime imaging enables direct comparison of drug-target engagement for different drug delivery routes and between in vitro and in vivo experiments. This uncovers different rates of cell killing for the same level of doxorubicin binding in vitro and in vivo
Lorentz invariant intrinsic decoherence
Quantum decoherence can arise due to classical fluctuations in the parameters
which define the dynamics of the system. In this case decoherence, and
complementary noise, is manifest when data from repeated measurement trials are
combined. Recently a number of authors have suggested that fluctuations in the
space-time metric arising from quantum gravity effects would correspond to a
source of intrinsic noise, which would necessarily be accompanied by intrinsic
decoherence. This work extends a previous heuristic modification of
Schr\"{o}dinger dynamics based on discrete time intervals with an intrinsic
uncertainty. The extension uses unital semigroup representations of space and
time translations rather than the more usual unitary representation, and does
the least violence to physically important invariance principles. Physical
consequences include a modification of the uncertainty principle and a
modification of field dispersion relations, in a way consistent with other
modifications suggested by quantum gravity and string theory .Comment: This paper generalises an earlier model published as Phys. Rev. A
vol44, 5401 (1991
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