Conceptual Trends and Implications for Risk Research. Report of the Task Force Meeting: Risk and Policy Analysis Under Conditions of Uncertainty, November 25-27,1985

The Task Force focused on the uncertainties in decision systems for choosing or modifying technologies intended to improve human well-being. The challenge was to delineate an international research agenda to assist communities to venture into the future with greater confidence in technological innovation. The Task Force recommended research in three interrelated areas: (1) Protocols -- Development of procedural advice for the integrated assessment of the contribution of technologies to environmental and economic achievements, and the associated uncertainties. (2) Case Studies -- Integrated assessments involving local or regional clusters of technologies and decision-making bodies, and investigation of ecosystem effects, economic effects, and effects on human well-being, as well as the structure and performance of institutions. (3) Educational Materials -- Development of educational materials to support integrated assessments

The Surface Area to Volume Ratio Changes the Pharmacokinetic and Pharmacodynamic Parameters in the Subcutaneous Tissue Cage Model:As Illustrated by Carprofen in Sheep

Introduction: Pharmacokinetic and pharmacodynamic models can be powerful tools for predicting outcomes. Many models are based on repetitive sampling of the vascular space, due to the simplicity of obtaining samples. As many drugs do not exert their effect in the vasculature, models have been developed to sample tissues outside the bloodstream. Tissue cages are hollow devices implanted subcutaneously, or elsewhere, that are filled with fluid allowing repetitive sampling to occur. The physical dimensions of the cage, namely, the diffusible surface area to volume ratio, would be expected to change the rate of drug movement into and out of tissue cages. Methods: Seven sheep were implanted with five pairs of tissue cages, subcutaneously. Each pair of cages had a different length but a fixed diffusible surface area, so the surface area to volume ratio differed. Carrageenan was injected into half of the cages in each animal during one sampling period in a cross-over design. Samples from each cage and the bloodstream were obtained at 14-time points during two sampling periods. The concentration of carprofen was measured using LC–MS/MS and the results were modeled using nonlinear mixed-effects techniques. Prostaglandin metabolites were also measured and the change over time was analyzed using linear mixed effect modeling. Results: The presence of carrageenan within an animal changed the systemic pharmacokinetics of carprofen. The rate of drug movement into and out of the tissue cages varied with the surface area to volume ratio. The concentration time curve for prostaglandin metabolites changed with cage size. Conclusion: The surface area volume ratio of tissue cages will influence the calculated pharmacokinetic parameters and may affect calculated pharmacodynamics, thus, it is an important factor to consider when using tissue cage data for dosing regimes

A Detailed Model Atmosphere Analysis of Cool White Dwarfs in the Sloan Digital Sky Survey

We present optical spectroscopy and near-infrared photometry of 126 cool white dwarfs in the Sloan Digital Sky Survey (SDSS). Our sample includes high proper motion targets selected using the SDSS and USNO-B astrometry and a dozen previously known ultracool white dwarf candidates. Our optical spectroscopic observations demonstrate that a clean selection of large samples of cool white dwarfs in the SDSS (and the SkyMapper, Pan-STARRS, and the Large Synoptic Survey Telescope datasets) is possible using a reduced proper motion diagram and a tangential velocity cut-off (depending on the proper motion accuracy) of 30 km/s. Our near-infrared observations reveal eight new stars with significant absorption. We use the optical and near-infrared photometry to perform a detailed model atmosphere analysis. More than 80% of the stars in our sample are consistent with either pure hydrogen or pure helium atmospheres. However, the eight stars with significant infrared absorption and the majority of the previously known ultracool white dwarf candidates are best explained with mixed hydrogen and helium atmosphere models. The age distribution of our sample is consistent with a Galactic disk age of 8 Gyr. A few ultracool white dwarfs may be as old as 12-13 Gyr, but our models have problems matching the spectral energy distributions of these objects. There are only two halo white dwarf candidates in our sample. However, trigonometric parallax observations are required for accurate mass and age determinations and to confirm their membership in the halo.Comment: ApJ Supplements, in pres

Hyper-Raman scattering analysis of the vibrations in vitreous boron oxide

Hyper-Raman scattering has been measured on vitreous boron oxide, $v-$B$_2$O$_3$. This spectroscopy, complemented with Raman scattering and infrared absorption, reveals the full set of vibrations that can be observed with light. A mode analysis is performed based on the local D$_{3h}$ symmetry of BO$_3$ triangles and B$_3$O$_3$ boroxol rings. The results show that in $v-$B$_2$O$_3$ the main spectral components can be succesfully assigned using this relatively simple model. In particular, it can be shown that the hyper-Raman boson peak arises from external modes that correspond mainly to librational motions of rigid boroxol rings.Comment: 13 pages, 11 figures, 2 table

Managed moves: schools collaborating for collective gain

Government guidance in the United Kingdom encourages groups of schools to take collective responsibility for supporting and making provision for excluded pupils and those at risk of exclusion. Managed-moves are one way that some schools and authorities are enacting such guidance. This paper presents the results of an evaluation of one such scheme. The scheme, involving seven neighbouring secondary schools, was nearing its first year of completion. The paper draws primarily on interview data with pupils, parents and school staff to describe a number of positive outcomes associated with the scheme and to explore how these were achieved. We found that while some of these could be attributed directly to the managed-move, others arose from the more inclusive ethos and practices of particular schools. The concepts of tailored support, care and commitment emerged as strong themes that underpinned the various practical ways in which some schools in the cluster were able to re-engage 'at-risk' pupils. As managed moves become more widely practiced it will be important to remember that it is how the move proceeds and develops rather than the move itself that will ultimately make the difference for troubled and troublesome pupils

Computational simulations of the effects of gravity on lymphatic transport

Physical forces, including mechanical stretch, fluid pressure and shear forces alter lymphatic vessel contractions and lymph flow. Gravitational forces can affect these forces, resulting in altered lymphatic transport, but the mechanisms involved have not been studied in detail. Here, we combine a lattice Boltzmann-based fluid dynamics computational model with known lymphatic mechanobiological mechanisms to investigate the movement of fluid through a lymphatic vessel under the effects of gravity that may either oppose or assist flow. Regularly spaced, mechanical bi-leaflet valves in the vessel enforce net positive flow as the vessel walls contract autonomously in response to calcium and nitric oxide (NO) levels regulated by vessel stretch and shear stress levels. We find that large gravitational forces opposing flow can stall the contractions, leading to no net flow, but transient mechanical perturbations can reestablish pumping. In the case of gravity strongly assisting flow, the contractions also cease due to high shear stress and NO production, which dilates the vessel to allow gravity-driven flow. In the intermediate range of oppositional gravity forces, the vessel actively contracts to offset nominal gravity levels or to modestly assist the favorable hydrostatic pressure gradients

Spectroscopy of Quasar Candidates from SDSS Commissioning Data

The Sloan Digital Sky Survey has obtained images in five broad-band colors for several hundred square degrees. We present color-color diagrams for stellar objects, and demonstrate that quasars are easily distinguished from stars by their distinctive colors. Follow-up spectroscopy in less than ten nights of telescope time has yielded 22 new quasars, 9 of them at $z> 3.65$, and one with $z = 4.75$, the second highest-redshift quasar yet known. Roughly 80% of the high-redshift quasar candidates selected by color indeed turn out to be high-redshift quasars.Comment: 4 pages, 3 figures, to appear in the proceedings of "After the Dark Ages: When Galaxies were Young (the Universe at 2<z<5)", 9th Annual October Astrophysics Conference in Marylan