449 research outputs found

    A Model for Classical Space-time Co-ordinates

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    Field equations with general covariance are interpreted as equations for a target space describing physical space time co-ordinates, in terms of an underlying base space with conformal invariance. These equations admit an infinite number of inequivalent Lagrangian descriptions. A model for reparametrisation invariant membranes is obtained by reversing the roles of base and target space variables in these considerations.Comment: 9 pages, Latex. This was the basis of a talk given at the Argonne National Laboratory 1996 Summer Institute : Topics on Non-Abelian Duality June 27-July 1

    The effects of alloying additions in polycrystalline Co-Ni Superalloys

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    New Co-Ni superalloys are being considered as a potential replacement for current Ni superalloys used in gas turbine applications. Utilizing the stable L12 phase Co3(Al,W) discovered in 20061 M.Knop et al. developed the new γ/γ’ polycrystalline superalloy V208C, which exhibited favourable strength and oxidation performance when compared to existing Ni and Co superalloys2. Further work has now been done to evolve the alloy chemistry of V208C in order to make a step towards the next iteration of a potential candidate alloy. Using the nominal composition of V208C, 36Co-35Ni-15Cr-10Al-3W-1Ta-0.15C-0.2B-0.04Zr (at%), further additions of 1Cr, 1Al, 1Mo, 2Mo, 0.5Nb and a swap of the C/B content were investigated using a laboratory-scale cast and wrought process to produce a series of ingots for characterization. Differential scanning calorimetry (DSC) was used to determine the γ’ solvus temperatures of each alloy, with the 1Al addition providing the most significant increase from 1000°C to 1020°C. The oxidation performance of each alloy at 800°C for 100 hours was examined via a combination of thermogravimetric analysis (TGA) and focused ion beam (FIB) cross-sectioning of the oxide layers. The 1Al addition, again, exhibited the best oxidation performance, with the 1Mo addition also performing well. High-temperature tensile testing determined the yield strength of each specimen at room temperature and at 50°C intervals from 650-900°C. The alloys all displayed the flow stress anomaly; with 2Mo possessing the highest yield stress at room temperature and 1Al at the high-temperature peak. The γ’ fraction, size and distribution were observed using electron microscopy, indicating that the addition of 1Al caused the most significant rise in γ’ fraction from 50% to 53%. Special consideration was given to the C/B content swap in order to understand how it may effect the mechanisms of grain boundary precipitate formation, as well as the subsequent impact on strength performance. References: J. Sato, T. Omori, K. Oikawa, I Ohnuma, R. Kainuma and K. Ishida. Cobalt-base high-temperature alloys. Science, p90-91, 2007 M. Knop, P. Mulvey, F. Ismail, A. Radecka, K.M. Rahman, T.C. Lindley, B.A. Shollock, M.C. Hardy, M.P. Moody, T.L. Martin, P.A.J. Bagot and D. Dye. New Polycrystalline Co-Ni Superalloy. JOM, 201

    Diisopropylamide and TMP turbo-grignard reagents : a structural rationale for their contrasting reactivities

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    A neutral dimeric molecule in crystal form, the diisopropylamido turbo-Grignard reagent "(iPr2N)MgCl⋅LiCl" (see structure; blue N, red O, green Mg, yellow Cl, black C) separates into several charged ate species in dynamic exchange with each other in THF solution as determined by a combination of EXSY and DOSY NMR studies

    Lithium and aluminium carbamato derivatives of the utility amide 2, 2, 6, 6- tetramethylpiperidide

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    Insertion of CO2 into the metal-N bond of a series of synthetically-important alkali-metal TMP (2,2,6,6-tetramethylpiperidide) complexes has been studied. Determined by X-ray crystallography, the molecular structure of the TMEDA-solvated Li derivative shows a central 8-membered (LiOCO)2 ring lying in a chair conformation with distorted tetrahedral lithium centres. While trying to obtain crystals of a THF solvated derivative, a mixed carbonato/carbamato dodecanuclear lithium cluster was formed containing two central (CO3)2- fragments and eight O2CTMP ligands with four distinct bonding modes. A bisalkylaluminium carbamato complex has also been prepared via two different methods (CO2 insertion into a pre-formed Al-N bond and ligand transfer from the corresponding lithium reagent) which adopts a dimeric structure in the solid state

    Forging Information Literacy Skills With ANVIL: An Innovative Game-based Approach to Teaching Information Literacy

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    At the University of Wisconsin-Oshkosh, library staff developed a game-based tool to aid in the teaching of the concepts and skills associated with information literacy. Students watch a series of videos based on the ACRL standards for information literacy. After viewing the videos, students test their comprehension of a particular standard by playing a “bar-trivia” style game. Points are awarded for accuracy and speed, and scores are posted to a global leaderboard to promote friendly competition. This presentation will highlight the process behind game development, campus-wide implementation, and user and faculty response

    Cell fault management using machine learning techniques

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    This paper surveys the literature relating to the application of machine learning to fault management in cellular networks from an operational perspective. We summarise the main issues as 5G networks evolve, and their implications for fault management. We describe the relevant machine learning techniques through to deep learning, and survey the progress which has been made in their application, based on the building blocks of a typical fault management system. We review recent work to develop the abilities of deep learning systems to explain and justify their recommendations to network operators. We discuss forthcoming changes in network architecture which are likely to impact fault management and offer a vision of how fault management systems can exploit deep learning in the future. We identify a series of research topics for further study in order to achieve this

    Roles of Putative Type II Secretion and Type IV Pilus Systems in the Virulence of Uropathogenic Escherichia coli

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    Type II secretion systems (T2SS) and the evolutionarily related type IV pili (T4P) are important virulence determinants in many Gram-negative bacterial pathogens. However, the roles of T2SS and T4P in the virulence of extraintestinal pathogenic Escherichia coli have not been determined.To investigate the functions of putative T2SS and T4P gene clusters present in the model uropathogenic E. coli (UPEC) strains UTI89 and CFT073, we deleted the secretin gene present in each cluster. The secretin forms a channel in the outer membrane that is essential for the function of T2S and T4P systems. We compared the secretin deletion mutants with their wild type counterparts using tissue culture assays and the CBA/J mouse model of ascending urinary tract infection. No deficiencies were observed with any of the mutants in adherence, invasion or replication in human bladder or kidney cell lines, but UTI89 DeltahofQ and UTI89 DeltagspD exhibited approximately 2-fold defects in fluxing out of bladder epithelial cells. In the mouse infection model, each of the knockout mutants was able to establish successful infections in the bladder and kidneys by day one post-infection. However, UTI89 DeltahofQ and a CFT073 DeltahofQ DeltayheF double mutant both exhibited defects in colonizing the kidneys by day seven post-infection.Based on our results, we propose that the putative T4P and T2S systems are virulence determinants of UPEC important for persistence in the urinary tract, particularly in renal tissues

    The ecology and evolution of Japanese encephalitis virus

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    Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus mainly spread by Culex mosquitoes that currently has a geographic distribution across most of Southeast Asia and the Western Pacific. Infection with JEV can cause Japanese encephalitis (JE), a severe disease with a high mortality rate, which also results in ongoing sequalae in many survivors. The natural reservoir of JEV is ardeid wading birds, such as egrets and herons, but pigs commonly play an important role as an amplifying host during outbreaks in human populations. Other domestic animals and wildlife have been detected as hosts for JEV, but their role in the ecology and epidemiology of JEV is uncertain. Safe and effective JEV vaccines are available, but unfortunately, their use remains low in most endemic countries where they are most needed. Increased surveillance and diagnosis of JE is required as climate change and social disruption are likely to facilitate further geographical expansion of Culex vectors and JE risk areas
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