The Expansion and Decline of The O’Donel Estate Newport, County Mayo 1785-1852

This thesis examines the history of the O’Donel estate in West Mayo, from the purchase of the estate by Sir Neal O’Donel in the late eighteenth century to the sale of most of the estate, in the 1850s in the Encumbered Estates Court, by his grandson Sir Richard Annesley O’Donel. The estate was purchased from John Thomas Medlicott and Thomas John Medlicott for £33,589 19s 4d, which was equal to nineteen years and a half purchase of the rental income minus the head rent amounting to £1722 11s 3d per year. 1 The O’Donels owned land in three baronies of Mayo, the Tarmon estate in the barony of Erris, the Cong estate in the barony of Kilmaine and the Newport estate in the barony of Burrishoole. Included in the sale of lands by the Medlicotts was also land in Counties Tipperary, Kilkenny and Waterford but this was probably disposed of almost immediately as the only reference to it in the O’Donel papers is in the deed of sale of 17 July 1774

A review of bovine Johne's disease control activities in 6 endemically infected countries

Mycobacterium avium subspecies paratuberculosis (MAP) is endemic in the bovine populations of many countries and can cause a significant reduction in animal welfare and production efficiency making control desirable. Effective control has proved very difficult to achieve despite multiple regionally coordinated programmes being in existence since the 1920s. The international community increasingly recognises the value in learning from the collective experiences of existing programmes to improve the effectiveness of control. The aim of this review is to outline key aspects of bovine Johne's disease control activities across 6 endemically infected countries to facilitate comparison of current international practice. The background, control activities and monitoring components of programmes in Australia, Canada, Denmark, the Netherlands, the United Kingdom and the United States of America were individually reviewed. Factual accuracy of each review was checked by individuals involved in the respective programmes before the reviews were condensed and combined into a single document presented here, with the complete reviews of each programme available as supplementary material. There was considerable heterogeneity in key aspects of control activity design including goals, responses to declining participation, herd classification, recommended control measures and associated test requirements. The data presented will be of interest to organisations that are involved in developing new or existing regionally coordinated BJD control activities

Bayesian estimation of prevalence of paratuberculosis in dairy herds enrolled in a voluntary Johne’s Disease Control Programme in Ireland

Bovine paratuberculosis is a disease characterised by chronic granulomatous enteritis which manifests clinically as a protein-losing enteropathy causing diarrhoea, hypoproteinaemia, emaciation and, eventually death. Some evidence exists to suggest a possible zoonotic link and a national voluntary Johne’s Disease Control Programme was initiated by Animal Health Ireland in 2013. The objective of this study was to estimate herd-level true prevalence (HTP) and animal-level true prevalence (ATP) of paratuberculosis in Irish herds enrolled in the national voluntary JD control programme during 2013–14. Two datasets were used in this study. The first dataset had been collected in Ireland during 2005 (5822 animals from 119 herds), and was used to construct model priors. Model priors were updated with a primary (2013–14) dataset which included test records from 99,101 animals in 1039 dairy herds and was generated as part of the national voluntary JD control programme. The posterior estimate of HTP from the final Bayesian model was 0.23–0.34 with a 95% probability. Across all herds, the median ATP was found to be 0.032 (0.009, 0.145). This study represents the first use of Bayesian methodology to estimate the prevalence of paratuberculosis in Irish dairy herds. The HTP estimate was higher than previous Irish estimates but still lower than estimates from other major dairy producing countries

Computational studies and optimization of wakefield accelerators

Laser- and particle beam-driven plasma wakefield accelerators produce accelerating fields thousands of times higher than radio-frequency accelerators, offering compactness and ultrafast bunches to extend the frontiers of high energy physics and to enable laboratory-scale radiation sources. Large-scale kinetic simulations provide essential understanding of accelerator physics to advance beam performance and stability and show and predict the physics behind recent demonstration of narrow energy spread bunches. Benchmarking between codes is establishing validity of the models used and, by testing new reduced models, is extending the reach of simulations to cover upcoming meter-scale multi-GeV experiments. This includes new models that exploit Lorentz boosted simulation frames to speed calculations. Simulations of experiments showed that recently demonstrated plasma gradient injection of electrons can be used as an injector to increase beam quality by orders of magnitude. Simulations are now also modeling accelerator stages of tens of GeV, staging of modules, and new positron sources to design next-generation experiments and to use in applications in high energy physics and light sources

The Expansion and Decline of The O’Donel Estate Newport, County Mayo 1785-1852

This thesis examines the history of the O’Donel estate in West Mayo, from the purchase of the estate by Sir Neal O’Donel in the late eighteenth century to the sale of most of the estate, in the 1850s in the Encumbered Estates Court, by his grandson Sir Richard Annesley O’Donel. The estate was purchased from John Thomas Medlicott and Thomas John Medlicott for £33,589 19s 4d, which was equal to nineteen years and a half purchase of the rental income minus the head rent amounting to £1722 11s 3d per year. 1 The O’Donels owned land in three baronies of Mayo, the Tarmon estate in the barony of Erris, the Cong estate in the barony of Kilmaine and the Newport estate in the barony of Burrishoole. Included in the sale of lands by the Medlicotts was also land in Counties Tipperary, Kilkenny and Waterford but this was probably disposed of almost immediately as the only reference to it in the O’Donel papers is in the deed of sale of 17 July 1774

The Expansion and Decline of The O’Donel Estate Newport, County Mayo 1785-1852

This thesis examines the history of the O’Donel estate in West Mayo, from the purchase of the estate by Sir Neal O’Donel in the late eighteenth century to the sale of most of the estate, in the 1850s in the Encumbered Estates Court, by his grandson Sir Richard Annesley O’Donel. The estate was purchased from John Thomas Medlicott and Thomas John Medlicott for £33,589 19s 4d, which was equal to nineteen years and a half purchase of the rental income minus the head rent amounting to £1722 11s 3d per year. 1 The O’Donels owned land in three baronies of Mayo, the Tarmon estate in the barony of Erris, the Cong estate in the barony of Kilmaine and the Newport estate in the barony of Burrishoole. Included in the sale of lands by the Medlicotts was also land in Counties Tipperary, Kilkenny and Waterford but this was probably disposed of almost immediately as the only reference to it in the O’Donel papers is in the deed of sale of 17 July 1774

A review of bovine Johne\u27s disease control activities in 6 endemically infected countries

Mycobacterium avium subspecies paratuberculosis (MAP) is endemic in the bovine populations of many countries and can cause a significant reduction in animal welfare and production efficiency making control desirable. Effective control has proved very difficult to achieve despite multiple regionally coordinated programmes being in existence since the 1920s. The international community increasingly recognises the value in learning from the collective experiences of existing programmes to improve the effectiveness of control. The aim of this review is to outline key aspects of bovine Johne\u27s disease control activities across 6 endemically infected countries to facilitate comparison of current international practice. The background, control activities and monitoring components of programmes in Australia, Canada, Denmark, the Netherlands, the United Kingdom and the United States of America were individually reviewed. Factual accuracy of each review was checked by individuals involved in the respective programmes before the reviews were condensed and combined into a single document presented here, with the complete reviews of each programme available as supplementary material. There was considerable heterogeneity in key aspects of control activity design including goals, responses to declining participation, herd classification, recommended control measures and associated test requirements. The data presented will be of interest to organisations that are involved in developing new or existing regionally coordinated BJD control activities.Animal Health Irelan

New Developments in the Simulation of Advanced Accelerator Concepts

Abstract. Improved computational methods are essential to the diverse and rapidly developing field of advanced accelerator concepts. We present an overview of some computational algorithms for laser-plasma concepts and high-brightness photocathode electron sources. In particular, we discuss algorithms for reduced laser-plasma models that can be orders of magnitude faster than their higher-fidelity counterparts, as well as important on-going efforts to include relevant additional physics that has been previously neglected. As an example of the former, we present 2D laser wakefield accelerator simulations in an optimal Lorentz frame, demonstrating >10 GeV energy gain of externally injected electrons over a 2 m interaction length, showing good agreement with predictions from scaled simulations and theory, with a speedup factor of ~2,000 as compared to standard particle-in-cell

Laser Plasma Particle Accelerators: Large Fields for Smaller Facility Sources

Compared to conventional particle accelerators, plasmas can sustain accelerating fields that are thousands of times higher. To exploit this ability, massively parallel SciDAC particle simulations provide physical insight into the development of next-generation accelerators that use laser-driven plasma waves. These plasma-based accelerators offer a path to more compact, ultra-fast particle and radiation sources for probing the subatomic world, for studying new materials and new technologies, and for medical applications