Characterizing the far-infrared properties of distant X-ray detected AGNs: evidence for evolution in the infrared–X-ray luminosity ratio

We investigate the far-infrared (FIR) properties of X-ray sources detected in the Chandra Deep Field-South (CDF-S) survey using the ultradeep 70 and 24 μm Spitzer observations taken in this field. Since only 30 (i.e. ≈ 10 per cent) of the 266 X-ray sources in the region of the 70 μm observations are detected at 70 μm, we rely on stacking analyses of the 70 μm data to characterize the average 70 μm properties of the X-ray sources as a function of redshift, X-ray luminosity and X-ray absorption. Using Spitzer-IRS data of the Swift-Burst Alert Telescope (BAT) sample of z ≈ 0 active galactic nuclei (AGNs), we show that the 70/24 μm flux ratio can distinguish between AGN-dominated and starburst-dominated systems out to z ≈ 1.5 . Among the X-ray sources detected at 70 μm, we note a large scatter in the observed 70/24 μm flux ratios, spanning almost a factor of 10 at similar redshifts, irrespective of object classification, suggesting a range of AGN:starburst ratios. From stacking analyses we find that the average observed 70/24 μm flux ratios of AGNs out to an average redshift of 1.5 are similar to z ≈ 0 AGNs with similar X-ray luminosities (L_X = 10^(42-44) erg s^(−1)) and absorbing column densities (N_H ≤ 10^(23) cm^(−2)) . Furthermore, both high-redshift and z ≈ 0 AGNs follow the same tendency towards warmer 70/24 μm colours with increasing X-ray luminosity (LX). From analyses of the Swift-BAT sample of z ≈ 0 AGNs, we note that the 70 μm flux can be used to determine the IR (8–1000 μm) luminosities of high-redshift AGNs. We use this information to show that L_X = 10^(42-43) erg s^(−1) AGNs at high redshifts (z = 1–2) have IR to X-ray luminosity ratios (L_(IR)/L_X) that are, on average, 4.7^(+10.2)_(−2.0) and 12.7+7.1−2.6 times higher than AGNs with similar X-ray luminosities at z = 0.5–1 and ≈0, respectively. By comparison, we find that the L_(IR)/L_X ratios of L_X= 10^(43-44) erg s^(−1) AGNs remain largely unchanged across this same redshift interval. We explore the consequences that these results may have on the identification of distant, potentially Compton-thick AGNs using L_(IR)/L_X ratios. In addition, we discuss possible scenarios for the observed increase in the L_(IR)/L_X ratio with redshift, including changes in the dust covering factor of AGNs and/or the star formation rates of their host galaxies. Finally, we show how deep observations to be undertaken by the Herschel Space Observatory will enable us to discriminate between these proposed scenarios and also identify Compton-thick AGNs at high redshifts

Mimotopes and Proteome Analyses Using Human Genomic and cDNA Epitope Phage Display

In the post-genomic era, validation of candidate gene targets frequently requires proteinbased strategies. Phage display is a powerful tool to define protein-protein interactions by generating peptide binders against target antigens. Epitope phage display libraries have the potential to enrich coding exon sequences from human genomic loci. We evaluated genomic and cDNA phage display strategies to identify genes in the 5q31 Interleukin gene cluster and to enrich cell surface receptor tyrosine kinase genes from a breast cancer cDNA library. A genomic display library containing 2 × 10 6 clones with exon-sized inserts was selected with antibodies specific for human Interleukin-4 (IL-4) and Interleukin-13. The library was enriched significantly after two selection rounds and DNA sequencing revealed unique clones. One clone matched a cognate IL-4 epitope; however, the majority of clone insert sequences corresponded to E. coli genomic DNA. These bacterial sequences act as ‘mimotopes’ (mimetic sequences of the true epitope), correspond to open reading frames, generate displayed peptides, and compete for binding during phage selection. The specificity of these mimotopes for IL-4 was confirmed by competition ELISA. Other E. coli mimotopes were generated using additional antibodies. Mimotopes for a receptor tyrosine kinase gene were also selected using a breast cancer SKBR-3 cDNA phage display library, screened against an anti-erbB2 monoclonal antibody. Identification of mimotopes in genomic and cDNA phage libraries is essential for phage display-based protein validation assays and two-hybrid phage approaches that examine protein-protein interactions. The predominance of E. coli mimotopes suggests that the E. coli genome may be useful to generate peptide diversity biased towards protein coding sequences

GOODS-Herschel: the far-infrared view of star formation in active galactic nucleus host galaxies since z ≈ 3

We present a study of the infrared properties of X-ray selected, moderate-luminosity (i.e. L_X= 10^(42)–10^(44) erg s^(−1)) active galactic nuclei (AGNs) up to z ≈ 3, in order to explore the links between star formation in galaxies and accretion on to their central black holes. We use 100 and 160 μ m fluxes from GOODS-Herschel – the deepest survey yet undertaken by the Herschel telescope – and show that in the vast majority of cases (i.e. >94 per cent) these fluxes are dominated by emission from the host galaxy. As such, these far-infrared bands provide an uncontaminated view of star formation in the AGN host galaxies. We find no evidence of any correlation between the X-ray and infrared luminosities of moderate AGNs at any redshift, suggesting that global star formation is decoupled from nuclear (i.e. AGN) activity in these galaxies. On the other hand, we confirm that the star formation rates of AGN hosts increase strongly with redshift, by a factor of 43^(+27)_(−18) from z < 0.1 to z = 2–3 for AGNs with the same range of X-ray luminosities. This increase is entirely consistent with the factor of 25–50 increase in the specific star formation rates (SSFRs) of normal, star-forming (i.e. main-sequence) galaxies over the same redshift range. Indeed, the average SSFRs of AGN hosts are only marginally (i.e. ≈20 per cent) lower than those of main-sequence galaxies at all surveyed redshifts, with this small deficit being due to a fraction of AGNs residing in quiescent (i.e. low SSFR) galaxies. We estimate that 79 ± 10 per cent of moderate-luminosity AGNs are hosted in main-sequence galaxies, 15 ± 7 per cent in quiescent galaxies and <10 per cent in strongly starbursting galaxies. We derive the fractions of all main-sequence galaxies at z < 2 that are experiencing a period of moderate nuclear activity, noting that it is strongly dependent on galaxy stellar mass (M_(stars)), rising from just a few per cent at M_(stars) ∼ 10^(10) M_⊙ to ≳20 per cent at M_(stars)≥ 10^(11) M_⊙. Our results indicate that it is galaxy stellar mass that is most important in dictating whether a galaxy hosts a moderate-luminosity AGN. We argue that the majority of moderate nuclear activity is fuelled by internal mechanisms rather than violent mergers, which suggests that high-redshift disc instabilities could be an important AGN feeding mechanism

Are the black hole masses in Narrow Line Seyfert 1 galaxies actually small?

Narrow Line Seyfert 1 galaxies (NLS1s) are generally considered peculiar objects among the broad class of Type 1 active galactic nuclei, due to the relatively small width of the broad lines, strong X-ray variability, soft X-ray continua, weak [OIII], and strong FeII line intensities. The mass M_BH of the central massive black hole (MBH) is claimed to be lighter than expected from known MBH-host galaxy scaling relations, while the accretion rate onto the MBH larger than the average value appropriate to Seyfert 1 galaxies. In this Letter, we show that NLS1 peculiar M_BH and L/L_Edd turn out to be fairly standard, provided that the broad line region is allowed to have a disc-like, rather than isotropic, geometry. Assuming that NLS1s are rather ``normal'' Seyfert 1 objects seen along the disc axis, we could estimate the typical inclination angles from the fraction of Seyfert 1 classified as NLS1s, and compute the geometrical factor relating the observed FWHM of broad lines to the virial mass of the MBH. We show that the geometrical factor can fully account for the "black hole mass deficit" observed in NLS1s, and that L/L_Edd is (on average) comparable to the value of the more common broad line Seyfert 1 galaxies.Comment: 5 pages, 3 figures. Accepted for publication in MNRAS Letters. Wrong version was uploaded! Check for the correct one in the replacemen

A roadmap for China to peak carbon dioxide emissions and achieve a 20% share of non-fossil fuels in primary energy by 2030

As part of its Paris Agreement commitment, China pledged to peak carbon dioxide (CO2) emissions around 2030, striving to peak earlier, and to increase the non-fossil share of primary energy to 20% by 2030. Yet by the end of 2017, China emitted 28% of the world's energy-related CO2 emissions, 76% of which were from coal use. How China can reinvent its energy economy cost-effectively while still achieving its commitments was the focus of a three-year joint research project completed in September 2016. Overall, this analysis found that if China follows a pathway in which it aggressively adopts all cost-effective energy efficiency and CO2 emission reduction technologies while also aggressively moving away from fossil fuels to renewable and other non-fossil resources, it is possible to not only meet its Paris Agreement Nationally Determined Contribution (NDC) commitments, but also to reduce its 2050 CO2 emissions to a level that is 42% below the country's 2010 CO2 emissions. While numerous barriers exist that will need to be addressed through effective policies and programs in order to realize these potential energy use and emissions reductions, there are also significant local environmental (e.g., air quality), national and global environmental (e.g., mitigation of climate change), human health, and other unquantified benefits that will be realized if this pathway is pursued in China

Searching for Compton-thick active galactic nuclei at z~0.1

Using a suite of X-ray, mid-IR and optical active galactic nuclei (AGN) luminosity indicators, we search for Compton-thick (CT) AGNs with intrinsic L_X>10^42erg/s at z~0.03-0.2, a region of parameter space which is currently poorly constrained by deep narrow-field and high-energy (E>10keV) all-sky X-ray surveys. We have used the widest XMM-Newton survey (the serendipitous source catalogue) to select a representative sub-sample (14; ~10%) of the 147 X-ray undetected candidate CT AGNs in the Sloan Digital Sky Survey (SDSS) with f_X/f_[OIII]<1; the 147 sources account for ~50% of the overall Type-2 AGN population in the SDSS-XMM overlap region. We use mid-IR spectral decomposition analyses and emission-line diagnostics, determined from pointed Spitzer-IRS spectroscopic observations of these candidate CT AGNs, to estimate the intrinsic AGN emission (predicted L_X,2-10keV (0.2-30)x10^42erg/s). On the basis of the optical [OIII], mid-IR [OIV] and 6um AGN continuum luminosities we conservatively find that the X-ray emission in at least 6/14 (>43%) of our sample appear to be obscured by CT material with N_H>1.5x10^24cm^-2. Under the reasonable assumption that our 14 AGNs are representative of the overall X-ray undetected AGN population in the SDSS-XMM parent sample, we find that >20% of the optical Type-2 AGN population are likely to be obscured by CT material. This implies a space-density of log(Phi) >-4.9Mpc^-3 for CT AGNs with L_X>10^42erg/s at z~0.1, which we suggest may be consistent with that predicted by X-ray background synthesis models. Furthermore, using the 6um continuum luminosity to infer the intrinsic AGN luminosity and the stellar velocity dispersion to estimate M_BH, we find that the most conservatively identified CT AGNs in this sample may harbour some of the most rapidly growing black holes (median M_BH~3x10^7M_o) in the nearby Universe, with a median Eddington ratio of ~0.2.Comment: 16 pages, 2 tables, 6 figures. Accepted for publication in MNRA

Cell-Cell Interactions and the Regulation of Testis Function

Regulatory interactions have been shown to occur between all the testicular cell types considered. The paracrine factors mediating these interactions generally influence either cellular growth or differentiation. The regulation of cellular growth is essential in the developing testis and is required for the maintenance of spermatogenesis in the adult testis. The rapid rate of germinal cell proliferation and the continuous but slowed growth of the peritubular cells and Leydig cells requires the presence of specific growth factors in the adult. Therefore, cell-cell interactions have evolved that involve growth factors such as IGF, TGF-alpha, TGF-beta and NGF. Other growth factors such as FGF or less characterized components like the seminiferous growth factor (SGF) also may be involved in the paracrine regulation of testis cell growth. An alternate cellular parameter to cell growth to consider is the regulation of cellular function and differentiation. A number of endocrine agents and locally produced paracrine factors have been shown to control and maintain testis cell function and differentiation. Cell-cell interactions mediated by factors such as androgens, POMC peptides, and PModS are all primarily directed at the regulation of cellular differentiation. Therefore, the agents which mediate cell-cell interactions in the testis can generally be categorized into factors that regulate cell growth or those which influence cellular differentiation. The specific cell-cell interactions identified will likely be the first of a large number of cellular interactions yet to be investigated. Although a number of potentially important cell-cell interactions have been identified, future research will require the elucidation of the in vivo physiological significance of these interactions. The existence of different cell types and potential cell-cell interactions in a tissue implies that the actions of an endocrine agent on a tissue will not simply involve a single hormone and single cell. The endocrine regulation of testis function will have effects on cell-cell interactions and be affected by local cell-cell interactions. The ability of LH to influence Leydig cell androgen production promotes a cascade of interactions mediated through several cell types to maintain the process of spermatogenesis. FSH actions on Sertoli cells also promote cell-cell interactions that influence germinal cell development, peritubular myoid cell differentiation and Leydig cell function. Therefore, elucidation of the endocrine regulation of testis function requires an understanding of the local cell-cell interactions in the testis

The Nustar Extragalactic Surveys: Initial Results and Catalog from the Extended Chandra Deep Field South

We present initial results and the source catalog from the NuSTAR survey of the Extended Chandra Deep Field South (hereafter, ECDFS) - currently the deepest contiguous component of the NuSTAR extragalactic survey program. The survey covers the full ~30 arcmin x 30 arcmin area of this field to a maximum depth of ~360 ks (~220 ks when corrected for vignetting at 3-24 keV), reaching sensitivity limits of ~1.3 x 10^-14 erg/cm2/s (3-8 keV), ~3.4 x 10^-14 erg/cm2/s (8-24 keV) and ~3.0 x 10^-14 erg/cm2/s (3-24 keV). Fifty four (54) sources are detected over the full field, although five of these are found to lie below our significance threshold once contaminating flux from neighboring (i.e., blended) sources is taken into account. Of the remaining 49 that are significant, 19 are detected in the 8-24 keV band. The 8-24 keV to 3-8 keV band ratios of the twelve sources that are detected in both bands span the range 0.39-1.7, corresponding to a photon index range of Gamma ~ 0.5-2.3, with a median photon index of 1.70 +/- 0.52. The redshifts of the 49 sources in our main sample span the range z = 0.21-2.7, and their rest-frame 10-40 keV luminosities (derived from the observed 8-24 keV fluxes) span the range L(10-40 keV) ~ (0.7-300) x 10^43 erg/s, sampling below the knee of the X-ray luminosity function out to z ~ 0.8-1. Finally, we identify one NuSTAR source that has neither a Chandra nor an XMM-Newton counterpart, but that shows evidence of nuclear activity at infrared wavelengths, and thus may represent a genuine, new X-ray source detected by NuSTAR in the ECDFS