16 T Diffusion microimaging of fixed prostate tissue: Preliminary findings

Diffusion tensor microimaging was used to investigate the water diffusion properties of formalin-fixed prostate tissue at spatial resolution approaching the cellular scale. Diffusion tensor microimaging was performed at 16.4 T with 40 mu m isotropic voxels. Diffusion tensor microimaging clearly demonstrated distinct microscopic diffusion environments and tissue architecture consistent with that seen on light microscopy of the same tissue. The most restricted diffusion environment is the secretory epithelial cell layer (voxel bulk mean diffusivity, D = 0.4 +/- 0.1 x 10(-3) mm(2)/sec). Diffusion in the fibromuscular stromal matrix is relatively less restricted (D = 0.7 +/- 0.1 x 10(-3) mm(2)/sec). In tumor tissue (Gleason pattern 4+4) distinct glandular and ductal structures are absent in the diffusion-weighted images and diffusivity is low (D = 0.5 +/- 0.1 x 10(-3) mm(2)/sec). Distinct stromal and epithelial diffusion compartments are the most likely origin of biexponential diffusion decay observed in vivo. Magn Reson Med 66:244-247, 2011. (C) 2011 Wiley-Liss, Inc

Alien Registration- Mulkern, Mary (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23629/thumbnail.jp

Multi‐system repeatability and reproducibility of apparent diffusion coefficient measurement using an ice‐water phantom

Purpose: To determine quantitative quality control procedures to evaluate technical variability in multi‐center measurements of the diffusion coefficient of water as a prerequisite to use of the biomarker apparent diffusion coefficient (ADC) in multi‐center clinical trials. Materials and Methods: A uniform data acquisition protocol was developed and shared with 18 participating test sites along with a temperature‐controlled diffusion phantom delivered to each site. Usable diffusion weighted imaging data of ice water at five b‐values were collected on 35 clinical MRI systems from three vendors at two field strengths (1.5 and 3 Tesla [T]) and analyzed at a central processing site. Results: Standard deviation of bore‐center ADCs measured across 35 scanners was 10%) vendor‐specific and system‐specific spatial nonuniformity ADC bias was detected for the off‐center measurement that was consistent with gradient nonlinearity. Conclusion: Standardization of DWI protocol has improved reproducibility of ADC measurements and allowed identifying spatial ADC nonuniformity as a source of error in multi‐site clinical studies. J. Magn. Reson. Imaging 2013;37:1238–1246. © 2012 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97442/1/23825_ftp.pd

Alien Registration- Mulkern, Mary (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23629/thumbnail.jp

Alien Registration- Mulkern, Catherine (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23749/thumbnail.jp

Promoting Mental Health in Schools

About 1 in 7 U.S. children aged 2-8 have a mental, behavioral or developmental disorder reported by a parent. The Maine CDC\u27s Pediatric Mental Health Care Access Grant provides behavioral health consultation to pediatric primary care providers and training and support to schools by strengthening policies and programs in school mental health.https://digitalcommons.library.umaine.edu/ccids_posters/1064/thumbnail.jp

Alien Registration- Mulkern, Catherine (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23749/thumbnail.jp

Alien Registration- Mulkern, Mary A. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23731/thumbnail.jp

Alien Registration- Mulkern, Mary A. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23731/thumbnail.jp

Alien Registration- Mulkern, Mary A. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/23731/thumbnail.jp