Analysis of microparticle penetration into human and porcine skin: non-invasive imaging with multiphoton excitation microscopy

At the University of Oxford and PowderJect Pharmaceuticals plc, a unique form of needle-free injection technology has been developed. Powdered vaccines and drugs in micro-particle form are accelerated in a high-speed gas flow to sufficient velocity to enter the skin, subsequently achieving a pharmaceutical effect. To optimize the delivery of vaccines and drugs with this method a detailed understanding of the interactive processes that occur between the microparticles and the skin is necessary. Investigations to date of micro-particle delivery into excised human and animal tissue have involved image analyses of histology sections. In the present study, a series of investigations were conducted on excised human and porcine skin using the technique of Multi-Photon fluorescence excitation Microscopy (MPM) to image particles and skin structures post-penetration. Micro-particles of various size and composition were imaged with infrared laser excitation. Three-dimensional images of stratum corneum and epidermal cell deformation due to micro-particle penetration were obtained. Measurements of micro-particle penetration depth taken from z-scan image stacks were used to successfully quantify micro-particle distribution within the skin, without invasively disrupting the skin target. This study has shown that MPM has great potential for the non-invasive imaging of particle skin interactive processes that occur with the transdermal delivery of powdered micro-particle vaccines and drugs

Experimental Observation of Total-Internal-Reflection Rainbows

A new class of rainbows is created when a droplet is illuminated from the inside by a point light source. The position of the rainbow depends on both the index of refraction of the droplet and the position of the light source, and the rainbow vanishes when the point source is too close to the center of the droplet. Here we experimentally measure the position of the transmission and one-internal-reflection total-internal-reflection rainbows, and the standard (primary) rainbow, as a function of light-source position. (C) 2003 Optical Society of America

Analysis of the Shadow-Sausage Effect Caustic

We analyze the optical caustic produced by light refracted at the curved meniscus surrounding a cylindrical rod standing partially out of a liquid-filled container. When the rod is tilted from the vertical or when light is diagonally incident, the caustic is a four-cusped astroid with two of its cusps obscured by the rod\u27s shadow. If a portion of the flat end of the rod is raised above the water level, the caustic evolves into a pattern of five interlocking cusps. The five cusps result from symmetry breaking of a three-cusped surface perturbation caustic. (C) 2003 Optical Society of America

From technology pathways to policy roadmaps to enabling measures – A multi-model approach

Integrating a range of complementary energy models is becoming an increasingly common method for informing low carbon energy pathways at both national and global levels. Multi-modelling approaches facilitate improved understanding of the detailed technology pathways required to meet decarbonisation targets; however, to-date there has been limited attention on the policy roadmaps and enabling measures that might achieve these decarbonisation targets. This paper addresses this gap by developing a multi-model approach using an energy systems optimisation model, a sectoral simulation model together with scrutiny of individual policy measures to explore decarbonisation of the private car sector in the Irish transport system commensurate with an 80% reduction in national carbon emissions by 2050. The results comprise a cost optimal technology pathway for private cars in a future energy system constrained by a maximum level of carbon emissions, a policy roadmap identifying annual changes in energy efficiency, renewable energy and electrification, and a suite of enabling measures including changes to vehicle registration tax, a biofuel obligation on suppliers and a suite of measures to increase the share of electric vehicles in the fleet. The level of confidence in the different enabling measures to achieve the policy goals is compared and discussed

The cost of electrifying private transport - evidence from an empirical consumer choice model of Ireland and Denmark

There is a growing consensus that moving to a low carbon future within the transport sector will require a substantial shift away from fossil fuels toward more sustainable means of transport. A particular emphasis has been given to battery electric vehicles (BEV) and plug in hybrid electric vehicles (PHEV), with many nations investing in improving their charging infrastructure and incentivising electric vehicle purchasing through offering grant schemes and tax relief to consumers. Despite these incentives, the uptake of BEVs and PHEVs has been low, while some countries, such as Ireland and Denmark, are in the process of removing the tax relief currently in place. This initial retraction has already been met with a fall in sales of BEVs and PHEVs, which is expected to continue decreasing as these incentives are further reduced. This study develops a socio-economic consumer choice model of the private transport sector based off national empirical data for Ireland and Denmark to analyse the long-term effects of these subsidy retractions, and to further analyse the policy measures and associated cost of moving toward a low carbon private transport sector

Etiology of severe childhood pneumonia in the Gambia, West Africa, determined by conventional and molecular microbiological analyses of lung and pleural aspirate samples.

Molecular analyses of lung aspirates from Gambian children with severe pneumonia detected pathogens more frequently than did culture and showed a predominance of bacteria, principally Streptococcus pneumoniae, >75% being of serotypes covered by current pneumococcal conjugate vaccines. Multiple pathogens were detected frequently, notably Haemophilus influenzae (mostly nontypeable) together with S. pneumoniae

The Grizzly, October 30, 1990

Ursinus Honored at Governor\u27s Mansion • Sam Stretton To Speak • Glassmoyer Retires • Heefner New Board President • The Gender of Speech: A Tri-Lambda Lecture • Career Day November 6th • Forbes to Speak to Clergy • Animal Lovers Unite • Mock DWI A Hit • Student Camp Experience • David is Great!! • Presenting Protheatre: The Changeling • Crutcher Leads Team• Muhlenberg Falls • Swimmers Open Season at Relay Meet • Women Running To MAC\u27s • Men Go for MAC Title • Soccer • Letters: Keep Ursinus Clean; Quad Keys Revoked?; Signs Stolen; Security, Please Hold • Environmentally Concerned? Get Active • Bush\u27s Environmental Lip Service • This Time for Real • Nature Versus Nurture: A Step in Solving the Puzzlehttps://digitalcommons.ursinus.edu/grizzlynews/1262/thumbnail.jp

The Grizzly, December 3, 1990

Wismer Hall to be Renovated by Next Fall • Quad Intruder Returns • Politics Honors Projects • Foreign Policy and the Press • Ursinus Offers St. Joseph\u27s Post-MBA Certificates • Dance Marathon Planned • Crazy Toys • Holiday Messages Encouraged • Exam Schedule • Mixed Up • Jane\u27s Addiction Concert Review • European Old Master Prints • At the Playhouse • Attention Skiers • Edie Brickell Reviewed • In the Spotlight • Swimmers Host Double-Header Weekend • Lady Hoopsters Shoot for Title • Are We Going to War? • Why are We Really There? • Hey! Who\u27s the New Guy? • Brain in Brief • Bonnie and SAM (not Clyde)https://digitalcommons.ursinus.edu/grizzlynews/1266/thumbnail.jp