Optimal recovery from microburst wind shear

Severe low-altitude wind variability represents an infrequent but significant hazard to aircraft taking off or landing. During the period from 1964 to 1985, microburst wind shear was a contributing factor in at least 26 civil aviation accidents involving nearly 500 fatalities and over 200 injuries. A microburst is a strong localized downdraft that strikes the ground, creating winds that diverge radially from the impact point. The physics of microbursts have only been recently understood in detail, and it has been found that effective recovery from inadvertent encounters may require piloting techniques that are counter-intuitive to flight crews. The goal of this work was to optimize the flight path of a twin-jet transport aircraft encountering a microburst during approach to landing. The objective was to execute an escape maneuver that maintained safe ground clearance and an adequate stall margin during the climb-out portion of the trajectory

Flight simulation for wind shear encounter

A real-time piloted flight simulator is under development in the Laboratory for Control and Automation at Princeton University. This facility will be used to study piloted flight through a simulated wind shear. It will also provide a testbed for real-time flight guidance laws. The hardware configuration and aerodynamic model used are discussed. The microburst model to be incorporated into the simulation is introduced, and some proposed cockpit display concepts are described

Designing for Self-Management of Multiple Chronic Conditions by the Aging-at-home

Many elderly individuals are aging at home (AAH) as the planet is graying. In the U.S., the number will rise to more than 64 million people by 2040. The AAH are more susceptible to health-related issues due to the normal process of aging coupled with the incidence of multiple chronic conditions (MCC). Self-management of MCC can be cognitively and operationally challenging for the AAH. We are designing digital resources for AAH with MCC following the action design research methodology. In this paper, we describe outcomes from early rounds, including problem formulation with semi-structured interviews of AAH with MCC, exploring theoretical precursors and technology frames, and evaluating design genres to establish a design vision. The outcomes are described as a theory-ingrained, layered digital artifact, MyHealthNotes; along with the results of an initial applicability check and formative usability test. The paper concludes with a discussion of contributions so far and next steps

MEDICAL PHYSIOLOGY AS A WALK OF LIFE -PAST, CURRENT, AND FUTURE PROSPECTIVE: AN INSIGHT

In exploring the epitome of Physiology, we come across a multitude of disciplines. The history of human Physiology can be traced back to 435 BC. Now, Physiology has become an integral part of our life. Physiology and Medicine are like two faces of the same coin. While swimming through the ocean of Physiology we discover many natal systems. Physiology forms the ground on which the study of Medicine works like our laptop. Forming substratum in the arch of medical and surgical knowledge, Physiology is gaining vanity. The relevance of Physiological ideas is just like the cherry on the cake. This review is a general topic of interest and discusses the history of Physiology and the importance of Physiology beyond academics in the epoch of translational research

Optimal nonlinear estimation for aircraft flight control in wind shear

The most recent results in an ongoing research effort at Princeton in the area of flight dynamics in wind shear are described. The first undertaking in this project was a trajectory optimization study. The flight path of a medium-haul twin-jet transport aircraft was optimized during microburst encounters on final approach. The assumed goal was to track a reference climb rate during an aborted landing, subject to a minimum airspeed constraint. The results demonstrated that the energy loss through the microburst significantly affected the qualitative nature of the optimal flight path. In microbursts of light to moderate strength, the aircraft was able to track the reference climb rate successfully. In severe microbursts, the minimum airspeed constraint in the optimization forced the aircraft to settle on a climb rate smaller than the target. A tradeoff was forced between the objectives of flight path tracking and stall prevention

MEDICAL PHYSIOLOGY AS A WALK OF LIFE -PAST, CURRENT, AND FUTURE PROSPECTIVE: AN INSIGHT

In exploring the epitome of Physiology, we come across a multitude of disciplines. The history of human Physiology can be traced back to 435 BC. Now, Physiology has become an integral part of our life. Physiology and Medicine are like two faces of the same coin. While swimming through the ocean of Physiology we discover many natal systems. Physiology forms the ground on which the study of Medicine works like our laptop. Forming substratum in the arch of medical and surgical knowledge, Physiology is gaining vanity. The relevance of Physiological ideas is just like the cherry on the cake. This review is a general topic of interest and discusses the history of Physiology and the importance of Physiology beyond academics in the epoch of translational research

Development of an Automated Physician Review Classification System: A hybrid Machine Learning Approach

Patients are increasingly turning to physician rating websites to help them make important healthcare decisions, such as selecting primary care doctors, specialists, and supplementary medical care providers. Previous research has identified a variety of topics and themes that emerge on these review platforms. However, there is little or no work that has been done to create an automated classifier that automatically categorizes these reviews into distinct topics after they have been explored in this context. Building such an automated classifier could assist IS developers and other stakeholders in automatically classifying patient reviews and understanding patient needs. Furthermore, using design science research we strategize how such machine learning systems can be built using design guidelines in turn having the potential to be generalized to other specific contextual problem spaces. Our work focuses on laying the foundation to design guidelines that need to be followed while building automated systems in specific contexts

A TOGAF Based Chatbot Evaluation Metrics: Insights from Literature Review

Chatbots have been used for basic conversational functionalities and task performance in today\u27s world. With the surge in the use of chatbots, several design features have emerged to cater to its rising demands and increasing complexity. Researchers have grappled with the issues of modeling and evaluating these tools because of the vast number of metrics associated with their measure of successful. This paper conducted a literature survey to identify the various conversational metrics used to evaluate chatbots. The selected evaluation metrics were mapped to the various layers of The Open Group Architecture Framework (TOGAF) architecture. TOGAF architecture helped us divide the metrics based on the various facets critical to developing successful chatbot applications. Our results show that the metrics related to the business layer have been well studied. However, metrics associated with the data, information, and system layers warrant more research. As chatbots become more complex, success metrics across the intermediate layers may assume greater significance

DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING HPTLC METHOD FOR DETERMINATION OF EPERISONE HYDROCHLORIDE IN BULK DRUG

Objective: A new, economical, precise and accurate stability indicating HPTLC method was developed and validated for the determination of Eperisone hydrochloride in bulk drug.Methods: Sample and standard solutions of Eperisone hydrochloride was applied on precoated silica gel G 60 F254 HPTLC plate and the plate was developed using Toluene: Chloroform: Ethanol (4:4:1v/v/v) as mobile phase. The detection was performed at 266 nmResults: The calibration curve was found to be linear between 100 to 700 ng/spot for Eperisone hydrochloride with correlation coefficients 0.999. The Rf value for Eperisone hydrochloride was found to be 0.26±0.03. The LOD and LOQ were found to be 100 ng/spot and 300 ng/spot for Eperisone hydrochloride. The selected drug was subjected to acid, alkali and oxidative degradation and study revealed, Eperisone hydrochloride is well resolved from pure form with significant differences in their Rf this method can be successfully employed for quantitative analysis of Eperisone hydrochloride in bulk drug.Conclusion: The proposed method has been validated as per ICH Q2 (R1) guidelines. This method can be used for routine quality control analysis of Eperisone hydrochloride in bulk drug.Â

Induction of somatic embryogenesis in different varieties of sugarcane (Saccharam officinarum L.)

This investigation for the first time highlights TDZ induced callus formation, somatic embryogenesis and plant regeneration using leaf explants of different varieties (Co94032,CoC671, Co86032, SNK754, SNK61 and SNK44) of sugarcane (Saccharam officinarum). Leaf explants cultured on the full strength inorganic salts Murashige and Skoog (1962) basal medium supplemented with 4.52 μM 2, 4-D and 4.54 μM TDZ induced embryogenic tissue after 3-4 weeks. The percentage of somatic embryogenesis was not similar in all the tested varieties of sugarcane. This study indicates a high embryogenic potential of leaf explants of tested sugarcane varieties, and also opened up the possibility for large-scale clonal propagation of sugarcane for the genetic improvement programmes