6 research outputs found
Prevalence of surgical site infection post caesarean with increased patient load during COVID-19 pandemic in tertiary care centre
Background: Increased referrals and workload during the pandemic lead to overcrowding in hospitals and increase in LSCS rates. Surgical site infection is one of the most common complication post LSCS causing physical and mental duress to the patients. The objective of the study was to analyse the effect of COVID-19 on SSI, the incidence, commonly associated factors and bacteriology of SSI. The design was prospective study design.Methods: 577 patients undergoing LSCS were studied from Day 1 till 30 days post LSCS from 1st August 2020 to 31st October 2020.Results: Out of 577, 28 (4.85%) patients developed SSI. 60% of SSI in our study were unbooked, 50% had haemoglobin less than 9.9 g/dl. Most common risk factor for developing of SSI included pre-eclampsia (32.14%) followed by previous LSCS (28.57%). Common organism isolate was MRSA (25%) and 75% required surgical management.Conclusions: Regular ANC visits can help in managing comorbidities at an earlier stage leading to reduction in SSI. Strict aseptic precautions should be followed to reduce SSI in cases with PROM and second stage arrest. SSI rate is not influenced by COVID-19 status but hospital facilities and overcrowding definitely have an effect
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Trade-offs in ecosystem impacts from nanomaterial versus organic chemical ultraviolet filters in sunscreens
Both nanoparticulate (nZnO and nTiO(2)) and organic chemical ultraviolet (UV) filters are active ingredients in sunscreen and protect against skin cancer, but limited research exists on the environmental effects of sunscreen release into aquatic systems. To examine the trade-offs of incorporating nano particles (NPs) into sunscreens over the past two decades, we targeted endpoints sensitive to the potential risks of different UV filters: solar reactive oxygen production in water and disruption of zebrafish embryo development. First, we developed methodology to extract nanoparticles from sunscreens with organic solvents. Zebrafish embryos exposed to parts-per-million NPs used in sunscreens displayed limited toxicological effects; nZnO particles appeared to be slightly more toxic than nTiO(2) at the highest concentrations. In contrast, seven organic UV filters did not affect zebrafish embryogenesis at or near aqueous solubility. Second, to simulate potent photo-initiated reactions upon release into water, we examined methylene blue (MB) degradation under UV light. nTiO(2) from sunscreen caused 10 times faster MB loss than nZnO and approached the photocatalytic degradation rate of a commercial nTiO(2) photo catalysts (P25). Organic UV filters did not cause measurable MB degradation. Finally, we estimated that between 1 and 10 ppm of sunscreen NPs in surface waters could produce similar steady state hydroxyl radical concentrations as naturally occurring fluvic acids under sunlight irradiation. Incorporation of NPs into sunscreen may increase environmental concentrations of reactive oxygen, albeit to a limited extent, which can influence transformation of dissolved substances and potentially affect ecosystem processes. (C) 2018 Elsevier Ltd. All rights reserved