WITHDRAWN: QSAR analysis and 3D QSAR kNN-MFA approach on a series of substituted quinolines derivatives as angiotensin II receptor antagonists

This article has been retracted at the request of the Editor-in-Chief because of excessive self-citations of the author in various articles submitted to the journal.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy

WITHDRAWN: An approach to design antihypertensive agents by 2D QSAR studies on series of substituted benzimidazoles derivatives as angiotensin II receptor antagonists

This article has been retracted at the request of the Editor-in-Chief because of excessive self-citations of the author in various articles submitted to the journal.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy

WITHDRAWN: Quantitative structure–activity analysis studies on triazolinone aryl and nonaryl substituents as angiotensin II receptor antagonists

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy

Benzimidazoles derivatives with (2-{6-Chloro-5-nitro-1-[2-(1H-tetrazol-5-yl) biphenyl-4-ylmethyl] 1H-benzoimidazol-2-yl}-phenyl)-(substituted-benzylidene)-amine with potential angiotensin II receptor antagonists as antihypertensive activity

In this study we have synthesized some Benzimidazole derivatives (2-{6-Chloro-5-nitro-1-[2-(1H-tetrazol-5-yl) biphenyl-4-ylmethyl] 1H-benzoimidazol-2-yl}-phenyl)-(Substituted-benzylidene)-amine and screened for their antihypertensive activity. 4-chloro-o-Phenylenediamine was condensed with anthranilic acid in presence of Polyphosphoric acid and different aryl aldehydes compounds with biphenyl tetrazole ring. The presence of specific functional group were analysed by IR spectroscopy, The determination of structure for the synthesized compounds by NMR and Mass spectroscopy 13C NMR, 1H NMR, FAB Mass. All the synthesized compounds showed significant antihypertensive activity.Keywords: Benzimidazole; Antihypertensive; 4-chloro-o-Phenylenediamine; Biphenyl tetrazole; Blood pressure

Synthesis and biological evaluation of some new benzimidazoles derivatives 4'-{5-amino-2-[2-substituted-phenylamino)-phenyl-methyl]-benzimidazol-1 ylmethyl}-biphenyl-2-carboxylic acid: Nonpeptide angiotensin II receptor antagonists

A new series of non peptide angiotensin (A-II) receptor antagonist has been prepared. This N-(biphenyl methyl) imidazoles e.g. Some new 4'-{5-amino-2-[2-substituted-phenylamino)-phenyl-methyl]-benzimidazol-1-ylmethyl}-biphenyl-2-carboxylic acid derivatives were synthesized by 2-( α -hydroxy benzyl) benzimidazole was converted to 2-(α-bromo benzyl) benzimidazole by reacting with HBr and Anhydrous ZnCl2 Schiff bases react with biphenyl carboxylic acid with different substituents amino group cyclocondensation with appropriate reagents. Differ from the previously reported and related compounds in that they produce a potent hypertensive effect. The compounds synthesized were identified by 1H NMR, 13C NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for their antihypertensive activity by tail cuff method and direct method measurement of blood pressure.Keywords: Benzimidazoles; Biphenyl Carboxylic acid; Angiotension-II

Quantitation of nitrofurantoin in human plasma by liquid chromatography tandem mass spectrometry

A reliable, selective and sensitive LC-MS/MS assay has been proposed for the determination of nitrofurantoin in human plasma. The analyte and nitrofurazone were extracted from 100 µL of human plasma via SPE on Strata-X 33 µm extraction cartridges. Chromatography was done on a BDS Hypersil C18 (100 mm × 4.6 mm, 5 µm) column under isocratic conditions. Quantitation was done using the multiple reaction monitoring (MRM) mode for deprotonated precursor to product ion transitions of nitrofurantoin (m/z 237.0 → 151.8) and nitrofurazone (m/z 197.0 →123.9). The limit of detection and the lowest limit of quantitation of the method were 0.25 ng mL–1 and 5.00 ng mL–1, respectively, with a linear dynamic range of 5.00–1500 ng mL–1 for nitrofurantoin. The intra-batch and inter-batch precision (RSD, %) was ≤ 5.8 %, while the mean extraction recovery was > 92 %. The method was successfully applied to a bioequivalence study of a 100 mg nitrofurantoin capsule formulation in 36 healthy subjects

Separation of albumin from bovine serum applying ionic-liquid-based aqueous biphasic systems

In this work, the extraction and separation of bovine serum albumin (BSA) from its original matrix, i.e., bovine serum, was performed using a novel ionic-liquid-based aqueous biphasic system (IL-based ABS). To this end, imidazolium-, phosphonium-, and ammonium-based ILs, combined with the anions’ acetate, arginate and derived from Good Buffers, were synthesized, characterized, and applied in the development of ABS with K2HPO4/KH2PO4 buffer aqueous solutions at pH 7. Initial studies with commercial BSA revealed a preferential migration of the protein to the IL-rich phase, with extraction efficiencies of 100% obtained in a single-step. BSA recovery yields ranging between 64.0% and 84.9% were achieved, with the system comprising the IL tetrabutylammonium acetate leading to the maximum recovery yield. With this IL, BSA was directly extracted and separated from bovine serum using the respective ABS. Different serum dilutions were further investigated to improve the separation performance. Under the best identified conditions, BSA can be extracted from bovine serum with a recovery yield of 85.6% and a purity of 61.2%. Moreover, it is shown that the BSA secondary structure is maintained in the extraction process, i.e., after being extracted to the IL-rich phase. Overall, the new ABS herein proposed may be used as an alternative platform for the purification of BSA from serum samples and can be applied to other added-value proteins.publishe

A study of habit of fast food eating among school going adolescents and parental advice and its relation with their nutritional status

Background:A study of habit of fast food eating among school going adolescents and parental advice and its relation with their nutritional status.Methods: Design: an epidemiological analytic observational study. Subjects: 600 adolescents’ 15-19 years of age, studying in 11 and 12 classes and included both boys and girls. A single observer interviewed each student and gathered the information regarding their eating habits. It was recorded on a pre-tested open and closed ended Performa. Nutritional status was assessed by BMI. The adolescents for the purpose of analysis were broadly grouped in two groups. Group I (those having normal BMI ranging 18.5 to 25) and group II (Malnourished i.e. those having BMI 25). Group II adolescents were further divided into group IIa (Underweight, BMI25).Results:Adolescents who took both fast food and soft drinks 73.1% were malnourished (group II) as compared to those who did not take both the things 13.7% in group II. Difference was found to be statistically significant (p value 25) subsequently. Incidence of malnutrition was significantly less in 12.4% adolescents’ interfered by their parents as compared to 69.6% of those where parents was not interfering. Difference was found to be statistically significant (P value <0.01).Conclusion: A habit of fast food eating and taking soft drink provokes malnutrition. Interference in eating by parents is beneficial among adolescents.

Pilot application of PalmGHG, the RSPO greenhouse gas calculator for oil palm products

International audienceThe Roundtable on Sustainable Palm Oil (RSPO) is a non-profit association promoting sustainable palm oil through a voluntary certification scheme. Two successive science-based working groups on greenhouse gas (GHG) were active in RSPO from 2009 to 2011, with the aim of identifying ways of achieving meaningful and verifiable reductions of GHG emissions. One of the outputs of the second group is PalmGHG, a GHG calculator using the life cycle assessment ap-proach to quantify major sources of emissions and sequestration for individual palm oil mills and their supply base. A pilot study was carried out in 2011 with nine RSPO member companies that gave an average of 1.67 t CO2e/t crude palm oil (CPO), with a range of -0.02 to +8.32t CO2e/t CPO. Previous land use and the area of peat soil used were the main causes of the variation. Further modifications to PalmGHG continue to be made in order to make the tool more flexible and comprehensive, to refine default values, and to render it more user-friendly