Whither sporting heritage : reflections on debates in Victoria about Waverley Park and the Melbourne Cricket Ground

The successful nomination of Waverley Park to the Victorian Historic Registerproved as controversial as the stadium was during its thirty-year existence. Thenomination was accepted primarily on the grounds of the social historical value of the site, rather than its architectural or engineering qualities, but in fact a range of different social histories were in conflict during the registration process. Four of the social histories involved are outlined and their influence on the outcome assessed. Some of the implications for the evaluation of sporting heritage sites emerge therefrom (Hay, R., Lazenby, C., Lewis, N., Haig-Muir, M., Mewett, P., 2001).<br /

Evolutionary dynamics of coexisting species.

Thesis (M.Sc.)-University of Natal, Pietermaritzburg, 2000.Ever since Maynard-Smith and Price first introduced the concept of an evolutionary stable strategy (ESS) in 1973, there has been a growing amount of work in and around this field. Many new concepts have been introduced, quite often several times over, with different acronyms by different authors. This led to other authors trying to collect and collate the various terms (for example Lessard, 1990 & Eshel, 1996) in order to promote better understanding ofthe topic. It has been noticed that dynamic selection did not always lead to the establishment of an ESS. This led to the development ofthe concept ofa continuously stable strategy (CSS), and the claim that dynamic selection leads to the establishment of an ESSif it is a CSS. It has since been proved that this is not always the case, as a CSS may not be able to displace its near neighbours in pairwise ecological competitions. The concept of a neighbourhood invader strategy (NIS) was introduced, and when used in conjunction with the concept of an ESS, produced the evolutionary stable neighbourhood invader strategy (ESNIS) which is an unbeatable strategy. This work has tried to extend what has already been done in this field by investigating the dynamics of coexisting species, concentrating on systems whose dynamics are governed by Lotka-Volterra competition models. It is proved that an ESNIS coalition is an optimal strategy which will displace any size and composition of incumbent populations, and which will be immune to invasions by any other mutant populations, because the ESNIS coalition, when it exists, is unique. It has also been shown that an ESNIS coalition cannot exist in an ecologically stable state with any finite number of strategies in its neighbourhood. The equilibrium population when the ESNIS coalition is the only population present is globally stable in a n-dimensional system (for finite n), where the ESNIS coalition interacts with n - 2 other strategies in its neighbourhood. The dynamical behaviour of coexisting species was examined when the incumbent species interacted with various invading species. The different behaviour ofthe incumbent population when invaded by a coalition using either an ESNIS or an NIS phenotype underlines the difference in the various strategies. Similar simulations were intended for invaders who were using an ESS phenotype, but unfortunately the ESS coalition could not be found. If the invading coalition use NIS phenotypes then the outcome is not certain. Some, but not all of the incumbents might become extinct, and the degree to which the invaders flourish is very dependent on the nature ofthe incumbents. However, if the invading species form an ESNIS coalition, one is certain of the outcome. The invaders will eliminate the incumbents, and stabilise at their equilibrium populations. This will occur regardless of the composition and number of incumbent species, as the ESNIS coalition forms a globally stable equilibrium point when it is at its equilibrium populations, with no other species present. The only unknown fact about the outcome in this case is the number ofgenerations that will pass before the system reaches the globally stable equilibrium consisting ofjust the ESNIS. For systems whose dynamics are not given by Lotka-Volterra equations, the existence ofa unique, globally stable ESNIS coalition has not been proved. Moreover, simulations of a non Lotka-Volterra system designed to determine the applicability ofthe proof were inconclusive, due to the ESS coalition not having unique population sizes. Whether or not the proof presented in this work can be extended to non Lotka-Volterra systems remains to be determined

Lacunarity Analysis: A Promising Method for the Automated Assessment of Melanocytic Naevi and Melanoma

The early diagnosis of melanoma is critical to achieving reduced mortality and increased survival. Although clinical examination is currently the method of choice for melanocytic lesion assessment, there is a growing interest among clinicians regarding the potential diagnostic utility of computerised image analysis. Recognising that there exist significant shortcomings in currently available algorithms, we are motivated to investigate the utility of lacunarity, a simple statistical measure previously used in geology and other fields for the analysis of fractal and multi-scaled images, in the automated assessment of melanocytic naevi and melanoma. Digitised dermoscopic images of 111 benign melanocytic naevi, 99 dysplastic naevi and 102 melanomas were obtained over the period 2003 to 2008, and subject to lacunarity analysis. We found the lacunarity algorithm could accurately distinguish melanoma from benign melanocytic naevi or non-melanoma without introducing many of the limitations associated with other previously reported diagnostic algorithms. Lacunarity analysis suggests an ordering of irregularity in melanocytic lesions, and we suggest the clinical application of this ordering may have utility in the naked-eye dermoscopic diagnosis of early melanoma

Assessing the impacts of the first year of rotavirus vaccination in the United Kingdom

The United Kingdom (UK) added rotavirus (RV) vaccine (Rotarix GlaxoSmithKline) to the national vaccine schedule in July 2013. During the 2012–2014 rotavirus seasons, children presenting to the Bristol Royal Hospital for Children Emergency Department with gastroenteritis symptoms had stool virology analysis (real-time PCR) and clinical outcome recorded. Nosocomial cases were identified as patients with non-gastroenteritis diagnosis testing positive for rotavirus &gt; 48h after admission. In comparison to average pre-vaccine seasons, in the first year after vaccine introduction there were 48% fewer attendances diagnosed with gastroenteritis, 53% reduction in gastroenteritis admissions and a total saving of 330 bed-days occupancy. There was an overall reduction in number of rotavirus-positive stool samples with 94% reduction in children aged under one year and a 65% reduction in those too old to have been vaccinated. In the first year after the introduction of universal vaccination against rotavirus we observed a profound reduction in gastroenteritis presentations and admissions with a substantial possible herd effect seen in older children. Extrapolating these findings to the UK population we estimate secondary healthcare savings in the first year of ca £7.5 (€10.5) million. Ongoing surveillance will be required to determine the long-term impact of the RV immunisation programme

Population density profiles of nasopharyngeal carriage of 5 bacterial species in pre-school children measured using quantitative PCR offer potential insights into the dynamics of transmission.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked FilesBacterial vaccines can reduce carriage rates. Colonization is usually a binary endpoint. Real time quantitative PCR (qPCR) can quantify bacterial DNA in mucosal samples over a wide range. Using culture and single-gene species-specific qPCRs for Streptococcus pneumoniae (lytA), Streptococcus pyogenes (ntpC), Moraxella catarrhalis (ompJ), Haemophilus influenzae (hdp) and Staphylococcus aureus (nuc) and standard curves against log-phase reference strain broth cultures we described frequency and peak density distributions of carriage in nasopharyngeal swabs from 161 healthy 2-4 y old children collected into STGG broth. In general, detection by qPCR and culture was consistent. Discordance mostly occurred at lower detection thresholds of both methods, although PCR assays for S. pyogenes and S. aureus were less sensitive. Density varied across 5-7 orders of magnitude for the 5 species with the abundant species skewed toward high values (modes: S. pneumoniae log3-4, M. catarrhalis & H. influenzae log4-5 CFU/ml broth). Wide ranges of bacterial DNA concentrations in healthy children carrying these bacteria could mean that different individuals at different times vary greatly in infectiousness. Understanding the host, microbial and environmental determinants of colonization density will permit more accurate prediction of vaccine effectiveness.ESPID research fellowshi

Regeneration and poverty: evidence and policy review. Final report

First paragraph: This review assesses the impact of regeneration on poverty. It is one of a series of evidence reviews produced for the Joseph Rowntree Foundation (JRF) as part of a programme of work to develop an anti-poverty strategy for the UK