Influence of near-fault characteristics on inelastic response of multi-storey building with intensity measurement analysis

Studija je izrađena kako bi se ostvarila tri cilja: (1) usporedba neelastičnih odziva građevina na bliske i udaljene pobude, (2) istraživanje utjecaja odnosa impulsnoga perioda i perioda konstrukcije te (3) ocjena niza mjerenja intenziteta (IM) za bliske potrese. Postojeća armiranobetonska zgrada s 35 katova analizira se u okviru prvoga i drugoga cilja, dok se u okviru trećega cilja analiziraju tri okvirne građevine s po 6, 13 i 20 katova. Rezultati pokazuju da kod bliske pobude može na građevinama doći do prekoračenja razine sposobnosti zaštite života. Osim toga, točnost mjerenja intenziteta u velikoj mjeri ovisi o periodu titranja građevine i o funkciji koja se rabi za izračunavanje vrijednosti IM.This study is presented to achieve three objectives: (1) to compare between the inelastic responses of buildings under near and far fault excitations, (2) to investigate the effect of the pulse to structural period ratio, and (3) to evaluate a set of intensity measurements (IMs) in terms of near fault (NF) earthquakes. A real reinforced concrete building with 35 storeys is analysed in the scope of the first and second objectives, whereas the third objective involves three general-frame buildings consisting of 6, 13, and 20 storeys. Results show that the NF excitation can drive the building to exceed its life safety performance level. Furthermore, the accuracy of the IM highly depends on the vibration period of the building and the function used to calculate the IM

Praziquantel coverage in schools and communities targeted for the elimination of urogenital schistosomiasis in Zanzibar: a cross-sectional survey

© 2015 Knopp et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. The attached file is the published version of the article

Comparison of Mycotoxin Contamination levels of Local and Imported Corn in Iraq

The study included determining pollution level of mycotoxin (aflatoxin, Ochratoxin, T2 / HT2) in local and imported corn in Iraq because it causes health damage and economic losses. In this study, 100 samples were collected from 50 samples of local corn, and 50 samples of imported corn and assed for mycotoxins test using ELISA technique and the results indicated the presence of the highest infection rates of mycotoxin in the local corn especially aflatoxin, where 28 sample at 56% were ranged between (20.1 - 157) ppb, which is higher than the allowable limits and 22 samples at (44%) were ranged between (5.1 to 2.9) ppb which is within the allowable limits , T2 / HT2 in 16 samples at (32%) of the total samples recorded less than (150) PPb which ranged between lowest value (25.8) ppb and the highest value (74.5) ppb and 34 samples at 68% with the value(0.0)ppb were is within the allowable limits, Ochratoxin, in 33 sample at 66% of the total samples less than(15) PPb recorded readings were  ranged between lowest value (1.5) ppb and the highest value (14.3) ppb, and 17 samples at  34% with the value (0.0)ppb,  which is also within the allowable limits in our country. Imported corn recorded readings in 24 samples at 48% as found by the three toxins and ranged the results of aflatoxin between the lowest value (0.8) PPb and the highest value (5.6) ppb and 26 samples at 52% with the value (0.0)ppb and T2 / HT2 results were ranged between the lowest value (3.1) ppb and the highest value (148) ppb and 26 samples at 52% with the value (0.0) ppb ochratoxin results were ranged between the lowest value (1.1) ppb and the highest value (5.7) ppb, and 26 samples at 52% with the value (0.0)ppb   and all of these results are within the allowable limits in our country. So we conclude from this study that the local corn was highest mycotoxin contamination than imported corn

Potential drivers for schistosomiasis persistence: population genetic analyses from a cluster-randomized urogenital schistosomiasis elimination trial across the Zanzibar islands

The World Health Organization's revised NTD Roadmap and the newly launched Guidelines target elimination of schistosomiasis as a public health problem in all endemic areas by 2030. Key to meeting this goal is elucidating how selective pressures imposed by interventions shape parasite populations. Our aim was to identify any differential impact of a unique cluster-randomized tri-armed elimination intervention (biannual mass drug administration (MDA) applied alone or in association with either mollusciciding (snail control) or behavioural change interventions) across two Zanzibarian islands (Pemba and Unguja) on the population genetic composition of Schistosoma haematobium over space and time. Fifteen microsatellite loci were used to analyse individual miracidia collected from infected individuals across islands and intervention arms at the start (2012 baseline: 1,522 miracidia from 176 children; 303 from 43 adults; age-range 6-75, mean 12.7 years) and at year 5 (2016: 1,486 miracidia from 146 children; 214 from 25 adults; age-range 9-46, mean 12.4 years). Measures of genetic diversity included allelic richness (Ar), Expected (He) and Observed heterozygosity (Ho), inbreeding coefficient (FST), parentage analysis, estimated worm burden, worm fecundity, and genetic sub-structuring. There was little evidence of differential selective pressures on population genetic diversity, inbreeding or estimated worm burdens by treatment arm, with only the MDA+snail control arm within Unguja showing trends towards reduced diversity and altered inbreeding over time. The greatest differences overall, both in terms of parasite fecundity and genetic sub-structuring, were observed between the islands, consistent with Pemba's persistently higher mean infection intensities compared to neighbouring Unguja, and within islands in terms of infection hotspots (across three definitions). These findings highlight the important contribution of population genetic analyses to elucidate extensive genetic diversity and biological drivers, including potential gene-environmental factors, that may override short term selective pressures imposed by differential disease control strategies. Trial Registration: ClinicalTrials.gov ISRCTN48837681

Evaluation of integrated interventions layered on mass drug administration for urogenital schistosomiasis elimination: a cluster-randomised trial

Elimination of schistosomiasis as a public health problem and interruption of transmission in selected areas are targets set by WHO for 2025. Our aim was to assess biannual mass drug administration (MDA) applied alone or with complementary snail control or behaviour change interventions for the reduction of Schistosoma haematobium prevalence and infection intensity in children from Zanzibar and to compare the effect between the clusters.; In a 5-year repeated cross-sectional cluster-randomised trial, 90 shehias (small administrative regions; clusters) in Zanzibar eligible owing to available natural open freshwater bodies and public primary schools were randomly allocated (ratio 1:1:1) to receive one of three interventions: biannual MDA with praziquantel alone (arm 1) or in combination with snail control (arm 2), or behaviour change activities (arm 3). Neither participants nor field or laboratory personnel were blinded to the intervention arms. From 2012 to 2017, annually, a single urine sample was collected from approximately 100 children aged 9-12 years in the main public primary school of each shehia. The primary outcome was S haematobium infection prevalence and intensity in 9-12-year-old children after 5 years of follow-up. This study is completed and was registered with the ISRCTN, number 48837681.; The trial was done from Nov 1, 2011, through to Dec 31, 2017 and recruitment took place from Nov 2, 2011, until May 17, 2017. At baseline we enrolled 8278 participants, of whom 2899 (35%) were randomly allocated to arm 1, 2741 (33%) to arm 2, and 2638 (32%) to arm 3. 120 (4·2%) of 2853 in arm 1, 209 (7·8%) of 2688 in arm 2, and 167 (6·4%) of 2613 in arm 3 had S haematobium infections at baseline. Heavy infections (≥50 eggs per 10 mL of urine) were found in 126 (1·6%) of 8073 children at baseline. At the 5-year endline survey, 46 (1·4%) of 3184 in arm 1, 56 (1·7%) of 3217 (odds ratio [OR] 1·2 [95% CI 0·6-2·7] vs arm 1) in arm 2, and 58 (1·9%) of 3080 (1·3 [0·6-2·9]) in arm 3 had S haematobium infections. Heavy infections were detected in 33 (0·3%) of 9462 children.; Biannual MDA substantially reduced the S haematobium prevalence and infection intensity but was insufficient to interrupt transmission. Although snail control or behaviour change activities did not significantly boost the effect of MDA in our study, they might enhance interruption of transmission when tailored to focal endemicity and applied for a longer period. It is now necessary to focus on reducing prevalence in remaining hotspot areas and to introduce new methods of surveillance and public health response so that the important gains can be maintained and advanced.; University of Georgia Research Foundation Inc and Bill & Melinda Gates Foundation

Associations between Season and Gametocyte Dynamics in Chronic Plasmodium falciparum Infections

Introduction: In a markedly seasonal malaria setting, the transition from the transmission-free dry season to the transmission season depends on the resurgence of the mosquito population following the start of annual rains. The sudden onset of malaria outbreaks at the start of the transmission season suggests that parasites persist during the dry season and respond to either the reappearance of vectors, or correlated events, by increasing the production of transmission stages. Here, we investigate whether Plasmodium falciparum gametocyte density and the correlation between gametocyte density and parasite density show seasonal variation in chronic (largely asymptomatic) carriers in eastern Sudan. Materials and Methods: We recruited and treated 123 malaria patients in the transmission season 2001. We then followed them monthly during four distinct consecutive epidemiological seasons: transmission season 1, transmission-free season, pre-clinical period, and transmission season 2. In samples collected from 25 participants who fulfilled the selection criteria of the current analysis, we used quantitative PCR (qPCR) and RT-qPCR to quantify parasite and gametocyte densities, respectively. Results and Discussion: We observed a significant increase in gametocyte density and a significantly steeper positive correlation between gametocyte density and total parasite density during the pre-clinical period compared to the preceding transmission-free season. However, there was no corresponding increase in the density or prevalence of total parasites or gametocyte prevalence. The increase in gametocyte production during the pre-clinical period supports the hypothesis that P. falciparum may respond to environmental cues, such as mosquito biting, to modulate its transmission strategy. Thus, seasonal changes may be important to ignite transmission in unstable-malaria settings

Studying The Effect of The Surface Roughness on the Maximum Eccentricity Ratio and The Load Carrying Capacity in The Journal Bearing

       The  focus of  this  investigation  is to study   the effect  of  the  two  dimensional  isotropic surface  roughness of  both , journal  and  bearing   on  the  maximum  eccentricity  ratio  and  the load  carrying  capacity   of   the  finite   length    plain  journal   bearing , on the basis  of  full film  lubrication  regime  to  reduce  the  wear  and  heat  produced  by  friction   to   extend  the  machine  element  life , in  the steady state operation conditions. The  appropriate  equation  to  predict   the  suitable  minimum  film  thickness which include the surface  roughness  is  used  . The  Conventional Reynolds equation in  two  dimensional   forms  are  solved  numerically . The change of  viscosity due to  temperature  and pressure , using  adiabatic solution ,were  taken  into  account.        To  investigate  the  effect  of   surface  roughness on the maximum  eccentricity  ratio value and  load  capacity  , it was  assumed  that  there are two surfaces smooth  and  rough  and  are compared  with each other . The  results  of  this  work  show  that  the increase of the  surface  roughness  case the  maximum  eccentricity  ratio   decreases  at  L / D  ratios  of   0.5 , 1 at  range of  roughness 0.3 –1.2 Mm,  which  means  that  the  limit  of  bearing  to  work  with  a steady  state , full  film  lubrication . The load  ratio  at  L / D = 0.5  is  greater  than  at  L / D = 1  for  clearance  ratio  0.001 , 0.002 . The  surface  roughness have no  influence  on  the bearings  that  have  90  mm  diameter  or larger  at  clearance  ratio  0.002 .