Automatic Vehicle Checking Agent (VCA)

A definition of intelligence is given in terms of performance that can be quantitatively measured. In this study, we have presented a conceptual model of Intelligent Agent System for Automatic Vehicle Checking Agent (VCA). To achieve this goal, we have introduced several kinds of agents that exhibit intelligent features. These are the Management agent, internal agent, External Agent, Watcher agent and Report agent. Metrics and measurements are suggested for evaluating the performance of Automatic Vehicle Checking Agent (VCA). Calibrate data and test facilities are suggested to facilitate the development of intelligent systems. Keywords: VCA, Agents

HIV prevalence in blood donors and recipients in Pakistan: a meta-analysis and analysis of blood-bank data

Background: The first instances of HIV-antibody detection in donated blood in Pakistan were reported in 1988. Since then, documentation of HIV in blood donors and of rates of transmission via transfusion has been limited. Previously assumed to have a low prevalence, HIV is an increasing health concern in Pakistan. Since there is no national, centralized blood-banking system, there are no reliable data on which to base estimated risks of transfusion-associated HIV infection. This study was therefore conducted to estimate the prevalence of HIV in blood donors and recipients in Pakistan between 1988 and 2012. Methods: Meta-analyses were undertaken of reported prevalences of HIV in blood donors and recipients published during 1988-2012. Papers were identified by searching PubMed, Google, CINAHL and PakMediNet and the websites of the World Health Organization, the national HIV/AIDS Surveillance Project and the National AIDS Control Programme of Pakistan. In addition, the 1998-2012 records of the Aga Khan University blood bank were analysed. Results: The 254 abstracts identified at the preliminary search were reviewed and, after removal of duplications, case-reports, editorials and reviews, 32 papers were selected that met the inclusion criteria. All studies that reported on HIV antibodies in blood donors/recipients were included, irrespective of the methodology used. Since seroconversion had only been confirmed through supplemental testing in a few papers, the results were analysed separately for reports based on screening only and confirmed cases. A total of 142 of 2 023 379 blood donors and 4 of 3632 blood recipients were HIV positive, giving an overall pooled seroprevalence of 0.00111% in blood donors and 0.00325% in blood recipients. The annual prevalences of HIV in donors at the Aga Khan University blood banks were similar, ranging from 0.013% to 0.116%. Conculsion: Very few reports on HIV in blood donors in Pakistan could be retrieved, and the overall pooled prevalence is low. However, the limited data and confounding factors mean that that these results may significantly underestimate the true situation. It is recommended that a complete survey of blood banks should be conducted throughout the country, in order to provide a more reliable estimate of the risk of transfusion-associated HIV infection in Pakistan

An ethnomedicinal appraisal of the Kurram Agency, tribal area, Pakistan

631-647The present work was conducted at the Pakistan-Afghanistan border in the agency of Kurram (33° 49' 07'' N and 70° 10' 24'' E), an administrative part of the late federally administered tribal area (FATA) of Pakistan. Aim of the study was to document the medicinal flora based on local information, i.e., local classification, part used, drug preparation and dosage. Ethnomedicinal data was obtained through semi structured interviews after obtaining the respondents prior informed consent. During field visits 72 people were interviewed 150 plant species belonging to 131 genera in 86 families were documented. The documented plants were found to be effective for 64 disorders, from simple to complicated health issues. In a quantitative analysis, 31 plant species showed fidelity level ranges from 33-100% and relative frequency of citation from 0.03 to 0.28. Conservation issues related to plant use need to be investigated

Human Cryptosporidiosis: An insight into Epidemiology, Modern Diagnostic Tools and Recent Drug Discoveries

Cryptosporidiosis is an emerging food and water borne zoonotic disease, which is caused by genusCryptosporidium. The first Cryptosporidium spp. was isolated from mice in 1907 and gained importance when it was found in an HIV positive patient. It usually causes self-limiting diarrhea in young children and immunocompetent patients. However, it may lead to chronic diarrhea with life threatening condition in immunocompromised patients. Other complications related to this transmittable infection may include respiratory problems, skin rashes and headache. HIV/AIDS patients are highly susceptible host for this parasite. Cryptosporidium parvum and Cryptosporidium hominis are the known pathogenic species, prevalent among humans and they are being transmitted through contaminated food and water. Usually, the diagnosis of Cryptosporidium spp. is dependent on microscopic technique in many countries, which has a low sensitivity and specificity leading to false positive results. However, for a step forward to successful epidemiological studies, advanced techniques (Serological and DNA-based) provide us the better ways of diagnosis with more sensitivity and specificity. Furthermore, no antiparasitic drug has found to be effective againstCryptosporidium spp. except Nitazoxanide which is FDA-approved and effective only when administered along with antiretroviral therapy. In this regard, present review summarizes the various epidemiological studies conducted around the globe along with modern diagnostic tools and the suitable treatment available now a days. This systemized review will help the scientists to better understand all the aspects of cryptosporidiosis at one platform which may help in designing surveillance studies through selection of sensitive diagnostic techniques. The new drugs mentioned in this review may also help to better control this parasite in humans, especially immunocompromised individuals

Sequence and phylogenetic analysis of H7N3 avian influenza viruses isolated from poultry in Pakistan 1995-2004

<p>Abstract</p> <p>Background</p> <p>Avian influenza virus (AIV) infections have caused heavy economic losses to the poultry industry in Pakistan as well as numerous other regions worldwide. The first introduction of H7N3 AIV to Pakistan occurred during 1995, since then H7N3, H9N2 and H5N1 AIVs have each been sporadically isolated. This report evaluates the genetic origin of the H7N3 viruses from Pakistan collected 1995-2004 and how they disseminated within the country. To accomplish this we produced whole genome sequences for 6 H7N3 viruses and data for the HA and NA genes of an additional 7 isolates. All available sequence from H7N3 AIV from Pakistan was included in the analysis.</p> <p>Results</p> <p>Phylogenetic analysis revealed that there were two introductions of H7 into Pakistan and one N3 introduction. Only one of the H7 introductions appears to have become established in poultry in Pakistan, while the other was isolated from two separate outbreaks 6 years apart. The data also shows that reassortment has occurred between H7N3 and H9N2 viruses in the field, likely during co-infection of poultry. Also, with the exception of these few reassortant isolates, all 8 genes in the predominant H7N3 virus lineage have evolved to be phylogenetically distinct.</p> <p>Conclusions</p> <p>Although rigorous control measures have been implemented in commercial poultry in Pakistan, AIV is sporadically transmitted to poultry and among the different poultry industry compartments (broilers, broiler breeders, table egg layers). Since there is one primary H7 lineage which persists and that has reassorted with the H9N2 AIV in poultry, it suggests that there is a reservoir with some link commercial poultry. On a general level, this offers insight into the molecular ecology of AIV in poultry where the virus has persisted despite vaccination and biosecurity. This data also illustrates the importance of sustained surveillance for AIVs in poultry.</p

An ethnomedicinal appraisal of the Kurram Agency, tribal area, Pakistan

The present work was conducted at the Pakistan-Afghanistan border in the agency of Kurram (33° 49' 07'' N and70° 10' 24'' E), an administrative part of the late federally administered tribal area (FATA) of Pakistan. Aim of the study wasto document the medicinal flora based on local information, i.e., local classification, part used, drug preparation and dosage.Ethnomedicinal data was obtained through semi structured interviews after obtaining the respondents prior informedconsent. During field visits 72 people were interviewed 150 plant species belonging to 131 genera in 86 families weredocumented. The documented plants were found to be effective for 64 disorders, from simple to complicated health issues.In a quantitative analysis, 31 plant species showed fidelity level ranges from 33-100% and relative frequency of citationfrom 0.03 to 0.28. Conservation issues related to plant use need to be investigated

Robust estimation based nonlinear higher order sliding mode control strategies for PMSG-WECS

The wind energy conversion systems (WECS) suffer from an intermittent nature of source (wind) and the resulting disparity between power generation and electricity demand. Thus, WECS are required to be operated at maximum power point (MPP). This research paper addresses a sophisticated MPP tracking (MPPT) strategy to ensure optimum (maximum) power out of the WECS despite environmental (wind) variations. This study considers a WECS (fixed pitch, 3KW, variable speed) coupled with a permanent magnet synchronous generator (PMSG) and proposes three sliding mode control (SMC) based MPPT schemes, a conventional first order SMC (FOSMC), an integral back-stepping-based SMC (IBSMC) and a super-twisting reachability-based SMC, for maximizing the power output. However, the efficacy of MPPT/control schemes rely on availability of system parameters especially, uncertain/nonlinear dynamics and aerodynamic terms, which are not commonly accessible in practice. As a remedy, an off-line artificial function-fitting neural network (ANN) based on Levenberg-Marquardt algorithm is employed to enhance the performance and robustness of MPPT/control scheme by effectively imitating the uncertain/nonlinear drift terms in the control input pathways. Furthermore, the speed and missing derivative of a generator shaft are determined using a high-gain observer (HGO). Finally, a comparison is made among the stated strategies subjected to stochastic and deterministic wind speed profiles. Extensive MATLAB/Simulink simulations assess the effectiveness of the suggested approaches

Characterizations of ordered semigroups in terms of (∈, ∈ ∨q)-fuzzy interior ideals

In this paper, we give characterizations of ordered semigroups in terms of (∈, ∈ ∨q)-fuzzy interior ideals. We characterize different classes regular (resp. intra-regular, simple and semisimple) ordered semigroups in terms of (∈, ∈ ∨q)-fuzzy interior ideals (resp. (∈, ∈ ∨q)-fuzzy ideals). In this regard, we prove that in regular (resp. intra-regular and semisimple) ordered semigroups the concept of (∈, ∈ ∨q)-fuzzy ideals and (∈, ∈ ∨q)-fuzzy interior ideals coincide. We prove that an ordered semigroup S is simple if and only if it is (∈, ∈ ∨q)-fuzzy simple. We characterize intra-regular (resp. semisimple) ordered semigroups in terms of (∈, ∈ ∨q)-fuzzy ideals (resp. (∈, ∈ ∨q)-fuzzy interior ideals). Finally, we consider the concept of implication-based fuzzy interior ideals in an ordered semigroup, in particular, the implication operators in Lukasiewicz system of continuous-valued logic are discussed