Fuzzy Logic Speed Regulator for D.C. Motor Tuning

A D.C. motor's rotational speed is regulated in this study using a PID controller and a fuzzy logic controller. In contrast to the fuzzy logic controller, which uses rules based on knowledge and experience, the proportional-integral-derivative (PID) controller requires a mathematical system model.   This study investigates the regulation of a DC motor's velocity using PID and fuzzy logic controllers. The PID controller utilizes a mathematical model and parameter tuning by trial and error. Still, the fuzzy logic controller (FLC) operates on rule-based knowledge, enabling it to handle the nonlinear features of the DC motor effectively. The FLC design entails intricate determinations, including the establishment of a rule base and the process of fuzzification. A total of 49 fuzzy rules have been devised to achieve precise control. Based on MATLAB/SIMULINK simulations, the study concludes that the Fuzzy Logic Controller (FLC) beats the Proportional-Integral-Derivative (PID) controller. The FLC exhibits superior transient and steady-state responses, shorter response times, reduced steady-state errors, and higher precision. This study emphasizes the efficacy of the FLC (Fuzzy Logic Controller) in dealing with the difficulties associated with DC motor control. It presents a strong argument for the suitability and efficiency of FLCs in industrial environments compared to conventional PID (Proportional-Integral-Derivative) controllers. There are a wide variety of ways to construct a fuzzy logic controller. The speed error and the rate of change in the speed error are two inputs to the FLC. Defuzzification is done by focusing on the core of the problem. The results show that FLC is superior to PID controllers in efficiency and effectiveness due to its reduced transient and steady-state factors

True prevalence of twin HDV-HBV infection in Pakistan: a molecular approach

Hepatitis Delta Virus (HDV) infects only patients that are already infected by hepatitis B virus (HBV) because this is sub satellite virus which depends on and propagate only in the presence of HBV. HDV causes co-infection or super infection with sever complication as compared to only HBV infection. No study on molecular level on HDV is available from this region; therefore, the aim of this study was to found out the molecular epidemiology of HDV (as a co-infection with HBV) in different geographical regions of Pakistan

FETAL HEART RATE WITH HYPERTENSIVE AND NON-HYPERTENSIVE MOTHERS ON ULTRASONOGRAPHY IN THIRD TRIMESTER- A SYSTEMATIC REVIEW

Background: Preeclampsia throughout pregnancy increase a women’s chance of developing cardiovascular disease. Women that develop preeclampsia are at higher risk for development of hypertension and cardiac disease. Objective: To evaluate the relationship between maternal health (blood pressure} and fetal heart rate (FHR) during third trimester, and differentiate FHR in male and female fetuses. Material & Methods: An electronic study including the articles of nearly a decade and half. The studies were added by means of Google Scholar, Research gate, NCBI and PubMed to name a few. All the articles were included in the official language English. Articles were included having sonographic relation between the hypertensive and non-hypertensive mothers with fetal heart rate. Results: Analyzing the topic, 14 articles were added to determine the exact correlation between fetal cardiac output and hypertensive mothers. 25 articles were added in introduction and technique while 4 articles were included to link pre-eclamptic mothers with adolescent offspring regarding their growth and cardiac output. Conclusion: Gestational hypertension has adverse effect on fetal heart rate and studies have proved the difference by comparing them with normotensive pregnancies. Keywords: Fetal, Heart, Maternal, Blood pressure. DOI: 10.7176/JHMN/90-16 Publication date:June 30th 202

SONOGRAPHIC EVALUATION OF ESTIMATED FETAL WEIGHT BY DIFFERENT METHOD AT TERM AND POST TERM

Objective: To determine fetal weight estimation by different method on ultrasound at term & to determine actual baby weight after birth Methodology: The research is conducted in Meer Children and Family Clinic Tajpura Lahore. 121 women participate in this study over a 4 month period from January 2021 to April 2021. Systematic random sampling was used to make the selection. The scanner has Hadlock, Shepard, shibozuka and warsof formula.  Results: Out of 70 pregnant women in which 36 (51.5%) nulliparous women and 34(48.5%) multiparous women. A total of 45(64.3%) by vaginal delivery while 25(35.7%) deliver by C – Section. The minimum maternal age for nulliparous women is 21 years and maximum maternal age for multiparous is 39 years. The minimum Actual birth weight i.e. 2.40 correlate with estimated fetal weight. The maximum Actual birth weight i.e. 4.00 correlate with estimated fetal weight. The mean Actual birth weight   is significantly increase with increase in both parity and maternal age at delivery Conclusion: For most pregnant women, estimated fetal weight based on multiple fetal parameters provides reliable and clinically useful information. Despite the fact that there is still an acceptable difference between the actual birth weight and the sonographically EFW. Keywords: Fetal Macrosomia, Term Pregnancy, Hadlocks Formula , Actual birth weight DOI: 10.7176/JHMN/91-11 Publication date:July 31st 202

Diagnostic Efficacy of MRCP and Ultrasound on Obstructive Jaundice-A Prospective Study

Background: Obstructive jaundice is a common pathological problem that occurs when there is an obstruction to the passage of conjugated bilirubin from liver cells to intestine. Bile, a digestive fluid secreted and produce by the liver. Most common cause of obstructive jaundice is due to gallstones. Objective: The aim of our study was to evaluate the diagnostic Efficacy of MRCP and Ultrasound on obstructive jaundice. Study design: A cross-sectional prospective study was performed. Material & Method: A cross-sectional prospective study was performed in 50 patients who came with the provisional diagnosis of obstructive jaundice were referred to ultrasound for primitive diagnosis and were then shifted to MRCP for a detailed diagnosis. The data was collected from the outpatient department facility of Pakistan Kidney and Liver Institute   Hospital, Lahore. After informed consent, data was collected from MRI GE 1.5 Tesla, Ultrasound Canon Xanio. Results: The results revealed that there are 50 patients of obstructive jaundice. 20 were females’ patients and 30 were males’ patients, with age raging from 20-40 years. There were 17 patients out of  50 in our study which ultrasound showed negative results that were positive on MRCP there were 28 patients that were positive on both ultrasound and MRCP. There were 3 patients that were positive on ultrasound but negative on MRCP and 2 patients that were negative on both modalities Conclusion: Our study concluded that higher ratio of males then females in our sample size, RHC was positive in all the patients with dominant cause of jaundice was stone with in biliary channel. We found that MRCP has better efficiency comparative to ultrasound to detect jaundice and its etiology i.e., 90% true positive. Keywords: Magnetic resonance cholangiopancreatography, Ultrasonography, Obstructive jaundice DOI: 10.7176/JHMN/91-03 Publication date:July 31st 202

Sonographic Correlation of Fetal Foot Length as a Reliable Parameter for Estimation of Gestational Age in 2ND and 3RD Trimester

Objective: To sonographic correlation fetal foot length as a reliable parameter for estimation of gestational age in 2nd and 3rd trimester. Study Design: An analytical cross-sectional prospective study was performed. Settings: The study was performed in Meer Children and family clinic, Tajpora Lahore. Period: An analytical cross-sectional study was conducted from 15 October, 2021 to 15 January, 2021. Material & Methods: The present study is conducted in the in the Meer Children and Family Clinic Tajpura Lahore .In pregnant women attending the OPD during 2nd and 3rd trimester for routine checkups. The present study done in 60 normal pregnant women who were sure about their last menstrual period, have regular menstrual cycle, not experienced any vaginal bleeding. Ultrasonographic fetal foot length measurements was done without previous knowledge of gestational age and then the gestational age confirmed by biparietal diameter, abdominal circumference and head circumference . Results: The present study is conducted in 63 pragnent women between 15 to 35 weeks  of gestational age attending the OPD for 2nd and 3rd trimester routine checkups the  in the Meer Children and Family Clinic Tajpura Lahore . Sonographically we calculated foot length from 15 to 35 weeks of gestation. In our study to Early  age at which fetal foot length could be seen and measured sonographically was found to be 15 weeks of  gestation age. In 27 weeks of gestational age and mean foot length 83.67 with std. deviation 5.718 and std. Error Mean -720 and the mean value of foot length by gestational age is 93.33 with std. deviation and std. error mean 338.740 and 42.677 respectivly.  Along with foot length bipraietal diameter(BPD),Abdominal circumference(AC),head circumference(HC) also measured for comparison. Conclusion: In the normal growing fetus the fetal foot length increases with increasing gestational age. Fetal foot length is a good parameter for gestational age especially in cases of femur achondroplasia, dolichocephaly or brachycephaly and in cases who are not sure about their L.M.P. Fetal foot length is  used as an investigational implement  to measured  of gestational age in the late second and third trimesters of pregnancy. Fetal foot length was especially useful when other parameters did not correctly estimate gestational age, e.g., in cases of short-limb dwarfism hydrocephalus or anencephaly. Keywords: Gestational age, Fetal foot length, Ultrasonographically age estimation DOI: 10.7176/JHMN/93-04 Publication date:September 30th 202

A mechanistic insight into chemical cues and interactions involved in herbivory induced jasmonate mediated plant defense mechanism

The first step in plant defense mechanism is to sense the insect attack stimulus. Plant sensitivity of an insect attack is the first step of defense. Molecules generated by the oral secretion of the insect interact with the plant receptors to trigger plant defense mechanisms. We selected some highly cited insect elicitors molecules, volicitin, caeliferin, bruchin which interact with plant defense by interacting with plant elicitors (systemin, inceptin and peps) located on the plant cell surface. This interaction activates plant receptors SYR1, LRR, PEPR and triggers downstream defense signaling. The octadecanoid pathways, involving enzymes allene oxide synthase (AOS) and Hydroxyperoxide lyase (HPL) are activated. These enzymes mediate production of green leafy volatiles and Jasmonic acid by interacting with hydroxperoxide molecules. We docked the elicitors with receptors and enzymes with substrates in the pathway of JA production. Phe was found to be an important amino acid that interacts with 13-hydroxyperoxides in the case of AOS to produce JA but not in the case of HPL. JA is converted to JA-Ile which shows strong binding with COI1 and COI1-JA-Ile complex docked with JAZ which showed strong interaction with ve hydrogens and one salt bridge bond. AOS and HPL showed less than 40% identity for sequence and structure alignment. AOS and HPL had shown an interaction between each other and showed a common interaction partner of the Lipoxygenase family. HPL shows interaction with ADH2 (Alcohol dehydrogenase) involved in GLVs production. AOS also showed interaction partner AOC, COI1 and OPR1 which are involved in JA-induced plant defense mechanism.peer-reviewe

Synpolydactyly and HOXD13 polyalanine repeat: addition of 2 alanine residues is without clinical consequences

<p>Abstract</p> <p>Background</p> <p>Type II syndactyly or synpolydactyly (SPD) is clinically very heterogeneous, and genetically three distinct SPD conditions are known and have been designated as SPD1, SPD2 and SPD3, respectively. SPD1 type is associated with expansion mutations in <it>HOXD13</it>, resulting in an addition of ≥ 7 alanine residues to the polyalanine repeat. It has been suggested that expansions ≤ 6 alanine residues go without medical attention, as no such expansion has ever been reported with the SPD1 phenotype.</p> <p>Methods</p> <p>We describe a large Pakistani and an Indian family with SPD. We perform detailed clinical and molecular analyses to identify the genetic basis of this malformation.</p> <p>Results</p> <p>We have identified four distinct clinical categories for the SPD1 phenotype observed in the affected subjects in both families. Next, we show that a milder foot phenotype, previously described as a separate entity, is in fact a part of the SPD1 phenotypic spectrum. Then, we demonstrate that the phenotype in both families segregates with an identical expansion mutation of 21 bp in <it>HOXD13</it>. Finally, we show that the HOXD13 polyalanine repeat is polymorphic, and the expansion of 2 alanine residues, evident in unaffected subjects of both families, is without clinical consequences.</p> <p>Conclusion</p> <p>It is the first molecular evidence supporting the hypothesis that expansion of ≤ 6 alanine residues in the HOXD13 polyalanine repeat is not associated with the SPD1 phenotype.</p

Manufacturing feature-based cost estimation of cast parts

Seventy percent of new product cost is committed in the design phase. Therefore, the cost needs to be minimized. Incorporating accurate cost estimation capabilities into manufacturing processes can help industries to minimize the cost and optimize the design. The casting process has been employed as a key process to manufacture parts having the advantage of low cost and customized products in foundry industry. This paper presents a cost estimation system for the casting process based on the design features, which incorporates the casting information at the design stage of castings. It aims to deliver the best cost-effective choice for casting design features of a product. Two kinds of knowledge, namely economical knowledge (describing the relation between the casting design considerations and the cost) and technical knowledge (involving the material of the casting features) were structured in this research work. On the basis of the minimum product cost, casting material selection can be carried out in detail. The developed system has been validated through an industrial case study

Simulation Based Measuring the Benefits of Converting to Lean Product Design and Development: A Case Study of Manufacturing Sector of Pakistan

Designers are facing the principle problems of effective decision making at initial design stage of product development, which ultimately cost it in the form of profit loss, low quality and increased time to bring the product to market. It needs a lot of knowledge and experience. Tools are required to analyze and ensure that crucial decisions have strong foundation before implementation. Discrete event simulation provides such a tool and has got potential to provide assistant in decision making before final implementation. This research work aims to measure the benefits of transformation to lean product development (LPD) via simulation. Simulink-MATLAB tool was used for this purpose. The whole work is limited to design and cost estimation cells of a manufacturing company and consists of two phases. The first phase deals with the assessment of current working model of design and cost estimation cells. Areas for improvements were recognized at this phase. The proposed model for transformation to LPD was developed in second phase. Four lean enablers naming product values, knowledge-based engineering, set-based concurrent engineering and poke-yoke have been incorporated to further enhance the working of proposed model. This research work is quite a useful case for practitioners