FARM-LEVEL INCENTIVES FOR FERTILIZER USE IN RWANDA'S KIGALI RURAL PROVINCE: A FINANCIAL ANALYSIS

The objective of this study was to evaluate the profitability of the main food crops in the context of the current government policy of promoting the use by farmers of improved inputs. This study tried to estimate the magnitudes of costs associated with the use of chemical fertilizer on climbing beans, maize, sorghum and soybeans grown in the province of Kigali rural and the benefits farmers would get by investing their labor and money in these crops. In less detail, this study analyzed some recent survey data seeking to put crop production in a wider perspective of the household's limitations and/or opportunities when dealing with the issue of improving crop yields on its land. Data analysis was done at the agroecological zone level and considered the three major agroecological zones of the Kigali rural province, namely, plateau de l'Est zone, plateau central zone and bugesera zone. Of the four crops selected in plateau de l'Est zone, the use of fertilizer would generate returns to family labor equal to or greater than the local agricultural labor wage for maize, soybeans and sorghum. The three crops provide also the best returns to the combination of organic and mineral fertilizer but production intensification by fertilizer use would be financially more attractive for soybeans and sorghum production. In plateau central zone the returns to family labor are greater than the agricultural labor wage for one crop, that is, sorghum grown with "DAP + urea" as mineral fertilizer. However, two crops, sorghum and soybeans, would give enough returns to the combination of organic and mineral fertilizer and their intensification by fertilizer use would be financially attractive. Sorghum was the only crop perceived by previous studies as potentially profitable with fertilizer use in Bugesera zone. The remuneration rate, the returns to family labor and the margins generated with the available data do not support that assumption for the use of NPK but they do for the combination "DAP + urea." The latter improves all the three crop budget analysis criteria, compared to the traditional modes of production. Hence, sorghum would be more profitable in Bugesera zone when grown with "DAP + Urea" as chemical fertilizer.Crop Production/Industries,

Acute pharmacokinetics of first line anti-tuberculosis drugs in patients with Pulmonary Tuberculosis and in patients with Pulmonary Tuberculosis co-infected with HIV

The aim of this study was to compare the pharmacokinetics of antituberculosis drugs in patients with pulmonary tuberculosis (PTB) and in patients with PTB and HIV during the first 24 h of treatment. Designed as a case-control study, it compares the pharmacokinetics of first line antituberculous drugs, in HIV-positive (cases) and HIV-negative (control) patients both presenting with pulmonary tuberculosis. Blood samples were collected before and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 8, 12 and 24 h after administration of drugs. Drugs plasma levels were tested using HPLC assays. Results: Fourteen HIV positive (7 males and 7 females) and 17 HIV negative (9 males and 8 females) enrolled. Rifafour, a combination tablet including rifampicin, isoniazid, pyrazinamide and ethambutol was used in HIV positive patients, CD4 counts were significantly lower, renal function mildly decreased in 85% patients and moderately decreased in 7% patients. Liver function was normal in both groups. None of these patients was on other drug therapy. In the HIV positive group isoniazid T1/2 and AUC were decreased and Cl increased whereas Tmax and Cmax were unchanged. Pyrazinamide Tmax and Cmax were significantly decreased in HIV positive patients and no significant changes were noticed in the T1/2, AUC and CL. Conclusion: The study suggest that ethambutol, pyrazinamide and rifampicin pharmacokinetics was not affected by HIV infection and that isoniazid disposition is affected by HIV.Web of Scienc

Nevirapine plasma concentrations in premature infants exposed to single-dose nevirapine for prevention of mother-to-child transmission of HIV-1

The original publication is available at http://www.samj.org.zaBackground. No pharmacokinetic data exist for premature infants receiving single-dose nevirapine (sd NVP) for prevention of mother-to-child transmission (MTCT) of HIV. Aim. To describe NVP decay pharmacokinetics in two groups of premature infants - those whose mothers either received or did not receive NVP during labour. Methods. Infants less than 37 weeks' gestation were prospectively enrolled. Mothers received sd NVP during labour if time allowed. Infants received sd NVP and zidovudine. Blood was collected on specified days after birth and NVP concentrations were determined by liquid chromatography-mass spectrometry. Results. Data were obtained from 81 infants, 58 born to mothers who received sd NVP during labour (group I) and 23 to mothers who did not receive NVP (group II). Of the infants 29.6% were small for gestational age (SGA). Median (range) maximum concentration (Cmax), time to reach maximum concentration (Tmax), area under the plasma concentration-time curve (AUC) and halflife (T) were 1 438 (350-3 832) ng/ml, 25h50 (9h40-83h45), 174 134 (22 308-546 408) ng×h/ml and 59.0 (15.4-532.6) hours for group I and 1 535 (635-4 218) ng/ml, 17h35 (7h40-29h), 168 576 (20 268-476 712) ng×h/ml and 69.0 (22.12-172.3) hours for group II. For group II, the median (range) volume of distribution (Vd) and body clearance (Cl) were 1 702.6 (623.7-6 189.8) ml and 34.9 (6.2-163.8) ml/h. The AUC was higher (p=0.006) and Cl lower (p<0.0001) in SGA infants. Plasma concentrations exceeding 100 ng/ml were achieved over 8 days in 78% infants in group I and 70.0% in group II. The MTCT rate was 4.8%. Conclusion. Women in preterm labour often deliver with little advance warning. Our study suggests that NVP dosing of preterm infants as soon as possible after birth without maternal intrapartum dosing may be as effective as combined maternal and infant dosing

Prevalence of Kidney Disease in HIV-Infected and Uninfected Rwandan Women

Background: In the United States, HIV-related kidney disease disproportionately affects individuals of African descent; however, there are few estimates of kidney disease prevalence in Africa. We evaluated the prevalence of kidney disease among HIV-infected and uninfected Rwandan women. Methods: The Rwandan Women's Interassociation Study and Assessment prospectively enrolled 936 women. Associations with estimated glomerular filtration rate (eGFR)<60 mL/min/1.73 m$^2$ and proteinuria were assessed in separate logistic regression models. Results: Among 891 non-pregnant women with available data, 2.4% had an eGFR<60 mL/min/1.73 m$^2$ (calculated by the Modification of Diet in Renal Disease equation, MDRD eGFR) and 8.7% had proteinuria $\ge$1+. The prevalence of decreased eGFR varied markedly depending on the estimating method used, with the highest prevalence by Cockcroft-Gault. Regardless of the method used to estimate GFR, the proportion with decreased eGFR or proteinuria did not differ significantly between HIV-infected and -uninfected women in unadjusted analysis. After adjusting for age and blood pressure, HIV infection was associated with significantly higher odds of decreased MDRD eGFR but not proteinuria. Conclusion: In a well-characterized cohort of Rwandan women, HIV infection was associated with decreased MDRD eGFR. The prevalence of decreased eGFR among HIV-infected women in our study was lower than that previously reported in African-Americans and in other Central and East African HIV populations, although there was substantial variability depending on the equation used to estimate GFR. Future studies are needed to optimize GFR estimates and to determine the impact of antiretroviral therapy on kidney disease in this population

PARTNERSHIPS IN HIGHLANDS OF RWANDA UNDER INTEGRATED AGRICULTURAL RESEARCH FOR DEVELOPMENT (IAR4D) ARRANGEMENTS

The Integrated Agricultural Research for Development (IAR4D) concept was proposed to respond to the failures of Agriculture Research and Development (ARD) systems in Sub-Saharan Africa. The key element of implementation and success of IAR4D was action sites called agricultural Innovation Platform (IPs) and their counterfactual sites. Social Network Analysis (SNA) is used to explain social relationships and partnerships. This study explored the patterns of agricultural partnerships among stakeholders in the highlands of Rwanda under IAR4D. Data were collected in action sites that included Mudende, Gataraga, Remera and Rwerere; and in their counterpart counterfactual sites that comprised of Bigogwe, Nyange and Gacaca. Results showed that in action sites, stakeholders were linked to different and diversified partners. Furthermore, many stakeholders were connected to several partners through agricultural partnerships, hence creating complex social networks with high density and degree of distribution. In the counterfactual sites, however, stakeholders were exclusively linked to the same kind of partners, and one stakeholder was connected to one partner through probably non-agricultural partnerships. These facts demonstrated that IAR4D created dense interfaces, significantly improved the networking system, and delivered technologies and innovations.Le concept de Recherche Agricole Int\ue9gr\ue9e pour le D\ue9veloppement (IAR4D) a \ue9t\ue9 propos\ue9 comme solution aux \ue9checs des syst\ue8mes Recherches Agricoles et D\ue9veloppement (ARD) en Afrique Sub-Saharienne. L\u2019\ue9l\ue9ment principal de la r\ue9ussite et du succ\ue8s d\u2019IAR4D \ue9tait l\u2019\ue9tablissement des sites d\u2019action appel\ue9s Plateformes Agricoles d\u2019innovation (IPs) ainsi que leurs sites t\ue9moins. L\u2019analyse du R\ue9seau Sociale (SNA) est utilis\ue9e pour expliquer les rapports et les relations sociaux des acteurs et des partenaires. La pr\ue9sente \ue9tude avait pour objectif d\u2019explorer les structures des relations socio-agricoles parmi les acteurs et les partenaires dans les hautes altitudes du Rwanda soumises \ue0 l\u2019IAR4D. Les donn\ue9es ont \ue9t\ue9 r\ue9colt\ue9es dans les sites d\u2019action comprenant\ua0: Mudende, Gataraga, Remera et Rwerere ainsi que dans leurs contreparties sites t\ue9moins incluant Bigogwe, Nyange et Gacaca. Les r\ue9sultats ont montr\ue9 que dans les sites d\u2019action, les acteurs \ue9taient associ\ue9s aux partenaires de natures diff\ue9rentes et un acteur \ue9tait li\ue9 \ue0 plusieurs partenaires a la fois. Dans les sites t\ue9moins par contre, les acteurs \ue9taient li\ue9s aux partenaires de m\ueames natures que ceux-ci et un acteur \ue9tait rarement li\ue9 \ue0 plus de deux partenaires. Ces faits ont montr\ue9 que l\u2019IAR4D a cr\ue9e un r\ue9seau socio-agricole tr\ue8s dense et sophistiqu\ue9 et ainsi a consid\ue9rablement am\ue9lior\ue9 le r\ue9seau socio-agricole. Par cons\ue9quent, l\u2019IAR4D peut \ueatre recommand\ue9 pour le transfert the technologies and des innovations agricoles

ADOPTION OF SOIL CONSERVATION THROUGH COLLECTIVE ACTIONS IN SOUTHWESTERN UGANDA

In developing countries, access to and use of renewable natural resources are essential for rural livelihoods to thrive. Hence, cooperation in the management of natural resources is increasingly an important strategy that can enhance long-term socio-ecological resilience. In most cases, collective actions have widely been recognised as an alternative institutional arrangement to centralised governance for the management of natural resources, but their success largely depends on factors that are specific to localities where they are implemented. In this study, factors that influence adoption and extent of adoption of natural resource conservation activities were identified using two case studies: Bubaare and Bufundi Innovation Platforms in Uganda. The drivers of adoption of community natural resource management strategies are analysed using an Ordered Logit Model while extent of adoption is analysed using a truncated regression model. The education level of a household head, membership in collective action group, and perception of plot slope and relevance of bye-laws were factors associated with likelihood of adoption. Value of livestock, membership in collective action group, access to credit and off-farm income were found to positively influence the level of investment. Thus, collective action increases opportunities for adoption; hence farmers should be supported to work collectively.Dans les pays en voie de d\ue9veloppement, l\u2019acc\ue8s et l\u2019utilisation des ressources naturelles sont essentiels pour la suivie en mileu rural et pour y prosp\ue9rer. Ainsi, la coop\ue9ration dans la gestion des ressources naturelles est de plus en plus une strat\ue9gie importante qui peut am\ue9liorer \ue0 long terme la coh\ue9sion socio-\ue9cologique. Dans beaucoup de cas; les actions collectives ont \ue9t\ue9 largement reconnues comme une alternative d\u2019organisation institutionnelle pour centraliser la gouvernance de la gestion des ressources naturelles, mais leur succ\ue8s d\ue9pend largement des facteurs qui sont sp\ue9cifiques aux milieux o\uf9 elles sont mise en oeuvre. Dans cette \ue9tude, les facteus qui influencent l\u2019adoption et le degr\ue9 d\u2019adoption des activit\ue9s de conservation des ressources naturelles \ue9taient identifi\ue9s en utilisant deux cas d\u2019\ue9tude: Les Plate-formes d\u2019Innovation de Bubaare et Bufundi en Ouganda. Les forces motrices d\u2019adoption des strategies de gestion des ressources naturelles communautaires sont analys\ue9es en utilsant un mod\ue8le Logit Ordonn\ue9 tandis que le degr\ue9 d\u2019adoption est analys\ue9 en utilisant un mod\ue8le de r\ue9gression tronqu\ue9. Le niveau d\u2019\ue9ducation du chef de m\ue9nage, l\u2019appartenance au groupe d\u2019action collective, et la perception de la pente de la parcelle et limportance des arr\ueat\ue9s \ue9taient les facteurs associ\ue9s au taux d\u2019adoption. La value du b\ue9tail, l\u2019appartenance au groupe d\u2019action collective, l\u2019acc\ue8s au cr\ue9dit et le revenu non- agricole \ue9taient les facteurs qui influencent positivement le niveau d\u2019investissement. Donc, les actions collectives augmentent les opportunit\ue9s pour l\u2019adoption; ainsi les producteurs devraient \ueatre encourag\ue9s \ue0 travailler de fa\ue7con collective

Selecting sites to prove the concept of IAR4D in the Lake Kivu Pilot Learning Site

Selecting sites is an essential step in enabling the assessment of the impact of Integrated Agricultural Research for Development (IAR4D) in the Lake Kivu Pilot Learning Site. This paper reports on the process of identifying distinct administrative territories (sites) in which to establish innovation platforms and to monitor similar communities that are experiencing alternative agricultural research for development interventions. We show how the research design for the Sub- Saharan Africa Challenge Programme (SSACP) has been modified to take into account the key conditioning factors of the LKPLS without relinquishing robustness. A key change is the explicit incorporation of accessibility to multiple markets. Candidate sites were stratified according to the national political context, followed by good and poor accessibility to markets and finally according to security considerations and agro-ecology. Randomisation was carried out at all levels, although the need for paired counterfactual sites required the diagnosis of conditioning factors at the site level. Potential sites were characterised in terms of existing or recent agricultural research initiatives, as well as local factors that would have a direct effect on the success of interventions seeking to improve productivity, ameliorate the degradation of natural resources and enhance incomes through better links to markets. Fourteen sites were selected during the initial phase, and a further ten sites were added one year afterwards due to the need for more innovation platforms to test IAR4D. The site selection was successful in pairing action and counterfactual sites in terms of the baseline socioeconomic conditions of farming households. The unavoidable proximity of action and counterfactual sites, however, allows the possibility of spill-over effects and could reduce the measurable impact of IAR4D

Institutional Innovations for Building Impact-oriented Agricultural Research, Knowledge and Development Institutions

The central development question in African agriculture is how to catalyze a more competitive, equitable and sustainable agricultural growth within the context of smallholder production systems, inefficient agricultural marketing, inefficient investments by private sector amidst degradation prone natural resources base (Lynam and Blackie, 1994; IAC, 2004; World bank, 2006 ). Concerted scholarly analyses of Science and Technology (S&T) strategies have given birth to Integrated Agricultural Research for Development (IAR4D) an organizing concept of the Innovation Systems Approach (ISA) as the promise holder. It is hypothesized that the generation, diffusion and application of impactful innovations critically depend on systemic integration of knowledge systems that promote communication, interaction and cooperation between agricultural research, education, extension, farmers, private sector and policy regulatory systems. This paper examines how the different institutional innovations arising from various permutations of linkages and interactions of ARD organizations (national, international advanced agricultural research centres and universities) influenced the different outcomes in addressing identified ARD problems. A multi-institutional, multi-disciplinary phased Participatory Action Research approach was used to pool knowledge to address outstanding and emerging challenges in three countries (DRC, Rwanda and Uganda) with 2, 16 and 24 years out of conflict, respectively) of the Lake Kivu Pilot Learning Site. A landmark institutional innovation was the participatory establishment of twelve (12) Innovation Platforms as tools for pooling knowledge across the agricultural business, education, research and extension systems. The knowledge “pool” was to generate, diffuse and apply innovations to reduce transactions costs and create value chain based “win-win” situations. A number of innovations (e.g. International Public Goods-IPGs, market binding contracts, registered brands and/or certification processes, diversity, density and quality of networks/collective action, bulking centres, ICT application and depth of knowledge pools) were initiated. There were major breakthroughs which included bringing on board non-traditional private sector and policy maker partners, overcoming the predominant “farmer handout syndrome”, building consensus and addressing common interest challenge. Making markets work, bringing various stakeholders including universities to the community and vice-versa, appreciation of indigenous knowledge system, propelling collective soil and water conservation and demand/utilization of technologies hitherto on-shelf were other very significant breakthroughs. Sustainable operations of the Innovation Systems knowledge “pool” nurturing institutional learning were ensured through the availability of a “functional body”. The body undertook the social enterprise of organizing farmers and traders, facilitating/brokering ARD organization linkages by using multi-media to build social capital to overcome emergent knowledge, credit, market, technology and resource degradation challenges under different policy regulatory systems