Description of Testing in Wavelet Video Coding

The provided testing scenario is intended to be used for evaluation of the coding performance of the JSVM coding scheme provided by JVT, with respect to the Exploration Wavelet Video Coding platform. The reference conditions have been derived from the JSVM testing conditions document JVT-P205 produced at the 16th JVT meeting in Poznan. Further details on JSVM configuration can be found in such document. The rate points to be used in all tests are derived from the combined scalability test sets. The applicable set of rate points is similar to the rate points originally applied in the Munich and Palma testing conditions. The target rates are arranged in a systematic manner. For each spatio-temporal resolution, the rate triples from the lowest rate point to the highest rate point. The settings are chosen such that an AVC compatible base layer can be provided for the base layer of combined and spatial scalability and for the QCIF sequences in the SNR scalability scenario. The encoder will generate embedded bit-streams. To extract the various bit-rates, frame-rates and resolutions specified in the tables below from the embedded bit-stream, an extractor shall be used. No transcoding is allowed for performing the decoding at the various bit-rates, frame-rates and resolutions. In the combined scalability settings, the testing addresses a broad range scalability and is motivated by the requirements of applications such as surveillance, broadcast and storage systems. This scenario is represented by the test sequences CITY, CREW, HARBOUR and SOCCER. Visual tests shall take place for the rates shown in green in the tables below for each spatial resolution, and for the Palma test at the rate points tested at Palma. PSNR curves will have to be provided for all other rate points

Traveling ionospheric disturbances induced by the secondary gravity waves from the Tonga eruption on 15 January 2022:Modeling with MESORAC-HIAMCM-SAMI3 and comparison with GPS/TEC and ionosonde data

We simulate the gravity waves (GWs) and traveling ionospheric disturbances (TIDs) created by the Hunga Tonga-Hunga Ha'apai (hereafter “Tonga”) volcanic eruption on 15 January 2022 at ∼04:15 UT. We calculate the primary GWs and forces/heatings generated where they dissipate with MESORAC, the secondary GWs with HIAMCM, and the TIDs with SAMI3. We find that medium and large-scale TIDs (MSTIDs and LSTIDs) are induced by the secondary GWs, with horizontal phase speeds cH ≃ 100–750 m/s, horizontal wavelengths λH ≃ 600–6,000 km, and ground-based periods τr ≃ 30 min to 3 hr. The LSTID amplitudes over New Zealand are ≃2–3 TECU, but decrease sharply ≃ 5,000 km from Tonga. The LSTID amplitudes are extremely small over Australia and South Africa because body forces create highly asymmetric GW fields and the GWs propagate perpendicular to the magnetic field there. We analyze the TIDs from SAMI3 and find that a 30 min detrend window eliminates the fastest far-field LSTIDs. We analyze the GPS/TEC via detrending with 2–3 hr windows, and find that the fastest LSTIDs reach the US and South America at ∼8:30–9:00 UT with cH ≃ 680 m/s, λH ≃ 3,400 km, and τr ≃ 83 min, in good agreement with model results. We find good agreement between modeled and observed TIDs over New Zealand, Australia, Hawaii, Japan and Norway. The observed F-peak height, hmF2, drops by ≃ 110–140 km over the western US with a 2.8 hr periodicity from 8:00 to 13:00 UT. We show that the Lamb waves (LWs) observed by AIRS with λH = 380 km have amplitudes that are ≃ 2.3% that of the primary GWs at z ≃ 110 km. We conclude that the observed TIDs can be fully explained by secondary GWs rather than by “leaked” LWs

Applied Artificial Intelligence and Machine Learning for Video Coding and Streaming : Editorial

The papers in this special section focus on applied artificial inteligence and machine learning for video coding and media streaming.publishedVersionNon peer reviewe

Post-mortem brain analyses of the Lothian Birth Cohort 1936:Extending lifetime cognitive and brain phenotyping to the level of the synapse

INTRODUCTION: Non-pathological, age-related cognitive decline varies markedly between individuals andplaces significant financial and emotional strain on people, their families and society as a whole.Understanding the differential age-related decline in brain function is critical not only for the development oftherapeutics to prolong cognitive health into old age, but also to gain insight into pathological ageing suchas Alzheimer’s disease. The Lothian Birth Cohort of 1936 (LBC1936) comprises a rare group of people forwhom there are childhood cognitive test scores and longitudinal cognitive data during older age, detailedstructural brain MRI, genome-wide genotyping, and a multitude of other biological, psycho-social, andepidemiological data. Synaptic integrity is a strong indicator of cognitive health in the human brain;however, until recently, it was prohibitively difficult to perform detailed analyses of synaptic and axonalstructure in human tissue sections. We have adapted a novel method of tissue preparation at autopsy toallow the study of human synapses from the LBC1936 cohort in unprecedented morphological andmolecular detail, using the high-resolution imaging techniques of array tomography and electronmicroscopy. This allows us to analyze the brain at sub-micron resolution to assess density, proteincomposition and health of synapses. Here we present data from the first donated LBC1936 brain andcompare our findings to Alzheimer’s diseased tissue to highlight the differences between healthy andpathological brain ageing. RESULTS: Our data indicates that compared to an Alzheimer’s disease patient, the cognitively normalLBC1936 participant had a remarkable degree of preservation of synaptic structures. However,morphological and molecular markers of degeneration in areas of the brain associated with cognition(prefrontal cortex, anterior cingulate cortex, and superior temporal gyrus) were observed. CONCLUSIONS: Our novel post-mortem protocol facilitates high-resolution neuropathological analysis of the well-characterized LBC1936 cohort, extending phenotyping beyond cognition and in vivo imaging to nowinclude neuropathological changes, at the level of single synapses. This approach offers an unprecedentedopportunity to study synaptic and axonal integrity during ageing and how it contributes to differences in agerelatedcognitive change. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40478-015-0232-0) contains supplementary material, which is available to authorized users

Bcl-2 Inhibits the Innate Immune Response during Early Pathogenesis of Murine Congenital Muscular Dystrophy

Laminin α2 (LAMA2)-deficient congenital muscular dystrophy is a severe, early-onset disease caused by abnormal levels of laminin 211 in the basal lamina leading to muscle weakness, transient inflammation, muscle degeneration and impaired mobility. In a Lama2-deficient mouse model for this disease, animal survival is improved by muscle-specific expression of the apoptosis inhibitor Bcl-2, conferred by a MyoD-hBcl-2 transgene. Here we investigated early disease stages in this model to determine initial pathological events and effects of Bcl-2 on their progression. Using quantitative immunohistological and mRNA analyses we show that inflammation occurs very early in Lama2-deficient muscle, some aspects of which are reduced or delayed by the MyoD-hBcl-2 transgene. mRNAs for innate immune response regulators, including multiple Toll-like receptors (TLRs) and the inflammasome component NLRP3, are elevated in diseased muscle compared with age-matched controls expressing Lama2. MyoD-hBcl-2 inhibits induction of TLR4, TLR6, TLR7, TLR8 and TLR9 in Lama2-deficient muscle compared with non-transgenic controls, and leads to reduced infiltration of eosinophils, which are key death effector cells. This congenital disease model provides a new paradigm for investigating cell death mechanisms during early stages of pathogenesis, demonstrating that interactions exist between Bcl-2, a multifunctional regulator of cell survival, and the innate immune response

Evidence for a wide extra-astrocytic distribution of S100B in human brain

BACKGROUND: S100B is considered an astrocytic in-situ marker and protein levels in cerebrospinal fluid (CSF) or serum are often used as biomarker for astrocytic damage or dysfunction. However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity. RESULTS: Contrary to glial fibrillary acidic protein (GFAP), which selectively labels astrocytes and shows only faint ependymal immunopositivity, a less uniform staining pattern was seen in the case of S100B. Cells with astrocytic morphology were primarily stained by S100B in the human cortex, while only 20% (14–30%) or 14% (7–35%) of all immunopositive cells showed oligodendrocytic morphology in the dorsolateral prefrontal and temporal cortices, respectively. In the white matter, however, most immunostained cells resembled oligodendrocytes [frontal: 75% (57–85%); temporal: 73% (59–87%); parietal: 79% (62–89%); corpus callosum: 93% (86–97%)]. S100B was also found in ependymal cells, the choroid plexus epithelium, vascular endothelial cells, lymphocytes, and several neurones. Anti-myelin basic protein (MBP) immunolabelling showed an association of S100B with myelinated fibres, whereas GFAP double staining revealed a distinct subpopulation of cells with astrocytic morphology, which solely expressed S100B but not GFAP. Some of these cells showed co-localization of S100B and A2B5 and may be characterized as O2A glial progenitor cells. However, S100B was not detected in microglial cells, as revealed by double-immunolabelling with HLA-DR. CONCLUSION: S100B is localized in many neural cell-types and is less astrocyte-specific than GFAP. These are important results in order to avoid misinterpretation in the identification of normal and pathological cell types in situ and in clinical studies since S100B is continuously used as an astrocytic marker in animal models and various human diseases

How university’s activities support the development of students’ entrepreneurial abilities: case of Slovenia and Croatia

The paper reports how the offered university activities support the development of students’ entrepreneurship abilities. Data were collected from 306 students from Slovenian and 609 students from Croatian universities. The study reduces the gap between theoretical researches about the academic entrepreneurship education and individual empirical studies about the student’s estimation of the offered academic activities for development of their entrepreneurial abilities. The empirical research revealed differences in Slovenian and Croatian students’ perception about (a) needed academic activities and (b) significance of the offered university activities, for the development of their entrepreneurial abilities. Additionally, the results reveal that the impact of students’ gender and study level on their perception about the importance of the offered academic activities is not significant for most of the considered activities. The main practical implication is focused on further improvement of universities’ entrepreneurship education programs through selection and utilization of activities which can fill in the recognized gaps between the students’ needed and the offered academic activities for the development of students’ entrepreneurial abilities