The Legacy Project: Rodney L. Custer, DTE

An interview with vice president of Dept. of Technical Education, Rodney Custer is presented. Topics discussed include interest in technology and engineering education; academic qualification; and experience as university department chair administrator and working with the Center for Math, Science, and Technology (CeMast)

Applying Task Force Recommendations on Integrating Science and Practice in Health Service Psychology Education

The proper role of research skills and training to conduct research in professional psychology education has been controversial throughout the history of the field. An extensive effort was undertaken recently to address that issue and identify ways the field might move forward in a more unified manner. In 2015, the American Psychological Association (APA) Board of Educational Affairs convened a task force to address one of the recommendations made by the Health Service Psychology Education Collaborative in 2013. That recommendation stated that the education and training of health service psychologists (HSPs) include an integrative approach to science and practice that incorporates scientific-mindedness, training in research skills, and goes well beyond merely “consuming” research findings. The task force subsequently developed recommendations related to the centrality of science competencies for HSPs and how these competencies extend beyond training in evidence-based practice. This article discusses the findings of the task force and the implications of its recommendations for education and training in HSP. The challenges and opportunities associated with implementing these recommendations in HSP graduate programs are examined

Chemotherapy and Survival for Patients With Multiple Myeloma: Findings From a Large Nationwide and Population-Based Cohort

Objective: To assess the patterns of chemotherapy use for patients with multiple myeloma and to determine if chemotherapy is effective in prolonging survival outside the clinical trial settings. Methods: We studied a nationwide and population-based retrospective cohort of 4902 patients ≥65 years of age with stage II or III multiple myeloma from 1992 to 1999, identified from the Surveillance, Epidemiology, and End-Results-Medicare data. Multivariate logistic regression was used to estimate the odds ratio of receiving chemotherapy and Cox proportional hazard model was used to estimate the hazard ratio of mortality associated with chemotherapy. Results: Of 4902 patients with stage II or III multiple myeloma, 52.0% received chemotherapy during the course of the disease. The receipt of chemotherapy decreased significantly with age from 65.7% in the 65- to 69-year age group to 34.3% in those ≥80 years. Blacks (47.6%) were less likely to receive chemotherapy than whites (52.8%). Use of chemotherapy decreased significantly with comorbidity scores and increased over time. Risk of all-cause mortality was significantly reduced in patients who received chemotherapy compared with those who did not (adjusted hazard ratio = 0.65; 95% confidence interval = 0.61-0.69). A similar pattern as observed for myeloma-specific mortality (0.61; 0.56-0.67). Survival benefit increased with increasing cycles of chemotherapy (P \u3c 0.001 for trend) and was significant across different age groups, gender, ethnic groups, and comorbidity scores. Conclusion: Chemotherapy was significantly associated with increased survival in patients with multiple myeloma outside the clinical trial settings. This survival benefit was significant across different groups by age, gender, race, and comorbidity. A substantial number of patients with multiple myeloma did not receive chemotherapy

Generation of Geochemical Exploration Targets from Regional Stream Sediment Data Using Principal Component and Factor Analysis: A Case Study of Kibaya-Kiteto, Manyara-Tanzania

A regional-scale stream sediment geochemical sampling was carried out with an average sampling density of one sample per nine square-kilometre in Kiteto District, Manyara Region. A total of 358 stream sediment samples were collected and analysed for major and trace elements by X-ray fluorescence (XRF) and fire assay with atomic absorption spectrometry (AAS) finish methods. In this study, Factor and Principal Component Multivariate (FPCM) analyses have been used to the stream geochemical data to delineate potential mineralization zones by plotting correlated factors as geochemical anomaly maps. Four factors that account for 73.7% of the total variance of the stream sediment geochemical data were established. Factor 1: Ni–Ba–Co–Cu–Sr which possibly defines the underlying metamorphosed granitic units with some contribution from mafic and ultramafic rocks. Factor 2: Cr–Zn–Mn which defines crustal forming elements reflecting the mafic rocks. Factor 3 which entails Rb and Pb probably attributed to metamorphosed granitic lithology. Factor 4 is arsenic, a chalcophile element with affinity to sulfide phases. The FPCM analyses have been successfully in delineating potential target areas for gold, nickel and copper exploration in the study area. Keywords:    Stream sediment; principal component; factor analysis; exploration targets; Kibaya-Kiteto, Manyara

Hoop/column antenna RF verification model. Volume 2: Analysis and correlation

As part of the Large Space System Technology Program, the theoretical and experimental results of the RF characteristic of a hoop/column, quad aperture antenna using an RF verification model are presented. To satisfy the primary purposes of the model, experimental pattern data is provided for the quad aperture configuration at different reflector edge illumination levels, from which the geometry and edge effects can be assessed, and experimental data which can be compared with calculations using various theoretical reflector scattering formulae are provided. It also experimentally determines the effects upon secondary patterns of scale model quartz cables, as used in the hoop/column design, upon secondary patterns in order to assess the importance of developing a scattering theory to predict such effects. In addition, a comprehensive theoretical study and the experimental pattern results of quad aperture antenna feeds, a discussion of the fundamental affect of parasitic side lobes, their amplitude, and location in space

Hoop/Column Antenna: RF Verification Model. Volume 1: Test Results

As part of the Large Space System Technology Program, this report, in two volumes, presents the theoretical and experimental results of the RF characteristic of a hoop/column, quad aperture antenna using an RF verification model. To satisfy the primary purposes of the model it provides experimental pattern data for the quad aperture configuration at different reflector edge illumination levels, from which the geometry and edge effects can be assessed, and provides experimental data which can be compared with calculations using various theoretical reflector scattering formulae. It also experimentally determines the effects upon secondary patterns of scale model quartz cables, as used in the hoop/column design, upon secondary patterns in order to assess the importance of developing a scattering theory to predict such effects. In addition, this report contains a comprehensive theoretical study and the experimental pattern results of quad aperture antenna feeds, a discussion of the fundamental affect of parasitic side lobes, their amplitude, and location in space

Four Kinds of Hard: An Understanding of Cancer and Death among Latino Community Leaders

Early integration of palliative care after a diagnosis of cancer improves outcomes, yet such care for Latino populations is lacking in rural regions of the United States. We used a participatory action research design with Latino community leaders from emerging immigrant communities in North Carolina to explore sociocultural perspectives on cancer and death. Thematic analysis was conceptualized as Four Kinds of Hard represented by four themes: Receiving an Eviction Notice, Getting in the Good Book, Talking is (Sometimes) Taboo, and Seeing Their Pain Makes us Suffer. These themes captured fears of deportation, coping with cancer through faithfulness, ambivalence about advance care planning, and a desire to spare families from suffering. Findings suggest strategies to improve conversations about end-of-life wishes when facing advanced illness and death. This study demonstrates the importance of training Latino community leaders to improve palliative care and bridge service gaps for Latino families living in emerging rural communities.OA publication support through Carolina Consortium agreement with Sag

Cancer-Associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression

© 2017 The Author(s). Cancer is a multifactorial disease driven by a combination of genetic and environmental factors. Many cancer driver mutations have been characterised in protein-coding regions of the genome. However, mutations in noncoding regions associated with cancer have been less investigated. G-quadruplex (G4) nucleic acids are four-stranded secondary structures formed in guanine-rich sequences and prevalent in the regulatory regions. In this study, we used published whole cancer genome sequence data to find mutations in cancer patients that overlap potential RNA G4-forming sequences in 5ⲠUTRs. Using RNAfold, we assessed the effect of these mutations on the thermodynamic stability of predicted RNA G4s in the context of full-length 5ⲠUTRs. Of the 217 identified mutations, we found that 33 are predicted to destabilise and 21 predicted to stabilise potential RNA G4s. We experimentally validated the effect of destabilising mutations in the 5ⲠUTRs of BCL2 and CXCL14 and one stabilising mutation in the 5ⲠUTR of TAOK2. These mutations resulted in an increase or a decrease in translation of these mRNAs, respectively. These findings suggest that mutations that modulate the G4 stability in the noncoding regions could act as cancer driver mutations, which present an opportunity for early cancer diagnosis using individual sequencing information.Link_to_subscribed_fulltex

Development of Fecal Coliform TMDL Protocols for Bass and Cinder Creeks on Kiawah Island

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio