Effect of Nepeta Menthoides on Cognitive Disorders in Alzheimer’s Disease: A Clinical Trial

Nowadays, given the outbreak of Alzheimer disease (AD) as a global phenomenon, it is absolutely essential to take efficacious measures against it. Heating up the brain is a recommended approach to decrease the symptoms of AD. Furthermore, using hot herb is an effective method to enhance the temperature of the brain. One of the hot herbs is Nepeta menthoides which is known as Ostokhodus and has neuroprotective effects. In the present paper, the effect of Nepeta on the treatment of Alzheimer was studied. A trial was carried out on two groups of AD patients. While the first group was prescribed the capsules of Nepeta extraction, the second group was given the placebo capsules. The results of the taken MMSE inventories from both of the tested groups as the comparison criteria revealed that Nepeta had positive influence on the treatment of AD

Effect of Nepeta Menthoides on Cognitive Disorders in Alzheimer’s Disease: A Clinical Trial

Nowadays, given the outbreak of Alzheimer disease (AD) as a global phenomenon, it is absolutely essential to take efficacious measures against it. Heating up the brain is a recommended approach to decrease the symptoms of AD. Furthermore, using hot herb is an effective method to enhance the temperature of the brain. One of the hot herbs is Nepeta menthoides which is known as Ostokhodus and has neuroprotective effects. In the present paper, the effect of Nepeta on the treatment of Alzheimer was studied. A trial was carried out on two groups of AD patients. While the first group was prescribed the capsules of Nepeta extraction, the second group was given the placebo capsules. The results of the taken MMSE inventories from both of the tested groups as the comparison criteria revealed that Nepeta had positive influence on the treatment of AD

Impacts of organizational arrangements on conservation agriculture: insights from interpretive structural modeling in Iran

Conservation agriculture (CA) has been promoted worldwide as an approach to sustainable resource management and better productivity. Promotion and adoption of CA in Iran have been receiving increased attention from the national government over recent years. Therefore, to speed up development of CA as a basis for sustainable development, drivers that influence the development of CA need to be identified and modeled. The main aim of this study is to present a comprehensive model for CA development in Iran by identifying the institutional drivers that influence its promotion and determining the relationship between drivers. At first, the drivers identified from the literature and interviews with experts, and the relationships among the drivers were explored and clarified using Interpretative Structural Modeling (ISM). A cross-impact matrix multiplication was applied to classification (MICMAC) analysis, which was then used to categorize the drivers in four sub-groups. The results showed that creating a suitable organizational structure is a very significant driving factor for CA development in Iran. Strong driving power and weak dependence associated with this factor should be treated as a critical driver. If CA shall expand more rapidly in future, then Iran’s government should invest in an appropriate organizational structure for it

Erratum: COMPARE CPM-RMI trial: Intramyocardial transplantation of autologous bone marrow-derived CD133+ cells and MNCs during CABG in patients with recent MI: A phase II/III, multicenter, placebo-controlled, randomized, double-blind clinical trial. (Cell Journal (2018) 20:3 (449) DOI: 10.22074/cellj.2018.5197)

This article published in Cell J (Yakhteh), Vol 20, No 2, Jul-Sep 2018, on pages 267-277, four affiliations (1, 4, 5, and 10) were changed based on authors request. © 2018 Royan Institute (ACECR). All rights reserved

COMPARE CPM-RMI Trial: Intramyocardial transplantation of autologous bone marrow-derived CD133+ Cells and MNCs during CABG in patients with recent MI: A Phase II/III, multicenter, placebo-controlled, randomized, double-blind clinical trial

Objective: The regenerative potential of bone marrow-derived mononuclear cells (MNCs) and CD133+ stem cells in the heart varies in terms of their pro-angiogenic effects. This phase II/III, multicenter and double-blind trial is designed to compare the functional effects of intramyocardial autologous transplantation of both cell types and placebo in patients with recent myocardial infarction (RMI) post-coronary artery bypass graft. Materials and Methods: This was a phase II/III, randomized, double-blind, placebo-controlled trial COMPARE CPM-RMI (CD133, Placebo, MNCs - recent myocardial infarction) conducted in accordance with the Declaration of Helsinki that assessed the safety and efficacy of CD133 and MNCs compared to placebo in patients with RMI. We randomly assigned 77 eligible RMI patients selected from 5 hospitals to receive CD133+ cells, MNC, or a placebo. Patients underwent gated single photon emission computed tomography assessments at 6 and 18 months post-intramyocardial transplantation. We tested the normally distributed efficacy outcomes with a mixed analysis of variance model that used the entire data set of baseline and between-group comparisons as well as within subject (time) and group�time interaction terms. Results: There were no related serious adverse events reported. The intramyocardial transplantation of both cell types increased left ventricular ejection fraction by 9 95% confidence intervals (CI): 2.14% to 15.78%, P=0.01 and improved decreased systolic wall thickening by -3.7 (95% CI: -7.07 to -0.42, P=0.03). The CD133 group showed significantly decreased non-viable segments by 75% (P=0.001) compared to the placebo and 60% (P=0.01) compared to the MNC group. We observed this improvement at both the 6- and 18-month time points. Conclusion: Intramyocardial injections of CD133+ cells or MNCs appeared to be safe and efficient with superiority of CD133+ cells for patients with RMI. Although the sample size precluded a definitive statement about clinical outcomes, these results have provided the basis for larger studies to confirm definitive evidence about the efficacy of these cell types (Registration Number: NCT01167751). © 2018 Royan Institute (ACECR). All Rights Reserved

Evidence of nonlinearity in digoxin pharmacokinetics

Six normal male volunteers received 0.5 mg label doses of digoxin as (a) a bolus intravenous injection over 2 min, (b) a constant rate intravenous infusion over 1 hr, (c) a constant rate intravenous infusion over 3 hr, and (d) a solution in 5% dextrose given orally. Plasma concentrations of digoxin were measured by radioimmunoassay for a 4 day period and urinary excretion for a 6 day period after the single doses. The mean (coefficient of variation) total areas under the plasma concentration-time curves per 0.5 mg of digoxin were (a) 35.55 (14.8%), (b) 30.20 (27.7%), (c) 25.80 (35.5%), and (d) 15.47 (49.9%); the means differed significantly (0.01>p>0.005). The mean (coefficient of variation) total amounts excreted in the urine as a fraction of the dose were (a) 0.689 (6.31%), (b) 0.517 (20.4%), (c) 0.588 (16.8%), and (d) 0.374 (23.4%); the means differed significantly (p<0.001. Both the total clearance and the nonrenal clearance of digoxin differed significantly with the method of intravenous administration. The slower the rate of input of digoxin to the body, the greater were both the total clearance and the nonrenal clearance of the drug, which strongly suggests nonlinear pharmacokinetics .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45078/1/10928_2005_Article_BF01068079.pd

Constipation due to Liver Disorder in Iranian Traditional Medicine`s Viewpoint

Introduction: Constipation is one of the most common pediatric disorders.In many cases, there is no anatomic endocrineor metabolic cause in explanation of chronic constipation.More than 85% of them called functional or idiopathic.Constipation is one of the serious disease in Iranian Traditional Medicine. Besides the problem it causes, chronic constipation can be the origin of many disease. That is why, ithas been called Mother of disease.The purpose of this study is to investigate the Constipation in children and the role of other organs such as the liver by view of Iranian Traditional Medicine   Materials and Method: This study is a review through Iranian traditional medicine references. At first, all the main available traditional books were reviewed. All the data about therapies of vaginal discharge in ITM were collected then classified.   Results: In traditional medicine different reasons have been mentioned for constipation especially for childrenwhich most of them are similar to etiology in Modern Medicine.Constipation due to liver disorder is one of the causes of constipation.In Iranian Traditional medicine` viewpoint, one of the mechanism for excretion is existence of secreted bile in intestine.If by any reason,measure or quality of its which secreted in intestine through bile changes or if intestinal mucous secretion becomes barrier for absorbing the food,it will caused disorder in excretion and finally will lead to constipation.Well known Iranian Traditional Medicine scientists, has mentioned all reasons for liver disorders and changing quality& quantity of secreted bile .he has mentioned the solutions as well.   Conclusion: It is hoped that by paying attention to constipation and with advanced clinical research we will be able to explain idiopathic constipation and prepare new ways of treatments for constipation. New researches have approved the effectiveness of these foods and drugs for treating the constipation.   Keywords: Constipation, Children, Liver, Iranian Traditional Medicine

Viewpoints of Iranian Traditional Medicine about Child Nutrition

Introduction: Optimal child development necessitates proper nutrition in childhood. Despite of improvements in child nutrition, there are still lots of challenges in proper child nutrition which shows the necessity of using the Past experiences more than ever. Despite of particular interest of Iranians to cardinal humors (temperaments), unfortunately, families and medical staffs are not appropriately familiar with these important issues. Whereas Traditional Medicine tries to protect & promote health through humors and temperaments that, unfortunately, these days this issue is not considered as noteworthy matter, this study tries to bring up new dimensions of child nutrition through different attitude.   Materials and Methods: Research methodology of this study is library research which surveys principles of child nutrition on some Iranian Traditional Medicine scientists ` works.   Results: According to Iranian Traditional Medicine findings, there are particular rules in child nutrition. Some important rules are: 1-Food with special properties, play important role in child development like mutton, beans. 2-Food combination also can help child development and decrease the side effects of some foods like combination of thyme and yogurt. 3-There are simple and practical instructions in Iranian Traditional Medicine for preventing and treating some disease like common cold and viral gastroenteritis. So, use of these instructions can decrease the use of medications in children. Effectiveness of some instructions has also been approved in modern medicine. 4- Incompatible food combination is one of the important issues in child nutrition that paying attention to it can promote children health.   Conclusion: Since the physical health and mental health of children necessitate proper nutrition; families` knowledge (specially mothers) about children`s food requirements can help children to have appropriate food program. It is hoped that with further research in this field & using the scientists` experiences of Iranian Traditional medicine, we will be able to play an important role in children health who are the future of our society. Keywords: Nutrition, Children, Development, Iranian Traditional Medicin

Effect of “Gol-e-ghand”, a mixture of rose petals and honey, on migraine attacks: a before-after pilot study

Background and objectives: Migraine is the seventh most common cause of disability among all ailments according to the World Health Organization. Despite the availability of some medicines for prevention of migraine, their complications are a cause for concern. Traditional system of medicine and use of medicinal herbs can be beneficial in management of migraine. “Gol-e-ghand” is one of the most commonly prescribed products for the management of headaches in the Iranian traditional medicine. The present study was designed to evaluate the effect of “Ghol-e-ghand” on decreasing the frequency of migraine attacks. Methods: Nineteen migraine patients, who met the eligibility criteria, according to the International Headache Society diagnostic criteria were assigned to the intervention. The study was conducted as a before-after clinical trial and included two phases of drug administration. Propranolol was given during the first phase, while “Ghol-e-ghand” was administered along with propranolol in the second phase. The severity, duration, and frequency of headaches were measured before and after the intervention. Results: The analysis showed that “Ghol-e-ghand” decreased the frequency of migraine (20%, p=0.04), but it was not effective in decreasing the duration and severity of the attacks. Conclusion: “Ghol-e-ghand”can be suggested in migraine patients for reducing frequency of attacks