Effect of sterilization on chlorhexidine loaded soft contact lenses

Poster presented at the First International Congress of CiiEM - From Basic Sciences to Clinical Research. 27-28 November 2015, Caparica, PortugalFundação para a Ciência e a Tecnologia: funding through projects UID/QUI/00100/2013 and M-ERA.NET/0005/201

Application of Cannabis Use Intention Questionnaire (CUIQ) to First Year University Students

Communication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health ad Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Cannabis is the illegal drug most used worldwide. Its long-term use increases the risk of depression and schizophrenia, causing a major public health problem. A validated questionnaire was applied to first year students of Instituto Universitário Egas Moniz to assess their intention regarding cannabis use. They do not consider cannabis to be much associated with well-being, they slightly consider the opinion of relatives, and they show a low intent to use the drug, believing themselves to have strong self-control. Scores are above average for 18-y.o. Portuguese students, except for belief in self-control.info:eu-repo/semantics/publishedVersio

Vitamin content in food supplements: are we getting what we need?

Poster apresentado no XVII Congresso de Nutrição e Alimentação & I Congresso Internacional de Nutrição e Alimentação. 10-11 Maio 2018, LisboaN/

Minerals content in food supplements: label doses survey

Poster apresentado no XVII Congresso de Nutrição e Alimentação & I Congresso Internacional de Nutrição e Alimentação. 10-11 Maio 2018, LisboaN/

Improving methodology to determine vitamin D3 in food supplements

Abstract in proceedings of the Fourth International Congress of CiiEM: Health, Well-Being and Ageing in the 21st Century, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from 3–5 June 2019.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/publishedVersio

About the effect of eye blinking on drug release from pHEMA-based hydrogels: an in vitro study

"The development of new ophthalmic drug delivery systems capable of increasing the residence time of drugs in the eye and improve its bioavailability relatively to eyedrops has been object of intense research in recent years. Several studies have shown that drug loaded therapeutic soft contact lenses (SCLs) constitute a promising approach, with several potential advantages as compared with collyria. The main objective of this work is to study the effect of repetitive load and friction cycles caused by the eye blinking, on the drug release from hydrogels used in SCLs which, as far as we know, was never investigated before. Two poly-2-hydroxyethylmethacrylate based hydrogels, pHEMA-T and pHEMA-UV, were used as model materials. Levofloxaxin was chosen as model drug. The hydrogels were fully characterized in what concerns structural and physicochemical properties. PHEMA-UV revealed some superficial porosity and a lower short range order than PHEMA-T. We observe that the load and friction cycles enhanced the drug release from pHEMAUV hydrogels. The application of a simple mathematical model, which takes into account the drug dilution caused by the tear flow, showed that the enhancement of the drug release caused by blinking on this hydrogel may be relevant in in vivo conditions. Conversely, the more sustained drug release from pHEMA-T is not affected by load and friction cycles. The conclusion is that, depending on the physicochemical and microstructural characteristics of the hydrogels, blinking is a factor that may affect the amount of drug delivered to the eye by SCLs and should thus be considered.

Laboratory performance evaluation of Malaria morphological identification in EQA Programs

Malaria, one of the main worldwide health diseases, is caused by Plasmodium species being of utmost importance the correct identification of each Plasmodium spp. Since 1995, the National Program for External Quality Assessment (PNAEQ) has implemented a Parasitic Morphology program which aims to evaluate the performance of participant laboratories in the identification of parasitic structures. To continually improve their performance, PNAEQ, in collaboration with a work group, provide updated scientific reports, courses and, when needed, implement corrective actions. The aim of this study is to evaluate performance of the participants in the Parasitic Morphology program, in the identification of Plasmodium falciparum, Plasmodium malariae and Plasmodium ovale, from 2011 to 2018.N/

O emprego das coroas pré-fabricadas e das resinas compostas em dentes decíduos anteriores

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Predicting Cancer Prognostics from Tumour Transcriptomics Using an Auto Machine Learning Approach

Cancer prognostics using tumour transcriptomics is a promising precision medicine approach for helping decisions during cancer treatment. However, currently used cancer prognostic biomarkers still have low predictive power. This work tested the potential of applying machine learning (ML) algorithms for generating patients’ survival prognostics on lung, breast, and kidney tumour transcriptomics datasets. We evaluated the performance of models generated by ML and reported their optimal sensitivity, specificity, accuracy, and computed ROC-AUC. The results support the potential for applying auto ML approaches for the future development of cancer prognostics tools based on transcriptomics data