Fractional Fokker-Planck Equations for Subdiffusion with Space-and-Time-Dependent Forces

We have derived a fractional Fokker-Planck equation for subdiffusion in a general space-and- time-dependent force field from power law waiting time continuous time random walks biased by Boltzmann weights. The governing equation is derived from a generalized master equation and is shown to be equivalent to a subordinated stochastic Langevin equation.Comment: 5 page

PHARMACOGNOSY AND NEW TRENDS OF B. PHARM SYLLABI

Objective: The Pharmacy profession has evolved from its conventional drug focused basis to an advanced patient focused basis over the years. Accordingly, many universities worldwide are modifying their Curricula in order to reflect this change.Methods: This paper investigates and compares the syllabi of B. Pharm for different Universities in Africa and Asia. Pharmacy Syllabi of the included Universities is presented in the form of Sectors, i.e. Pharmaceutical Sciences, Clinical Pharmacy, Biomedical, Training and University Requirements. Percentage analysis of credit hours allotted to courses of each Sector performed with special emphasis on courses of Pharmacognosy and Pharmaceutical Science in comparison to courses of Clinical Pharmacy.There is a substantial decrease in teaching hours of Pharmaceutical Sciences, particularly Pharmacognosy within the B. Pharm Curricula of some of the included Universities at the expense of including more courses in Clinical Pharmacy.Results: Pharmacists are scientists as well as clinicians, and basic science knowledge such as pharmaceutical sciences, give pharmacy graduates critical scientific foundations, in this regard, the reduction in pharmaceutical sciences content in a pharmacy curriculum may compromise the competence of pharmacy graduates, as the drug experts from the basic science level to the clinical level.Conclusion: The impact of reducing pharmaceutical science content, may compromise the Pharmacist ability to assume certain duties in the countries included in the study. This in consideration that Clinical Pharmacy is not widely practiced in the investigated countries and its application is limited compared to other job opportunities available for Pharmacy graduates of these countries such as Community Pharmacy, Pharmaceutical Industries, marketing and sales and utilization of natural resources of medicinal plants by research and development units.Recommendations on how to avoid such decrease in teaching hours of Pharmaceutical Courses and fulfil the job requirements in the above countries are given

Review of Researches on Techno-Economic Analysis and Environmental Impact of Hybrid Energy Systems

Hybrid energy systems, which are combinations of two or more renewable and non-renewable energy sources, have been identified as a viable mechanism to address the limitations of a single renewable energy source, utilized for electricity generation. In view of this, several research works have been carried out to determine the optimal mix of different renewable and non-renewable energy resources used for electricity generation. This paper presents a comprehensive review of the optimization approaches proposed and adopted by various authors in the literature for optimal sizing of hybrid energy systems. It is observed that the objective functions - considered by a large percentage of researchers to optimize the sizing of hybrid energy systems - are cost minimization of the generated electricity, system reliability enhancement and environmental pollution reduction. Other factors covered in the literature are equally discussed in this article. Similarly, simulation and optimization software used for the same purpose are covered in the paper. In essence, the main aim of this paper is to provide a scope into the works that have been carried out in the field of hybrid energy systems, used for electricity generation with the view to informing researchers and members of the public alike, on trends in methods applied in optimal sizing of hybrid energy systems. It is believed that the information provided in this paper is very crucial in advancing research in the field

Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas

Background: Under inflammatory conditions, the activation of corticotropin-releasing factor (CRF) receptor has been shown to inhibit pain through opioid peptide release from immune cells or neurons. CRF's effects on human and animal pain modulation depend, however, on the distribution of its receptor subtypes 1 and 2 (CRF-R1 and CRF-R2) along the neuraxis of pain transmission. The objective of this study is to investigate the respective role of each CRF receptor subtype on centrally administered CRF-induced antinociception during inflammatory pain. Methods: The present study investigated the role of intracerebroventricular (i.c.v.) CRF receptor agonists on nociception and the contribution of cerebral CRF-R1 and/or CRF-R2 subtypes in an animal model of Freund's complete adjuvant (FCA)-induced hind paw inflammation. Methods used included behavioral experiments, immunofluorescence confocal analysis, and reverse transcriptase-polymerase chain reaction. Results: Intracerebroventricular, but systemically inactive, doses of CRF elicited potent, dose-dependent antinociceptive effects in inflammatory pain which were significantly antagonized by i.c.v. CRF-R1-selective antagonist NBI 27914 (by approximately 60%) but less by CRF-R2-selective antagonist K41498 (by only 20%). In line with these findings, i.c.v. administration of CRF-R1 agonist stressin I produced superior control of inflammatory pain over CRF-R2 agonist urocortin-2. Intriguingly, i.c.v. opioid antagonist naloxone significantly reversed the CRF as well as CRF-R1 agonist-elicited pain inhibition. Consistent with existing evidence of high CRF concentrations in brain areas such as the thalamus, hypothalamus, locus coeruleus, and periaqueductal gray following its i.c.v. administration, double-immunofluorescence confocal microscopy demonstrated primarily CRF-R1-positive neurons that expressed opioid peptides in these pain-relevant brain areas. Finally, PCR analysis confirmed the predominant expression of the CRF-R1 over CRF-R2 in representative brain areas such as the hypothalamus. Conclusion: Taken together, these findings suggest that CRF-R1 in opioid-peptide-containing brain areas plays an important role in the modulation of inflammatory pain and may be a useful therapeutic target for inflammatory pain control

Functional and Anatomical Characterization of Corticotropin-Releasing Factor Receptor Subtypes of the Rat Spinal Cord Involved in Somatic Pain Relief

Corticotropin-releasing factor (CRF) orchestrates our body's response to stressful stimuli. Pain is often stressful and counterbalanced by activation of CRF receptors along the nociceptive pathway, although the involvement of the CRF receptor subtypes 1 and/or 2 (CRF-R1 and CRF-R2, respectively) in CRF-induced analgesia remains controversial. Thus, the aim of the present study was to examine CRF-R1 and CRF-R2 expression within the spinal cord of rats with Freund's complete adjuvant-induced unilateral inflammation of the hind paw using reverse transcriptase polymerase chain reaction, Western blot, radioligand binding, and immunofluorescence confocal analysis. Moreover, the antinociceptive effects of intrathecal (i.t.) CRF were measured by paw pressure algesiometer and their possible antagonism by selective antagonists for CRF-R1 and/or CRF-R2 as well as for opioid receptors. Our results demonstrated a preference for the expression of CRF-R2 over CRF-R1 mRNA, protein, binding sites and immunoreactivity in the dorsal horn of the rat spinal cord. Consistently, CRF as well as CRF-R2 agonists elicited potent dose-dependent antinociceptive effects which were antagonized by the i.t. CRF-R2 selective antagonist K41498, but not by the CRF-R1 selective antagonist NBI35965. In addition, i.t. applied opioid antagonist naloxone dose-dependently abolished the i.t. CRF- as well as CRF-R2 agonist-elicited inhibition of somatic pain. Importantly, double immunofluorescence confocal microscopy of the spinal dorsal horn showed CRF-R2 on enkephalin (ENK)-containing inhibitory interneurons in close opposition of incoming mu-opioid receptor-immunoreactive nociceptive neurons. CRF-R2 was, however, not seen on pre- or on postsynaptic sensory neurons of the spinal cord. Taken together, these findings suggest that i.t. CRF or CRF-R2 agonists inhibit somatic inflammatory pain predominantly through CRF-R2 receptors located on spinal enkephalinergic inhibitory interneurons which finally results in endogenous opioid-mediated pain inhibition

The effect of climate temperature and daily water intake on the diversity of uropathogens causing urinary tract infections in adult hospital patients

Background: The most frequent bacterium causing urinary tract infection (UTI) is Escherichia coli (E.coli), followed by Staphylococcus saprophytic. These infections are more prevalent among pregnant women, particularly in summer, due to dehydration and insufficient uptake of drinking water. Objective: The aim was to assess the effect of climate temperature on diversity of uropathogens causing UTIs, and investigate whether infection increases during specific months. Patients and Methods: 741 patients aged 20 years or above in General Zakho Hospital were investigated for urinary tract infection status, and the daily drinking water uptake was assessed. The monthly climate temperatures were analyzed. Urine samples were collected using mid-stream method, and the samples were cultured to isolate uropathogens identified by biochemical tests. Results: The results indicate that 494 (66.66%) out of 741 patients were infected with UTIs, with seasonal trends of a peak plateau from June to July and a sharp decline after September. The percentage of UTI was 71% among patients who drank less than 2 liters of water per day, and 60% for other infections. Pregnant women had significantly higher prevalence of uropathogens due to the physiological changes during pregnancy. E.coli was the most common isolated pathogen (51.7%) in male and female patients. Conclusion: The results support evidence suggesting that dehydration due to low water intake, especially in summer, leads to low urine output, which increases the occurrence of urinary tract infection

Electron impact excitation cross sections for allowed transitions in atoms

We present a semiempirical Gaunt factor for widely used Van Regemorter formula [Astrophys. J. 136, 906 (1962)] for the case of allowed transitions in atoms with the LS coupling scheme. Cross sections calculated using this Gaunt factor agree with measured cross sections to within the experimental error.Comment: RevTeX, 3 pages, 10 PS figures, 2 PS tables, submitted to Phys. Rev.

Alarming update on incidence of Crimean-Congo hemorrhagic fever in Iraq in 2023

Objectives: In 2021, large outbreak of Crimean-Congo hemorrhagic fever (CCHF) was reported in Iraq and cases have increased without any significant control measures. To raise awareness about the increasing cases in different regions of Iraq, hence remind the necessity to tackle contributing factors and potential outbreak interventions. Methods: The study included 511 polymerase chain reaction-confirmed CCHF infection cases out of 1827 suspected cases from 18 Provinces from January to August 2023. Approval from the Ministry of Health for data analyzed. Results: Out of 1827 suspected cases, 511 were confirmed positive by polymerase chain reaction. The total case fatality rate (CFR) was 12.7 with varying severity levels among provinces. Erbil had the highest CFR, 38.5, while Sulaimaniya and Anbar report no deaths. Independent t-test showed a significant difference in CFR between provinces west and south of Baghdad compared to north (P <0.05). Trend showed significant surges after Iftar and Adha holidays. Conclusion: Differences in CFR among provinces around the religious ceremonies, highlight the need for one public health intervention strategy. Increased temperatures affected vector behavior. Uncontrolled animal movement with neighboring countries is an important factor. Virus or host determinants can shape the clinical case outcomes, which need clinical and extensive laboratory studies to unravel the reasons leading to death

A new flat shell finite element for the linear analysis of thin shell structures

In this paper, a new rectangular flat shell element denoted ‘ACM_RSBE5’ is presented. The new element is obtained by superposition of the new strain-based membrane element ‘RSBE5’ and the well-known plate bending element ‘ACM’. The element can be used for the analysis of any type of thin shell structures, even if the geometry is irregular. Comparison with other types of shell elements is performed using a series of standard test problems. A correlation study with an experimentally tested aluminium shell is also conducted. The new shell element proved to have a fast rate of convergence and to provide accurate results