1,633 research outputs found
Dataset concerning the analytical approximation of the Ae3 temperature.
In this paper we present a new polynomial function for calculating the local phase transformation temperature (Ae3 ) between the austenite+ferrite and the fully austenitic phase fields during heating and cooling of steel:[Formula: see text] The dataset includes the terms of the function and the values for the polynomial coefficients for major alloying elements in steel. A short description of the approximation method used to derive and validate the coefficients has also been included. For discussion and application of this model, please refer to the full length article entitled "The role of aluminium in chemical and phase segregation in a TRIP-assisted dual phase steel" 10.1016/j.actamat.2016.05.046 (Ennis et al., 2016) [1]
Issues and trends in the provision of public library services in Nigeria: A literature survey
The philosophy, orientation and nature of public library are routed in the responsibility of disseminating diverse and current information services to the members of its community. Waller and Mcshare (2008) posit two major challenges in the provision and use of public library services which are; lack of obtaining a thorough understanding of the nature of the environment which bothers majorly on information provision and use; and the development of policy frameworks that clarifies institutions goals and brings coherence to diverse and sometimes conflicting policy demands. This paper looks at issues and trends concerning some of the challenges bedeviling the provision and utilisation of public library services in Nigeria such as in-appropriate policies, lack of sufficient professionals, inadequate facilities and services and lack of awareness and proper understanding of the concept of public library services which led to non-use of the available services by potential users. Yield shift theory of satisfaction phenomena was used to explain the satisfaction phenomenon of public library services by users. Identified challenges were discussed and recommendations made towards developing a framework for improved public library services in Nigeria
Issues and trends in the provision of public library services in Nigeria: A literature survey
The philosophy, orientation and nature of public library are routed in the responsibility of disseminating diverse and current information services to the members of its community. Waller and Mcshare (2008) posit two major challenges in the provision and use of public library services which are; lack of obtaining a thorough understanding of the nature of the environment which bothers majorly on information provision and use; and the development of policy frameworks that clarifies institutions goals and brings coherence to diverse and sometimes conflicting policy demands. This paper looks at issues and trends concerning some of the challenges bedeviling the provision and utilisation of public library services in Nigeria such as in-appropriate policies, lack of sufficient professionals, inadequate facilities and services and lack of awareness and proper understanding of the concept of public library services which led to non-use of the available services by potential users. Yield shift theory of satisfaction phenomena was used to explain the satisfaction phenomenon of public library services by users. Identified challenges were discussed and recommendations made towards developing a framework for improved public library services in Nigeria
Circulation Tumor Cells: counts and characteristics
In recent years, many new anti-cancer agents have been developed and introduced into
clinical care. While these new agents have led to substantial gains in response rates and
life expectancies, they have also increased the need for tools to select those patients
benefitting from said therapies. Once patients develop metastatic disease, treatment is aimed
at improving quality of life and prolonging life expectancy, but is always a trade-off against
the side-effects that are inevitably associated with anti-tumor therapy, underscoring the need
to select only those patients who are likely to respond to a particular drug. However, there is
still an unmet need for such an array of reliable predictive factors, a need that can be met by
designing studies in which patient subgroups are defined and stratified based on rational,
biology-driven but feasible tumor characteristics. An increasing number of studies is being
designed in which, for example, only patients with a specific gain-of-function mutation are
subjected to a monoclonal antibody therapy aimed at the activated pathway this gene is
involved in. While substantial progress is being made with this approach, patient selection
has thus far been far from perfect. Even a powerful predictor such as a KRAS mutation for
EGFR-inhibiting therapy results in a response in just 20% of patients who are deemed
sensitive based on their KRAS wild-type status. One of the reasons for the disappointing
performance of predictive factors could be the fact that they are most often based on
primary tumor characteristics, while at the time of metastatic disease, a patients’ prognosis is
determined by their metastatic tumor load and its biological phenotype. Through processes
such as clonal selection and the inherent genomic instability of the tumor or as a consequence
of therapy pressure, metastatic tumor cells can differ substantially and vitally from primary
tumor cells. Analysis of metastatic tissue would thus probably be better indicative of
the actual tumor load and its underlying biology, and lead to better response prediction.
Unfortunately, repetitive metastatic biopsies are invasive and painful, understandably limiting
their use in clinical practice. Circulating tumor cells (CTCs) provide a very promising solution
for this problem, as they can be obtained and characterized repetitively and non-invasively
through venipunctures, and thus serve as a surrogate ‘liquid biopsy’ of metastases
Rentmeesterskap in die Nederduitse Gereformeerde Kerk van Wes- Transvaal : 'n beskrywend-verklarende studie.
Abstract available in pdf file
Some classifications of biharmonic hypersurfaces with constant scalar curvature
We give some classifications of biharmonic hypersurfaces with constant scalar
curvature. These include biharmonic Einstein hypersurfaces in space forms,
compact biharmonic hypersurfaces with constant scalar curvature in a sphere,
and some complete biharmonic hypersurfaces of constant scalar curvature in
space forms and in a non-positively curved Einstein space. Our results provide
additional cases (Theorem 2.3 and Proposition 2.8) that supports the conjecture
that a biharmonic submanifold in a sphere has constant mean curvature, and two
more cases that support Chen's conjecture on biharmonic hypersurfaces
(Corollaries 2.2,2.7).Comment: 11 page
Popular progression differences in vector spaces II
Green used an arithmetic analogue of Szemer\'edi's celebrated regularity
lemma to prove the following strengthening of Roth's theorem in vector spaces.
For every , , and prime number , there is a least
positive integer such that if ,
then for every subset of of density at least there is
a nonzero for which the density of three-term arithmetic progressions with
common difference is at least . We determine for the
tower height of up to an absolute constant factor and an
additive term depending only on . In particular, if we want half the random
bound (so ), then the dimension required is a tower of
twos of height . It turns
out that the tower height in general takes on a different form in several
different regions of and , and different arguments are used
both in the upper and lower bounds to handle these cases.Comment: 34 pages including appendi
Job characteristics and coping strategies associated with negative and positive work-home interference in a nursing environment
The aim of this study is to determine which job characteristics and coping strategies predict negative and positive work-home interference (WHI) in the nursing environment. Random samples (n=300) were taken of registered nurses in the Johannesburg, Klerksdorp, Krugersdorp, Potchefstroom and Pretoria regions. A self-constructed questionnaire was used to measure job characteristics. The Coping Strategy Indicator (CSI) was used to measure coping strategies, and the Survey Work-Home Interaction-Nijmegen (SWING) to measure WHI. The results show that time demands, pressure, role clarity and colleague support are the main job characteristics that predict negative WHI. Problem-solving coping predicts less negative WHI and avoidance coping predicts more negative WHI. Time demands, autonomy and role clarity are the main variables that predict positive WHI. Problem-solving coping is the only coping strategy that predicts positive WHI
Diagnostic applications of cell-free and circulating tumor cell-associated miRNAs in cancer patients
Summary:
Circulating tumor cells (CTCs) have rapidly developed as important cancer biomarkers after their enumeration proved to be prognostic in metastatic breast, colorectal and prostate cancer, and their rise or decline after the first cycle of therapy showed to predict therapy response. Besides mere counting, CTCs can be isolated and subsequently analyzed using various molecular applications, including miRNA expression analysis. Recently, miRNA expression profiling in primary tumors has yielded promising results. However, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA determination in oncology. Additionally to CTC-associated miRNAs, free circulating miRNAs have been identified in whole blood, plasma and serum.
Since determination of miRNAs in peripheral blood, either cell-free or CTC-associated, is expected to become important in oncology, especially when linked to and interpreted together with epithelial CTCs, this review focuses on measuring miRNAs in the circulation of cancer patients
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