1,683 research outputs found
The influence of phosphate and other nutrients on the development of vesicular-arbuscular mycorrhiza in culture
RESP-652
Cultures of caste and rural development in the social network of a south Indian village
Cultures of caste in much of rural India have become entangled with institutions of rural development. In community-driven development, emphasis on âlocal resource personsâ and âcommunity spokespersonsâ has created new opportunities for brokerage and patronage within some villages, which interact with existing forms of authority and community afforded by caste identity and intra-caste headmanship. In this article, we study how these entangled cultures of caste and development translate into social network structures using data on friendship ties from a south Indian village. We find that although caste continues to be important in shaping community structures and leadership in the villageâs network, its influence varies across different communities. This fluidity of casteâs influence on community network structures is argued to be the result of multiple distinct yet partially overlapping cultural-political forces, which include sharedness afforded by caste identity and new forms of difference and inequality effected through rural development
Testing in resource constrained execution environments
Software for resource constrained embedded devices is often implemented in the Java programming language because the Java compiler and virtual machine provide enhanced safety, portability, and the potential for run-time optimization. It is important to verify that a software application executes correctly in the environment in which it will normally execute, even if this environment is an embedded one that severely constrains memory resources. Testing can be used to isolate defects within and establish a confidence in the correctness of a Java application that executes in a resource constrained environment. However, executing test suites with a Java virtual machine (JVM) that uses dynamic compilation to create native code bodies can introduce significant testing time overheads if memory resources are highly constrained. This paper describes an approach that uses adaptive code unloading to ensure that it is feasible to perform testing in the actual memory constrained execution environment. The experiments demonstrate that code unloading can reduce both the test suite execution time by 34 % and the code size of the test suite and application under test by 78 % while maintaining the overall size of the JVM. Categories and Subject Descriptors: D.2.5 [Software Engineering]: Testing and Debugging-Testing tools; D.3.4 [Programming Languages]: Processors-code generation
Caste in Britain: Socio-legal Review: Equality and Human Rights Commission Research Report no. 91.
Power and the durability of poverty: a critical exploration of the links between culture, marginality and chronic poverty
Towards a new theory of practice for community health psychology
The article sets out the value of theorizing collective action from a social science perspective that engages with the messy actuality of practice. It argues that community health psychology relies on an abstract version of Paulo Freireâs earlier writing, the Pedagogy of the Oppressed, which provides scholar-activists with a âmapâ approach to collective action. The article revisits Freireâs later work, the Pedagogy of Hope, and argues for the importance of developing a âjourneyâ approach to collective action. Theories of practice are discussed for their value in theorizing such journeys, and in bringing maps (intentions) and journeys (actuality) closer together
Determinants of HDL Cholesterol Efflux Capacity after Virgin Olive Oil Ingestion: Interrelationships with Fluidity of HDL Monolayer
Scope: Cholesterol efflux capacity of HDL (CEC) is inversely associated with cardiovascular risk. HDL composition, fluidity, oxidation, and size are related with CEC. We aimed to assess which HDL parameters were CEC determinants after virgin olive oil (VOO) ingestion. Methods and results: Postâhoc analyses from the VOHF study, a crossover intervention with three types of VOO. We assessed the relationship of 3âweek changes in HDLârelated variables after intervention periods with independence of the type of VOO. After univariate analyses, mixed linear models were fitted with variables related with CEC and fluidity. Fluidity and Apolipoprotein (Apo)AâI content in HDL was directly associated, and HDL oxidative status inversely, with CEC. A reduction in free cholesterol, an increase in triglycerides in HDL, and a decrease in small HDL particle number or an increase in HDL mean size, were associated to HDL fluidity. Conclusions: HDL fluidity, ApoAâI concentration, and oxidative status are major determinants for CEC after VOO. The impact on CEC of changes in free cholesterol and triglycerides in HDL, and those of small HDL or HDL mean size, could be mechanistically linked through HDL fluidity. Our work points out novel therapeutic targets to improve HDL functionality in humans through nutritional or pharmacological interventions.Fil: FernĂĄndez Castillejo, Sara. Universitat Rovira I Virgili; EspañaFil: RubiĂł, Laura. Universitat Rovira I Virgili; España. Universidad de Lleida; EspañaFil: HernĂĄez, Ălvaro. Centro de InvestigaciĂłn BiomĂ©dica en Red FisiopatologĂa de la Obesidad y NutriciĂłn; EspañaFil: CatalĂĄn, Ărsula. Universitat Rovira I Virgili; EspañaFil: Pedret, Anna. Universitat Rovira I Virgili; EspañaFil: Valls, Rosa M.. Universitat Rovira I Virgili; EspañaFil: Mosse, Juana InĂ©s. Universidad de Lleida; España. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Covas, Maria Isabel. Centro de InvestigaciĂłn BiomĂ©dica en Red FisiopatologĂa de la Obesidad y NutriciĂłn; EspañaFil: Remaley, Alan T.. National Institutes of Health; Estados UnidosFil: Castañer, Olga. Centro de InvestigaciĂłn BiomĂ©dica en Red FisiopatologĂa de la Obesidad y NutriciĂłn; EspañaFil: Motilva, Maria JosĂ©. Universidad de Lleida; EspañaFil: SolĂĄ, Rosa. Universitat Rovira I Virgili; Españ
Caste in Britain: Experts' Seminar and Stakeholders' Workshop: Equality and Human Rights Commission Research Report no. 92.
First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Childrenâs Oncology Group Phase 1/Pilot Consortium
Characterize the pharmacokinetics of oral crizotinib in children with cancer
Disulfonated tetraphenyl chlorin (TPCS2a)âinduced photochemical internalisation of bleomycin in patients with solid malignancies: A first-in-man phase I dose escalation clinical trial
BACKGROUND: Photochemical internalisation, a novel minimally invasive treatment, has shown promising preclinical results in enhancing and site-directing the effect of anticancer drugs by illumination, which initiates localised chemotherapy release. We assessed the safety and tolerability of a newly developed photosensitiser, disulfonated tetraphenyl chlorin (TPCS2a), in mediating photochemical internalisation of bleomycin in patients with advanced and recurrent solid malignancies. METHODS: In this phase 1, dose-escalation, first-in-man trial, we recruited patients (aged â„18 to <85 years) with local recurrent, advanced, or metastatic cutaneous or subcutaneous malignancies who were clinically assessed as eligible for bleomycin chemotherapy from a single centre in the UK. Patients were given TPCS2a on day 0 by slow intravenous injection, followed by a fixed dose of 15â000 IU/m2 bleomycin by intravenous infusion on day 4. After 3 h, the surface of the target tumour was illuminated with 652 nm laser light (fixed at 60 J/cm2). The TPCS2a starting dose was 0·25 mg/kg and was then escalated in successive dose cohorts of three patients (0·5, 1·0, and 1·5 mg/kg). The primary endpoints were safety and tolerability of TPCS2a; other co-primary endpoints were dose-limiting toxicity and maximum tolerated dose. The primary analysis was per protocol. This study is registered with ClinicalTrials.gov, number NCT00993512, and has been completed. FINDINGS: Between Oct 3, 2009, and Jan 14, 2014, we recruited 22 patients into the trial. 12 patients completed the 3-month follow-up period. Adverse events related to photochemical internalisation were either local, resulting from the local inflammatory process, or systemic, mostly as a result of the skin-photosensitising effect of TPCS2a. The most common grade 3 or worse adverse events were unexpected higher transient pain response (grade 3) localised to the treatment site recorded in nine patients, and respiratory failure (grade 4) noted in two patients. One dose-limiting toxicity was reported in the 1·0 mg/kg cohort (skin photosensitivity [grade 2]). Dose-limiting toxicities were reported in two of three patients at a TPCS2a dose of 1·5 mg/kg (skin photosensitivity [grade 3] and wound infection [grade 3]); thus, the maximum tolerated dose of TPCS2a was 1·0 mg/kg. Administration of TPCS2a was found to be safe and tolerable by all patients. No deaths related to photochemical internalisation treatment occurred. INTERPRETATION: TPCS2a-mediated photochemical internalisation of bleomycin is safe and tolerable. We identified TPCS2a 0·25 mg/kg as the recommended treatment dose for future trials. FUNDING: PCI Biotech
- âŠ