Optimization of Chemical Processes by the Hydrodynamic Simulation Method (HSM)

We describe a hydrodynamic simulation method (HSM) that is based on hydrodynamic considerations in Batch and Semi Batch stirred reactor systems. The method combines hydrodynamic studies of the mixing procedure obtained from experiments in small and large scale stirred reactors together with process simulation by VisiMix software. We describe how this hydrodynamic simulation method can aid in process optimization and scale up. The use of the simulation method described in this article, will offer the user the possibility to achieve the best results during production stage, saving time and currency, and at the same time increasing the knowledge of the performed process. Several examples in the article demonstrate the benefits of the proposed method

Diffusion Enhanced Amide Bond Formation on Solid Support

Performing amino acids coupling reactions on solid support using fast overhead stirring is far more efficient than the common shaking mixing methods. Stirring does not harm the polystyrene beads and allows to decrease dramatically the amount of reagents used and wasted in these transformations