Image Gallery: Brain? no, melanoma

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Sinfonía en verde y azul

La rica región esmeraldífera de Muzo, ha dado inmenso prestigio a Colombia en el exterior: las esmeraldas que allí se han encontrado son las más hermosas del mundo y sus tamaños han superado muchas veces la imaginación de las mentes más afiebradas; pero no solo las esmeraldas han hecho famoso el nombre de la provincia de Muzo, se encuentran allí también unas mariposas de singular belleza y colorido que han cautivado la atención de algunos importantes poetas latinoamericanos

¿Afectan las estructuras sociales el desempeño de las organizaciones?

Este trabajo se desarrolla a través de la siguienta temática la relación entre las organizaciones y las estructuras sociales. El imbricamiento y clasificación de las relaciones que existen. Así como también el imbricamiento y la relación de mercado, ventajas y desventajas de cada una.Desarrollo. Relación entre las organizaciones y las estructuras sociales. El imbricamiento y Clasificación de las relaciones que hay. Categorización de las relaciones entre empresas en imbricadas y de mercado, ventajas y desventajas de cada una. GEA como caso probatorio de dicha relación. Conclusión.Administrador de EmpresasPregrad

De la tarantela al caimán. Inmigración italiana en la provincia de Santa Marta

Este libro múltiple de Javier Moscarella es, en el fondo, y en la superficie, una novela, aunque tenga la forma de un texto histórico. Mejor: es un poliedro verbal construido a partir de la complicidad, los sueños, la amistad y el amor a un terruño diverso y risueño en el que sus abuelos paternos italianos sentaron reales luego de cruzar un mar, un océano y otro mar. Quiero decir que estamos ante un teatro de máscaras. Y, como enseñó Nietzsche, actor de pies a cabeza, «todo lo que es profundo ama la máscara». Máscara equivale, por supuesto, a juego y fiesta. Bienvenidos todos a esta fiesta de la palabra con motivo de un libro que revisa las marcas de la inmigración italiana en tierras de la antigua Provincia de Santa Marta. Un texto oportuno, sin duda, cuando estamos a una mirada de conmemorar los 500 años de la fundación de Santa Marta

Dermoscopy and Reflectance Confocal Microscopy for Monitoring the Treatment of Actinic Keratosis with Ingenol Mebutate Gel: Report of Two Cases

Introduction: A relatively novel application for dermoscopy and reflectance confocal microscopy (RCM) is their use in the monitoring of topical treatment response for non-melanoma skin cancer. Actinic keratosis (AK) is the early phase of a multistep biologic continuum leading to invasive squamous cell carcinoma. A number of topical therapies are now available for the treatment of AK but their disadvantages include long treatment duration and prolonged local reactions. Ingenol mebutate is a newer therapy for AK which is only applied for 2 or 3 days. Case Report: Dermoscopy and RCM findings in two patients with AK treated with ingenol mebutate confirm that it induces rapid lesion necrosis and specific neutrophil-mediated, antibody-dependent cellular cytotoxicity. Necrosis occurs via mitochondrial membrane disruption, with subsequent eradication of residual tumor cells via transient inflammation. Local skin reactions to ingenol mebutate should be considered part of the drug’s mechanism of action rather than an adverse effect. Conclusion: Ingenol mebutate is a valuable therapy for the treatment of AK. This case report adds further evidence to the usefulness of dermoscopy and RCM in the assessment and monitoring of treatment outcome

A solitary pink lesion: dermoscopy and RCM features of lichen planus

We present an unusual onset of cutaneous lichen planus (LP) in a middle-aged patient. The initial presentation as solitary, indolent pink lesion required further investigations to rule out malignancy, especially amelanotic melanoma. Dermoscopy and reflectance confocal microscopy findings were found to be helpful in our case in addressing the correct diagnosis

Trends in cutaneous melanoma mortality in Italy from 1982 to 2016

Background In Italy, comprehensive national studies, about mortality rates for cutaneous melanoma, are missing. The aim of this study was to analyze the trend of cutaneous melanoma mortality in Italy from 1982 to 2016. Methods Data on death certificates were obtained from Italian National Institute of Statistics (ISTAT: Istituto nazionale di STATistica, Indagine sulle cause di morte). Mortality rates were age-standardized on the European population 2013 and presented per 100,000 individuals. Age-adjusted mortality rates (AMRs) were calculated by sex, age group, and geographic areas. To identify changes in mortality rate trends, a joinpoint regression model was used, and the annual percent change (APC) was estimated. Results In Italy, a total number of 49,312 patients (44.0% women) died for cutaneous melanoma from 1982 to 2016. Melanoma mortality rates significantly increased in the study period in both sexes, with higher AMR values and a steeper increase in men (from 2.71 to 4.02; APC: 1.43; 95% CI 1.26-1.61) than women (from 1.94-2.10; APC: 0.23; 95% CI 0.00-0.46). The largest difference between men and women was observed in patients aged >= 65 years with APC of 2.17 in men (95% CI 1.97-2.37) and 0.37 in women (95% CI 0.08-0.66). Conclusion In conclusion, the melanoma mortality rate in Italy progressively increased especially in elderly men. Several hypotheses might explain the observed age and geographic differences such as sun exposure habits or different strategies of prevention campaigns

Dermoscopic Ulceration is a Predictor of Basal Cell Carcinoma Response to Imiquimod: A Retrospective Study

Imiquimod is considered one of the treatments of choice for low-risk superficial basal cell carcinoma (sBCC) and an alternative option for non-superficial tumours when surgery is contraindicated or not feasible (1\u20133). In addition to its well-known value in the diagnosis of BCC, dermoscopy has recently been shown to provide valid information about the histopathological subtype or the presence of clinically undetectable pigmentation (4\u20136). The aim of the present study was to investigate whether dermoscopic criteria (especially ulceration) of the primary tumour can predict a favourable response of BCC to imiquimod

Mixed Student Ideas about Mechanisms of Human Weight Loss

Recent calls for college biology education reform have identified “pathways and transformations of matter and energy” as a big idea in biology crucial for students to learn. Previous work has been conducted on how college students think about such matter-transforming processes; however, little research has investigated how students connect these ideas. Here, we probe student thinking about matter transformations in the familiar context of human weight loss. Our analysis of 1192 student constructed responses revealed three scientific (which we label “Normative”) and five less scientific (which we label “Developing”) ideas that students use to explain weight loss. Additionally, students combine these ideas in their responses, with an average number of 2.19 ± 1.07 ideas per response, and 74.4% of responses containing two or more ideas. These results highlight the extent to which students hold multiple (both correct and incorrect) ideas about complex biological processes. We described student responses as conforming to either Scientific, Mixed, or Developing descriptive models, which had an average of 1.9 ± 0.6, 3.1 ± 0.9, and 1.7 ± 0.8 ideas per response, respectively. Such heterogeneous student thinking is characteristic of difficulties in both conceptual change and early expertise development and will require careful instructional intervention for lasting learning gains