On the accuracy of surface spline interpolation on the unit sphere

This paper considers a novel modification to the surface splines that have previously been used on the unit sphere. The surface splines considered are a natural analogue of surface splines in IRd and possess a unique Fourier expansion in terms of an orthonormal basis of spherical harmonics. Knowing the decay of the associated Fourier coefficients is important because they enable error estimates for spherical interpolation. In this paper we explicitly compute the Fourier coefficients of the surface splines and employ a recent theoretical result [8] to provide a useful error bound. We illuminate our theoretical findings by performing numerical experiments on the sphere and also on the hemisphere

A Duchon framework for the sphere

In his fundamental paper (RAIRO Anal. Numer. 12 (1978) 325) Duchon presented a strategy for analysing the accuracy of surface spline interpolants to sufficiently smooth target functions. In the mid-1990s Duchon's strategy was revisited by Light and Wayne (J. Approx. Theory 92 (1992) 245) and Wendland (in: A. Le Méhauté, C. Rabut, L.L. Schumaker (Eds.), Surface Fitting and Multiresolution Methods, Vanderbilt Univ. Press, Nashville, 1997, pp. 337–344), who successfully used it to provide useful error estimates for radial basis function interpolation in Euclidean space. A relatively new and closely related area of interest is to investigate how well radial basis functions interpolate data which are restricted to the surface of a unit sphere. In this paper we present a modified version Duchon's strategy for the sphere; this is used in our follow up paper (Lp-error estimates for radial basis function interpolation on the sphere, preprint, 2002) to provide new Lp error estimates (p[1,∞]) for radial basis function interpolation on the sphere

L_(p)-error estimates for radial basis function interpolation on the sphere

In this paper we review the variational approach to radial basis function interpolation on the sphere and establish new Lp-error bounds, for p[1,∞]. These bounds are given in terms of a measure of the density of the interpolation points, the dimension of the sphere and the smoothness of the underlying basis function

Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: Study design

Background: Second primary malignancies are a major cause of excess morbidity and mortality in cancer survivors. Hodgkin lymphoma survivors who were treated with infradiaphragmatic radiotherapy and/or high-dose procarbazine have an increased risk to develop colorectal cancer. Colonoscopy surveillance plays an important role in colorectal cancer prevention by removal of the precursor lesions (adenomas) and early detection of cancer, resulting in improved survival rates. Therefore, Hodgkin lymphoma survivors treated with infradiaphragmatic radiotherapy and/or high-dose procarbazine could benefit from colonoscopy, or other surveillance modalities, which are expected to reduce colorectal cancer incidence and mortality. Current knowledge on clinicopathological and molecular characteristics of therapy-related colorectal cancer is limited. The pathogenesis of such colorectal cancers might be different from the pathogenesis in the general population and therefore these patients might require a different clinical approach. We designed a study with the primary aim to assess the diagnostic yield of a first surveillance colonoscopy among Hodgkin lymphoma survivors at increased risk of colorectal cancer and to compare these results with different screening modalities in the general population. Secondary aims include assessment of the test characteristics of stool tests and evaluation of burden, acceptance and satisfaction of CRC surveillance through two questionnaires. Methods/Design: This prospective multicenter cohort study will include Hodgkin lymphoma survivors who survived =8years after treatment with infradiaphragmatic radiotherapy and/or procarbazine (planned inclusion of 259 participants). Study procedures will consist of a surveillance colonoscopy with removal of precursor lesions (adenomas) and 6-8 normal colonic tissue biopsies, a fecal immunochemical test and a stool DNA test. All neoplastic lesions encountered will be classified using relevant histomorphological, immunohistochemical and molecular analyses in order to obtain more insight into colorectal carcinogenesis in Hodgkin lymphoma survivors. The Miscan-model will be used for cost-effectiveness analyses. Discussion: Evaluation of the diagnostic performance, patient acceptance and burden of colorectal cancer surveillance is necessary for future implementation of an individualized colorectal cancer surveillance program for Hodgkin lymphoma survivors. In addition, more insight into treatment-induced colorectal carcinogenesis will provide the first step towards prevention and personalized treatment. This information may be extrapolated to other groups of cancer survivors. Trial registration: Registered at the Dutch Trial Registry (NTR): NTR4961

Is alcohol consumption a risk factor for prostate cancer? A systematic review and meta-analysis.

Background: Research on a possible causal association between alcohol consumption and risk of prostate cancer is inconclusive. Recent studies on associations between alcohol consumption and other health outcomes suggest these are influenced by drinker misclassification errors and other study quality characteristics. The influence of these factors on estimates of the relationship between alcohol consumption and prostate cancer has not been previously investigated. Methods: PubMed and Web of Science searches were made for case–control and cohort studies of alcohol consumption and prostate cancer morbidity and mortality (ICD–10: C61) up to December 2014. Studies were coded for drinker misclassification errors, quality of alcohol measures, extent of control for confounding and other study characteristics. Mixed models were used to estimate relative risk (RR) of morbidity or mortality from prostate cancer due to alcohol consumption with study level controls for selection bias and confounding. Results: A total of 340 studies were identified of which 27 satisfied inclusion criteria providing 126 estimates for different alcohol exposures. Adjusted RR estimates indicated a significantly increased risk of prostate cancer among low (RR = 1.08, P 1.3, <24 g per day). This relationship is stronger in the relatively few studies free of former drinker misclassification error. Given the high prevalence of prostate cancer in the developed world, the public health implications of these findings are significant. Prostate cancer may need to be incorporated into future estimates of the burden of disease alongside other cancers (e.g. breast, oesophagus, colon, liver) and be integrated into public health strategies for reducing alcohol related disease

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physical parameters and a synthetically accessible scaffold. We show that the exemplar, OSM-S-106, has potent activity against parasite cultures, low mammalian cell toxicity and low propensity for resistance development. In vitro evolution of resistance using a slow ramp-up approach pointed to the Plasmodium falciparum cytoplasmic asparaginyl-tRNA synthetase (PfAsnRS) as the target, consistent with our finding that OSM-S-106 inhibits protein translation and activates the amino acid starvation response. Targeted mass spectrometry confirms that OSM-S-106 is a pro-inhibitor and that inhibition of PfAsnRS occurs via enzyme-mediated production of an Asn-OSM-S-106 adduct. Human AsnRS is much less susceptible to this reaction hijacking mechanism. X-ray crystallographic studies of human AsnRS in complex with inhibitor adducts and docking of pro-inhibitors into a model of Asn-tRNA-bound PfAsnRS provide insights into the structure-activity relationship and the selectivity mechanism.</p

Oral abstracts 1: SpondyloarthropathiesO1. Detecting axial spondyloarthritis amongst primary care back pain referrals

Background: Inflammatory back pain (IBP) is an early feature of ankylosing spondylitis (AS) and its detection offers the prospect of early diagnosis of AS. However, since back pain is very common but only a very small minority of back pain sufferers have ASpA or AS, screening of back pain sufferers for AS is problematic. In early disease radiographs are often normal so that fulfilment of diagnostic criteria for AS is impossible though a diagnosis of axial SpA can be made if MRI evidence of sacroiliitis is present. This pilot study was designed to indicate whether a cost-effective pick up rate for ASpA/early AS could be achieved by identifying adults with IBP stratified on the basis of age. Methods: Patients aged between 18 and 45 years who were referred to a hospital physiotherapy service with back pain of more than 3 months duration were assessed for IBP. All were asked to complete a questionnaire based on the Berlin IBP criteria. Those who fulfilled IBP criteria were also asked to complete a second short questionnaire enquiring about SpA comorbidities, to have a blood test for HLA-B27 and CRP level and to undergo an MRI scan of the sacroiliac joints. This was a limited scan, using STIR, diffusion-weighted, T1 and T2 sequences of the sacroiliac joints to minimize time in the scanner and cost. The study was funded by a research grant from Abbott Laboratories Ltd. Results: 50 sequential patients agreed to participate in the study and completed the IBP questionnaire. Of these 27 (54%) fulfilled criteria for IBP. Of these, 2 patients reported a history of an SpA comorbidity - 1 psoriasis; 1 ulcerative colitis - and 3 reported a family history of an SpA comorbidity - 2 psoriasis; 1 Crohn's disease. 4 were HLA-B27 positive, though results were not available for 7. Two patients had marginally raised CRP levels (6, 10 -NR ≤ 5). 19 agreed to undergo MRI scanning of the sacroiliac joints and lumbar spine; 4 scans were abnormal, showing evidence of bilateral sacroiliitis on STIR sequences. In all cases the changes met ASAS criteria but were limited. Of these 4 patients 3 were HLA-B27 positive but none gave a personal or family history of an SpA-associated comorbidity and all had normal CRP levels. Conclusions: This was a pilot study yielding only limited conclusions. However, it is clear that: Screening of patients referred for physiotherapy for IBP is straightforward, inexpensive and quick. It appears that IBP is more prevalent in young adults than overall population data suggest so that targeting this population may be efficient. IBP questionnaires could be administered routinely during a physiotherapy assessment. HLA-B27 testing in this group of patients with IBP is a suitable screening tool. The sacroiliac joint changes identified were mild and their prognostic significance is not yet clear so that the value of early screening needs further evaluation. Disclosure statement: C.H. received research funding for this study from Abbott. A.K. received research funding for this study, and speaker and consultancy fees, from Abbott. All other authors have declared no conflicts of interes

Field efficacy and persistence of synthetic pesticidal dusts on stored maize grain under contrasting agro-climatic conditions

Grain storage trials were conducted in two districts of Zimbabwe with contrasting agro-climatic conditions (mean annual temperature of 18–30 °C and 28–42 °C; total rainfall of 750–1000 mm per annum and <450 mm per annum; respectively) to determine the comparative efficacy of commercially-available grain storage synthetic pesticides under contrasting climatic conditions. The five grain protectants, namely Shumba super dust® (fenitrothion 1% + deltamethrin 0.13%), Actellic gold dust® (pirimiphos-methyl 1.6% + thiamethoxam 0.36%), Super guard® (pirimiphos-methyl 1.6% + permethrin 0.4%), Chikwapuro® (pirimiphos-methyl 2.5% + deltamethrin 0.1%) and Ngwena yedura® (pirimiphos-methyl 2.5% + deltamethrin 0.2%) were evaluated at manufacturer's rates on stored shelled maize. The trials were conducted for a 40 week-long storage season in 2014/15 and again in 2015/16. Samples were analysed for insect grain damage, total insects per kilogram, grain weight loss, insect feeding dust and chaff as well as grain moisture content. Temperature and relative humidity within stores were recorded using data loggers. The results highlighted the generally poor efficacy of the synthetic pesticides under both cooler and hotter climatic test conditions. The pesticides failed to prevent insect grain damage or suppress insect pest numbers. Only Actellic gold dust®, introduced in the 2015/16 storage season was effective under both the agro-climatic conditions. The current study suggests that only Actellic gold dust® can be recommended for smallholder farm grain protection under both cooler and hotter climatic conditions. The findings confirm the frequent claims of smallholder farmers in east and southern Africa regarding poor storage pesticide performance, and emphasize the need to develop alternative effective storage insect pest control options

American Gut: an Open Platform for Citizen Science Microbiome Research

McDonald D, Hyde E, Debelius JW, et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018;3(3):e00031-18