12 research outputs found
Special Report: Arctic Cryosphere - Changes and Impacts Preface
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
Preface
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Gene expression patterns in multiple organs in experimentally induced <em>Staphylococcus aureus</em> sepsis in pigs
- Author
- Publication venue
- Publication date
- 01/01/2013
- Field of study
Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue
- Author
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Life-long regular endurance exercise is known to counteract the deterioration of cardiovascular and metabolic function and overall mortality. Yet it remains unknown if life-long regular endurance exercise can influence the connective tissue accumulation of advanced glycation endproducts (AGEs) that is associated with aging and lifestyle-related diseases. We therefore examined two groups of healthy elderly men: 15 master athletes (64 ± 4 years) who had been engaged in life-long endurance running and 12 old untrained (66 ± 4 years) together with two groups of healthy young men; ten young athletes matched for running distance (26 ± 4 years), and 12 young untrained (24 ± 3 years). AGE cross-links (pentosidine) of the patellar tendon were measured biochemically, and in the skin, it was assessed by a fluorometric method. In addition, we determined mechanical properties and microstructure of the patellar tendon. Life-long regular endurance runners (master athletes) had a 21 % lower AGE cross-link density compared to old untrained. Furthermore, both master athletes and young athletes displayed a thicker patellar tendon. These cross-sectional data suggest that life-long regular endurance running can partly counteract the aging process in connective tissue by reducing age-related accumulation of AGEs. This may not only benefit skin and tendon but also other long-lived protein tissues in the body. Furthermore, it appears that endurance running yields tendon tissue hypertrophy that may serve to lower the stress on the tendon and thereby reduce the risk of injury
SWIPA Synthesis: Implications of Findings
- Author
- Publication venue
- Arctic Monitoring and Assessment Programme (AMAP)
- Publication date
- 01/01/2011
- Field of study
Complement profiles in patients with amyotrophic lateral sclerosis:A prospective observational cohort study
- Author
- Publication venue
- 'Dove Medical Press Ltd.'
- Publication date
- 01/01/2021
- Field of study
Prediction of survival in amyotrophic lateral sclerosis:a nationwide, Danish cohort study
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer
- Author
- A Masuda
- Amy Calhoun
- Anne Goriely
- Anne-Mette Hartung
- Barbara Guerra
- BD Theophilus
- Brage S. Andresen
- Cecily Vaughn
- CJ Tabin
- D Matern
- David A. Stevenson
- E Giannoulatou
- E Kim
- EM Burkitt-Wright
- EP Reddy
- F Supek
- F Zammarchi
- G Dreyfuss
- G Singh
- GS Wang
- Henriette Skovgaard Andersen
- I Talukdar
- IFM Lo
- Inaki E. Uriz
- JA Bauman
- Jeanne Mari V. Bang
- Jeff Swensen
- JL Manley
- John C. Carey
- Karen Kristjansdottir
- KB Nielsen
- KW Gripp
- L Cartegni
- Lars Dyrskjøt
- LF Parada
- LR Coulter
- M Cohen-Eliav
- M Dewaele
- M Santoro
- Martin R. Larsen
- MC Schaub
- Morten Lapin
- O Fasano
- PD Ellis
- PH Seeburg
- Ping Yu
- R Jia
- R Karni
- RK Olsen
- S Lorenz
- SF Dobrowolski
- Steven F. Dobrowolski
- Ulrika S. S. Petersen
- V Rimoldi
- WW Colby
- Y Aoki
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
The Germanic Iron Age and Viking Age in Danish Archaeology
- Author
- Aaby BENT
- Aaby BENT
- Ahrens CLAUS
- Ambrosiani KRISTINA
- Ambrosiani KRISTINA
- Ambrosiani KRISTINA
- Andersen H. HELLMUTH
- Andersen H. HELLMUTH
- Andersen HARALD
- Andersen SVEND TH.
- Andersson THORSTEN
- Andren ANDERS
- Andren ANDERS
- Andren ANDERS
- Arrhenius BIRGIT
- Arwidsson GRETA
- Astill G.
- Axboe MORTEN
- Backe MARGARETA
- Balint CSANAD
- Becker C. J.
- Becker C. J.
- Becker C. J.
- Behre KARL-ERNST
- Bencard MOGENS
- Bender JØRGENSEN
- Bender JØRGENSEN
- Bennike PIA
- Björhem NILS
- Bonde NIELS
- Brøndsted JOHANNES
- Callmer JOHAN
- Callmer JOHAN
- Callmer JOHAN
- Callmer JOHAN
- Callmer JOHAN
- Campbell JAMES
- Capelle TORSTEN
- Carlsson DAN
- Carlsson DAN
- Christensen ANEMETTE S.
- Christensen TOM
- Christensen TOM
- Christiansen TAGE E.
- Christlein RAINER
- Christophersen AXEL
- Cinthio HAMPUS
- Clarke HOWARD B.
- Crumlin-pedersen OLE
- Crumlin-pedersen OLE
- Crumlin-pedersen OLE
- Crumlin-pedersen OLE
- Dalberg VIBEKE
- Dansgaard WILLI
- Donat PETER
- Donat PETER
- Düwel KLAUS
- Eckstein DIETER
- Eckstein DIETER
- Ellmers DETLEF
- Ethelberg PER
- Feffer LAURE-CHARLOTTE
- Fenger OLE
- Fonnesbech-sandberg ELIZA
- Frandsen LENE B.
- Fuglesang SIGNE HORN
- Fuglesang SIGNE HORN
- Fuglesang SIGNE HORN
- Gebers WILHELM
- Graham-campbell JAMES
- Groenman-van wateringe WILLY
- Gräslund ANNE-SOFIE
- Gräslund ANNE-SOFIE
- Hansen TORBEN EGEBERG
- Hansen ULLA LUND
- Hansen VAGNER
- Haseloff GÜNTHER
- Haseloff GÜNTHER
- Hauck KARI
- Hauck KARI
- Hauck KARI
- Hedeager LOTTE
- Hedeager LOTTE
- Hedeager LOTTE
- Hedeager LOTTE
- Hedeager LOTTE
- Helbaek HANS
- Herrmann JOACHIM
- Herschend FRANDS
- Hill DAVID
- Hines JOHN
- Hodges RICHARD
- Hodges RICHARD
- Hoffmann ERICH
- Holmberg BENTE
- Hvass LONE
- Hvass STEEN
- Hvass STEEN
- Hvass STEEN
- Hvass STEEN
- Hvass STEEN
- Hägg INGA
- Hårdh BIRGITTA
- Hårdh BIRGITTA
- Ilkjær JØRGEN
- Ilkjær JØRGEN
- Ilkjær JØRGEN
- Iversen METTE
- Iversen Mette
- Iversen METTE
- Jacobsen LIS
- Jankuhn HERBERT
- Jankuhn HERBERT
- Jankuhn Herbert
- Jansson INGMAR
- Jansson INGMAR
- Jensen ANNA-ELISABETH
- Jensen JØRGEN
- Jensen JØRGEN
- Jensen STIG
- Jensen STIG
- Jensen STIG
- Jensen STIG
- Jensen STIG
- Jensen STIG
- Jensen STIG
- Jensen STIG
- Jeppesen TORBEN GRØNGAARD
- Joachim REICHSTEIN
- Johansen ARNE B.
- Johansen ARNE B.
- Jørgensen BENT
- Jørgensen BENT
- Jørgensen LARS
- Jørgensen LISE BENDER
- Jørgensen LISE BENDER
- Jørgensen MOGENS SCHOU
- Karlsson LENNART
- Knudsen SVEND AAGE
- Kossack Georg
- Kristensen HANS KRONGAARD
- Kristensen HANS KRONGAARD
- Kristensen HANS KRONGAARD
- Kristiansen KRISTIAN
- Krogh KNUD J.
- Kroll HELMUT
- Kromann ANNE
- Kyhlberg OLA
- Larsen ERLING BENNER
- Larsson LARS
- Laur WOLFGANG
- Liebgott NIELS-KNUD
- Lindkvist THOMAS
- Lindquist SVEN-OLOF
- Lund NIELS
- Lund NIELS
- Lund NIELS
- Lund NIELS
- Lönnroth ERIK
- Lønstrup JØRN
- Madsen HELGE BRINCH
- Madsen HELGE BRINCH
- Madsen JAN SKAMBY
- Madsen JAN SKAMBY
- Madsen ORLA
- Madsen TORSTEN
- Magnusson GERT
- Mahler DITLEV L.
- Malmer BRITA
- Malmros RIKKE
- Meier DIETRICH
- Mejdahl VAGN
- Menghin WILFRIED
- Metcalf D. M.
- Metcalf D. M.
- Mildenberger GERHARD
- Moltke ERIK
- Moltke ERIK
- Montelius OSCAR
- Mortensen PEDER
- Mortensen PEDER
- Myrvoll SIRI
- Mårtensson ANDERS
- Møller JENS THYGE
- Müller-wille MICHAEL
- Müller-wille MICHAEL
- Müller-wille MICHAEL
- Müller-wille MICHAEL
- Müller-wille MICHAEL
- Müller-wille MICHAEL
- Müller-wille MICHAEL
- Neumann HANS
- Nielsen BJARNE HENNING
- Nielsen HELGE
- Nielsen INGRID
- Nielsen JENS N.
- Nielsen JENS N.
- Nielsen JENS N.
- Nielsen JENS N.
- Nielsen KAREN HØILUND
- Nielsen LEIF CHR
- Nielsen LEIF CHR
- Nielsen LEIF CHR
- Nielsen SVEND
- Noonan THOMAS S.
- Näsman ULF
- Näsman ULF
- Näsman ULF
- Näsman ULF
- Näsman ULF
- Odgaard BENT
- Ohlsson TOM
- Olafsson GUDMUNDUR
- Olsen OLAF
- Olsen OLAF
- Olsen OLAF
- Persson Ove
- Petersen JAN
- Petersen PETER VANG
- Porsmose ERLAND
- Porsmose ERLAND
- Périn PATRICK
- Ramskou THORKILD
- Ramskou THORKILD
- Ramskou THORKILD
- Randsborg KLAVS
- Randsborg KLAVS
- Randsborg KLAVS
- Resi HEID GJOSTEIN
- Ringtved JYTTE
- Robinson D.
- Robinson DAVID E.
- Roesdahl ELSE
- Roesdahl ELSE
- Roesdahl ELSE
- Roesdahl ELSE
- Roesdahl ELSE
- Roesdahl ELSE
- Roesdahl ELSE
- Roesdahl ELSE
- Rowley-conwy PETER
- Ryding OTTO
- Rønne PREBEN
- Sawyer BIRGIT
- Sawyer BIRGIT
- Sawyer BIRGIT
- Sawyer PETER H.
- Sawyer PETER H.
- Sawyer PETER H.
- Sawyer PETER H.
- Schietzel KURT
- Schietzel KURT
- Schovsbo PER OLE
- Schulze MECHTHILD
- Sellevold BERIT JANSEN
- Skaarup JØRGEN
- Skovgaard-petersen INGE
- Skovgaard-petersen INGE
- Steensberg AXEL
- Stilling NIELS PETER
- Stjernquist BERTA
- Stjernquist BERTA
- Stoklund MARIE
- Stoumann INGRID
- Straume ELDRID
- Strömberg MÄRTA
- Strömberg MÄRTA
- Sørensen JOHN KOUSGÁRD
- Sørensen JOHN KOUSGÁRD
- Sørensen JOHN KOUSGÁRD
- Thomsen PER O.
- Thomsen PER O.
- Thorvildsen ELISE
- Thrane HENRIK
- Thrane HENRIK
- Tornbjerg SVEND ÅGE
- Ulbricht INGRID
- vej. Kumll 976
- Verhulst ADRIAN
- Vierck HATO
- Vierck HATO
- Voss OLFERT
- Wagner PETER
- Waterbolk H. T.
- Watt MARGRETHE
- Watt MARGRETHE
- Watt MARGRETHE
- Weibull CURT
- Weibull CURT
- Welch MARTIN B.
- Wenskus REINHARD
- Widgren MATS
- Willroth KARL-HEINZ
- Wilson DAVID M.
- Wolfram HERWIG
- Wood IAN
- Wormald C. PATRICK
- Zak JAN
- Zimmermann W. HAIO
- ørsnes MOGENS
- ørsnes MOGENS
- ørsnes MOGENS
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Prospective observational cohort study on grading the severity of postoperative complications in global surgery research
- Author
- Abayasinghe Chamika
- Abbas Muntadhar
- Abbott T. E. F.
- Abbott Tom
- Abdullah Noor Hairiza
- Abdur-Rahman Lukman
- Abeloos Jacques
- Abernethy Caroline
- Abidin Ucu Nurhadiat
- Abrunhosa Alexandra
- Absar Mohammed
- Adam Suwayba
- Adams George
- Adamson Michael
- Adekola Oyebola
- Adelaja Yemi
- Ademola Adeyinka
- Adenekan Anthony
- Adenike Odewabi
- Adeolu Augustine A
- Adetoye Adedapo
- Adewale Badru
- Adigun Tinuola
- Adolfsson Anne
- Aflori Laura
- Africander Cucu
- Afshari Arash
- Agarwal Vandana
- Agodirin Olayide
- Aguzzoli Crisitiano
- Ahmad Abdurrahman
- Ahmad Norfaizan
- Ahmad T.
- Ahmad Tahania
- Ahmad Yousra
- Ahmed Ahmed
- Ahmed Jamil
- Ahmed Tahania
- Ai Yanqiu
- Aignatoaie Mariana
- Aimoniotou-Georgiou Eleni
- Akanmu Olanrewaju
- Akerman Nik
- Akinwale Mukaila
- Al Amri Khalid
- Al Hussaini Sabah
- Al-Soudaine Yassr
- Aladin Hafiz
- Alagbe-Briggs Olubusola
- Albaj Safauldeensalem
- Alcock David
- Alcock Liam
- Aldecoa Cesar
- Aldecoa Cesar
- Aleixo Fábia Berganton
- Alexander Hazel
- Alexander Maini
- Alexander-Sefre Farhad
- Alherz Fadhel
- Ali Hani
- Ali Marlynn
- Ali Sarah
- Alias Abdul Hafiz
- Alias Anita
- Alias Raja Liza Raja
- Allen Samantha
- Allen Sara Jane
- Allison Joanna
- Alloj Chiara
- Allorto Nikki Leigh
- Allsop Joanne
- Almeida William
- Alonso Eduardo
- Alonso José Ignacio
- Alphonsus Christella
- Alvares Danielle
- Alves Maria Joao
- Amador Juan Carlos Bravo
- Ameer Yusuf
- Amendola Cristina Prata
- Ami Noam
- Amstrup-Hansen Louise
- Anagnou Athina
- Andersen Cheme
- Anderson Charlotte
- Anderson Colette
- Anderson Frank
- Anderson Philip
- Andreadaki Evangelia
- Andreou Alexandros
- Andreou Prematie
- Andrew Alyson
- Andrews Emma
- Angel Miguel Paludi
- Angermair Stefan
- Angus Kirsty
- Anillo Victor
- Anizi Mashel Al
- Antal Oana
- Antill Philip
- Antoniadou Eleni
- Apagaki Eymorfia
- Apostolou Konstantinos
- Applewhaite Christopher
- Applewhaite Christopher
- Aquino Laura Patricia González
- Ar Praburaj
- Araujo Daniela Marques
- Arawwawala Dilshan
- Ardern Diane
- Argue Ruth
- Aribawa Mahaalit Alit
- Arkalaki Eleni
- Armaganidis Apostolos
- Armstrong John
- Armstrong Richard
- Arnaoutoglou Christina
- Arnaoutoglou Elena
- Arnold Glenn
- Arrandale Lindsay
- Arrich James
- Arrigo Mario
- Arshad Homa
- Arshad Mohammed Asif
- Artiles Tania Socorro
- Arumugam Swarna
- Arustei Mirela
- Arvaniti Kostoula
- Arvaniti Kostoula
- Arya Aryabiantara
- Arya Shobhit
- Asimakos Andreas
- Aslam M
- Asudo Felicia
- Athanasakis Elias
- Atiku Mamuda
- Attrill Elizabeth
- Attwood Clare
- Auer Patrick
- Avidan Michael
- Avila Erendira Jocelin Dominguez
- Avis Joanne
- Awad Hadi
- Axioti Elena
- Azam Ummi Azmira Ahmad
- Azambuja Pedro
- Azevedo Caroline
- Aziz Faizal Zuhri
- Baas Peter
- Baghirzada Leyla
- Bai Hui-Ping
- Baillie Shelley
- Baines Duncan
- Baio Thalissa Hermínia
- Bairaktari Aggeliki
- Baker Gerard
- Baker Katie-Anne
- Baker Paul
- Balain Birender
- Balajonda Naraida
- Balanescu Andreea
- Balasubramaniam Madhu
- Baldisserotto Sérgio
- Baldwin Jacqueline
- Baldwin Matthew
- Balfoussia Danai
- Bali Christina
- Bandeira Maria Expedito
- Banerjee Robin
- Bankewitz Carla
- Banner-Goodspeed Valerie
- Bao Qi
- Barcraft-Barnes Helena
- Barneto Lisa
- Barnett Andrew
- Barraclough James
- Barras Jean-Pierre
- Barrett Stephen
- Barrett Wendy Joan
- Basanth Sujith
- Batchelor Nick
- Bateman Brian
- Bates Alexander
- Bates Sarah
- Batista Hugo Dias
- Bauchmuller Kris
- Bauer Marlene
- Baumgarten Georg
- Baxter Linden
- Beaton Ceri
- Beattie Scott
- Beattie Scott
- Beattie Scott
- Beavis Vanessa
- Beavis Vanessa
- Bechan Sudha
- Beer Johan
- Bejia Tarek
- Belciu Ioana
- Belda Margarita Tormo
- Bell Gillian
- Bell Rachel
- Bell Rachel
- Bell Stephanie
- Bellandi Mattia
- Bello Jibril
- Beloeil Helene
- Belskiy Vladislav
- Beltran Anna Valle
- Ben-Menachem Erez
- Benavent Pau
- Benevento Angelo
- Bengeri Sheshagiri
- Bennett Cambell
- Bennett Michael
- Bennett Rachael
- Bennett Victoria
- Bentley Conor
- Beretta Luigi
- Berg Andrew
- Berg Bianca
- Bergin Colin
- Bernard Andre
- Bernard Andre
- Bernard Andre
- Bernat Maria Jose
- Berntsen Emer
- Berntsen Emer
- Bertram Wendy
- Bester Delia
- Bester Marlet
- Bettega Fernanda
- Bettinelli Alessandra
- Bhardwaj Neeraj
- Bhatia Kailash
- Bhula Chettan
- Bi Yanbing
- Biais M.
- Biais Matthieu
- Biais Matthieu
- Biccard Bruce
- Biccard Bruce M
- Bidd Heena
- Bidd Heena
- Bidgoli Jawad
- Biffen Andrew
- Bignami Elena
- Bilolikar Anjali
- Birch Julie
- Bishop David Gray
- Biyase Thuli
- Bizios Christol
- Blackwell Clare
- Blackwood Douglas
- Blaj Mihaela
- Blakemore Stephen P
- Bland Martin
- Blunt Mark
- Blyth Katharine
- Bocchino Speranza
- Bodansky Daniella
- Bodger Phoebe
- Boer Christa
- Boer Hans Donald
- Boereboom Catherine
- Boggiano Victoria
- Bokkel-Andela Janneke
- Bolaji Benjamin
- Bolton David
- Boone Myles
- Boschi Luca
- Boshier Piers
- Botes Marisa
- Botis Ioannis
- Bottini Corrado
- Bottrill Fiona
- Bouchez Stefaan
- Boulton Kerenza
- Bouris Vasilios
- Bourner Lynsey
- Boutsikos Georgios
- Bouwman Arthur
- Bouwman Arthur
- Bowrey Sarah
- Boxall Leigh
- Boyd Christine
- Bradburn Mike
- Bradburn Mike
- Bradley Jacqueline
- Branagan Graham
- Branco Teresa
- Brand Bastiaan
- Brandsborg Birgitte
- Breitenstein Stefan
- Brennan Andrew
- Brennan Emma
- Brenner Laura
- Brincat Maximilian
- Briscoe Richard
- Bristogiannis Sotirios
- Brooke Jenny
- Brookes Jamie
- Brookes Morag
- Brooks Carolyn
- Broomby Rupert
- Brotto Ana Flavia
- Brown Andrew
- Brown Caroline Wrey
- Brown Gemma
- Brown Jamie
- Brown Janette
- Brown Lynne
- Brown Richard
- Brown Robyn
- Browning Julie
- Bruma Dana
- Brunete Tamara
- Brunswicker Annemarie
- Bryant Helen
- Bua Emmanuel
- Buccimazza Ines
- Buckley Sarah
- Buerkle Christian
- Buhre Wolfgang
- Buhre Wolfgang
- Builu Pierre Monji
- Buise Marc
- Bullock Clare
- Bunwarie Bimalshakth
- Burns Karen
- Burrows Lorna
- Burrows Tom
- Burston Ben
- Burtenshaw Andrew
- Burton Megan
- Busuioc Mihai
- Butryn Izabella
- Butt Georgina
- Byrne Kelly
- Bührer Thomas
- Cabezuelo Estefania
- Cabral Raquel
- Cabrini Luca
- Cacala Sharon
- Cai Fang
- Cai Yunfei
- Cain Helen
- Cairns Carel
- Cakova Veronika
- Calderwood Claire
- Callaghan Mark
- Campbell Debbie
- Campbell Doug
- Campbell Doug
- Campbell Douglas
- Campbell Gill
- Campbell Graham
- Campbell Kathleen
- Campbell Marta
- Campbell Tara
- Campey Lorraine
- Campos Ferreira Mariana Fosch
- Camsooksai Julie
- Cancho David
- Candido Keulle
- Cang Jing
- Cannavo Maurizio
- Cao Jianqiao
- Cao Ying
- Cao Zhongming
- Cardellino Silvano
- Cardosa Jorge
- Cardoso Gutemberg
- Cardy Jon
- Carmino Livio
- Carp Cristina Paula
- Carr Adrienne
- Carrera Ronald
- Carroll Christine
- Carroll Jo
- Caser Eliana
- Castaño Beatriz
- Castle Gail
- Castro Gabriel Isaac Pereira
- Cavanagh Sarah
- Cawthorn Louise
- Cernea Daniela Denisa
- Chaddock Mark
- Chaloulis Panagiotis
- Chan Alexander
- Chan Hey Man Heymans
- Chan Mathew
- Chan Matthew
- Chan Matthew
- Chan Peter
- Chan Vincent
- Chan Wai Kit Jacky
- Chan Weng Ken
- Chan Yik Lam
- Chande Shiv
- Chandler Ben
- Chandra Susilo
- Chandra Susilo
- Chandrasekharan Shardha
- Chang Yuan Hsuan
- Chaniotaki Fotini
- Charitos Efthimios
- Charlalampidoy Alexandra
- Charles Rob
- Chatterjee Devnandan
- Chatterjee Jayanta
- Chatzimichali Aikaterini
- Chau Simon
- Chazova Elena
- Cheah Clarissa
- Cheah Seleen
- Cheeseman Michelle
- Cheing Yushio
- Chen Chao
- Chen Chen
- Chen Feifei
- Chen Fumei
- Chen Hong
- Chen James
- Chen Junping
- Chen Lee-lynn
- Chen Lee-lynn
- Chen Linbi
- Chen Liyong
- Chen Pushan
- Chen Qiang
- Chen Rong
- Chen Shasha
- Chen Shiyu
- Chen Sijia
- Chen Yaqiu
- Chen Yijiao
- Chen Yijun
- Chen Yongjie
- Chen Zhang
- Cheng Baoli
- Cheng Ka Ho
- Cherian Ritchie
- Cherrett Veronica
- Chetty Rubendraj R
- Chew Michelle
- Chew Michelle
- Chhabra Ashok
- Chicken Dennis-Wayne
- Chilinciuc Ion
- Chin Im Im
- Chirkut Subash
- Chlorou Dimitra
- Choi Hyun-min David
- Choi Stephen
- Chow Lorraine
- Christian Rachel
- Christiansen Ida Cecilie
- Christmas Natasha
- Christodoulidis Gregory
- Christodoulopoulou Theodora
- Christofaki Maria
- Christoforidis Dimitri
- Chronis Christos
- Chu Hiu Man
- Chu Susanna
- Chua Pandora
- Chukkambotla Srikanth
- Chung Chun Kwong Eric
- Cifra Elna
- Ciobanu Cristina
- Ciobotaru Oana Roxana
- Cirstea Emanuel
- Clark Richard
- Clarkson Aisling
- Clavien Pierre-Alain
- Claxton Andrew
- Clemmons Karen
- Cloro Luigi Maria
- Clyde Antony
- Cobzaru Isabelle
- Codita Anisoara
- Colangelo Antonio
- Colangelo Chiara
- Colling Kerry
- Collins Michelle
- Collins Nwokoro
- Colvin Carolyn
- Commey Thelma
- Comptaer Nicolas
- Conceição Soares Maria
- Conde Carlos
- Conradie Alae
- Constantin Kathryn
- Cook Tim
- Cooper Lauren
- Cooper Lucy
- Cooper Mariese
- Cooper Richard
- Cooper Sarah
- Copaciu Elena
- Cope Jennifer
- Copley Edward
- Copotoiu Sanda Maria
- Coppens Marc
- Corneci Dan
- Cornell Jonathan
- Cornish Julie
- Corti Daniele
- Costa Fischer Bruna Ferreira
- Costa Ana Cristina Miranda Martins
- Costanzo Eleonora
- Costelloe Hannah
- Cotter Rochelle
- Cotterell Sharon
- Cotterill Donna
- Coughlan Elaine
- Coulter Ian
- Coulter Suzanne
- Coutinho Francisco
- Cowton Amanda
- Cox Hannah
- Cozar Octavian Ionut
- Craig Jayne
- Craven Rachael
- Craw Nicholas
- Craw Sarah
- Creary Thais
- Cripps Heather
- Critchley Rebecca
- Cronje Larissa
- Cruickshank Ross
- Cruikshanks Andrew
- Cruz Salome
- Cuenca Vicente Chisbert
- Cueva Andreu
- Cunha Pedro
- Currow Helen
- Currow Helen
- Czepanski Carolyn
- Czeslick Elke
- Cádiz Maria José Hernández
- D'Andrea Rocco
- Dafnios Nikolaos
- Dai Qingqing
- Dai Qinxue
- Dai Si Yuan
- Daikou Panagoula
- Dalamagka Maria
- Dalampini Eleftheria
- Dali-Kemmery Lola
- Dalton Emma
- Damant Rose
- Daniel Conway
- Daniel Gayatri Daniel
- Daniel Harvey
- Daniel Hull
- Daniel Sonya
- Darko Julia
- Darwish Sharif
- Das Suparna
- Dasrath Ashish
- Datson Amanda
- Daubeny Thomas
- Daugaard Morten
- Davari Maria
- Dave Tejal
- Davies Charlotte
- Davies Helen
- Davies Keith
- Davies Kirsty
- Davies Leigh
- Davies Zoe
- Davis Edward
- Davis Fiona
- Davis Simon
- Daya Bhavika
- De Andres Jose
- De Baerdemaeker Luc
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- Delgado García David R
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- Zettergren Jan
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- Zhang Weiwei
- Zhang Xiaoguang
- Zhang Xiaolin
- Zhang Xiaoyan
- Zhang Yan
- Zhang Yapping
- Zhang Ye
- Zhang Yuan
- Zhao Bing
- Zhao Bo
- Zhao Chong
- Zhao Jiashi
- Zhao Jinning
- Zhao Lei
- Zhao Shuna
- Zhao Ting
- Zhao Weihong
- Zhao Weilu
- Zhao Xiaoying
- Zhen Jungang
- Zheng Kang
- Zheng Lina
- Zheng Tianzhao
- Zhong Yi
- Zhou Ce
- Zhou Dachun
- Zhou Haidong
- Zhou Haiyan
- Zhou Jiali
- Zhou Jialong
- Zhou Jing
- Zhou Xian-jin
- Zhu Xiaomao
- Zhu Yi
- Zhu Zhipeng
- Zhuang Xiuxiu
- Zilis Georgios
- Zin Nor Hafizah Mohd
- Zingerle Nicolette
- Zingg Urs
- Zoerner Frank
- Zonneveldt Harry
- Zou Xiaohua
- Zoulamoglou Menelaos
- Zsisku Lajos
- Zundert Tom
- Zyl Rebekka
- åkring Irene
- Ögren Katrin
- Publication venue
- 'Wiley'
- Publication date
- 22/10/2018
- Field of study
Background
The Clavien–Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien–Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).
Methods
This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien–Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs.
Results
A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien–Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59).
Conclusion
Caution is recommended when using a treatment approach to grade complications in global surgery studies, as this may introduce bias unintentionally