Business model configuration and dynamics for technology commercialization in mature markets.

Purpose The food industry is a well-established and complex industry. New entrants attempting to penetrate it via the commercialization of a new technological innovation could face high uncertainty and constraints. The capability to innovate through collaboration and to identify suitable strategies and innovative business models (BMs) can be particularly important for bringing a technological innovation to this market. However, although the potential for these capabilities has been advocated, we still lack a complete understanding of how new ventures could support the technology commercialization process via the development of BMs. The paper aims to discuss these issues. Design/methodology/approach To address this gap, this paper builds a conceptual framework that knits together the different bodies of extant literature (i.e. entrepreneurship, strategy and innovation) to analyze the BM innovation processes associated with the exploitation of emerging technologies; determines the suitability of the framework using data from the exploratory case study of IT IS 3D – a firm which has started to exploit 3D printing in the food industry; and improves the initial conceptual framework with the findings that emerged in the case study. Findings From this analysis it emerged that: companies could use more than one BM at a time; hence, BM innovation processes could co-exist and be run in parallel; the facing of high uncertainty might lead firms to choose a closed and/or a familiar BM, while explorative strategies could be pursued with open BMs; significant changes in strategies during the technology commercialization process are not necessarily reflected in a radical change in the BM; and firms could deliberately adopt interim strategies and BMs as means to identify the more suitable ones to reach the market. Originality/value This case study illustrates how firms could innovate the processes of their BM development to face the uncertainties linked with the entry into a mature and highly conservative industry (food)

Business model configuration and dynamics for technology commercialization in mature markets

Purpose: The food industry is a well-established and complex industry. New entrants attempting to penetrate it via the commercialization of a new technological innovation could face high uncertainty and constraints. The capability to innovate through collaboration and to identify suitable strategies and innovative business models can be particularly important for bringing a technological innovation to this market. However, although the potential for these capabilities has been advocated, we still lack a complete understanding of how new ventures could support the technology commercialization process via the development of business models. Design/methodology/approach: To address this gap, this paper 1) builds a conceptual framework that knits together the different bodies of extant literature (i.e. entrepreneurship, strategy and innovation) to analyse the business model innovation processes associated with the exploitation of emerging technologies; 2) determines the suitability of the framework using data from the exploratory case study of ISIT3D - a firm which has started to exploit 3D printing in the food industry; 3) improves the initial conceptual framework with the findings that emerged in the case study. Findings: From this analysis it emerged that: 1) companies could use more than one BM at a time; hence, BM innovation processes could coexist and be run in parallel; 2) the facing of high uncertainty might lead firms to choose a closed and/or a familiar business model, while explorative strategies could be pursued with open business models; 3) significant changes in strategies during the technology commercialisation process are not necessarily reflected in a radical change in the business model and 4) firms could deliberately adopt interim strategies and BMs as means to identify the more suitable ones to reach the market. Originality/value: This case study illustrates how firms could innovate the processes of their BM development to face the uncertainties linked with the entry into a mature and highly conservative industry (food).This research work was supported by the Roma Tre Scholarship and the “Bit by bit: Capturing the value from the digital fabrication revolution” project, funded by the UK Engineering and Physical Science Research Council (EPSRC) and Economic and Social Research Council (ESRC) (Ref. EP/K039598/1)

Alpine gullies system evolution : erosion drivers and control factors. Two examples from the western Italian Alps

Denudation processes affecting mountain slopes may vary according to different factors (e.g., lithology and structural setting of bedrock, climate, relief features), which may be very diverse at the local scale. Gully complex systems, characterised by morphological features similar to those developing in other climate contexts (i.e., pseudo-badlands) are also becoming common at higher altitudes and latitudes. The selected study cases of Gran Gorgia (Susa Valley) and Saint Nicolas (Aosta Valley), in the Western Italian Alps, are sites of geomorphological interest as they are specifically relevant for their scientific features. The aims of this work are (i) reconstructing the morphometric evolution of gully systems and vegetation colonisation time by means of multitemporal spatial analysis on surface morphological changes under water erosion; (ii) reconstructing in detail, through dendrogeomorphological analysis, the progressive spatial surface denudation and changes in erosion rates, by analysing trees and exposed roots and using different indicators (i.e., compression wood, traumatic resin ducts); (iii) obtaining data on successive aggradation/degradation episodes along slopes surrounding such hotspots through geopedological investigations; and (iv) identifying which control factors exert a predominant role on denudation patterns in such contexts. Multidisciplinary analyses regarding the study sites allowed for detailing of erosional history of the studied slopes detecting the prevailing drivers of their evolution. According to the results and considering the common climate and bedrock conditions, the structural background seems to have more influence on slope evolution at the Saint Nicolas site, while superficial geomorphic processes seem to be more relevant at the Gran Gorgia site. Because the sites have already been recognised as part of geoheritage by local authorities, the data obtained in the present research on their genesis, evolution, and local drivers affecting the rates of denudation (i.e., scientific relevance of the site) suggests that description of the sites for dissemination purposes should include links to the entire slope history

Effect of combination therapy of hydroxychloroquine and azithromycin on mortality in patients with COVID-19

Conflicting evidence regarding the use of hydroxychloroquine (HCQ) and azithromycin for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection do exist. We performed a retrospective single-center cohort study including 377 consecutive patients admitted for pneumonia related to coronavirus disease 2019 (COVID-19). Of these, 297 were in combination treatment, 17 were on HCQ alone, and 63 did not receive either of these 2 drugs because of contraindications. The primary end point was in-hospital death. Mean age was 71.8 ± 13.4 years and 34.2% were women. We recorded 146 deaths: 35 in no treatment, 7 in HCQ treatment group, and 102 in HCQ + azithromycin treatment group (log rank test for Kaplan–Meier curve P < 0.001). At multivariable Cox proportional hazard regression analysis, age (hazard ratio (HR) 1.057, 95% confidence interval (CI) 1.035–1.079, P < 0.001), mechanical ventilation/continuous positive airway pressure (HR 2.726, 95% CI 1.823–4.074, P < 0.001), and C reactive protein above the median (HR 2.191, 95% CI 1.479–3.246, P < 0.001) were directly associated with death, whereas use of HCQ + azithromycin (vs. no treatment; HR 0.265, 95% CI 0.171–0.412, P < 0.001) was inversely associated. In this study, we found a reduced in-hospital mortality in patients treated with a combination of HCQ and azithromycin after adjustment for comorbidities. A large randomized trial is necessary to confirm these findings

Production of crystallizable human chymase from a Bacillus subtilis system

AbstractA Bacillus subtilis strain deficient in seven extracellular proteases was used to produce human mast cell chymase and is a viable expression system for serine proteases and other classes of proteins. Chymase is produced at 0.3–0.5 mg/l and is purified by three chromatography steps. Two crystal forms of PMSF-treated chymase were optimized. The first is C2 with a=47.94 Å, b=85.23 Å, c=174.18 Å, β=96.74°, and diffracts to at least 2.1 Å, while the second is P212121, with cell dimensions a=43.93 Å, b=58.16 Å, and c=86.09 Å, and a diffraction limit of approximately 1.9 Å. The first crystal form has either three or four molecules/asymmetric unit, while the second has one molecule/asymmetric unit

Reduced resting-state functional connectivity of the somatosensory cortex predicts psychopathological symptoms in women with bulimia nervosa.

Background: Alterations in the resting-state functional connectivity (rs-FC) of several brain networks have been demonstrated in eating disorders. However, very few studies are currently available on brain network dysfunctions in bulimia nervosa (BN). The somatosensory network is central in processing body-related stimuli and it may be altered in BN. The present study therefore aimed to investigate rs-FC in the somatosensory network in bulimic women. Methods: Sixteen medication-free women with BN (age = 23 ± 5 years) and 18 matched controls (age = 23 ± 3 years) underwent a functional magnetic resonance resting-state scan and assessment of eating disorder symptoms. Within-network and seed-based functional connectivity analyses were conducted to assess rs-FC within the somatosensory network and to other areas of the brain. Results: Bulimia nervosa patients showed a decreased rs-FC both within the somatosensory network (t = 9.0, df = 1, P = 0.005) and with posterior cingulate cortex and two visual areas (the right middle occipital gyrus and the right cuneus) (P = 0.05 corrected for multiple comparison). The rs-FC of the left paracentral lobule with the right middle occipital gyrus correlated with psychopathology measures like bulimia (r = −0.4; P = 0.02) and interoceptive awareness (r = −0.4; P = 0.01). Analyses were conducted using age, BMI (body mass index), and depressive symptoms as covariates. Conclusion: Our findings show a specific alteration of the rs-FC of the somatosensory cortex in BN patients, which correlates with eating disorder symptoms. The region in the right middle occipital gyrus is implicated in body processing and is known as extrastriate body area (EBA). The connectivity between the somatosensory cortex and the EBA might be related to dysfunctions in body image processing. The results should be considered preliminary due to the small sample size

Bridging Geometry and Semantics for Object Manipulation and Grasping

In this paper, we present our on-going work towards grasping in an object manipulation context. Our proposal is a novel method that combines a tubular feature classification algorithm, a hand grasp posture generation algorithm and an animation framework for human-object interactions. This method works on objects with tubular or elongated parts, and accepts a number of parameter inputs to control the grasp posture