Challenges Associated with Implementing an Education Program in a Residential Aged Care Setting

The link between independence and well-being of older people in residential care is well established. This paper reports some challenges encountered during implementation of an education program designed to assist nursing staff to adopt an independence-supporting model of residential care. The education program was part of a larger project aimed at developing an example of best practice in supported care which promotes independence, well-being and community linkages. Implementation of the program created many interesting challenges which were overcome by strategies and facilitating forces such as support from management and some staff, and the collaborative nature of the project. Positive outcomes of the education program included increased awareness of, and change in, practice; increased staff-resident interaction; and increased encouragement for residents to be independent and to engage with the wider community. Moreover, a facilitator manual - Promoting Independence: A Learning Resource for Aged Care Workers was subsequently developed so that the program can be implemented in aged care facilities elsewhere

Alien Registration- Morrison, Helen P. (Bradford, Penobscot County)

https://digitalmaine.com/alien_docs/10276/thumbnail.jp

Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal

Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC expansion and behaviour. In this study, we determined whether alterations in the BMP pathway gene signature had any predictive value for therapeutic response by profiling 60 CML samples at diagnosis from the UK SPIRIT2 trial and correlating the data to treatment response using the 18-month follow-up data. There was significant deregulation of several genes involved in the BMP pathway with ACV1C, INHBA, SMAD7, SNAIL1 and SMURF2 showing differential expression in relation to response. Therapeutic targeting of CML cells using BMP receptor inhibitors, in combination with tyrosine kinase inhibitor (TKI), indicate a synergistic mode of action. Furthermore, dual treatment resulted in altered cell cycle gene transcription and irreversible cell cycle arrest, along with increased apoptosis compared to single agents. Targeting CML CD34+ cells with BMP receptor inhibitors resulted in fewer cell divisions, reduced numbers of CD34+ cells and colony formation when compared to normal donor CD34+ cells, both in the presence and absence of BMP4. In an induced pluripotent stem cell (iPSC) model generated from CD34+ hematopoietic cells, we demonstrate altered cell cycle profiles and dynamics of ALK expression in CML-iPSCs in the presence and absence of BMP4 stimulation, when compared to normal iPSC. Moreover, dual targeting with TKI and BMP inhibitor prevented the self-renewal of CML-iPSC and increased meso-endodermal differentiation. These findings indicate that transformed stem cells may be more reliant on BMP signalling than normal stem cells. These changes offer a therapeutic window in CML, with intervention using BMP inhibitors in combination with TKI having the potential to target LSC self-renewal and improve long-term outcome for patients

Community Nurse Workforce Planning Project

The purpose of this project was to explore the potential for developing a flexible and innovative approach to community workforce planning that took account of the synergies between community health needs and the expertise and skill sets of community nurses. Workshops were held with community nurses in three localities within NHS Highland in 2010 and at the beginning of 2011. Information that emerged from the workshops provided a picture of the responsibilities and activities that community nurses are engaged in, as well as some of the challenges of delivering a service across the diverse localities in NHS Highland. In May 2011 a wider stakeholder workshop was held, facilitated by one of the NMSH CHP general managers. The workshop considered the findings of the project to date, and proposed some changes. These changes were incorporated into the final report

Harnessing Technology Schools Survey 2009: data report - part 2, data analysis

This document sets out the details of the sampling processes and the methodology of the 2009 Schools Survey and the choices made in organising the analysis

Harnessing Technology Schools Survey 2009: analysis report

The Harnessing Technology schools survey (HTSS) report presents the key survey findings from the academic year 2008-09 set out according to the five system outcomes against which impact of the strategy was measured. The HTSS was an annual national survey of ICT in primary, secondary and special schools. (The data report that accompanied this analysis provides further details of the sample and the characteristics of respondents and is listed separately.

Harnessing Technology Schools Survey 2009: data report – part 1, descriptive analysis

This document, the data report, is a reference document which presents the data in tabular form for anyone who wants to examine the findings of the Harnessing Technology Schools Survey (HTSS) in depth, for example in relation to specific areas of technology or policy, or by school sector. The findings for each question are also set out by school sector by primary, secondary and special school sub-samples

The Forensic Evaluation and Treatment

This article will review the history of ethics and values in the forensic evaluations and treatment of children. Topics to be discussed include paternalism, advocacy, parental responsibility, and legal doctrine of parens patriae. Various aspects of the treatment of children, including medications, behavior modification, and psychotherapy, are also examined for ethical considerations. Agency consultation in conflicts of ethics that are associated with public laws are also addressed. The ethical implications of the use of children in any research as research subjects is also addressed